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Chapter 16 - Delayed Neurologic Disorders after Toxic or Metabolic Insults

Published online by Cambridge University Press:  27 July 2023

Robert Laureno
Robert Laureno
Affiliation:
Georgetown University, Washington DC
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Summary

Although the neurologic effects of toxic or metabolic insults typically occur without much delay, there are exceptions. Dimethylmercury, diethylene glycol, ethylene glycol, methanol, tri-o-crysyl phosphate, and thallium sulfate are among the toxins that cause delayed neurologic effects.

Myelinolysis after correction of hyponatremia and post-anoxic leukoencephalopathy are among the metabolic disorders whose neurologic effects are typically delayed. The delay in these conditions offers the investigator opportunities to study disease mechanism and therapy.

Keywords

MyelinolysisPost anoxic leukoencephalopathyMethanolDimethyl mercuryDiethylene glycolEthylene glycol
Type
Chapter
Information
Insights into Clinical Neurology , pp. 82 - 84
Publisher: Cambridge University Press
Print publication year: 2023

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References

Laureno, R.. Central pontine myelinolysis following rapid correction of hyponatremia. Ann Neurol 1983; 13: 232–242.Google Scholar
Nierenberg, D. W., Nordgren, R. E., Chang, M. B. et al. Delayed cerebellar disease and death after accidental exposure to dimethylmercury. N Engl J Med 1998; 338: 1672–1676.CrossRefGoogle ScholarPubMed
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Rollins, Y. D., Filley, C. M., McNutt, J. T. et al. Fulminant ascending paralysis as a delayed sequela of diethylene glycol (Sterno) ingestion. Neurology 2002; 59: 1460–1463.CrossRefGoogle ScholarPubMed
Hasbani, M. J., Sansing, L. H., Perrone, J. et al. Encephalopathy and peripheral neuropathy following diethylene glycol ingestion. Neurology 2005; 64: 1273–1275.CrossRefGoogle ScholarPubMed
Bennett, I. L., Cary, F. H., Mitchell, G. L. et al. Acute methyl alcohol poisoning: a review based on experiences in an outbreak of 323 cases. Medicine (Baltimore) 1953; 32: 431–463.CrossRefGoogle Scholar
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Spencer, P. S., Shaumburg, H. H.. Experimental and Clinical Neurotoxicology. Baltimore, Williams & Wilkins, 1980.Google Scholar

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