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Progress in Chlamydia psittaci vaccine development in poultry

  • A.M.M. QUILICOT (a1) (a2), Ž. GOTTSTEIN (a1), D. HORVATEK TOMIĆ (a1) and E. PRUKNER-RADOVČIĆ (a1)
Abstract

Chlamydia psittaci, depending on its serovar, can infect humans, birds, and other animals and livestock. Its economic impact on poultry production, especially on turkeys and chickens, and potential zoonotic risk have driven the search for an effective vaccination protocol to prevent and control the infection and shedding of the organism. Currently, no vaccine is approved for use against avian chlamydiosis despite efforts in the past decades. The present genomic era presents an opportunity to establish an effective vaccination scheme, taking advantage of the major outer membrane protein (MOMP) as the major protective antigen of C. psittaci. The plasmid DNA expressing MOMP can be coupled with optimisation of controllable factors during vaccination such as codon optimisation (through formation of polyplexes and lipoplexes), route of administration, vaccination schedule, addition of adjuvants/co-stimulatory factors such as cytokines and CpG motifs, and recombination with other poultry pathogens such as viruses. The development of an effective vaccine against C. psittaci will protect susceptible poultry from infection and production performance losses and reduce the zoonotic risk and minimise the emergence of antibiotic-resistant C. psittaci strains.

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Corresponding author
Corresponding author: gottstei@vef.hr
References
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ANDERSEN A.A. and VANROMPAY D. (2000) Avian chlamydiosis. Revue Scientifique Et Technique De L'Office International Des Epizooties 19: 396-404.
BEECKMAN D.S.A. and VANROMPAY D.C.G. (2009) Zoonotic Chlamydophila psittaci infections from a clinical perspective. Clinical Microbiology and Infection 15: 11-17.
BRUNHAM R.C., ZHANG D.J., YANG X. and MCCLARTY G.M. (2000) The potential for vaccine development against chlamydial infection and disease. Journal of Infectious Diseases 181: 538-543.
DUNHAM S.P. (2002) The application of nucleic acid vaccines in veterinary medicine. Research in Veterinary Science 73: 9-16.
EKO F.O., HE Q., BROWN T., MCMILLAN L., IFERE G.O., ANANABA G.A., LYN D., LUBITZ W., KELLAR K.L., BLACK C.M. and IGIETSEME J.U. (2004) A novel recombinant multisubunit vaccine against Chlamydia . The Journal of Immunology 173: 3375-3382.
GAEDE W., RECKLING K.-F., DRESENKAMP B., KENKLIES S., SCHUBERT E., NOACK U., IRMSCHER H.-M., LUDWIG C., HOTZEL H. and SACHSE K. (2008) Chlamydophila psittaci infections in humans during an outbreak of psittacosis from poultry in Germany. Zoonoses and Public Health 55: 184-188.
GRANDI G. (2001) Antibacterial vaccine design using genomics and proteomics. Trends in Biotechnology 19: 181-188.
HE C., LI S., YANG L., HE G., LIU W. and YAO B. (2007) Induction of a protective immune response against Chlamydophila psittaci in SPF chicken following vaccination with Omp-1 DNA and CpG oligonucleotides as an adjuvant. Bulletin-Veterinary Institute in Pulawy 51: 351.
IGIETSEME J.U. and BLACK C.M. (2013) Chlamydia vaccine development, in: BLACK, C.M. (Ed) Chlamydial Infection: A Clinical and Public Health Perspective, Vol. 7, pp. 115-130 (Basel, Switzerland, Karger Publishers).
KAISER P. (2010) Advances in avian immunology—prospects for disease control: a review. Avian Pathology 39: 309-324.
KNITTLER M.R. and SACHSE K. (2015) Chlamydia psittaci: update on an underestimated zoonotic agent. Pathogens and Disease 73: 1-15.
LAGAE S. and VANROMPAY D. (2015) Innate immune response in avian macrophages elicited by Chlamydia psittaci . Vlaams Diergeneeskundig Tijdschrift 84: 133-141.
LIU S., SUN W., CHU J., HUANG X., WU Z., YAN M., ZHANG Q., ZHAO P., IGIETSEME J.U., BLACK C.M., HE C. and LI Y. (2015) Construction of recombinant HVT expressing PmpD, and immunological evaluation against Chlamydia psittaci and Marek's disease virus. PLOS ONE 10: 1-16.
LONGBOTTOM D. (2003) Chlamydial vaccine development. Journal of Medical Microbiology 52: 537-540.
LOOTS K., LOOCK M.V., VANROMPAY D. and GODDEERIS B.M. (2006) CpG motifs as adjuvant in DNA vaccination against Chlamydophila psittaci in turkeys. Vaccine 24: 4598-4601.
OSHOP G.L., ELANKUMARAN S. and HECKERT R.A. (2002) DNA vaccination in the avian. Veterinary Immunology and Immunopathology 89: 1-12.
QIU C., ZHOU J., CAO X., LIN G., ZHENG F. and GONG X. (2010) Immunisation trials with an avian chlamydial MOMP gene recombinant adenovirus. Bioengineered Bugs 1: 269-275.
RADOMSKI N., EINENKEL R., MÜLLER A. and KNITTLER M.R. (2016) Chlamydia-host cell interaction not only from a bird's eye view: some lessons from Chlamydia psittaci . FEBS Letters 590: 3920-3940.
RAPPUOLI R., BLACK S. and LAMBERT P.H. (2011) Vaccine discovery and translation of new vaccine technology. The Lancet 378: 360-368.
SACHSE K., LAROUCAU K. and VANROMPAY D. (2015) Avian chlamydiosis. Current Clinical Microbiology Reports 2: 10-21.
SCARSELLI M., GIULIANI M.M., ADU-BOBIE J., PIZZA M. and RAPPUOLI R. (2005) The impact of genomics on vaccine design. Trends in Biotechnology 23: 84-91.
SERRUTO D. and RAPPUOLI R. (2006) Post-genomic vaccine development. FEBS Letters 580: 2985-2992.
SETTE A. and RAPPUOLI R. (2010) Reverse Vaccinology: Developing vaccines in the era of genomics. Immunity 33: 530-541.
SINGH M. and O'HAGAN D.T. (2003) Recent advances in veterinary vaccine adjuvants. International Journal for Parasitology 33: 469-478.
VAN DRUNEN LITTEL-VAN DEN HURK S., GERDTS V., LOEHR B.I., PONTAROLLO R., RANKIN R., UWIERA R. and BABIUK L.A. (2000) Recent advances in the use of DNA vaccines for the treatment of diseases of farmed animals. Advanced Drug Delivery Reviews 43: 13-28.
VANROMPAY D., COX E., KAISER P., LAWSON S., VAN LOOCK M., VOLCKAERT G. and GODDEERIS B. (2001) Protection of turkeys against Chlamydophila psittaci challenge by parenteral and mucosal inoculations and the effect of turkey interferon-γ on genetic immunisation. Immunology 103: 106-112.
VANROMPAY D., COX E., VANDENBUSSCHE F., VOLCKAERT G. and GODDEERIS B. (1999a) Protection of turkeys against Chlamydia psittaci challenge by gene gun-based DNA immunisations. Vaccine 17: 2628-2635.
VANROMPAY D., COX E., VOLCKAERT G. and GODDEERIS B. (1999b) Turkeys are protected from infection with Chlamydia psittaci by plasmid DNA vaccination against the major outer membrane protein. Clinical and Experimental Immunology 118: 49-55.
VANROMPAY D., HARKINEZHAD T., VAN DE WALLE M., BEECKMAN D., van DROOGENBROECK C., VERMINNEN K., LETEN R., MARTEL A. and CAUWERTS K. (2007) Chlamydophila psittaci transmission from pet birds to humans. Emerging Infectious Disease 13: 1108-1110.
VERMINNEN K., BEECKMAN D.S.A., SANDERS N.N., DE SMEDT S. and VANROMPAY D.C.G. (2010) Vaccination of turkeys against Chlamydophila psittaci through optimised DNA formulation and administration. Vaccine 28: 3095-3105.
WYRICK P.B. (2000) Intracellular survival by Chlamydia . Cellular Microbiology 2: 275-282.
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World's Poultry Science Journal
  • ISSN: 0043-9339
  • EISSN: 1743-4777
  • URL: /core/journals/world-s-poultry-science-journal
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