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Chapter 4 - Maternal caregiving, oxytocin and mental illness

from Section 1 - The social, genetic and environmental aspects

Published online by Cambridge University Press:  05 March 2016

David J. Castle
Affiliation:
University of Melbourne
Kathryn M. Abel
Affiliation:
University of Manchester
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Publisher: Cambridge University Press
Print publication year: 2016

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References

Ainsworth, M. D. S., Blehar, M. C., Waters, E. & Wall, S. (1978). Patterns of attachment: A psychological study of the strange situation. Hillsdale, NJ: Erlbaum.Google Scholar
Atzil, S., Hendler, T. & Feldman, R. (2011). Specifying the neurobiological basis of human attachment: Brain, hormones, and behavior in synchronous and intrusive mothers. Neuropsychopharmacology 36, 113.Google Scholar
Avagianou, P. A. & Zafiropoulou, M. (2008). Parental bonding and depression: Personality as a mediating factor. International Journal of Adolescent Medicine and Health 20, 261269.Google Scholar
Bakermans-Kranenburg, M. J. & van IJzendoorn, M. H. (2015). The hidden efficacy of interventions: Gene×environment experiments from a differential susceptibility perspective. Annual Review of Psychology 3(66), 381409.CrossRefGoogle Scholar
Bakermans-Kranenburg, M. J., van IJzendoorn, M. H. & Juffer, F. (2003). Less is more: Meta-analyses of sensitivity and attachment interventions in early childhood. Psychological Bulletin 129, 195215.CrossRefGoogle ScholarPubMed
Baumgartner, T., Heinrichs, M., Vonlanthen, A., Fischbacher, U. & Fehr, E. (2008). Oxytocin shapes the neural circuitry of trust and trust adaptation in humans. Neuron 58, 639650.Google Scholar
Bee, P., Berzins, K., Calam, R., Pryjmachuk, S. & Abel, K. M. (2013). Defining quality of life in the children of parents with severe mental illness. A preliminary stakeholder-led model. PLOS One 8(9), doi: 10.1371/journal.pone.0073739.CrossRefGoogle ScholarPubMed
Bee, P., Bower, P., Byford, S., Churchill, R., Calam, R., Stallard, P., Pryjmachuk, S., Berzins, K., Cary, M., Wan, M. & Abel, K. (2014). The clinical-effectiveness, cost-effectiveness and acceptability of community-based interventions aimed at improving or maintaining quality of life in children of parents with serious mental illness; a systematic review. Health Technology Assessment 18(8), 1250. doi: 10.3310/hta18080.CrossRefGoogle ScholarPubMed
Bigelow, A. E, et al. (2010). Maternal sensitivity throughout infancy: Continuity and relation to attachment security. Infant Behavior and Development 33, 5060.CrossRefGoogle ScholarPubMed
Blumberg, N. L. (1980). Effects of neonatal risk, maternal attitude, and cognitive style on early postpartum adjustment Journal of Abnormal Psychology 89, 139150.CrossRefGoogle ScholarPubMed
Caba, M., Silver, R., Gonzalez-Mariscal, G., Jimenez, A. & Beyer, C. (1996). Oxytocin and vasopressin immunoreactivity in rabbit hypothalamus during estrus, late pregnancy, and postpartum. Brain Research 720, 716.Google Scholar
Campbell, S. B., Matestic, P., von Stauffenberg, C., Mohan, R. & Kirchner, T. (2007). Trajectories of maternal depressive symptoms, maternal sensitivity, and children’s functioning at school entry. Developmental Psychology 43, 12021215.CrossRefGoogle ScholarPubMed
Cardinal, R. N., Parkinson, J. A., Hall, J. & Everitt, B. J. (2002). Emotion and motivation: The role of the amygdala, ventral striatum, and prefrontal cortex. Neuroscience & Biobehavioral Reviews 26, 321352.CrossRefGoogle ScholarPubMed
Carter, D. A. & Murphy, D. (1989). Independent regulation of neuropeptide mRNA level and poly (A) tail length. Journal of Biological Chemistry 264, 66016603.Google Scholar
Cassidy, J., Woodhouse, S. S, Cooper, G., Hoffman, K., Powell, B. & Rodenberg, M. (2005). Examination of the precursors of infant attachment security: Implications for early intervention and intervention research. In: Berlin, L. J., Amaya-Jackson, L. & Greenberg, M. T. (eds.) Enhancing early attachments: Theory, research, intervention, and policy. New York: Guilford Press, pp. 3460.Google Scholar
Champagne, F. A. (2008). Epigenetic mechanisms and the transgenerational effects of maternal care. Frontiers in Neuroendocrinology 29, 386397.CrossRefGoogle ScholarPubMed
Champagne, F. A. & Curley, J. P. (2010). Maternal care as a modulating influence on infant development. In: Blumberg, M. S., Freeman, J. H. & Robinson, S. R. (eds.) Developmental and comparative neuroscience: Epigenetics, evolution & behavior. Oxford, UK: Oxford University Press, p. 323341.Google Scholar
Champagne, F., Diorio, J., Sharma, S. & Meaney, M. J. (2001). Naturally occurring variations in maternal behavior in the rat are associated with differences in estrogen-inducible central oxytocin receptors. Proceedings of the National Academy of Sciences of the United States of America 98, 1273612741.CrossRefGoogle ScholarPubMed
Champagne, F. A., Francis, D. D., Mar, A. & Meaney, M. J. (2003). Variations in maternal care in the rat as a mediating influence for the effects of environment on development. Physiology & Behavior 79, 359371.CrossRefGoogle ScholarPubMed
Champagne, F. A. & Meaney, M. J. (2007). Transgenerational effects of social environment on variations in maternal care and behavioral response to novelty. Behavioral Neuroscience 121, 13531363.Google Scholar
Crosnoe, R., Leventhal, T., Wirth, R. J., Pierce, K. M. & Pianta, R. C.; NICHD Early Child Care Research Network. (2010). Family socioeconomic status and consistent environmental stimulation in early childhood. Child Development 81, 972987.Google Scholar
Dabrowska, J., Hazra, R., Ahern, T. H., Dong Guo, J., McDonald, A. J., Mascagni, F., Muller, J. F., Young, L. J. & Rainnie, D. G. (2011). Neuroanatomical evidence for reciprocal regulation of the corticotrophin-releasing factor and oxytocin systems in the hypothalamus and the bed nucleus of the stria terminalis of the rat: Implications for balancing stress and affect. Psychoneuroendocrinology 36, 13121326.CrossRefGoogle ScholarPubMed
Ditzen, B., Neumann, I. D., Bodenmann, G., Von Dawans, B., Turner, R. A., Ehlert, U. & Heinrichs, M. (2007). Effects of different kinds of couple interaction on cortisol and heart rate responses to stress in women. Psychoneuroendocrinology 32, 565574.CrossRefGoogle ScholarPubMed
Elliott, R., Zahn, R., Deakin, J. FW. & Anderson, I. M. (2011). Affective cognition in mood disorder. Neuropsychopharmacology 36, 153182.Google Scholar
Elmadih, A., Wan, M. W., Numan, M., Elliott, R., Downey, D. & Abel, K. M. (2014). Does oxytocin modulate variation in maternal caregiving in healthy new mothers? Brain Research 1580, 143150.CrossRefGoogle ScholarPubMed
Feldman, R. (2012). Oxytocin and social affiliation in humans. Hormones and Behavior 61, 380391.Google Scholar
Feldman, R. & Eidelman, A. I. (2003). Direct and indirect effect of breast milk on neurobehavioural and cognitive development of premature infants. Developmental Psychobiology 43, 109119.Google Scholar
Feldman, R., Gordon, I., Schneiderman, I., Weisman, O. & Zagoory-Sharon, O. (2010a). Natural variations in maternal and paternal care are associated with systematic changes in oxytocin following parent-infant contact. Psychoneuroendocrinology. 35, 11331141.Google Scholar
Feldman, R., Gordon, I. & Zagoory-Sharon, O. (2010b). The cross-generation transmission of oxytocin in humans. Hormones and Behavior 58, 669676.Google Scholar
Feldman, R., Gordon, I. & Zagoory-Sharon, O. (2011). Maternal and paternal plasma, salivary, and urinary oxytocin and parent–infant synchrony: Considering stress and affiliation components of human bonding. Developmental Science 14, 752761.Google Scholar
Feldman, R. & Klein, P. S. (2003). Toddlers’ selfregulated compliance to mothers, caregivers, and fathers: Implications for theories of socialization. Developmental Psychology 39, 680692.CrossRefGoogle ScholarPubMed
Feldman, R., Weller, A., Zagoory-Sharon, O. & Levine, A. (2007). Evidence for a neuroendocrinological foundation of human affiliation: Plasma oxytocin levels across pregnancy and the postpartum period predict mother-infant bonding. Psychological Science 18, 965970.Google Scholar
Francis, D. D., Champagne, F. C. & Meaney, M. J. (2000). Variations in maternal behaviour are associated with differences in oxytocin receptor levels in the rat. Journal of Neuroendocrinology 12, 11451148.Google Scholar
Francis, D., Diorio, J., Liu, D. & Meaney, M. J. (1999). Nongenomic transmission across generations of maternal behavior and stress responses in the rat. Science, 268(5442), 11551158.Google Scholar
Francis, D. D., Young, L. J., Meaney, M. J. & Insel, T. R. (2002). Naturally occurring differences in maternal care are associated with the expression of oxytocin and vasopressin (V1a) receptors: Gender differences. Journal of Neuroendocrinology 14, 349353.Google Scholar
Fuchs, A. R., Fields, M. J., Freidman, S., Shemesh, M. & Ivell, R. (1995). Oxytocin and the timing of parturition. Influence of oxytocin receptor gene expression, oxytocin secretion, and oxytocin-induced prostaglandin F2a and E2 release. Advances in Experimental Medicine and Biology 395, 405420.Google Scholar
Galbally, M., Lewis, A. J., Ijzendoorn, M. V. & Permezel, M. (2011). The role of oxytocin in mother-infant relations: A systematic review of human studies. Harvard Review of Psychiatry 19, 114.Google Scholar
Ghera, M. M., Hane, A. A., Malesa, E. E. & Fox, N. A. (2006). The role of infant soothability in the relation between infant negativity and maternal sensitivity. Infant Behavior and Development 29, 289293.Google Scholar
Gimpl, G. & Fahrenholz, F. (2001). The oxytocin receptor system: Structure, function, and regulation. Physiological Reviews 81, 629683.CrossRefGoogle ScholarPubMed
Gordon, I., Zagoory-Sharon, O., Leckman, J. F. & Feldman, R. (2010). Oxytocin and the development of parenting in humans. Bilological Psychiatry 68, 377382.Google Scholar
Gordon, I., Zagoory-sharon, O., Schneiderman, I., Leckman, J. F., Weller, A. & Feldman, R. (2008). Oxytocin and cortisol in romantically unattached young adults: Associations with bonding and psychological distress. Psychophysiology 45, 349352.Google Scholar
Grippo, A. J., Gerena, D., Huang, J., Kumar, N., Shah, M., Ughreja, R. & Carter, C. S. (2007). Social isolation induces behavioral and neuroendocrine disturbances relevant to depression in female and male prairie voles. Psychoneuroendocrinology 32, 966980.Google Scholar
Guttentag, C. L. et al. (2006). Individual variability in parenting profiles and predictors of change: Effects of an intervention with disadvantaged mothers. Journal of Applied Developmental Psychology 27, 349369.Google Scholar
Harmer, C. J. et al. (2011). Efficacy markers in depression. Journal of Psychopharmacology 25, 11481158.Google Scholar
Harwin, J. et al. (2014). Final Report of the Evaluation of the Family Drug and Alcohol Court Pilot. www.brunel.ac.uk/__data/assets/pdf_file/0007/366370/FDAC_May2014_FinalReport_V2.pdfGoogle Scholar
Hill, J., Pickles, A., Burnside, E., Byatt, M., Rollinson, L., Davis, R. & Harvey, K. (2001). Child sexual abuse, poor parental care and adult depression: Evidence for different mechanisms. British Journal of Psychiatry 179, 104109.Google Scholar
Insel, T. (1990). Oxytocin and maternal behavior. In Krasnegor, N. A. & Bridges, R. B. (eds.), Mammalian parenting: biochemical, neurobiological and behavioral determinants. New York: Oxford University Press, 260280.Google Scholar
Joosen, K. J., Mesman, J., Bakermans-Kranenburg, M. J. & van IJzendoorn, M. H. (2012). Maternal sensitivity to infants in various settings predicts harsh discipline in toddlerhood. Attachment & Human Development 14, 101117.CrossRefGoogle ScholarPubMed
Juffer, F., Bakermans-Kranenburg, M. J. & van IJzendoorn, M. H. (2008). Promoting positive parenting: An attachment-based intervention. Lawrence Erlbaum.Google Scholar
Kemppinen, K., Kumpulainen, K., Raita-Hasu, J. & Moilanen, I. (2006). The continuity of maternal sensitivity from infancy to toddler age. Journal of Reproductive and infant Psychology, 24, 199212.Google Scholar
Kim, P., Feldman, R., Mayes, L. C., Eicher, V., Thompson, N., Leckman, J. F. & Swain, J. E. (2011). Breastfeeding, brain activation to own infant cry, and maternal sensitivity. Journal of Child Psychology and Psychiatry 52, 907915.Google Scholar
Kow, L. M. & Pfaf, D. W. (1998). Mapping of neural and signal transduction pathways for lordosis in the search for estrogen actions on the central nervous system. Behavioural Brain Research 92, 169180.Google Scholar
Landgraf, R., Neumann, I. & Pittman, Q. J. (1991). Septal and hippocampal release of vasopressin and oxytocin during late pregnancy and parturition in the rat. Neuroendocrinology 54, 378383.Google Scholar
Lee, H. J., Macbeth, A. H., Pagani, J. H. & Young, W. S. 3rd. (2009). Oxytocin: The Great Facilitator of Life. Progress in Neurobiology 88, 127151.Google ScholarPubMed
Legros, J. J. (2001). Inhibitory effect of oxytocin on corticotrope function in humans: Are vasopressin and oxytocin ying-yang neurohormones? Psychoneuroendocrinology 26, 649655.Google Scholar
Leng, G., Meddle, S. L. & Douglas, A. J. (2008). Oxytocin and the maternal brain. Current Opinion in Pharmacology 8, 731734.Google Scholar
Levine, A., Zagoory-Sharon, O., Feldman, R. & Weller, A. (2007). Oxytocin during pregnancy and early postpartum: Individual patterns and maternal–fetal attachment. Peptides 28, 11621169.CrossRefGoogle ScholarPubMed
Levy, F., Kendrick, K. M., Goode, J. A., Guevara-Guzman, R. & Keverne, E. B. (1995). Oxytocin and vasopressin release in the olfactory bulb of parturient ewes: Changes with maternal experience and effects on acetylcholine, gamma-aminobutyric acid, glutamate and noradrenaline release. Brain Research 669, 197206.Google Scholar
Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D. & Freedman, A. (1997). Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science 277, 16591662.Google Scholar
Luby, J., Belden, A., Botteron, K., et al. (2013). The Effects of Poverty on Childhood Brain Development The Mediating Effect of Caregiving and Stressful Life Events. The Journal of the American Medical Association Pediatrics, doi:10.1001/jamapediatrics.2013.3139.Google Scholar
Marazziti, D., Dell’Osso, B., Baroni, S., Mungai, F., Catena, M., Rucci, P., Albanese, F., Giannaccini, G., Betti, L., Fabbrini, L., Italiani, P., Del Debbio, P., Lucacchini, A. & Dell’Osso, L. (2006). A relationship between oxytocin and anxiety of romantic attachment. Clinical Practice and Epidemiology in Mental Health 28, doi:10.1186/1745-0179-2-28.Google Scholar
Meddle, S. L., Bishop, V. R., Gkoumassi, E., van Leeuwen, F. W. & Douglas, A. J. (2007). Dynamic changes in oxytocin receptor expression and activation at parturition in the rat brain. Endocrinology 148, 50955104.CrossRefGoogle ScholarPubMed
Meyer-Lindenberg, A. (2008). Impact of prosocial neuropeptides on human brain function. Progress in Brain Research 170, 463470.Google Scholar
Mills-Koonce, W. R., Gariepy, J. L., Sutton, K. & Cox, M. J. (2008). Changes in maternal sensitivity across the first three years: Are mothers from different attachment dyads differentially influenced by depressive symptomatology? Attachment & Human Development 10, 299317.Google Scholar
Milner, J. S. (1993). Social information-processing and physical child-abuse. Clinical Psychology Review 13, 275294.Google Scholar
Milner, J. S. (2003). Social information processing in high-risk and physically abusive parents. Child Abuse and Neglect 27, 720.Google Scholar
Moran, G. et al. (2005). Maternal unresolved attachment status impedes the effectiveness of interventions with adolescent mothers. Infant Mental Health Journal 26, 231249.Google Scholar
Muller-Nix, C., Forcada-Guex, M., Pierrehumbert, B., Jaunin, L., Borghini, A. & Ansermet, F. (2004). Prematurity, maternal stress and mother-child interactions. Early Human Development and Psychopathology 79, 145158.Google Scholar
Murray, L., Fiori-Cowley, A., Hooper, R. & Cooper, P. (1996). The impact of postnatal depression and associated adversity on early mother-infant interactions and later infant outcome. Child Development 67, 25122526.Google Scholar
NICHD. (1999). Chronicity of maternal depressive symptoms, maternal sensitivity, and child functioning at 36 months. Developmental Psychology 35, 12971310.Google Scholar
Nicol-Harper, R., Harvey, A. G. & Stein, A. (2007). Interactions between mothers and infants: Impact of maternal anxiety. Infant Behavior and Development 30, 161167.Google Scholar
Numan, M. (2006). Hypothalamic neural circuits regulating maternal responsiveness toward infants. Behavioral and Cognitive Neuroscience Reviews 5, 163190.Google Scholar
Numan, M. & Stolzenberg, D. S. (2009). Medial preoptic area interactions with dopamine neural systems in the control of the onset and maintenance of maternal behavior in rats. Frontiers in Neuroendocrinology 30, 4664.Google Scholar
Numan, M. & Woodside, B. (2010). Maternity: Neural mechanisms, motivational processes, and physiological adaptations. Behavioral Neuroscience 124, 715741.Google Scholar
Olazabal, D. E. & Young, L. J. (2006). Oxytocin receptors in the nucleus accumbens facilitate “spontaneous” maternal behavior in adult female prairie voles. Neuroscience, 559–568.Google Scholar
Pearson, R. M., Heron, J., Melotti, R., Joinson, C., Stein, A., Ramchandani, P. G. & Evans, J. (2011). The association between observed non-verbal maternal responses at 12 months and later infant development at 18 months and IQ at 4 years: A longitudinal study. Infant Behavior and Development 34, 525533.Google Scholar
Pedersen, C. A., Ascher, J. A., Monroe, Y. L. & Prange, A. J. Jr. (1982). Oxytocin induces maternal behavior in virgin female rats. Science 216, 648650.Google Scholar
Pedersen, C. A. & Prange, A. J. Jr. (1979). Induction of maternal behavior in virgin rats after intracerebroventricular administration of oxytocin. Proceedings of the National Academy of Sciences of the United States of America 76, 66616665.CrossRefGoogle ScholarPubMed
Pollack, M. H. (2005). Comorbid anxiety and depression. Journal of Clinical Psychiatry 66, 2229.Google Scholar
Pruessner, J. C., Champagne, F., Meaney, M. J., Dagher, A. (2004). Dopamine release in response to a psychological stress in humans and its relationship to early life maternal care: A positron emission tomography study using [11C]Raclopride. The Journal of Neuroscience 24(11), 28252831.Google Scholar
Ragnauth, A. K., Devidze, N., Moy, V., Finley, K., Goodwillie, A., Kow, L. M., Muglia, L. J. & Pfaff, D. W. (2005). Female oxytocin gene-knockout mice, in a semi-natural environment, display exaggerated aggressive behavior. Genes, Brain, and Behaviour 4, 229239.Google Scholar
Ross, H. E. & Young, L. J. (2009). Oxytocin and the neural mechanisms regulating social cognition and affiliative behavior. Frontiers in Neuroendocrinology 30, 534547.Google Scholar
Rutter, M. (1966). Children of sick parents: An environmental and psychiatric study (Institute of Psychiatry, Maudsley Monographs No. 16). London: Oxford University Press.Google Scholar
Sidor, A., Kunz, E., Schweyer, D., Eickhorst, A. & Cierpka, M. (2011). Links between maternal postpartum depressive symptoms, maternal distress, infant gender and sensitivity in a high-risk population. Child and Adolescent Psychiatry and Mental Health 5.Google Scholar
Singer, L. T., Salvator, A., Guo, S., Collin, M., Lilien, L. & Baley, J. (1999). Maternal psychological distress and parenting stress after the birth of a very low-birth-weight infant. Journal of the American Medical Association 281, 799805.Google Scholar
Sroufe, L. (2000). Early relationships and the development of children. Infant Mental Health Journal 21, 6774.Google Scholar
Stachowiak, A., Macchi, C., Nussdorfer, G. G. & Malendowicz, L. K. (1995). Effects of oxytocin on the function and morphology of the rat adrenal cortex: In vitro and in vivo investigations. Research in Experimental Medicine 195, 265274.Google Scholar
Strathearn, L., Fonagy, P., Amico, J. & Montague, P. R. (2009). Adult attachment predicts maternal brain and oxytocin response to infant cues. Neuropsychopharmacology 34, 26552666.Google Scholar
Swain, J. E., Kim, P., Spicer, J., Ho, S. S., Dayton, C. J., Elmadih, A. & Abel, K. M. (2014). Approaching the biology of human parental attachment: Brain imaging, oxytocin and coordinated assessments of mothers and fathers. Brain Research. doi: 10.1016/j.brainres.2014.03.007.Google Scholar
Tabak, B. A., McCullough, M. E., Szeto, A., Mendez, A. J. & McCabe, P. M. (2011). Oxytocin indexes relational distress following interpersonal harms in women. Psychoneuroendocrinology 36, 115122.Google Scholar
Taylor, S. E., Gonzaga, G. C., Klein, L. C., Hu, P., Greendale, G. A. & Seeman, S. E. (2006). Relation of oxytocin to psychological stress responses and hypothalamic-pituitary-adrenocortical axis activity in older women. Psychosomatic Medicine 68, 238245.Google Scholar
Taylor, S. E., Saphire-Bernstein, S. & Seeman, T. E. (2010). Are plasma oxytocin in women and plasma vasopressin in men biomarkers of distressed pair bond relationships? Psychological Science 21, 37.Google Scholar
Tronick, E. & Reck, C. (2009). Infants of depressed mothers. Harvard Review of Psychiatry 17, 147156.Google Scholar
Turner, R. A., Altemus, M., Yip, D. N., Kupferman, E., Fletcher, D., Bostrom, A., Lyons, D. M. & Amico, J. A. (2002). Effects of emotion on oxytocin, prolactin, and ACTH in women. Stress 5, 269276.Google Scholar
Uvnas-Moberg, K. (1998). Oxytocin may mediate the benefits of positive social interaction and emotions. Psychoneuroendocrinology 23, 819835.Google Scholar
Van Leengoed, E., Kerker, E. & Swanson, H. H. (1987). Inhibition of postpartum maternal behaviour in the rat by injecting an oxytocin antagonist into the cerebral ventricles. Journal of Endocrinology 112, 275282.CrossRefGoogle ScholarPubMed
Wan, M. & Green, J. (2009). The impact of maternal psychopathology on child-mother attachment. Archives of Women’s Mental Health 12, 123134.Google Scholar
Wan, M. W., Moulton, S. & Abel, K. M. (2008a). What interventions might improve the relationships of mothers with schizophrenia with their children? A Review. Archives of Women’s Mental Health 11(3), 171179.Google Scholar
Wan, M. W., Warren, K., Salmon, M. & Abel, K. M. (2008b). Patterns of maternal responding in postpartum mothers with Schizophrenia. Infant Behavior and Development 31, 532538.Google Scholar
Wang, Z. X., Liu, Y., Young, L. J. & Insel, T. R. (2000). Hypothalamic vasopressin gene expression increases in both males and females postpartum in a biparental rodent. Journal of Neuroendocrinology 12, 111120.CrossRefGoogle Scholar
Warren, S. L. & Simmens, S. J. (2005). Predicting toddler anxiety, depressive symptoms: Effects of caregiver sensitivity on temperamentally vulnerable children. Infant Mental Health Journal 26, 4055.Google Scholar
Webb, R., Pickles, A., Appleby, L., Mortensen, P. B. & Abel, K. M. (2007). Death by unnatural causes during childhood and early adulthood in offspring of psychiatric inpatients. The Journal of the American Medical Association Psychiatry 64, 345352.Google ScholarPubMed
Williams, J. R., Catania, K. C. & Carter, C. S. (1992). Development of partner preferences in female prairie voles (Microtus ochrogaster): The role of social and sexual experience. Hormones and Behaviors 26, 339349.Google Scholar
Wolpert, M., Hoffman, J., Martin, A., Fagin, L. & Cooklin, A. (2014). An exploration of the experience of attending the Kidstime programme for children with parents with enduring mental health issues: Parents’ and young people’s views. Clinical Child Psychology and Psychiatry 1359104514520759.Google Scholar
Zhang, T. Y. & Meaney, M. J. (2010). Epigenetics and the environmental regulation of the genome and its function. Annual Review of Psychology 61, 439466.Google Scholar

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