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Perinatal Outcomes in Preterm Growth-Restricted Twins: Effects of Gestational Age and Fetal Condition

  • Sebastián Manzanares (a1), Mar Sanchez-Gila (a1), María D. Moreno-Martinez (a1), Alejandro Ramirez-Arredondo (a2) and Alicia Pineda (a1)...


Objective: To evaluate the perinatal outcome of intrauterine growth-restricted preterm twins and contribution of prematurity to morbidity and mortality. Study design: A case–control study of 211 preterm twins: 108 growth-restricted twins matched with 103 normal growth twins of the same gestational age. Mortality and morbidity rates were compared between groups. Result: Fetal and overall perinatal mortality rates of growth-restricted fetuses were higher than normal growth ones. Respiratory distress syndrome incidence was lower and neurologic sequelae incidence higher in growth-restricted twins. No differences were observed between groups with respect to neonatal mortality, low Apgar score, neonatal intensive care unit admission, periventricular hemorrhage, sepsis, jaundice, and hematologic or metabolic disorders. Conclusion: Adverse perinatal outcomes of preterm twins complicated with intrauterine growth restriction are represented by a higher antepartum mortality rate, but once born alive, neonatal outcomes seem to be associated only with gestational age at birth, excluding a protective effect on lung maturation and a higher risk of long-term neurologic sequelae.

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Corresponding author

address for correspondence: Sebastián Manzanares, Obstetrics and Gynecology Department, Virgen de las Nieves University Hospital, Fuerzas Armadas Av. 18014, Granada, Spain. E-mail:


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Twin Research and Human Genetics
  • ISSN: 1832-4274
  • EISSN: 1839-2628
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