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Developing Bio-Stable and Biodegradable Composites for Tissue Replacement and Tissue Regeneration

Published online by Cambridge University Press:  01 February 2011

Min Wang
Min Wang*
Affiliation:
Rehabilitation Engineering Centre, Hong Kong Polytechnic University Hung Hom, Kowloon, Hong Kong
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Abstract

Bone is the substantial unit of human skeletal system, which supports the body and its movement. At the ultra-structure level, the bone matrix is a composite material consisting of bone mineral particles, which are mainly substituted, calcium-deficient hydroxyapatite, and collagen, which is a natural polymer. Bone serves as the template for developing bone replacement materials. Research on biomaterials analogous to bone was started in the early 1980s by incorporating bioactive particles into biocompatible polymers so as to produce bone substitutes. Over the last two decades, a variety of bioactive polymer matrix composites have been developed for tissue substitution and tissue regeneration. The bioactive phases in these composites are normally one of the calcium phosphates, especially synthetic hydroxyapatite (HA, Ca10(PO4)6(OH)2) which closely resembles bone apatite and exhibits osteoconductivity. If enhanced bioactivity is required, bioceramics having higher bioactivity such as Bioglass® and A-W glass-ceramic can be used as the bioactive phase in the composites. For tissue replacement, bio-stable polymers such as polyethylene (PE) and polysulfone (PSU) are used as the matrix polymer. For tissue regeneration, natural, biodegradable polymers such as polyhydroxybutyrate (PHB) and chitin are used as matrices. Furthermore, mechanical as well as biological performance of a particular composite can be controlled by varying the amount of the bioactive phase in the composite, thus meeting specific clinical requirements. For bioactive ceramic-polymer composites, major influencing factors such as shape, size and size distribution of bioactive particles, mechanical properties and volume percentage of the bioactive phase, properties of the matrix polymer, distribution of bioactive particles in the matrix and the particle-matrix interfacial state should be controlled in order to obtain materials of desirable properties. Various techniques are used to evaluate the composites.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 724: Symposium N – Biological and Biomimetic Materials Properties to Function , 2002 , N5.1
Copyright
Copyright © Materials Research Society 2002

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References

1. Bonfield, W., Metals and Materials, Vol.3 (1987), 712–716 Google Scholar
2. Bonfield, W., Wang, M., Tanner, K.E., Acta Materialia, Vol.46 (1998), 2509–2518 Google Scholar
3. Bonfield, W., Bioceramics, Vol.8, (1995), 375–380 Google Scholar
4. Park, J.B., Biomaterials: An Introduction, Plenum Press, New York, (1979)Google Scholar
5. Evans, F.G., Lebow, M., American Journal of Surgery, Vol.83 (1952), 326–331 Google Scholar
6. Gibson, L.J., Ashby, M.F., Cellular Solids: Structure and Properties, 2nd Edition, Cambridge University Press, Cambridge, (1997)Google Scholar
7. Bonfield, W., Grynpas, M.D., Tully, A.E., Bowman, J., Abram, J., Biomaterials, Vol.2 (1981), 185–186 Google Scholar
8. Wang, M., Porter, D., Bonfield, W., British Ceramic Transactions, Vol.93 (1994), 91–95 Google Scholar
9. Tang, F., Wang, M., Proceedings of the 8th International Conference on Processing and Fabrication of Advanced Materials, Singapore, (1999), 299–306 Google Scholar
10. Wang, M., Bonfield, W., Polymer Processing Towards AD2000, Singapore, (1996), 203–204 Google Scholar
11. Wang, M., Joseph, R., Bonfield, W., Biomaterials, Vol.19 (1998), 2357–2366 Google Scholar
12. Tang, F., Ng, C.H., Wang, M., Proceedings of the International Conference on Thermophysical Properties of Materials, Singapore, (1999), 502–508 Google Scholar
13. Wang, M., Berry, C., Braden, M., Bonfield, W., Journal of Materials Science: Materials in Medicine, Vol.9 (1998), 621–624 Google Scholar
14. Fung, Y.C., Biomechanics: Mechanical Properties of Living Tissues, 2nd Edition, Springer-Verlag, New York, (1993)Google Scholar
15. Suwanprateeb, J., Tanner, K.E., Turner, S., Bonfield, W., Journal of Materials Science: Materials in Medicine, Vol.6 (1995), 804–807 Google Scholar
16. Suwanprateeb, J., Tanner, K.E., Turner, S., Bonfield, W., Journal of Materials Science: Materials in Medicine, Vol.8 (1997), 469–472 Google Scholar
17. Wang, M., Chua, B., Tang, F., Proceedings of the 10th International Conference on Biomedical Engineering, Singapore, (2000), 219–220 Google Scholar
18. Neo, M.C., Chandrasekaran, M., Wang, M., Loh, N.L., Bonfield, W., Bioceramics, Vol.12, (1999), 449–452 Google Scholar
19. Huang, J., L.Di Silvio, Wang, M., Tanner, K.E., Bonfield, W., Journal of Materials Science: Materials in Medicine, Vol.8 (1997), 775–779 Google Scholar
20. Bonfield, W., Behiri, J.C., Doyle, C., Bowman, J., Abram, J., in Biomaterials and Biomechanics, Edited by Ducheyne, P., Perre, G.Van der and Aubert, A.E., Elsevier Science Publishers, Amsterdam, (1984), 421–426 Google Scholar
21. Bonfield, W., Luklinska, Z.B., in The Bone-Biomaterial Interface, Edited by Davies, J.E., University of Toronto Press, Toronto, (1991), 89–93 Google Scholar
22. Downs, R.N., Vardy, S., Tanner, K.E., Bonfield, W., Bioceramics, Vol.4, (1991), 239–246 Google Scholar
23. Tanner, K.E., Downes, R.N., Bonfield, W., British Ceramic Transactions, Vol.93 (1994), 104–107 Google Scholar
24. Swain, R.E., Wang, M., Beale, B., Bonfield, W., Biomedical Engineering: Applications, Basis & Communications, Vol.11 (1999), 315–320 Google Scholar
25. Wang, M., Ward, I.M., Bonfield, W., Proceedings of the 11th International Conference on Composite Materials, Gold Coast, Australia, (1997), Vol.1, 488–495 Google Scholar
26. Wang, M., Deb, S., Tanner, K.E., Bonfield, W., Proceedings of the 7th European Conference on Composite Materials, London, U.K., (1996), Vol.2, 455–460 Google Scholar
27. Black, J., Hastings, G., (eds.), Handbook of Biomaterial Properties, Chapman & Hall, London, (1998)Google Scholar
28. Chua, B., Wang, M., MRS Symposium Proceedings, Vol.599, (1999), 45–50 Google Scholar
29. Wang, M., Bonfield, W., Hench, L.L., Bioceramics, Vol.8, (1995), 383–388 Google Scholar
30. Wang, M., Kokubo, T., Bonfield, W., Bioceramics, Vol.9, (1996), 387–390 Google Scholar
31. Wang, M., Wang, C.X., Weng, J., Ni, J., Transactions of the 6th World Biomaterials Congress, Hawaii, USA, (2000), 81 Google Scholar
32. Wang, M., Weng, J., Goh, C.H., Ni, J., Wang, C.X., Bioceramics, Vol.13, (2000), 741–744 Google Scholar
33. Weng, J., Wang, M., Bioceramics, Vol.13, (2000), 657–660 Google Scholar