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Positron Emission Tomography Study of Brain Benzodiazepine Receptors in Friedreich's Ataxia

Published online by Cambridge University Press:  18 September 2015

C. Chavoix ,
Y. Samson ,
S. Pappata ,
C. Prenant ,
M. Mazière ,
A. Seck  and
Y. Agid
C. Chavoix*
Affiliation:
Du Service Hospitalier Frédéric Joliot, CEA, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France
Y. Samson
Affiliation:
Du Service Hospitalier Frédéric Joliot, CEA, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France
S. Pappata
Affiliation:
Du Service Hospitalier Frédéric Joliot, CEA, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France
C. Prenant
Affiliation:
Du Service Hospitalier Frédéric Joliot, CEA, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France
M. Mazière
Affiliation:
Du Service Hospitalier Frédéric Joliot, CEA, Département de Biologie, Hôpital d'Orsay, 91406 Orsay, France
A. Seck
Affiliation:
Clinique de Neurologie et de Neuropsychologie and INSERM U289, Hôpital de la Salpêtrière, 75013 Paris, France
Y. Agid
Affiliation:
Clinique de Neurologie et de Neuropsychologie and INSERM U289, Hôpital de la Salpêtrière, 75013 Paris, France
*
National Institute of Health, Laboratory of Neuropsychology, Bdg 9, Rm 1N107, Bethesda, Maryland 20892, USA
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Abstract:

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Central type benzodiazepine receptors were studied in 9 patients with Friedreich's ataxia and 12 healthy subjects using positron emission tomography (PET) and [11C]Ro 15-1788, a specific antagonist of the central type benzodiazepine receptors, as radioligand. A standard PET procedure was used in 5 patients and 8 controls to obtain brain kinetics of the total binding of the radioligand. The remaining subjects were intravenously injected with a saturating dose of unlabeled Ro 15-1788, 30 minutes after the tracer injection, to determine the nondisplaceable binding of [11C]Ro 15-1788. A semi-quantitative method was used to quantify the [11C]Ro 15-1788 data. None of the quantification indices in the cerebellar hemispheres, or in the other brain areas investigated, was significantly modified in patients with Friedreich's ataxia. These findings suggest that brain benzodiazepine receptors are unaffected in Friedreich's ataxia.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 17 , Issue 4 , November 1990 , pp. 404 - 409
Copyright
Copyright © Canadian Neurological Sciences Federation 1990

References

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