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Postprandial coagulation factor VII activity: the effect of monounsaturated fatty acids

Published online by Cambridge University Press:  24 July 2007

Helen M. Roche  and
Michael J. Gibney
Helen M. Roche
Affiliation:
Unit of Nutrition and Dietetics, Trinity Centre for Health Sciences, St James's Hospital, James's Street, Dublin 8, Ireland
Michael J. Gibney
Affiliation:
Unit of Nutrition and Dietetics, Trinity Centre for Health Sciences, St James's Hospital, James's Street, Dublin 8, Ireland
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Abstract

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The present study investigated the effect of monounsaturated fatty acids (MUFA) on postprandial coagulation factor VII activity. Fifteen healthy male volunteers consumed three meals containing equal amounts (40g) of fat, but providing different proportions of MUFA (12,17 and 24% energy)in random order. Fasting and postprandial blood samples were drawn every hour for 9 h. The magnitude of the postprandial triacylglycerolaemic response and the postprandial plasma nonesterifled fatty acid (NEFA) concentrations were not significantly different following the three meals. Coagulation factor VII was activated during postprandial triacylglycerolaemia but the area under the curve of postprandial coagulation factor VII activity was not significantly different following the three meals. Regression analysis showed that fasting factor VII activity was the single mast important factor affecting postprandial factor VII activity, irrespective of plasma lipid concentrations and meal fat composition. Peak postprandial factor VII activity was attained significantly earlier following the high-MUFA meal compared with the low-MUFA meal (6·33 (SD 2·16) h, 3·60 (SD 1·81)h respectively; P = 0·016). Regression analysis showed that meal MUFA content was the primary determinant of time to peak postprandial factor VII activity. Although the magnitude of postprandial coagulation factor VII activity was not affected by meal MUFA content, peak postprandial factor VII activity occurred earlier and fasting activity levels were quickly restored following the high-MUFA meal. A short-lived increase in factor VII activity may be more beneficial than a prolonged thrombotic response.

Keywords

Dietary fatty acidsFactor VII activityPostprandial triacylglycerolaemia
Type
Human and Clinical Nutrition
Information
British Journal of Nutrition , Volume 77 , Issue 4 , April 1997 , pp. 537 - 549
Copyright
Copyright © The Nutrition Society 1997

References

REFERENCES

Carvalho de Sousa, J. C., Azevedo, C., Soria, C., Barros, F., Ribeiro, C., Parreira, F. & Caen, J. P. (1988). Factor VII hyperactivity in acute myocardial thrombosis. A relation to the coagulation activation. Thrombosis Research 51, 165–173.CrossRefGoogle Scholar
Carvalho de Sousa, J. C., Bruckert, E., Giral, P., Chapman, J., Truffert, J., Dairou, F., DeGennes, J. L. & Caen, J. P. (1989). Coagulation factor VII and plasma triglycerides. Decreased catabolism as a possible mechanism of factor VII hyperactivity. Haemostasis 19, 125–130.Google ScholarPubMed
De Bruin, T. W. A., Brouwer, C. B., van Linde-Sibenius, M., Jansen, H. & Erkelens, D. W. (1993). Different postprandial metabolism of olive oil and soybean oil: a possible mechanism of the high-density lipoprotein conserving effect of olive oil. American Journal of Clinical Nutrition 58, 477–483.CrossRefGoogle ScholarPubMed
Gibney, M. J. & Daly, E. (1994) The incorporation of n−3 polyunsaturated fatty acids into plasma lipid and lipoprotein fractions in the postprandial phase in healthy volunteers. European Journal of Clinical Nutrition 48, 866–872.Google ScholarPubMed
Gregory, J., Foster, K., Tyler, H. & Wiseman, M. (1990). The Dietary and Nutritional Survey of British Adults. London: H. M. Stationery Office.Google Scholar
Kafatos, A. & Mamalakis, G. (1993). Changing patterns of fat intake in Crete. European Journal of Clinical Nutrition 47, Suppl. 1, S21–S24.Google ScholarPubMed
Karpe, F., Steiner, G., Uffelman, K., Olivecrona, T. & Hamsten, A. (1994). Postprandial lipoproteins and progression of coronary atherosclerosis. Atherosclerosis 106, 83–97.CrossRefGoogle ScholarPubMed
Kitchen, S., Malia, R. G. & Preston, F. E. (1992). A comparison of methods for the measurement of activated factor VII. Thrombosis and Haemstasis 68, 301–305.Google ScholarPubMed
Marckmann, P., Sandstrom, B. & Jespersen, J. (1993). Dietary effects on circadian fluctuation in human blood coagulation factor VII and fibrinolysis. Atherosclerosis 101, 225–234.CrossRefGoogle ScholarPubMed
Matthews, J. N. S., Altman, D. G., Campbell, M. J. & Royson, P. (1990) Analysis of serial measurements in medical research. British Medical Journal 300, 230–235.CrossRefGoogle ScholarPubMed
Meade, T. W., Mellows, S., Brozovic, M., Miller, G. J., Chakrabarti, R. R., North, W. R. S., Haines, A. P., Stirling, Y., Imeson, J. D. & Thompson, S. G. (1986). Haemostatic function and ischaemic heart disease: principal results of The Northwick Park Heart Study. Lancet ii, 533–537.CrossRefGoogle Scholar
Meade, T. W., Ruddock, V., Stirling, Y., Chakrabarti, R. & Miller, G. J. (1993). Fibrinolytic activity, clotting factors, and long-term incidence of ischaemic heart disease in the Northwick Park Heart Study. Lancet 342, 1076–1079.CrossRefGoogle ScholarPubMed
Miller, G. J., Martin, J. C., Mitropoulos, K. A., Reeves, B. E. A., Thompson, R. L., Meade, T. W., Cooper, J. A. & Cruickshank, J. K. (1991). Plasma factor VII is activated by postprandial triglyceridaemia, irrespective of dietary fat composition. Atherosclerosis 86, 163–171.CrossRefGoogle ScholarPubMed
Miller, G. J., Martin, J. C., Webster, J., Wilkes, H., Wilkinson, W. H. & Meade, T. W. (1986). Association between dietary fat intake and plasma factor VII coagulant activity - A predictor of cardiovascular mortality. Atherosclerosis 60, 269–277.CrossRefGoogle ScholarPubMed
Mitropoulos, K. A. (1994). Lipoprotein metabolism and thrombosis. Current Opinions in Lipidology 5, 227–235.CrossRefGoogle ScholarPubMed
Mitropoulos, K. A., Miller, G. J., Martin, J. C., Reeves, B. E. A. & Cooper, J. (1994). Dietary fat induces changes in factor VII coagulant activity through effects on plasma free stearic acid concentration. Arteriosclerosis and Thrombosis 14, 214–222.CrossRefGoogle ScholarPubMed
Mitropoulos, K. A., Miller, G. J., Reeves, B. E. A., Wilkes, H. C. & Cruickshank, J. K. (1989). Factor VII coagulant activity is strongly associated with the plasma concentration of large lipoprotein particles in middleaged men. Atherosclerosis 76, 203–208.CrossRefGoogle Scholar
Mitropoulos, K. A., Miller, G. J., Watts, G. F. & Durrington, P. N. (1992). Lipolysis of triglyceride rich lipoproteins activates coagulant factor XII: a study in familial lipoprotein-lipase deficiency. Atherosclerosis 95, 119–125.CrossRefGoogle ScholarPubMed
Orlando, M., Leri, O., Macioce, G., Mattia, G. & Ferri, G. M. (1987). Factor VII in subjects at risk of thromboembolism: activation or increased synthesis? Haemstusis 17, 340–343.Google ScholarPubMed
Patsch, J. R., Miesenbock, G., Hopferwieser, T., Muhlberger, V., Knapp, E., Dunn, J. K., Gotto, A. M. & Patsch, W. (1993). Relation of triglyceride metabolism and coronary artery disease. Arteriosclerosis and Thrombosis 12, 1336–1345.CrossRefGoogle Scholar
Roche, H. & Gibney, M. J. (1994). The effect of consumption of fish oil-enriched spreadable fats on platelet phospholipid fatty acid composition in human volunteers. International Journal of Vitamin and Nutrition Research 64, 237–242.Google ScholarPubMed
Roche, H. M. & Gibney, M. J. (1995 a). Postprandial triacylglycerolaemia - Nutritional implications. Progress in Lipid Research 34, 249–266.CrossRefGoogle ScholarPubMed
Roche, H. M. & Gibney, M. J. (1994 b) Manipulation of postprandial triacylglycerol concentration and coagulation factor VII activity with low-fat diet and or fish oil supplementation. Proceedings of the Nutrition Society 54, 89A.Google Scholar
Ruddock, V. & Meade, T. W. (1994). Factor VII activity and ischaemic heart disease: fatal and non-fatal events. Quarterly Journal of Medicine 87, 403–406.Google ScholarPubMed
Salomaa, V., Rasi, V., Pekkanen, J., Jauhiainen, M., Vahtera, E., Pietinen, P., Korhonen, H., Kuulasmaa, K. & Ehnholm, C. (1993). The effects of saturated fat and n−6 polyunsaturated fat on postprandial lipemia and hemostatic activity. Atherosclerosis 103, 1–11.CrossRefGoogle ScholarPubMed
Snedecor, G. W. & Cochran, W. G. (1989). Analysis of variance. In Statistical Methods, 8th ed. pp 217–246. Ames: Iowa State University Press.Google Scholar
Tholstrup, T., Marckmann, P., Jespersen, J. & Sandstrom, B. (1994). Fat high in stearic acid favourably affects blood lipids and factor VII coagulant activity in comparison with fats high in palmitic acid or high in myristic and lauric acids. American Journal of Clinical Nutrition 59, 371–377.CrossRefGoogle ScholarPubMed
Zampelas, A., Peel, A. S., Gould, B. J., Wright, J. & Williams, C. M. (1994). Polyunsaturated fatty acids of the n−6 and n−3 series: effects on postprandial lipid and apolipoprotein levels in healthy men. European Journal of Clinical Nutrition 48, 842–848.Google ScholarPubMed