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Searching for Smart Durable Coatings to Promote Bone Marrow Stromal Cell Growth While Preventing Biofilm Formation

Published online by Cambridge University Press:  01 February 2011

Fereydoon Namavar ,
John D. Jackson ,
J. Graham Sharp ,
Ethan E. Mann ,
Kenneth Bayles ,
Barry Chin Li Cheung ,
Connie A Feschuk ,
Shailaja Varma ,
Hani Haider  and
Kevin L. Garvin
Fereydoon Namavar
Affiliation:
fnamavar@unmc.edu, ., ., ., ., NE, ., United States
John D. Jackson
Affiliation:
jdjackson@unmc.edu, University of Nebraska Medical Center, Dept of Pathology & Microbiology, 985360 Nebraska Medical Center, Omaha, NE, 68198, United States
J. Graham Sharp
Affiliation:
jsharp@unmc.edu, University of Nebraska Medical Center,, Dept. of Genetics, Cell Biology and Anatomy, 985360 Nebraska Medical Center,, Omaha, NE, 68198-5360, United States
Ethan E. Mann
Affiliation:
emann@unmc.edu, University of Nebraska Medical Center, Dept of Pathology & Microbiology, 985360 Nebraska Medical Center, Omaha, NE, 68198, United States
Kenneth Bayles
Affiliation:
kbayles@unmc.edu, University of Nebraska Medical Center, Dept of Pathology & Microbiology, 985360 Nebraska Medical Center, Omaha, NE, 68198, United States
Barry Chin Li Cheung
Affiliation:
ccheung2@unl.edu, University of Nebraska, Lincoln, Dept of Chemistry, 514A Hamilton Hall, Lincoln, NE, 68588, United States
Connie A Feschuk
Affiliation:
cfeschuk@unmc.edu, University of Nebraska Medical Center, Orthopaedic Surgery, 981080 Nebraska Medical Center, Omaha, NE, 68198, United States
Shailaja Varma
Affiliation:
svarma@unmc.edu, University of Nebraska Medical Center, Orthopaedic Surgery, 981080 Nebraska Medical Center, Omaha, NE, 68198, United States
Hani Haider
Affiliation:
hhaider@unmc.edu, University of Nebraska Medical Center, Orthopaedic Surgery, 981080 Nebraska Medical Center, Omaha, NE, 68198, United States
Kevin L. Garvin
Affiliation:
kgarvin@unmc.edu, University of Nebraska Medical Center, Orthopaedic Surgery, 981080 Nebraska Medical Center, Omaha, NE, 68198, United States
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Abstract

There is a great need to develop methods to regulate cellular growth in order to enhance or prevent cell proliferation as needed, to either improve health or prevent disease. In this work we evaluated the adhesion, survival and growth of bone marrow stromal cells on the surface of several new ion beam engineered nano-crystals of ceramic hard coatings such as zirconium, titanium, tantalum and cerium oxides. Cell adhesion and growth on the ceramic coatings were compared to adhesion and growth on a nano-crystalline silver coating which is known to possess antibacterial properties. The initial results of a study to determine the effect of nanocrystalline titanium and silver coating on staphylococcus aureus biofilm growth is also discussed.

Keywords

ion-beam assisted depositionnanostructureAg
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 954: Symposium H – Biofilm-Material Interactions — New Tools, Technologies and Opportunities , 2006 , 0954-H04-04
Copyright
Copyright © Materials Research Society 2007

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References

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