Hostname: page-component-7bb8b95d7b-2h6rp Total loading time: 0 Render date: 2024-09-21T05:16:21.783Z Has data issue: false hasContentIssue false
  • English
  • Français

Biocompatible Polymeric Nanoparticles and Films Containing Hydrophobic Quantum Dots

Published online by Cambridge University Press:  01 February 2011

Jisook Lee ,
Ick Chan Kwon ,
Kyoungja Woo  and
Hesson Chung
Jisook Lee
Affiliation:
jslee@kist.re.kr, Korea Inst Sci Tech, Biomedical Research Center, 39-1 Hawolgok Dong, Sungbuk Gu, Seoul, 136-791, Korea, Republic of, 822-958-5906, 822-958-5909
Ick Chan Kwon
Affiliation:
ikwon@kist.re.kr, Korea Institute of Science and Technology, Biomedical Research Center, 39-1 Hawolgok dong, Sungbuk gu, Seoul, 136-791, Korea, Republic of
Kyoungja Woo
Affiliation:
kjwoo@kist.re.kr, Korea Institute of Science and Technology, Biomedical Research Center, 39-1 Hawolgok dong, Sungbuk gu, Seoul, 136-791, Korea, Republic of
Hesson Chung
Affiliation:
heschung@kist.re.kr, Korea Institute of Science and Technology, Biomedical Research Center, 39-1 Hawolgok dong, Sungbuk gu, Seoul, 136-791, Korea, Republic of
Get access

Abstract

Micro- or nano-particles encapsulating hydrophobic quantum dots were prepared by the emulsion technique. Films containing quantum dots were also prepared by film casting methods. Quantum dots without hydrophilic coating were directly mixed with polymer solution to prepared extremely stable films or particles that do not phase-separate with time. The surface of the particles or films could be modified to have different hydrophilicity and/or functional groups. Particles with 1.5 ± 0.16 μm and 320 ± 26 nm in diameters and films of 300 μm in thickness were prepared. NIH 3T3 and EMT-6 were culture on the films containing quantum dots for 8 – 20 h. Compared to the control, quantum dot were delivered directly and efficiently into the cells without toxicity. When implanted near tumor cells in Balb/C mice, quantum dots migrated from the films into the tumor cells for at least 3 days. Considering that the quantum dot dispersion in aqueous media is relatively unstable and difficult to handle, our stable particles or films containing hydrophobic quantum dots can become versatile probes for biological applications.

Keywords

filmcellular (material form)biomaterial
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 950: Symposium D – Biosurfaces and Biointerfaces , 2006 , 0950-D04-09
Copyright
Copyright © Materials Research Society 2007

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Zimmer, J. P., Kim, S., Ohnishi, S., Tanaka, E., Frangioni, J. V., Bawendi, M. G., JACS, 128, 2526 (2006)Google Scholar
2. So, M., Xu, C., Loening, A. M., Ganbhir, S.S., Rao, J., Nat. Biotech., 24, 339 (2006)Google Scholar
3. Hoshino, A., Fugioka, K., Oku, T., Suga, M, Sasaki, Y., Ohta, T., Yahuhara, M., Suzuki, K., Yamamoto, K., Nano lett., 4, 2163 (2004)Google Scholar
4. Medintz, I.L., Clapp, A.R., Mattoussi, H., Goldman, E. R., Fisher, B., Mauro, J. M., Nat. Mater., 9, 630 (2003)Google Scholar
5. Li, J. J., Wang, Y. A., Guo, W., Keay, J. C., Mishima, T. D., Johnson, M. B. and Peng, X., JACS, 125, 12367 (2003)Google Scholar
6. Yu, W. W., Qu, L., Guo, W., X. Peng Chem. Mater., 15, 2854 (2003)Google Scholar
7. Zweers, M. L. T., Engbers, G. H. M., Grijpma, D. W., Feigen, J., J. Controlled Release 100, 347 (2004)Google Scholar
8. Wan, Y., Chen, W., Yang, J., Bei, J., Wang, S., Biomaterials, 24, 2195 (2003)Google Scholar
9. Lee, J. H., Go, A. K., Oh, S. H., Lee, K. E., Yuk, S. H., Biomaterials, 26, 671 (2005)Google Scholar
10. Derfus, A. M., Chan, W. C. W., Bhatia, S. N., Nano Lett., 4, 11 (2004)Google Scholar
11. Grizzi, I., Garreau, H., Li, S., Vert, M., Biomaterials, 16, 305 (1995)Google Scholar
12. Gao, X., Cui, Y., Levenson, R. M., Chung, L. W. K., Nie, S., Nat. Biotech., 22, 969 (2004)Google Scholar