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Effects of lipase inhibition on gastric emptying and alcohol absorption in healthy subjects

Published online by Cambridge University Press:  08 March 2007

Reawika Chaikomin ,
Antonietta Russo ,
Christopher K. Rayner ,
Christine Feinle-Bisset ,
Deirdre G. O'Donovan ,
Michael Horowitz  and
Karen L. Jones
Reawika Chaikomin
Affiliation:
Discipline of Medicine, University of Adelaide, Royal Adelaide Hospital, North Terrace Adelaide, South Australia, Australia, 5000
Antonietta Russo
Affiliation:
Discipline of Medicine, University of Adelaide, Royal Adelaide Hospital, North Terrace Adelaide, South Australia, Australia, 5000
Christopher K. Rayner
Affiliation:
Discipline of Medicine, University of Adelaide, Royal Adelaide Hospital, North Terrace Adelaide, South Australia, Australia, 5000
Christine Feinle-Bisset
Affiliation:
Discipline of Medicine, University of Adelaide, Royal Adelaide Hospital, North Terrace Adelaide, South Australia, Australia, 5000
Deirdre G. O'Donovan
Affiliation:
Discipline of Medicine, University of Adelaide, Royal Adelaide Hospital, North Terrace Adelaide, South Australia, Australia, 5000
Michael Horowitz
Affiliation:
Discipline of Medicine, University of Adelaide, Royal Adelaide Hospital, North Terrace Adelaide, South Australia, Australia, 5000
Karen L. Jones*
Affiliation:
Discipline of Medicine, University of Adelaide, Royal Adelaide Hospital, North Terrace Adelaide, South Australia, Australia, 5000
*
*Corresponding author: Dr Karen L. Jones, fax +61 8 8223 3870, email karen.jones@adelaide.edu.au
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Abstract

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The rate of alcohol absorption is dependent on gastric emptying (GE). As the slowing of GE by fat is dependent on lipolysis, orlistat may increase the rise in blood alcohol when alcohol is consumed with, or after, fat. The aim of the study was to evaluate the effects of orlistat on GE and blood alcohol after an alcohol-containing drink following a fat ‘preload’, in healthy subjects. Ten healthy males consumed 120 ml cream with or without 120 mg orlistat, 30 min before an alcohol-containing drink labelled with 20 MBq [99 mTc]sulfur colloid on 2 d. GE, plasma alcohol and blood glucose were measured. GE was slightly faster with orlistat (P<0·05) compared with control. Plasma alcohol at 15 min was slightly higher with orlistat (0·034 (sem 0·006) g/100 ml) v. control (0·029 (sem 0·005) g/100 ml) (P<0·05), but there was no effect on the area under the curve 0–240 min. The increase in blood glucose was greater with orlistat, for example, at 15 min (1·07 (sem 0·2) mmol/l) v. control (0·75 (sem 0·2) mmol/l) (P=0·05). The rise in blood glucose and plasma alcohol were related (for example, at 15 min r 0·49; P=0·03). In conclusion, lipase inhibition accelerates GE of an alcohol-containing drink following a fat ‘preload’ with a minor increase in the initial rise in plasma alcohol.

Keywords

Gastric emptyingOrlistatPlasma alcoholBlood glucose
Type
Research Article
Information
British Journal of Nutrition , Volume 96 , Issue 5 , November 2006 , pp. 883 - 887
Copyright
Copyright © The Nutrition Society 2006

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