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Effect of nucleotide intake and nutritional recovery on insulin-like growth factor I and other hormonal biomarkers in severely malnourished children

Published online by Cambridge University Press:  08 March 2007

Edgar Vásquez-Garibay ,
Katja Stein ,
Juergen Kratzsch ,
Enrique Romero-Velarde  and
Gerhard Jahreis
Edgar Vásquez-Garibay*
Affiliation:
Institute of Human Nutrition, University Center of Health Sciences, University of Guadalajara, Unit of Infant Nutrition Studies, Civil Hospital of Guadalajara ‘Dr. Juan I. Menchaca’, Guadalajara, Jalisco, Mexico
Katja Stein
Affiliation:
Institute of Human Nutrition, University Center of Health Sciences, University of Guadalajara, Unit of Infant Nutrition Studies, Civil Hospital of Guadalajara ‘Dr. Juan I. Menchaca’, Guadalajara, Jalisco, Mexico
Juergen Kratzsch
Affiliation:
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnosis, University Hospital, Leipzig, Germany
Enrique Romero-Velarde
Affiliation:
Institute of Human Nutrition, University Center of Health Sciences, University of Guadalajara, Unit of Infant Nutrition Studies, Civil Hospital of Guadalajara ‘Dr. Juan I. Menchaca’, Guadalajara, Jalisco, Mexico
Gerhard Jahreis
Affiliation:
Institute of Nutrition, Friedrich Schiller University, Jena, Germany
*
*Corresponding author: Dr Edgar Vásquez-Garibay, fax +52 33 3618 9667, email inhu@cucs.udg.mx
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Abstract

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The objective of the present study is to demonstrate the effect of nucleotide intake and intensive nutritional support on the concentration of insulin-like growth factor I (IGF-I) and other hormonal biomarkers in severely malnourished children. Twenty-six severely malnourished children <48 months of age received formula without lactose via enteral feeding for 2 weeks and ad libitum for an additional 2 weeks. Anthropometrical measurements were performed and serum concentrations of IGF-I, insulin-like growth factor binding protein-3 (IGFBP-3), leptin, soluble leptin receptor (sOB-R), as well as the estimated molar excess of sOB-R over leptin were obtained. Two groups were formed. One group received formula with nucleotides (NT+; n 13) and the other without nucleotides (NT−; n 13). A control group was included (n 13). Parametric and non-parametric tests as well as ANOVA models were used. Nutritional recovery, nucleotides intake, type of malnutrition, age and the interaction between gender and malnutrition influenced the concentration of IGF-I (P<0·001). Nutritional recovery, nucleotides intake, gender and type of malnutrition had an effect on IGFBP-3 (P<0·001). Nutritional recovery had a significant effect on serum leptin (P=0·001). Age and nutritional recovery had an effect on sOB-R (P<0·001); all variables included affected the molar excess of sOB-R over leptin (P<0·001). In conclusion, nucleotide intake and nutritional recovery had a notable effect on IGF-I, IGFBP-3 and other hormonal biomarkers. This outcome could stimulate the catch-up growth of severely malnourished infants and toddlers during the nutritional recovery period.

Keywords

ChildrenMalnutritionNucleotidesNutritional recoveryInsulin-like growth factor ILeptin
Type
Research Article
Information
British Journal of Nutrition , Volume 96 , Issue 4 , October 2006 , pp. 683 - 690
Copyright
Copyright © The Nutrition Society 2006

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