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n-3 Fatty acid supplementation reduces hypertriacylglycerolaemia and improves lipid peroxidation and inflammation in patients with chronic renal failure

Published online by Cambridge University Press:  30 June 2021

K. Mekki ,
N. Bekada ,
A. Boukaddoum ,
D. Krouf ,
A. Kaddous  and
M. Bouchenak
K. Mekki
Affiliation:
Laboratoire de Nutrition Clinique et Métabolique, Faculté des Sciences, Université d'Oran Es-Sénia, Oran, Algeria
N. Bekada
Affiliation:
Laboratoire de Nutrition Clinique et Métabolique, Faculté des Sciences, Université d'Oran Es-Sénia, Oran, Algeria
A. Boukaddoum
Affiliation:
Laboratoire de Nutrition Clinique et Métabolique, Faculté des Sciences, Université d'Oran Es-Sénia, Oran, Algeria
D. Krouf
Affiliation:
Laboratoire de Nutrition Clinique et Métabolique, Faculté des Sciences, Université d'Oran Es-Sénia, Oran, Algeria
A. Kaddous
Affiliation:
Service de Néphrologie, Centre Hospitalo-Universitaire d'Oran, Oran, Algeria
M. Bouchenak
Affiliation:
Laboratoire de Nutrition Clinique et Métabolique, Faculté des Sciences, Université d'Oran Es-Sénia, Oran, Algeria
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Abstract

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Information
Proceedings of the Nutrition Society , Volume 67 , Issue OCE5: Joint meeting of the Société Française de Nutrition and The Nutrition Society, 6–7 December 2007 , May 2008 , E185
Copyright
Copyright © The Authors 2008

The aim of the present study was to evaluate the effect of n-3 fatty acid supplementation on dyslipidaemia, lipid peroxidation and inflammation markers in patients with chronic renal failure (CRF).

Seventy-five patients with CRF (58 (sd 9) years) were identified in the hospital in Oran (west Algeria). Thirty patients with hypertriacylglycerolaemia (TAG>1.7 mmol/l) and/or hypercholesterolaemia (total cholesterol (TC) >5 mmol/l) were recruited for the nutritional intervention. All patients received nutritional counselling adapted for CRF (energy intake 0.12 MJ/kg body weight per d, protein intake 0.8 g/kg body weight per d, lipid intake 35% total energy intake). Fifteen patients received an n-3 fatty acid supplement (2.1 g/d; 33% EPA and 12% DHA) for 90 d. Fifteen patients were used as controls. Blood samples were withdrawn at the beginning (T0) and at 30 d (T1), 60 d (T2) and 90 d (T3) after initiating treatment.

TAG level was reduced by 43% at T1, and decreased with time from T1 to T3. TC, HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), apo A-I, apo B, TC:HDL-C, TC:LDL-C and apo A-I:apo B were similar for both groups, whereas apo B values were lower at T2 compared with T0 (P<0.05). Decreases in TC:HDL-C and TC:LDL-C were found at T3 compared with T0 (P<0.05). Thiobarbituric acid-reactive substances (TBARS) were lower in treated patients compared with controls (P<0.001), and decreased with time from T1 to T3 (P<0.001). Albumin concentrations were not affected by the nutritional intervention, whereas a significant reduction in C-reactive protein (CRP) was found in treated patients compared with controls.

In patients with CRF n-3 PUFA supplementation reduces hypertriacylglycerolaemia and improves lipid peroxidation and inflammation and can be beneficial in the prevention of CVD.