Skip to main content

Genetic and Environmental Influences on Migraine: A Twin Study Across Six Countries

  • Elles J. Mulder (a1), Caroline van Baal (a2), David Gaist (a3), Mikko Kallela (a4), Jaakko Kaprio (a5), Dan A. Svensson (a6), Dale R. Nyholt (a7), Nicholas G. Martin (a8), Alex J. MacGregor (a9), Lynn F. Cherkas (a10), Dorret I. Boomsma (a11) and Aarno Palotie (a12)...

Migraine is a common neurovascular brain disorder that is manifested in recurrent episodes of disabling headache. The aim of the present study was to compare the prevalence and heritability of migraine across six of the countries that participate in GenomEUtwin project including a total number of 29,717 twin pairs. Migraine was assessed by questionnaires that differed between most countries. It was most prevalent in Danish and Dutch females (32% and 34%, respectively), whereas the lowest prevalence was found in the younger and older Finnish cohorts (13% and 10%, respectively). The estimated genetic variance (heritability) was significant and the same between sexes in all countries. Heritability ranged from 34% to 57%, with lowest estimates in Australia, and highest estimates in the older cohort of Finland, the Netherlands, and Denmark. There was some indication that part of the genetic variance was non-additive, but this was significant in Sweden only. In addition to genetic factors, environmental effects that are non-shared between members of a twin pair contributed to the liability of migraine. After migraine definitions are homogenized among the participating countries, the GenomEUtwin project will provide a powerful resource to identify the genes involved in migraine.

Corresponding author
*Address for correspondence: Elles J. Mulder, Dept of Biological Psychology, FPP, Vrije Universiteit. Van der Boechorststraat 1, Room 1F-58, 1081 BT, Amsterdam, the Netherlands.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Twin Research and Human Genetics
  • ISSN: 1832-4274
  • EISSN: 1839-2628
  • URL: /core/journals/twin-research-and-human-genetics
Please enter your name
Please enter a valid email address
Who would you like to send this to? *


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed