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Chapter 29 - Global Health Research

Changing the Agenda

from Section 6 - Shaping the Future

Published online by Cambridge University Press:  04 February 2021

Solomon Benatar
Affiliation:
Emeritus Professor of Medicine, University of Cape Town
Gillian Brock
Affiliation:
Professor of Philosophy, University of Auckland
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Summary

With the launch of the United Nations’ Sustainable Development Goals (SDGs), the new global compact replacing the Millennium Development Goals (MDGs), global health research remains critical in the development and implementation of inclusive, equitable, and sustainable policies and interventions. While there is a health-specific SDG 3 on good health and well-being, about 11 of the 17 SDGs have embedded and integrated health-related goals in at least 29 targets and 37 indicators (GBD 2016 SDG Collaborators, 2017). These goals reflect global priorities for global sustainable development and will attract critical funding from governments and development assistance, as was the case with the MDGs, and increasingly from philanthropies, the private sector, and public-private partnerships.

Type
Chapter
Information
Global Health
Ethical Challenges
, pp. 370 - 382
Publisher: Cambridge University Press
Print publication year: 2021

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References

Allen, L., & Bloomfield, A. (2016). Engaging the private sector to strengthen NCD prevention and control. Lancet Global Health 4, e897e898.Google Scholar
Al-Shahi Salman, R., Beller, E., Kagan, J., et al. (2014). Increasing value and reducing waste in biomedical research regulation and management. Lancet 383, 176–85.Google ScholarPubMed
Baum, F.E., Sanders, D.M., Fisher, M., et al. (2016). Assessing the health impact of transnational corporations: its importance and a framework. Globalization and Health, 12, 27.CrossRefGoogle ScholarPubMed
Benatar, S., Daibes, I., & Tomsons, S. (2016). Inter-philosophies dialogue: creating a paradigm for global health ethics. Kennedy Institute of Ethics Journal 26, 323346.Google Scholar
Brende, B., Farrar, J., Gashumba, D., et al. (2017). CEPI: a new global R&D organisation for epidemic preparedness and response. Lancet 389, 233235.Google Scholar
Brown, R. J., & Head, M. G. (2018). Sizing Up Pneumonia Research: Assessing Global Investments in Pneumonia Research, 2000–2015. Southampton, UK: ResIn.Google Scholar
Callaway, E. (2018). CRISPR plants now subject to tough GM laws in European Union. Nature 560, 16.CrossRefGoogle ScholarPubMed
Chalmers, I., & Glasziou, P. (2009). Avoidable waste in the production and reporting of research evidence. Lancet 374, 8689.Google Scholar
Chalmers, I., Bracken, M. B., Djulbegovic, B., et al. (2014). How to increase value and reduce waste when research priorities are set. Lancet 383, 156165.CrossRefGoogle ScholarPubMed
Chan, A. W., Song, F., Vickers, A., et al. (2014). Increasing value and reducing waste: addressing inaccessible research. Lancet 383: 257266.Google Scholar
Coalition for Epidemic Preparedness Innovation (CEPI) (2019). Progress. Available at https://cepi.net/get_involved/support-cepi/ (accessed February 11, 2019).Google Scholar
Dauda, B., Denier, Y., & Dierickx, K. (2016). What do the various principles of justice mean within the concept of benefit sharing? Journal of Bioethical Inquiry 13, 281293.Google Scholar
Drugs for Neglected Diseases Initiative (DNDi) (2018). Global Antibiotic Research and Development Partnership. Available at www.gardp.org/about/ (accessed September 21, 2018).Google Scholar
EvaluatePharma (2016). EvaluatePharma World Preview 2016, Outlook to 2022. London: Evaluate, Ltd. Available at http://info.evaluategroup.com/rs/607-YGS-364/images/wp16.pdf (accessed July 31, 2018).Google Scholar
Evans, J. A., Shim, J. M., & Ionnidis, J. P. A. (2014). Attention to local health burden and the global disparity of health research. PLoS ONE 9, e90147.CrossRefGoogle ScholarPubMed
Ezzati, M., Pearson-Stuttard, J., Bennett, J. E., & Mathers, C. D. (2018). Acting on non-communicable diseases in low- and middle-income tropical countries. Nature 559, 507516.Google Scholar
Fabbri, A., Lai, A., Grundy, Q., & Bero, L. A. (2018). The influence of industry sponsorship on the research agenda: a scoping review. American Journal of Public Health 108, e9e16.CrossRefGoogle ScholarPubMed
Fitchett, J. R. A., Lichtman, A., Soyode, D. T., et al. (2016). Ebola research funding: a systematic analysis, 1997–2015. Journal of Global Health 6, 020703.CrossRefGoogle Scholar
Forero, D. A., Oermann, M. H., Manca, A., et al. (2018). Negative effects of “predatory” journals on global health research. Annals of Global Health 84, 584589.Google Scholar
Freudenberg, N. (2016). Lethal but Legal: Corporations, Consumption, and Protecting Public Health. New York: Oxford University Press.Google Scholar
GBD 2016 SDG Collaborators (2017). Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016. Lancet 390, 14231459.CrossRefGoogle Scholar
GBD Health Financing Collaborator Network (2018). Trends in future health financing and coverage: future health spending and universal health coverage in 188 countries, 2016–2040. Lancet 391, 17831798.CrossRefGoogle Scholar
Global Code of Conduct for Research in Resource-Poor Settings (2018). Global Code of Conduct for Research in Resource-Poor Settings. Available at www.globalcodeofconduct.org/wp-content/uploads/2018/05/Global-Code-of-Conduct-Brochure.pdf (accessed September 24, 2018).Google Scholar
Global Health Innovative Technology (GHIT) Fund (2018). Portfolio analysis. Available at www.ghitfund.org/investment/portfolioanalysis (accessed September 7, 2018).Google Scholar
Global Health Investment Fund (GHIF) (2018). Current GHIF portfolio investments. Available at www.ghif.com/portfolio/ (accessed September 7, 2018).Google Scholar
Glover, M., Buxton, M., Guthrie, S., et al. (2014). Estimating the returns to UK publicly funded cancer-related research in terms of the net value of improved health outcomes. BMC Medicine 12, 99.CrossRefGoogle Scholar
Glover, M., Montague, E., Pollitt, A., et al. (2018). Estimating the returns to United Kingdom publicly funded musculoskeletal disease research in terms of net value of improved health outcomes. Health Research Policy and Systems 16, 124.Google Scholar
Glasziou, P., Altman, D. G., Bossuyt, P., et al. (2014). Reducing waste from incomplete or unusable reports of biomedical research. Lancet 383, 267276.Google Scholar
Grant, J., & Buxton, M. J. (2018). Economic returns to medical research funding. BMJ Open 8, e022131.CrossRefGoogle ScholarPubMed
Greenhalgh, T. (2018). What have the social sciences ever done for equity in health policy and health systems? International Journal for Equity in Health 17, 124127.CrossRefGoogle ScholarPubMed
Guerrier, G., Sicard, D., & Brey, P. T. (2012). Informed consent: cultural differences. Nature 483, 36.Google Scholar
Gutmann, A., & Moreno, J. D. (2018). Keep CRISPR safe: regulating a genetic revolution. Foreign Affairs 97, 3, 171176.Google Scholar
Head, M. G., Fitchett, J. R., Cooke, M. K., et al. (2013). UK investments in global infectious disease research 1997–2010: a case study. Lancet Infectious Diseases 13, 5564.Google Scholar
Health Economics Research Group, Office of Health Economics, RAND Europe (2008). Medical Research: What’s It Worth? Estimating the Economic Benefits from Medical Research in the UK. London: UK Evaluation Forum.Google Scholar
Ioannidis, J. P., Greenland, S., Hlatky, M. A., et al. (2014). Increasing value and reducing waste in research design, conduct, and analysis. Lancet 383, 166175.Google Scholar
Jamison, D. T., Alwan, A., Mock, C. N., et al. (2017). Universal health coverage and intersectoral action for health: key messages from Disease Control Priorities, 3rd edition. Lancet 391, 11081120.CrossRefGoogle ScholarPubMed
Kelly, R., Zoubiane, G., Walsh, D., et al. (2016). Public funding for research on antibacterial resistance in the JPIAMR countries, the European Commission, and related European Union agencies: a systematic observational analysis. Lancet Infectious Diseases 16, 431440.Google Scholar
Kickbusch, I., Allen, L., & Franz, C. (2016). The commercial determinants of health. Lancet Global Health 4, e895e896.Google Scholar
Knai, C., Petticrew, M., Mays, N., et al. (2018). Systems thinking as a framework for analyzing commercial determinants of health. Milbank Quarterly 96, 472498.Google Scholar
Lancet Global Health (2018). Closing the door on parachutes and parasites. Lancet Glob Health 6,6, e593.Google Scholar
Lewin, S., Booth, A., Glenton, C., et al. (2018). Applying GRADE-CERQual to qualitative evidence synthesis findings: introduction to the series. Implementation Science 13(Suppl 1), 170.CrossRefGoogle ScholarPubMed
Lévy, Y., Lane, C., Piot, P., et al. (2018). Prevention of Ebola virus disease through vaccination: where we are in 2018. Lancet 392, 787790.CrossRefGoogle ScholarPubMed
Lexchin, J. (2012). Sponsorship bias in clinical research. International Journal of Risk and Safety in Medicine 24, 233242.Google Scholar
Li, Y., Wu, C., Yan, E., & Li, K. (2018). Will open access increase journal CiteScores? An empirical investigation over multiple disciplines. PLoS ONE 13, e0201885.Google Scholar
Lima, J.M. and Galea, S. (2018). Corporate practices and health: a framework and mechanisms. Globalization and Health 14, 21.Google Scholar
London, A. J. (2012). Justice and the human development approach to international research. Hastings Center Report 35, 2437.Google Scholar
McKee, M., Stuckler, D., & Basu, S. (2012). Where there is no health research: what can be done to fill the global gaps in health research? PLoS Medicine 9, 4, e1001209.Google Scholar
McKee, M., & Stuckler, D. (2018). Revisiting the corporate and commercial determinants of health. American Journal of Public Health 108, 11671170.Google Scholar
McLean, R. K. D., Graham, I. D., Tetroe, J. M., & Volmink, J. A. (2018). Translating research into action: an international study of the role of research funders. Health Research Policy and Systems 16, 44.Google Scholar
Merson, L., Guérin, P. J., Barnes, K. I., et al. (2018). Secondary analysis and participation of those at the data source. Lancet Global Health 6, 9, e965.Google Scholar
Moher, D., Glasziou, P., Chalmers, I., et al. (2016). Increasing value and reducing waste in biomedical research: who’s listening? Lancet 387, 15731586.Google Scholar
Morgan, R. L., Florez, I., Falavigna, M., et al. (2018). Development of rapid guidelines: 3. GIN-McMaster Guideline Development Checklist extension for rapid recommendations. Health Research Policy and Systems 16, 63.Google Scholar
Myhrvold, C., Freije, C. A., Gootenberg, J. S., et al. (2018). Field-deployable viral diagnostics using CRISPR-Cas13. Science 360, 6387, 444448.Google Scholar
Norddeutscher Rundfunk (NDR) (2018). More than 5,000 German scientists have published papers in pseudo-scientific journals. Available at www.ndr.de/der_ndr/presse/More-than-5000-German-scientists-have-published-papers-in-pseudo-scientific-journals,fakescience178.html (accessed September 24, 2018).Google Scholar
National Institutes of Health (NIH) (2019). World Report (last updated September 24, 2018). Available at https://worldreport.nih.gov/app/#!/#!%2F (accessed January 18, 2019).Google Scholar
Orton, L., Lloyd-Williams, F., Taylor-Robinson, D., et al. (2011). The use of research evidence in public health decision making processes: systematic review. PloS ONE 6, 7, e21704.Google Scholar
Pang, T. (2011). Global health research: changing the agenda, in Benatar, S., & Brock, G. (eds.), Global Health and Global Health Ethics, 1st ed. New York: Cambridge University Press.Google Scholar
Parker, M., & Kingori, P. (2016). Good and bad research collaborations: researchers’ views on science and ethics in global health research. PloS ONE 11, 10, e0163579.Google Scholar
Pang, T., Terry, R. F., & PLOS Medicine Editors (2011). WHO/PLoS Collection “No health without research”: a call for papers. PLoS Medicine 8, 1, e1001008.Google Scholar
Pang, T., & Amul, G. G. H. (2018). Rapid guidelines: timely and important guidance needed for setting standards and best practices. Health Research Policy and Systems 16, 56.Google Scholar
Peters, D. H. (2018). Health policy and systems research: the future of the field. Health Research Policy and Systems 16, 84.CrossRefGoogle ScholarPubMed
PLOS Medicine Editors (2012). The World Health Report 2012 that wasn’t. PLoS Medicine 9, 9, e1001317.Google Scholar
Policy Cures Research (2018). Neglected Disease Research and Development: Reaching New Heights, G-FINDER. Available at www.policycuresresearch.org/wp-content/uploads/2019/01/Y11_G-FINDER_Full_report_Reaching_new_heights.pdf (accessed February 12, 2019).Google Scholar
Pratt, B., Sheehan, M., Barsdorf, N., & Hyder, A.A. (2018). Exploring the ethics of global health research priority-setting. BMC Medical Ethics 19, 94.CrossRefGoogle ScholarPubMed
Research Investments in Global Health (ResIn) (2018). About the study. Available at http://researchinvestments.org/about-the-study/ (accessed September 21, 2018).Google Scholar
Røttingen, J. A., Regmi, S., Eide, M., et al. (2013). Mapping of available health research and development data: what’s there, what’s missing, and what role is there for a global observatory? Lancet 382, 12861307.Google Scholar
Rudan, I., & Sridhar, D. (2016) Structure, function and five basic needs of the global health research system. Journal of Global Health 6, 1,010505.Google Scholar
Schroeder, D. (2014). Sharing of benefits, in ten Have, H. A. M. J., & Gordijn, B. (eds.), Handbook of Global Bioethics. New York: Springer, pp.203223.Google Scholar
Sheel, M., & Kirk, M. D. (2018). Parasitic and parachute research in global health. Lancet Global Health 6, 8, e839.Google Scholar
Smith, E., Haustein, S., Mongeon, P., et al. (2017). Knowledge sharing in global health research: the impact, uptake and cost of open access to scholarly literature. Health Research Policy and Systems 15, 73.Google Scholar
Smith, J. (2018). Parasitic and parachute research in global health. Lancet Global Health 6, 8, e838.CrossRefGoogle ScholarPubMed
Stevens, G. A., Alkema, L., Black, R. E., et al. (2016). Guidelines for accurate and transparent health estimates reporting: the GATHER statement. Lancet 388, e19e23.Google Scholar
Stop Predatory Journals (2018). About Stop Predatory Journals. Available at https://predatoryjournals.com/about/ (accessed September 27, 2018).Google Scholar
Sussex, J., Feng, Y., Mestre-Ferrandiz, J., et al. (2016). Quantifying the economic impact of government and charity funding of medical research on private research and development funding in the United Kingdom. BMC Medicine 14, 32.Google Scholar
Theobald, S., Brandes, N., Gyapong, M., et al. (2018). Implementation research: new imperatives and opportunities in global health. Lancet 392, 22142228.Google Scholar
Tricco, A. C., Langlois, E. V., & Straus, S.E. (eds.) (2017). Rapid Reviews to Strengthen Health Policy and Systems: A Practical Guide. Geneva: WHO.Google Scholar
University of Washington (2018). DCP3: Disease Control Priorities, About the Project. Available at http://dcp-3.org/about-project (accessed September 7, 2018).Google Scholar
Viergever, R. F., & Hendriks, T. C. C. (2016). The 10 largest public and philanthropic funders of health research in the world: what they fund and how they distribute their funds. Health Research Policy and Systems 14, 12.Google Scholar
West, D. M., Villasenor, J., & Schneider, J. (2017). Private Sector Investment in Global Health R&D: Spending Levels, Barriers and Opportunities. Washington, DC: Brookings Institution, Center for Technology Innovation.Google Scholar
WHO ICTRP (2018). ICTRP Search Portal: List by Regions/Countries, as of July 28, 2018. Available at http://apps.who.int/trialsearch/ListBy.aspx?TypeListing=2 (accessed August 1, 2018).Google Scholar
World Health Organization (WHO) (2012). The WHO Strategy on Research for Health. Geneva: WHO.Google Scholar
World Health Organization (WHO) (2012). Research and development to meet health needs in developing countries: strengthening global financing and coordination. Available at www.who.int/phi/CEWG_Report_5_April_2012.pdf (accessed July 31, 2018).Google Scholar
World Health Organization (WHO) (2013). WHA Resolution 66.22: Follow-up of the report of the Consultative Expert Working Group on Research and Development – Financing and Coordination. Geneva: WHO. Available at www.who.int/phi/resolution_WHA-66.22.pdf (accessed July 31, 2018).Google Scholar
World Health Organization (WHO) (2017a). World Report on Health Policy and Systems Research. Geneva: WHO.Google Scholar
World Health Organization (WHO) (2017b). Global Priority List of Antibiotic-Resistant Bacteria to Guide Research, Discovery and Development of New Antibiotics. Geneva: WHO. Available at www.who.int/medicines/publications/WHO-PPL-Short_Summary_25Feb-ET_NM_WHO.pdf (accessed July 31, 2018).Google Scholar
World Health Organization (WHO) (2017c). Major research funders and international NGOs to implement WHO standards on reporting clinical trial results. WHO news release. Available at www.who.int/en/news-room/detail/18-05-2017-major-research-funders-and-international-ngos-to-implement-who-standards-on-reporting-clinical-trial-results (accessed May 20, 2017).Google Scholar
World Health Organization (WHO) (2017d). Ten Years in Public Health, 2007–2017: Report by Dr Margaret Chan, Director-General, World Health Organization. Geneva: WHO.Google Scholar
World Health Organization (WHO) (2018). One year on, Global Observatory on Health R&D identifies striking gaps and inequalities. WHO: Features. Available at: http://www.who.int/features/2018/health-research-and-development/en/ (Accessed 28 February 2018).Google Scholar
World Health Organization (WHO) (2020). About the Global Health Observatory on Health R&D. Available at www.who.int/research-observatory/why_what_how/en/index3.html.Google Scholar
WHO Research and Development Blueprint. (2018). 2018 Annual review of diseases prioritized under the Research and Development Blueprint, Meeting Report. Available at www.who.int/emergencies/diseases/2018prioritization-report.pdf (accessed July 31, 2018).Google Scholar
Yegros, A., Tijssen, R., Abad-Garcia, M. F., & Ràfols, I. (2018). Drug research priorities at odds with global disease toll. Nature Index, March 16. Available at www.natureindex.com/news-blog/drug-research-priorities-at-odds-with-global-disease-toll (accessed March 25, 2018).Google Scholar

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