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Host immune responses and vaccination against avian pathogenic Escherichia coli

  • T. AZEEM (a1), S.A. ABID (a1), W. AHMAD (a1), A. ASLAM (a1), M.L. SOHAIL (a2), S. JALEEL (a3) and S. UMAR (a4) (a5)...
Abstract

Avian pathogenic Escherichia coli (APEC) is one of the most economically damaging diseases affecting the poultry industry. This group of extra-intestinal E. coli causes a variety of clinical conditions including air-sacculitis and cellulitis. The economic impact of APEC is mainly due to mortality, slower growth rates and carcass downgrading. In commercial broiler operations, APEC infections are controlled indirectly by vaccination against other respiratory diseases and minimising stress conditions, and directly by administration of antimicrobial agents to suppress symptoms in infected flocks. Several studies have demonstrated that the most common virulence factors studied in APEC are rarely present in the same isolate, showing that APEC strains constitute a heterogeneous group. Different isolates may harbour different associations of virulence factors, each able to induce colibacillosis. Despite its economical relevance, the pathogenesis of colibacillosis is poorly understood. The O antigen, a component of the surface lipopolysaccharide, has been identified as a promising vaccine target. With the availability of a novel bioconjugation technology it is expected that multivalent O antigen conjugate vaccines can be produced on an industrial scale. Despite the potential for developing an efficacious vaccine to combat this economically important poultry disease, several obstacles hinder such efforts. These include cost, vaccine delivery method and timing of vaccination. The present discusses current knowledge on APEC virulence, host response to infection and various attempts to develop an effective vaccine

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Corresponding author: salmanhashmi313@yahoo.com
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L. ARP (1980) Consequences of active or passive immunisation of turkeys against Escherichia coli O78. Avian Diseases 24: 808-815.

N. BERTRAND , S. HOULE , G. LEBIHAN , É. POIRIER , C.M. DOZOIS and J. HAREL (2010) Increased pho regulon activation correlates with decreased virulence of an avian pathogenic Escherichia coli O78 strain. Infection and immunity 78: 5324-5331.

M. CAZA , F. LÉPINE , S. MILOT and C. M. DOZOIS (2008) Specific roles of the irobcden genes in virulence of an avian pathogenic Escherichia coli O78 strain and in production of salmochelins. Infection and Immunity 76: 3539-3549.

I. CHOUIKHA , P. GERMON , A. BRÉE , P. GILOT , M. MOULIN-SCHOULEUR and C. SCHOULER (2006) A selc-associated genomic island of the extraintestinal avian pathogenic escherichia coli strain ben2908 is involved in carbohydrate uptake and virulence. Journal of Bacteriology 188: 977-987.

J.B. DE PAIVA , J.L. LEITE , L.P.M. DA SILVA , T.C.G. ROJAS , F. DE PACE , R.A. CONCEIÇÃO , V. SPERANDIO and W.D. DA SILVEIRA (2015) Influence of the major nitrite transporter nirc on the virulence of a swollen head syndrome avian pathogenic E. coli (apec) strain. Veterinary Microbiology 175: 123-131.

C.M. DOZOIS , M. DHO-MOULIN , A. BRÉE , J. M. FAIRBROTHER , C. DESAUTELS and R. CURTISS (2000) Relationship between the tsh autotransporter and pathogenicity of avian Escherichia coli and localisation and analysis of the tsh genetic region. Infection and Immunity 68: 4145-4154.

F. DZIVA , H. HAUSER , T.R. CONNOR , P.M. VAN DIEMEN , G. PRESCOTT , G.C. LANGRIDGE , S. ECKERT , R.R. CHAUDHURI , C. EWERS and M. MELLATA (2013) Sequencing and functional annotation of avian pathogenic escherichia coli serogroup O78 strains reveal the evolution of E.coli lineages pathogenic for poultry via distinct mechanisms. Infection and Immunity 81: 838-849.

F. DZIVA and M.P. STEVENS (2008) Colibacillosis in poultry: Unravelling the molecular basis of virulence of avian pathogenic Escherichia coli in their natural hosts. Avian Pathology 37: 355-366.

C. EWERS , E.-M. ANTÃO , I. DIEHL , H.-C. PHILIPP and L.H. WIELER (2009) Intestine and environment of the chicken as reservoirs for extraintestinal pathogenic Escherichia coli strains with zoonotic potential. Applied and Environmental Microbiology 75: 184-192.

C. EWERS , T. JANßEN , S. KIEßLING , H.-C. PHILIPP and L.H. WIELER (2004) Molecular epidemiology of avian pathogenic Escherichia coli (apec) isolated from colisepticemia in poultry. Veterinary Microbiology 104: 91-101.

M.F. FELDMAN , M. WACKER , M. HERNANDEZ , P.G. HITCHEN , C.L. MAROLDA , M. KOWARIK , H.R. MORRIS , A. DELL , M.A. VALVANO and M. AEBI (2005) Engineering n-linked protein glycosylation with diverse o antigen lipopolysaccharide structures in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America 102: 3016-3021.

T.F. FILHO , C. (Jr) FÁVARO , M. INGBERMAN , B.C. BEIRÃO , A. INOUE , L. GOMES and L.F. CARON (2013) Effect of spray Escherichia coli vaccine on the immunity of poultry. Avian Diseases 57: 671-676.

A. FROMMER , P. FREIDLIN , R.R. BOCK , G. LEITNER , M. CHAFFER and E. HELLER (1994) Experimental vaccination of young chickens with a live, non-pathogenic strain of Escherichia coli. Avian Pathology 23: 425-433.

Q. GAO , X. JIA , X. WANG , L. XIONG , S. GAO and X. LIU (2015a) The avian pathogenic Escherichia coli O2 strain e058 carrying the defined aerobactin-defective iucd or iucdiuta mutation is less virulent in the chicken. Infection, Genetics and Evolution 30: 267-277.

Q. GAO , X. WANG , H. XU , Y. XU , J. LING , D. ZHANG , S. GAO and X. LIU (2012) Roles of iron acquisition systems in virulence of extraintestinal pathogenic Escherichia coli: Salmochelin and aerobactin contribute more to virulence than heme in a chicken infection model. BMC Microbiology 12: 1.

Q. GAO , Z. YE , X. WANG , X. MU , S. GAO and X. LIU (2015b) Rsta is required for the virulence of an avian pathogenic Escherichia coli O2 strain e058. Infection, Genetics and Evolution 29: 180-188.

H. GHUNAIM , M.A. ABU-MADI and S. KARIYAWASAM (2014) Advances in vaccination against avian pathogenic Escherichia coli respiratory disease: Potentials and limitations Veterinary Microbiology 172: 13-22.

C.D. HERREN , A. MITRA , S.K. PALANIYANDI , A. COLEMAN , S. ELANKUMARAN and S. MUKHOPADHYAY (2006) The bara-uvry two-component system regulates virulence in avian pathogenic Escherichia coli O78: K80: H9. Infection and Immunity 74: 4900-4909.

F. HORN , A.M.R. CORRÊA , N.L. BARBIERI , S. GLODDE , K.D. WEYRAUCH , B. KASPERS , D. DRIEMEIER , C. EWERS and L.H. WIELER (2012) Infections with avian pathogenic and faecal Escherichia coli strains display similar lung histopathology and macrophage apoptosis. PloS One 7: e41031.

S.M. HORNE , S.J. PFAFF-MCDONOUGH , C.W. GIDDINGS and L.K. NOLAN (2000) Cloning and sequencing of the iss gene from a virulent avian Escherichia coli. Avian Diseases 44: 179-184.

D. IDESES , U. GOPHNA , Y. PAITAN , R.R. CHAUDHURI , M.J. PALLEN and E.Z. RON (2005) A degenerate type iii secretion system from septicemic Escherichia coli contributes to pathogenesis. Journal of Bacteriology 187: 8164-8171.

C.A. JANSEN , P.M. VAN DE HAAR , D. VAN HAARLEM , P. VAN KOOTEN , S. DE WIT , W. VAN EDEN , B.C. VIERTLBÖCK , T.W. GÖBEL and L. VERVELDE (2010) Identification of new populations of chicken natural killer (nk) cells. Developmental & Comparative Immunology 34: 759-767.

S. KARIYAWASAM and L.K. NOLAN (2009) Pap mutant of avian pathogenic Escherichia coli O1, an O1: K1: H7 strain, is attenuated in vivo. Avian Diseases 53: 255-260.

S. KARIYAWASAM , B. WILKIE and C. GYLES (2004a) Construction, characterisation, and evaluation of the vaccine potential of three genetically defined mutants of avian pathogenic Escherichia coli. Avian Diseases 48: 287-299.

S. KARIYAWASAM , B. WILKIE and C. GYLES (2004b) Resistance of broiler chickens to Escherichia coli respiratory tract infection induced by passively transferred egg-yolk antibodies. Veterinary Microbiology 98: 273-284.

S. KARIYAWASAM , B. WILKIE , D. HUNTER and C. GYLES (2002) Systemic and mucosal antibody responses to selected cell surface antigens of avian pathogenic escherichia coli in experimentally infected chickens. Avian Diseases 46: 668-678.

A.M. KEESTRA , M.R. DE ZOETE , L.I. BOUWMAN and J.P. VAN PUTTEN (2010) Chicken tlr21 is an innate cpg DNA receptor distinct from mammalian tlr9. The Journal of Immunology 185: 460-467.

M.H. KOGUT , K.J. GENOVESE and V.K. LOWRY (2001) Differential activation of signal transduction pathways mediating phagocytosis, oxidative burst, and degranulation by chicken heterophils in response to stimulation with opsonised salmonella enteritidis. Inflammation 25: 7-15.

M.H. KOGUT , L. ROTHWELL and P. KAISER (2003) Differential regulation of cytokine gene expression by avian heterophils during receptor-mediated phagocytosis of opsonised and nonopsonised salmonella enteritidis. Journal of Interferon & Cytokine Research 23: 319-327.

R. LA RAGIONE , W. COOLEY and M.J. WOODWARD (2000) The role of fimbriae and flagella in the adherence of avian strains of Escherichia coli O78: K80 to tissue culture cells and tracheal and gut explants. Journal of Medical Microbiology 49: 327-338.

M.G. LAMARCHE , C.M. DOZOIS , F. DAIGLE , M. CAZA , R. CURTISS , J.D. DUBREUIL and J. HAREL (2005) Inactivation of the pst system reduces the virulence of an avian pathogenic Escherichia coli O78 strain. Infection and Immunity 73: 4138-4145.

W. LANDMAN , G. BUTER , R. DIJKMAN and J. VAN ECK (2014) Molecular typing of avian pathogenic escherichia coli colonies originating from outbreaks of E. Coli peritonitis syndrome in chicken flocks. Avian Pathology 43: 345-356.

W. LANDMAN , A. HEUVELINK and J. VAN ECK (2013) Reproduction of the escherichia coli peritonitis syndrome in laying hens. AvianPathology 42: 157-162.

G. LI , C. EWERS , C. LATURNUS , I. DIEHL , K. ALT , J. DAI , E.-M. ANTAO , K. SCHNETZ and L.H. WIELER (2008) Characterisation of a yjjq mutant of avian pathogenic Escherichia coli (apec). Microbiology 154: 1082-1093.

G. LI , Y. FENG , S. KARIYAWASAM , K.A. TIVENDALE , Y. WANNEMUEHLER , F. ZHOU , C.M. LOGUE , C.L. MILLER and L.K. NOLAN (2010) Aata is a novel autotransporter and virulence factor of avian pathogenic Escherichia coli . Infection and Immunity 78: 898-906.

J. LOWENTHAL , A. BEAN and M. KOGUT (2013) What's so special about chicken immunology? Developmental and Comparative Immunology 41: 307-309

M.H. LYMBEROPOULOS , S. HOULE , F. DAIGLE , S. LÉVEILLÉ , A. BRÉE , M. MOULIN-SCHOULEUR , J.R. JOHNSON and C.M. DOZOIS (2006) Characterisation of stg fimbriae from an avian pathogenic Escherichia coli O78: K80 strain and assessment of their contribution to colonisation of the chicken respiratory tract. Journal of Bacteriology 188: 6449-6459.

A.M. LYNNE , S.L. FOLEY and L.K. NOLAN (2006) Immune response to recombinant Escherichia coli iss protein in poultry. Avian Diseases 50: 273-276.

A.M. LYNNE , S. KARIYAWASAM , Y. WANNEMUEHLER , T.J. JOHNSON , S.J. JOHNSON , A.S. SINHA , D.K. LYNNE , H.W. MOON , D.M. JORDAN and C.M. LOGUE (2012) Recombinant iss as a potential vaccine for avian colibacillosis. Avian Disease 56: 192-199.

J. MA , Y. BAO , M. SUN , W. DONG , Z. PAN , W. ZHANG , C. LU and H. YAO (2014) Two functional type vi secretion systems in avian pathogenic Escherichia coli are involved in different pathogenic pathways. Infection and immunity 82: 3867-3879.

D. MELAMED , G. LEITNER and E.D. HELLER (1991) A vaccine against avian colibacillosis based on ultrasonic inactivation of Escherichia coli. Avian Diseases 35: 17-22.

M. MELLATA , K. AMEISS , H. MO and R. CURTISS (2010) Characterisation of the contribution to virulence of three large plasmids of avian pathogenic Escherichia coli χ7122 (O78: K80: H9). Infection and Immunity 78: 1528-1541.

M. MELLATA , M. DHO-MOULIN , C.M. DOZOIS , R. CURTISS III , P.K. BROWN , P. ARNÉ , A. BRÉE , C. DESAUTELS and J.M. FAIRBROTHER (2003) Role of virulence factors in resistance of avian pathogenic Escherichia coli to serum and in pathogenicity. Infection and Immunity 71: 536-540.

X. MU , H. HUAN , H. XU , Q. GAO , L. XIONG , R. GAO , S. GAO and X. LIU (2013) The transfer-messenger rna-small protein b system plays a role in avian pathogenic Escherichia coli pathogenicity. Journal of Bacteriology 195: 5064-5071.

L. NOLAN , S. HORNE , C. GIDDINGS , S. FOLEY , T. JOHNSON , A. LYNNE and J. SKYBERG (2003) Resistance to serum complement, iss, and virulence of avian escherichia coli. Veterinary Research Communications 27: 101-110.

V. PARREIRA and C. GYLES (2003) A novel pathogenicity island integrated adjacent to the thrw trna gene of avian pathogenic Escherichia coli encodes a vacuolating autotransporter toxin. Infection and Immunity 71: 5087-5096.

S. PEIGHAMBARI , D. HUNTER , P. SHEWEN and C. GYLES (2002) Safety, immunogenicity, and efficacy of two Escherichia coli cya crp mutants as vaccines for broilers. Avian Diseases 46: 287-297.

J.T. POOLMAN and M. WACKER (2015) Extra-intestinal pathogenic Escherichia coli (expec), a common human pathogen: Challenges for vaccine development and progress in the field. Journal of Infectious Diseases 213: 6-13.

K.E. RODRIGUEZ-SIEK , C.W. GIDDINGS , C. DOETKOTT , T.J. JOHNSON and L.K. NOLAN (2005) Characterizing the apec pathotype. Veterinary Research 36: 241-256.

K. ROLAND , R. CURTISS III and D. SIZEMORE (1999) Construction and evaluation of a cya crp Salmonella typhimurium strain expressing avian pathogenic escherichia coli o78 lps as a vaccine to prevent airsacculitis in chickens. Avian Diseases 43: 429-441.

C.R. ROY and E.S. MOCARSKI (2007) Pathogen subversion of cell-intrinsic innate immunity. Nature Immunology 8: 1179-1187.

M. SABRI , M. CAZA , J. PROULX , M.H. LYMBEROPOULOS , A. BRÉE , M. MOULIN-SCHOULEUR , R. CURTISS and C.M. DOZOIS (2008) Contribution of the sitabcd, mnth, and feob metal transporters to the virulence of avian pathogenic Escherichia coli O78 strain χ7122. Infection and Immunity 76: 601-611.

J.-R. SADEYEN , Z. WU , H. DAVIES , P.M. VAN DIEMEN , A. MILICIC , R.M. LA RAGIONE , P. KAISER , M.P. STEVENS and F. DZIVA (2015) Immune responses associated with homologous protection conferred by commercial vaccines for control of avian pathogenic Escherichia coli in turkeys. Veterinary Research 46: 1-5. DOI: 10.1186/s13567-014-0132-5.

T.Z. SALEHI , S. TABATABAEI , V. KARIMI , B.N. FASAEI , A. DERAKHSHANDEH and O.A.N. JAHROMI (2012) Assessment of immunity against avian colibacillosis induced by an aroa mutant containing increased serum survival gene in broilers. Brazilian Journal of Microbiology 43: 363-370.

E.E. SANDFORD , M. ORR , M. SHELBY , X. LI , H. ZHOU , T.J. JOHNSON , S. KARIYAWASAM , P. LIU , L.K. NOLAN and S.J. LAMONT (2012) Leukocyte transcriptome from chickens infected with avian pathogenic Escherichia coli identifies pathways associated with resistance. Results in Immunology 2: 44-53.

B. SPERLING , B.C. VIERTLBOECK and T.W. GÖBEL (2015) Chicken cd300a homolog is found on b lymphocytes, various leukocytes populations and binds to phospholipids. Developmental & Comparative Immunology 50: 121-128.

A.K. STACY , N.M. MITCHELL , J.T. MADDUX , A. MIGUEL , L. DURÁN , J.A. GIRÓN , R. CURTISS 3RD and M. MELLATA (2014) Evaluation of the prevalence and production of Escherichia coli common pilus among avian pathogenic E. coli and its role in virulence. PloS One 9: e86565.

C. STRAUB , M.-L. NEULEN , B. SPERLING , K. WINDAU , M. ZECHMANN , C.A. JANSEN , B.C. VIERTLBOECK and T.W. GÖBEL (2013) Chicken nk cell receptors. Developmental & Comparative Immunology 41: 324-333.

S. UMAR , M.A.A. SHAH and M.T. MUNIR (2015) Infectious bronchitis virus: Evolution and vaccination. World's Poultry Science Journal 72: 49-60.

S. UMAR , S. SUBHAN , T. AZAM , M.T. MUNIR and M.A.A. SHAH (2017a) Mycoplasmosis in poultry: update on diagnosis and preventive measures. World's Poultry Science Journal 73: xx-xx (accepted).

S. UMAR , M.T. MUNIR , U. AHSAN , I. RAZA , M.R. CHOWDHURY , Z. AHMED and M.A.A. SHAH (2017b) Immunosuppressive interactions of viral diseases in poultry. World's Poultry Science Journal 73: xx-xx (accepted).

F. VANDEMAELE , N. BLEYEN , O. ABUABOUD , E. VANDERMEER , A. JACOBS and B.M. GODDEERIS (2006) Immunisation with the biologically active lectin domain of papgii induces strong adhesion-inhibiting antibody responses but not protection against avian pathogenic Escherichia coli. Avian Pathology 35: 238-249.

G.K.-S. WONG , B. LIU , J. WANG , Y. ZHANG , X. YANG , Z. ZHANG , Q. MENG , J. ZHOU , D. LI and J. ZHANG (2004) A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms. Nature 432: 717-722.

Q.-Y. ZHUANG , S.-C. WANG , J.-P. LI , D. LIU , S. LIU , W.-M. JIANG and J.-M. CHEN (2014) A clinical survey of common avian infectious diseases in china. Avian Diseases 58: 297-302.

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World's Poultry Science Journal
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