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Chapter 2 - Disruptive and Dangerous Agitation

Published online by Cambridge University Press:  20 July 2023

Mark Curato
Affiliation:
Weill Cornell Medicine, New York
Kaushal Shah
Affiliation:
Weill Cornell Medicine, New York
Christopher Reisig
Affiliation:
Weill Cornell Medicine, New York
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Summary

Agitation is a cardinal emergency medicine and prehospital presentation and occurs across a spectrum of severity and risk. Moderately agitated patients can be adequately assessed to exclude dangerous conditions, and if verbal de-escalation fails, may be treated with small doses of a titratable sedative or combination of sedatives, repeated as needed to calm the patient. Dangerously severe agitation is an uncommon medical emergency requiring prompt recognition and treatment in a high-resource care setting. Management focuses on the immediate treatment of agitation so that the patient and others are protected from uncontrolled violence, and so that dangerous causes and effects of agitation are quickly identified and addressed. Once adequate personnel are assembled to safely approach and subdue the patient, face mask oxygen is applied and dangerous restraint holds are relieved. Maximally effective calming medications are administered intramuscularly to quickly treat agitation. As the patient calms, resuscitation-level monitoring and care proceeds, with particular attention to ventilation, as the range of immediately dangerous causes and consequences of agitation are addressed.

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Publisher: Cambridge University Press
Print publication year: 2023

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References

Peisah, C, Chan, DK, McKay, R, Kurrle, SE, Reutens, SG. Practical guidelines for the acute emergency sedation of the severely agitated older patient. Internal Med J. 2011;41(9):651657.Google Scholar
Klein, LR, Driver, BE, Miner, JR, Martel, ML, Hessel, M, Collins, JD, Horton, GB, Fagerstrom, E, Satpathy, R, Cole, JB. Intramuscular midazolam, olanzapine, ziprasidone, or haloperidol for treating acute agitation in the emergency department. Ann Emerg Med. 2018;72(4):374385.CrossRefGoogle ScholarPubMed
Wilson, MP, Pepper, D, Currier, GW, Holloman Jr, GH, Feifel, D. The psychopharmacology of agitation: consensus statement of the American Association for Emergency Pyschiatry project beta workshop. West J Emerg Med. 2012;13(1):2634. PMID: 22461918.Google Scholar
Strayer, R. Jon Cole on Ketamine for Agitation. Emergency Medicine Updates. Available from: https://emupdates.com/jon-cole-on-ketamine-for-agitation (accessed April 23, 2022).Google Scholar
Isbister, GK, Calver, LA, Page, CB, Stokes, B, Bryant, JL, Downes, MA. Randomized controlled trial of intramuscular droperidol versus midazolam for violence and acute behavioral disturbance: the DORM study. Ann Emerg Med. 2010;56(4):392401.CrossRefGoogle ScholarPubMed
Knott, JC, Taylor, DM, Castle, DJ. Randomized clinical trial comparing intravenous midazolam and droperidol for sedation of the acutely agitated patient in the emergency department. Ann Emerg Med. 2006;47(1):6167.CrossRefGoogle ScholarPubMed
Martel, M, Sterzinger, A, Miner, J, Clinton, J, Biros, M. Management of acute undifferentiated agitation in the emergency department: a randomized double‐blind trial of droperidol, ziprasidone, and midazolam. Acad Emerg Med. 2005;12(12):11671172.Google Scholar
Lenzer, J, Solomon, RC. The droperidol dilemma: is the FDA’s black box warning necessary. ACEP News. 2002;3(8).Google Scholar
Hernández-Rodríguez, L, Bellolio, F, Cabrera, D, Mattson, AE, VanMeter, D, Grush, AE, Silva, LJE. Prospective real-time evaluation of the QTc interval variation after low-dose droperidol among emergency department patients. Am J Emerg Med. 2022;52: 212219.Google Scholar
American College of Emergency Physicians. Policy statements. Ann Emerg Med. 2021;77(6):e127e133.Google Scholar
Cole, JB, Lee, SC, Martel, ML, Smith, SW, Biros, MH, Miner, JR. The incidence of QT prolongation and torsades des pointes in patients receiving droperidol in an urban emergency department. West J Emerg Med. 2020;21(4):728736.Google Scholar
Gaw, CM, Cabrera, D, Bellolio, F, Mattson, AE, Lohse, CM, Jeffery, MM. Effectiveness and safety of droperidol in a United States emergency department. Am J Emerg Med. 2020;38(7):13101314.Google Scholar
Calver, L, Page, CB, Downes, MA, Chan, B, Kinnear, F, Wheatley, L, Spain, D, Isbister, GK. The safety and effectiveness of droperidol for sedation of acute behavioral disturbance in the emergency department. Ann Emerg Med. 2015;66(3):230238.Google Scholar
Yap, CY, Taylor, DM, Knott, JC, Taylor, SE, Phillips, GA, Karro, J, Chan, EW, Kong, DC, Castle, DJ. Intravenous midazolam–droperidol combination, droperidol or olanzapine monotherapy for methamphetamine‐related acute agitation: subgroup analysis of a randomized controlled trial. Addiction. 2017;112(7):12621269.CrossRefGoogle ScholarPubMed
Taylor, DM, Yap, CY, Knott, JC, Taylor, SE, Phillips, GA, Karro, J, Chan, EW, Kong, DC, Castle, DJ. Midazolam–droperidol, droperidol, or olanzapine for acute agitation: a randomized clinical trial. Ann Emerg Med. 2017;69(3):318326.Google Scholar
Westefer, L, Faust, J. Olanzapine + Benzodiazepines – What Is the FDA Warning About? FOAMcast. Available from: https://foamcast.org/2019/10/29/olanzapine-benzodiazepines-what-is-the-fda-warning-about (accessed April 12, 2022).Google Scholar
Jeffers, T, Darling, B, Edwards, C, Vadiei, N. Efficacy of combination haloperidol, lorazepam, and diphenhydramine vs. combination haloperidol and lorazepam in the treatment of acute agitation: a multicenter retrospective cohort study.J Emerg Med. 2022;62(4):516523.Google Scholar
Witting, MD, Hsu, S, Granja, CA. The sensitivity of room-air pulse oximetry in the detection of hypercapnia. Am J Emerg Med. 2005;23(4):497500.Google Scholar
Strömmer, EM, Leith, W, Zeegers, MP, Freeman, MD. The role of restraint in fatal excited delirium: a research synthesis and pooled analysis. Forensic Sci Med Pathol. 2020;16(4):680692.Google Scholar
Fiscella, K, Pinals, DA, Shields, CG. “Excited delirium,” erroneous concepts, dehumanizing language, false narratives, and threat to Black lives. Acad Emerg Med. 2022;29(7):911913.Google Scholar
Saadi, A, Naples-Mitchell, J, da Silva Bhatia, B, Heisler, M. End the use of “excited delirium” as a cause of death in police custody. Lancet. 2022;399(10329):10281030.Google Scholar
Storey, ML. Explaining the unexplainable: excited delirium syndrome and its impact on the objective reasonableness standard for allegations of excessive force. St Louis Univ Law J. 2012;56(2):10.Google Scholar
Kraines, SH. Bell’s mania. Am J Psychiatry. 1934;91(1):2940.Google Scholar
ACEP Hyperactive Delirium Task Force. ACEP Task Force Report on Hyperactive Delirium with Severe Agitation in Emergency Settings. American College of Emergency Physicians; 2021. www.acep.org/globalassets/new-pdfs/education/acep-task-force-report-on-hyperactive-delirium-final.pdf (accessed April 28, 2022).Google Scholar
Kupas, DF, Wydro, GC, Tan, DK, Kamin, R, Harrell IV, AJ, Wang, A. Clinical care and restraint of agitated or combative patients by emergency medical services practitioners. Prehosp Emerg Care. 2021;25(5):721723.Google Scholar
Wong, AH, Ray, JM, Cramer, LD, Brashear, TK, Eixenberger, C, McVaney, C, Haggan, J, Sevilla, M, Costa, DS, Parwani, V, Ulrich, A. Design and implementation of an agitation code response team in the emergency department. Ann Emerg Med. 2022;79(5):453464.Google Scholar
Stratton, SJ, Rogers, C, Green, K. Sudden death in individuals in hobble restraints during paramedic transport. Ann Emerg Med. 1995;25(5):710712.Google Scholar
Strömmer, EM, Leith, W, Zeegers, MP, Freeman, MD. The role of restraint in fatal excited delirium: a research synthesis and pooled analysis. Forensic Sci Med Pathol. 2020;16(4):680692.Google Scholar
Khawaja, RA, Sikandar, R, Qureshi, R, Jareno, RJ. Routine skin preparation with 70% isopropyl alcohol swab: is it necessary before an injection? Quasi study. J Liaquat Uni Med Health Sci. 2013;12(02):109114.Google Scholar
Fleming, DR, Jacober, SJ, Vandenberg, MA, Fitzgerald, JT, Grunberger, G. The safety of injecting insulin through clothing. Diabetes Care. 1997;20(3):244247.Google Scholar
Scheppke, KA, Braghiroli, J, Shalaby, M, Chait, R. Prehospital use of IM ketamine for sedation of violent and agitated patients. West J Emerg Med. 2014;15(7):736741.Google Scholar
Hopper, AB, Vilke, GM, Castillo, EM, Campillo, A, Davie, T, Wilson, MP. Ketamine use for acute agitation in the emergency department. J Emerg Med. 2015;48(6):712719.Google Scholar
Green, SM, Andolfatto, G, Krauss, BS. Ketamine and intracranial pressure: no contraindication except hydrocephalus. Ann Emerg Med. 2015;65(1):5254.Google Scholar
Drayna, PC, Estrada, C, Wang, W, Saville, BR, Arnold, DH. Ketamine sedation is not associated with clinically meaningful elevation of intraocular pressure. Am J Emerg Med. 2012;30(7):12151218.Google Scholar
Halstead, SM, Deakyne, SJ, Bajaj, L, Enzenauer, R, Roosevelt, GE. The effect of ketamine on intraocular pressure in pediatric patients during procedural sedation. Acad Emerg Med. 2012;19(10):11451150.Google Scholar
Le Cong, M, Humble, I. A ketamine protocol and intubation rates for psychiatric air medical retrieval. Air Med J. 2015 Nov 1;34(6):357–9.Google Scholar
Swaminathan, A. Is Ketamine Contraindicated in Patients with Psychiatric Disorders? RebelEM. Available from: https://rebelem.com/is-ketamine-contraindicated-in-patients-with-psychiatric-disorders (accessed April 23, 2022).Google Scholar
Cole, JB, Moore, JC, Nystrom, PC, Orozco, BS, Stellpflug, SJ, Kornas, RL, Fryza, BJ, Steinberg, LW, O’Brien-Lambert, A, Bache-Wiig, P, Engebretsen, KM. A prospective study of ketamine versus haloperidol for severe prehospital agitation. Clin Toxicol. 2016;54(7):556562.Google Scholar
Olives, TD, Nystrom, PC, Cole, JB, Dodd, KW, Ho, JD. Intubation of profoundly agitated patients treated with prehospital ketamine. Prehosp Disaster Med. 2016;31(6):593602.Google Scholar
Lin, J, Figuerado, Y, Montgomery, A, Lee, J, Cannis, M, Norton, VC, Calvo, R, Sikand, H. Efficacy of ketamine for initial control of acute agitation in the emergency department: a randomized study. Am J Emerg Med. 2021;44:306311.Google Scholar
Mo, H, Campbell, MJ, Fertel, BS, Lam, SW, Wells, EJ, Casserly, E, Meldon, SW. Ketamine safety and use in the emergency department for pain and agitation/delirium: a health system experience. West J Emerg Med. 2020;21(2):272281.Google Scholar
Barbic, D, Andolfatto, G, Grunau, B, Scheuermeyer, FX, Macewan, B, Qian, H, Wong, H, Barbic, SP, Honer, WG. Rapid agitation control with ketamine in the emergency department: a blinded, randomized controlled trial. Ann Emerg Med. 2021;78(6):788795.Google Scholar
Riddell, J, Tran, A, Bengiamin, R, Hendey, GW, Armenian, P. Ketamine as a first-line treatment for severely agitated emergency department patients. Am J Emerg Med. 2017;35(7):10001004.Google Scholar
Friedman, MS, Saloum, D, Haaland, A, Drapkin, J, Likourezos, A, Strayer, RJ. Description of adverse events in a cohort of dance festival attendees with stimulant-induced severe agitation treated with dissociative-dose ketamine. Prehosp Emerg Care. 2021;25(6):761767.Google Scholar
Heydari, F, Gholamian, A, Zamani, M, Majidinejad, S. Effect of intramuscular ketamine versus haloperidol on short-term control of severe agitated patients in emergency department; a randomized clinical trial. Bull Emerg Trauma. 2018;6(4):292299.Google Scholar
Gangathimmaiah, V, Le Cong, M, Wilson, M, Hooper, K, Perry, A, Burman, L, Puckeridge, N, Maguire, BJ. Ketamine sedation for patients with acute behavioral disturbance during aeromedical retrieval: a retrospective chart review. Air Med J. 2017;36(6):311314.Google Scholar
Parsch, CS, Boonstra, A, Teubner, D, Emmerton, W, McKenny, B, Ellis, DY. Ketamine reduces the need for intubation in patients with acute severe mental illness and agitation requiring transport to definitive care: an observational study. Emerg Med Australas. 2017;29(3):291296.Google Scholar
Isoardi, KZ, Parker, LE, Page, CB, Humphreys, MA, Harris, K, Rashford, S, Isbister, GK. Ketamine as a rescue treatment for severe acute behavioural disturbance: a prospective prehospital study. Emerg Med Australas. 2021;33(4):610614.Google Scholar
Bernard, S, Roggenkamp, R, Delorenzo, A, Stephenson, M, Smith, K, Ketamine in Severely Agitated Patients Study Investigators, Augello, M, Buntine, P, Costa, S, Gaeboc, M, Graudins, A. Use of intramuscular ketamine by paramedics in the management of severely agitated patients. Emerg Med Australas. 2021;33(5):875882.Google Scholar
Isbister, GK, Calver, LA, Downes, MA, Page, CB. Ketamine as rescue treatment for difficult-to-sedate severe acute behavioral disturbance in the emergency department. Ann Emerg Med. 2016;67(5):581587.Google Scholar
Nash, KA, Tolliver, DG, Taylor, RA, Calhoun, AJ, Auerbach, MA, Venkatesh, AK, Wong, AH. Racial and ethnic disparities in physical restraint use for pediatric patients in the emergency department. JAMA Pediatr. 2021;175(12):12831285.Google Scholar
Wong, AH, Taylor, RA, Ray, JM, Bernstein, SL. Physical restraint use in adult patients presenting to a general emergency department. Ann Emerg Med. 2019;73(2):183192.CrossRefGoogle ScholarPubMed
Schnitzer, K, Merideth, F, Macias‐Konstantopoulos, W, Hayden, D, Shtasel, D, Bird, S. Disparities in care: the role of race on the utilization of physical restraints in the emergency setting. Acad Emerg Med. 2020;27(10):943950.Google Scholar
Wong, AH, Whitfill, T, Ohuabunwa, EC, Ray, JM, Dziura, JD, Bernstein, SL, Taylor, RA. Association of race/ethnicity and other demographic characteristics with use of physical restraints in the emergency department. JAMA Network Open. 2021;4(1):e2035241.Google Scholar

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