Autonomy is the concept of self-rule, or the ability to control our personal choices. This chapter starts with a discussion of the dubious practice of selling herbal weight-loss products and asks whether regulations should try to protect consumers from making bad choices or if buyers should be solely in control of their own decisions. Advertising can be a challenge to autonomy, especially if it misleads or manipulates by triggering unreflective psychological dynamics, and capitalism relies on consumers being informed and able to make voluntary choices. The challenges posed by internet commerce are also discussed. The morality of workplace restrictions on individuals is examined, as well as the challenges of intrusive psychological testing and reduced barriers between professional and private lives. Whistleblowing is also introduced as emblematic of the tension between individual values and loyalty to a company. The concluding case examines the Wells Fargo banking scandal where customers were unaware of accounts opened in their name and the firm coerced employees to act against their best moral judgment.