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Chapter 29 - Polar Body Biopsy for IVF

from Section 6 - Embryo Assessment: Morphology and Beyond

Published online by Cambridge University Press:  07 August 2023

By
Markus H. M. Montag
Edited by
Markus H. M. Montag  and
Dean E. Morbeck
Markus H. M. Montag
Affiliation:
ilabcomm GmbH, St Augustin, Germany
Dean E. Morbeck
Affiliation:
Kindbody Inc, New York City
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Summary

In 2011, the Istanbul Consensus Workshop on Embryo Assessment by the Alpha Scientists in Reproductive Medicine and the European Society of Human Reproduction and Embryology (ESHRE) Special Interest Group in Embryology simplified pronuclear scoring by assigning one of three classifications: symmetrical, asymmetrical and abnormal.

Keywords

polar bodyaneuploidymaternal agechromosomepre-implantation genetic testingPGT
Type
Chapter
Information
Principles of IVF Laboratory Practice
Laboratory Set-Up, Training and Daily Operation
 , pp. 213 - 217
Publisher: Cambridge University Press
Print publication year: 2023

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References

Verlinsky, Y., Ginsberg, N., Lifchez, A., et al. Analysis of the first polar body: preconception genetic diagnosis. Hum Reprod 1990; 5:826–9.CrossRefGoogle ScholarPubMed
Munne, S., Dailey, T., Sultan, K. M., et al. The use of first polar bodies for preimplantation diagnosis of aneuploidy. Mol Hum Reprod 1995; 10:1014–20.Google ScholarPubMed
Handyside, A. H., Montag, M., Magli, M. C., et al. Multiple meiotic errors caused by predivision of chromatids in woman of advanced maternal age undergoing in vitro fertilisation. Eur J Hum Genet 2012; 20:742–7.CrossRefGoogle ScholarPubMed
Montag, M., van der Ven, K., Delacrétaz, G., et al. Laser assisted microdissection of zona pellucida facilitates polar body biopsy. Fertil Steril 1998; 69:539–42.CrossRefGoogle ScholarPubMed
Harton, G. L., Magli, M. C., Lundin, K., et al. ESHRE PGD Consortium/ Embryology Special Interest Group: best practice guidelines for polar body and embryo biopsy for preimplantation genetic diagnosis/screening (PGD/PGS). Hum Reprod 2011; 26:41–6.CrossRefGoogle ScholarPubMed
Magli, C., Montag, M., Köster, M., et al. Polar body array CGH for prediction of the status of the corresponding oocyte: I. Technical aspects. Hum Reprod 2011; 26:3181–5.CrossRefGoogle Scholar
Verpoest, W., Staessen, C., Bossuyt, P. M., et al. Preimplantation genetic testing for aneuploidy by microarray analysis of polar bodies in advanced maternal age: a randomized clinical trial. Hum Reprod 2018; 33:1767–76.CrossRefGoogle ScholarPubMed
Montag, M., Köster, M.. Strowitzki, T. and Toth, B. Polar body biopsy. Fertil Steril 2013; 100:603–7.CrossRefGoogle ScholarPubMed
Salvaggio, C. N., Forman, E. J., Garnsey, H. M., et al. Polar body based aneuploidy screening is poorly predictive of embryo ploidy and reproductive potential. J Assist Reprod Genet 2014; 31: 1221–6.CrossRefGoogle ScholarPubMed
Cieslak, J., Ivakhenko, V., Wolf, G., et al. Three-dimensional partial zona dissection for preimplantation genetic diagnosis and assisted hatching. Fertil Steril 1999; 71:308–13.CrossRefGoogle ScholarPubMed

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