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Chapter 2 - Embryo Developmental Programming

Published online by Cambridge University Press:  26 April 2023

By
Virginia N. Bolton
Edited by
Catherine Racowsky ,
Jacques Cohen  and
Nicholas Macklon
Catherine Racowsky
Affiliation:
Hôpital Foch, France
Jacques Cohen
Affiliation:
IVF 2.0, New York
Nicholas Macklon
Affiliation:
London Women's Clinic
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Summary

The developmental potential of individual human embryos varies, presenting clinical scientists with the challenge of developing methods enabling them to distinguish between those embryos destined to fail and those that have the potential to lead to a viable pregnancy. This chapter will summarise what is currently understood about the developmental programme of the human embryo. Through greater understanding of the underlying cellular and molecular mechanisms regulating pre-implantation development, the different approaches to embryo selection for use in ART treatment may be explored and evaluated.

Type
Chapter
Information
Manual of Embryo Selection in Human Assisted Reproduction , pp. 10 - 19
Publisher: Cambridge University Press
Print publication year: 2023

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References

Fauser, BCJM. Towards the global coverage of a unified registry of IVF outcomes. Reprod Biomed Online. 2019;38:133–7.Google Scholar
Niakan, KK, Han, JH, Pederson, RA, Simon, C, Reijo, Pera RA. Human pre-implantation development. Dev. 2012;139:829–41.Google Scholar
Rossant, J, Tam, PL. New insights into early human development: lessons for stem cell derivation and differentiation. Cell Stem Cell. 2017;20:18–28.Google Scholar
Eckersley-Maslin, MA, Alda-Catalinas, C, Reik, W. Dynamics of the epigenetic landscape during the maternal-to-zygotic transition. Nat Rev Mol Cell Biol. 2018;19:436–50.Google Scholar
Guo, H, Zhu, P, Yan, L, Li, R, Hu, B, Lian, Y, et al. The DNA methylation landscape of human early embryos. Nature. 2014;31:606–61.Google Scholar
De Paepe, C, Krivega, M, Cauffman, G, Geens, M, Van de Velde, H. Totipotency and lineage segregation in the human embryo. Mol Hum Reprod. 2014;20:599–618.CrossRefGoogle ScholarPubMed
Smith, HL, Stevens, A, Minogue, B, Sneddon, S, Shaw, L, Wood, L, et al. Systems based analysis of human embryos and gene networks involved in cell lineage allocation. BMC Genomics. 2019;20:171.Google Scholar
Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology. The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Hum Reprod. 2011;26:1270–83.Google Scholar
Wong, C, Chen, AA, Behr, B, Shen, S. Time-lapse microscopy and image analysis in basic and clinical embryo development research. RBMO. 2013;26:120–9.Google Scholar
Fleming, TP, Watkins, A, Velazquez, MA, Mathers, JC, Prentice, AM, Stephenson, J, et al. Origins of lifetime health around the time of conception: causes and consequences. Lancet. 2018;391:1842–52.CrossRefGoogle ScholarPubMed
Velasquez, MA, Fleming, TP, Watkins, AJ. Periconceptional environment and the developmental origins of disease. J Endocrinol. 2019;242:T33–T49.Google Scholar
Whitelaw, N, Bhattacharya, S, Hoad, G, Horgan, GW, Hamilton, M, Haggarty, P. Epigenetic status in the offspring of spontaneous and assisted conception. Hum Reprod. 2014;29:1452–8.Google Scholar
Market-Velker, BA, Fernandes, AD, Mann, MR. Side-by-side comparison of five commercial media systems in a mouse model: suboptimal in vitro culture interferes with imprint maintenance. Biol Reprod. 2010;83:938–50.CrossRefGoogle Scholar
Canovas, S, Ivanova, E, Romar, R, Garcia-Martinez, S, Soriano-Ubeda, C, Garcia-Vazquez, FA, et al. DNA methylation and gene expression changes derived from assisted reproductive technologies can be decreased by reproductive fluids. eLife 2017;6:e23670.CrossRefGoogle ScholarPubMed
Leese, HJ. What does an embryo need? Hum Fertil. 2003;6:180–5.CrossRefGoogle ScholarPubMed
Johnson, MH, Nasr-Esfahani, MH. Radical solutions and cultural problems: could free oxygen radicals be responsible for the impaired development of preimplantation mammalian embryos in vitro? Bioessays. 1994;16:31–8.CrossRefGoogle ScholarPubMed
Van Winkle, LJ. Amino acid transport regulation and early embryo development. Biol Reprod. 2001;64:1–12.CrossRefGoogle ScholarPubMed
Scott, R, Zhang, M, Seli, E. Metabolism of the oocyte and the preimplantation embryo: implications for assisted reproduction. Crr Opin Obstet Gynecol. 2018;30:163–70.Google ScholarPubMed
Leese, HJ. Quiet please, do not disturb: a hypothesis of embryo metabolism and viability. Bioessays. 2002;24:845–9.CrossRefGoogle Scholar
Baumann, CG, Morris, DG, Sreenan, JM, Leese, HJ. The quiet embryo hypothesis: molecular characteristics favoring viability. Mol Reprod Dev. 2007; 74:1345–53.Google Scholar

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