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Genetic Linkage of the Huntington’s Disease Gene to a DNA Marker

Published online by Cambridge University Press:  18 September 2015

James F. Gusella
James F. Gusella*
Affiliation:
the Neurology Service and Genetics Unit, Massachusetts General Hospital and Department of Genetics, Harvard Medical School, Boston, Massachusetts
*
Genetics Unit, Massachusetts General Hospital, Boston, Ma. 02114, U.S.A.
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Abstract

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Recombinant DNA techniques have provided the means to generate large numbers of new genetic linkage markers. This technology has been used to identify a DNA marker that coinherits with the Huntington’s Disease (HD) gene in family studies. The HD locus has thereby been mapped to human chromosome 4. The discovery of a genetic marker for the inheritance of HD has implications both for patient care and future research. The same approach holds considerable promise for the investigation of other genetic diseases, including Dystonia Musculorum Deformans.

Type
Special Features
Information
Canadian Journal of Neurological Sciences , Volume 11 , Issue 4 , November 1984 , pp. 421 - 425
Copyright
Copyright © Canadian Neurological Sciences Federation 1984

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