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Chapter 8 - Pathologic Prognostic Factors of Prostate Cancer

Published online by Cambridge University Press:  04 November 2017

Antonio Lopez-Beltran
Affiliation:
Cordoba University Medical School, Spain
Liang Cheng
Affiliation:
Indiana University School of Medicine, USA
Rodolfo Montironi
Affiliation:
University of Ancona, Italy
Maria Rosaria Raspollini
Affiliation:
University Hospital Careggi, Florence, Italy
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Pathology of the Prostate
An Algorithmic Approach
, pp. 101 - 113
Publisher: Cambridge University Press
Print publication year: 2017

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Berney, DM, Algaba, F, Camparo, P, Compérat, E, Griffiths, D, Kristiansen, G, Lopez-Beltran, A, Montironi, R, Varma, M, Egevad, L. Variation in Reporting of Cancer Extent and Benign Histology in Prostate Biopsies among European Pathologists. Virchows Arch. 2014 Mar 4. [Epub ahead of print].Google Scholar
McKenney, JK, Wei, W, Hawley, S, Auman, H, Newcomb, LF, Boyer, HD, Fazli, L, Simko, J, Hurtado-Coll, A, Troyer, DA, Tretiakova, MS, Vakar-Lopez, F, Carroll, PR, Cooperberg, MR, Gleave, ME, Lance, RS, Lin, DW, Nelson, PS, Thompson, IM, True, LD, Feng, Z, Brooks, JD. Histologic Grading of Prostatic Adenocarcinoma Can Be Further Optimized: Analysis of the Relative Prognostic Strength of Individual Architectural Patterns in 1275 Patients from the Canary Retrospective Cohort. Am J Surg Pathol. 2016 Nov; 40(11): 1439–56.CrossRefGoogle ScholarPubMed
Ayala, GE, Muezzinoglu, B, Hammerich, KH, Frolov, A, Liu, H, Scardino, PT, Li, R, Sayeeduddin, M, Ittmann, MM, Kadmon, D, Miles, BJ, Wheeler, TM, Rowley, DR. Determining Prostate Cancer-specific Death through Quantification of Stromogenic Carcinoma Area in Prostatectomy Specimens. Am J Pathol. 2011 Jan; 178(1): 7987.Google Scholar
Berney, DM, Algaba, F, Camparo, P, Compérat, E, Griffiths, D, Kristiansen, G, Lopez-Beltran, A, Montironi, R, Varma, M, Egevad, L. The Reasons behind Variation in Gleason Grading of Prostatic Biopsies: Areas of Agreement and Misconception among 266 European Pathologists. Histopathology. 2014 Feb; 64(3): 405–11. doi: 10.1111/his.12284. Epub 2013 Nov 6.CrossRefGoogle ScholarPubMed
Yossepowitch, O, Briganti, A, Eastham, JA, Epstein, J, Graefen, M, Montironi, R, Touijer, K. Positive Surgical Margins after Radical Prostatectomy: A Systematic Review and Contemporary Update. Eur Urol. 2014 Feb; 65(2): 303–13. doi: 10.1016/j.eururo.2013.07.039. Epub 2013 Aug 3.Google Scholar
Schelling, LA, Williamson, SR, Zhang, S, Yao, JL, Wang, M, Huang, J, Montironi, R, Lopez-Beltran, A, Emerson, RE, Idrees, MT, Osunkoya, AO, Man, YG, Maclennan, GT, Baldridge, LA, Compérat, E, Cheng, L. Frequent TMPRSS2-ERG Rearrangement in Prostatic Small Cell Carcinoma Detected by Fluorescence in Situ Hybridization: The Superiority of Fluorescence in Situ Hybridization over ERG Immunohistochemistry. Hum Pathol. 2013 Oct; 44(10): 2227–33. doi: 10.1016/j.humpath.2013.05.005. Epub 2013 Jul 12.Google Scholar
Montironi, R, Cheng, L, Lopez-Beltran, A, Mazzucchelli, R, Scarpelli, M. Combined Handling of Prostate Base/Bladder Neck and Seminal Vesicles in Radical Prostatectomy Specimens: Our Approach with the Whole Mount Technique. Histopathology. 2013 Sep; 63(3): 431–35. doi: 10.1111/his.12158. Epub 2013 Jun 24. No abstract available.CrossRefGoogle ScholarPubMed
Montironi, R, Lopez-Beltran, A, Cheng, L, Montorsi, F, Scarpelli, M. Central Prostate Pathology Review: Should It Be Mandatory? Eur Urol. 2013 Aug; 64(2): 199201. Discussion 202–03. doi: 10.1016/j.eururo.2013.04.002. Epub 2013 Apr 16. No abstract available.Google Scholar
Varinot, J, Drouin, S, Rouprêt, M, Montironi, R, Lopez-Beltran, A, Compérat, E. Prostate Cancer with Clear Cell Features and an Unusual Nested-like Pattern of Growth: A Case Report. Anal Quant Cytol Histol. 2012 Oct; 34(5): 289–92.Google Scholar
Cheng, L, MacLennan, GT, Lopez-Beltran, A, Montironi, R. Anatomic, Morphologic and Genetic Heterogeneity of Prostate Cancer: Implications for Clinical Practice. Expert Rev Anticancer Ther. 2012 Nov; 12(11): 1371–74. doi: 10.1586/era.12.127.Google Scholar
Egevad, L, Ahmad, AS, Algaba, F, Berney, DM, Boccon-Gibod, L, Compérat, E, Evans, AJ, Griffiths, D, Grobholz, R, Kristiansen, G, Langner, C, Lopez-Beltran, A, Montironi, R, Moss, S, Oliveira, P, Vainer, B, Varma, M, Camparo, P. Standardization of Gleason Grading among 337 European Pathologists. Histopathology. 2013 Jan; 62(2): 247–56. doi: 10.1111/his.12008.Google Scholar
Varma, M, Berney, DM, Algaba, F, Camparo, P, Compérat, E, Griffiths, DF, Kristiansen, G, Lopez-Beltran, A, Montironi, R, Egevad, L. Prostate Needle Biopsy Processing: A Survey of Laboratory Practice across Europe. J Clin Pathol. 2013 Feb; 66(2): 120–23. doi: 10.1136/jclinpath-2012-200993.Google Scholar
Brimo, F, Montironi, R, Egevad, L, Erbersdobler, A, Lin, DW, Nelson, JB, Rubin, MA, van der Kwast, T, Amin, M, Epstein, JI. Contemporary Grading for Prostate Cancer: Implications for Patient Care. Eur Urol. 2013 May; 63(5): 892901. doi: 10.1016/j.eururo.2012.10.015.Google Scholar
Mazzucchelli, R, Scarpelli, M, Lopez-Beltran, A, Cheng, L, Montironi, R. Spectrum of Prostatic Nonepithelial Tumors and Tumorlike Conditions with Spindle Cell Features. Anal Quant Cytol Histol. 2012 Jun; 34(3): 139–44.Google Scholar
Quick, Charles M. MDa, Gokden, Neriman MDa, Sangoi, Ankur R. MDb, Brooks, James D. MDc, McKenney, Jesse K. MDa. The Distribution of PAX-2 Immunoreactivity in the Prostate Gland, Seminal Vesicle, and Ejaculatory Duct: Comparison with Prostatic Adenocarcinoma and Discussion of Prostatic Zonal Embryogenesis. Human Pathology. 2010; 41: 1145–49.Google Scholar
Montironi, R, Lopez Beltran, A, Mazzucchelli, R, Cheng, L, Scarpelli, M. Handling of Radical Prostatectomy Specimens: Total Embedding with Large-format Histology. Int J Breast Cancer. 2012; 2012: 932784. Epub 2012 Jul 10.CrossRefGoogle Scholar
Montironi, R, Scarpelli, M, Cheng, L, Lopez-Beltran, A, Zhou, M, Montorsi, F. Do Not Misinterpret Intraductal Carcinoma of the Prostate as High-grade Prostatic Intraepithelial Neoplasia! Eur Urol. 2012 Sep; 62(3): 518–22. Epub 2012 Jun 5.Google Scholar
Lopez-Beltran, A, Cheng, L, Blanca, A, Montironi, R. Cell Proliferation and Apoptosis in Prostate Needle Biopsies with Adenocarcinoma Gleason Score 6 or 7. Anal Quant Cytol Histol. 2012 Apr; 34(2): 6165.Google Scholar
Scarpelli, M, Mazzucchelli, R, Barbisan, F, Santinelli, A, Lopez-Beltran, A, Cheng, L, Montironi, R. Is There a Role for Prostate Tumour Overexpressed-1 in the Diagnosis of HGPIN and of Prostatic Adenocarcinoma? A Comparison with Alpha-Methylacyl CoA Racemase. Int J Immunopathol Pharmacol. 2012 Jan–Mar; 25(1): 6774.Google Scholar
Camparo, P, Egevad, L, Algaba, F, Berney, DM, Boccon-Gibod, L, Compérat, E, Evans, AJ, Grobholz, R, Kristiansen, G, Langner, C, Lopez-Beltran, A, Montironi, R, Oliveira, P, Vainer, B, Varma, M. Utility of Whole Slide Imaging and Virtual Microscopy in Prostate Pathology. APMIS. 2012 Apr; 120(4): 298304. doi: 10.1111/j.1600-0463.2011.02872.x. Review.Google Scholar
Montironi, R, Scarpelli, M, Mazzucchelli, R, Cheng, L, Lopez-Beltran, A, Montorsi, F. Extent of Cancer of Less than 50% in Any Prostate Needle Biopsy Core: How Many Millimeters Are There? Eur Urol. 2012 Apr; 61(4): 751–56. Epub 2012 Jan 5. No abstract available.CrossRefGoogle Scholar
Cheng, L, Montironi, R, Bostwick, DG, Lopez-Beltran, A, Berney, DM. Staging of Prostate Cancer. Histopathology. 2012 Jan; 60(1): 87117. doi: 10.1111/j.1365-2559.2011.04025.x. Review.CrossRefGoogle ScholarPubMed
Montironi, R, Lopez-Beltran, A, Scarpelli, M, Mazzucchelli, R, Cheng, L. Handling of Radical Prostatectomy Specimens: Total Embedding with Whole Mounts, with Special Reference to the Ancona Experience (Letter). Histopathology. 2011 Nov; 59(5): 1006–10.CrossRefGoogle Scholar
Egevad, L, Algaba, F, Berney, DM, Boccon-Gibod, L, Compérat, E, Evans, AJ, Grobholz, R, Kristiansen, G, Langner, C, Lockwood, G, Lopez-Beltran, A, Montironi, R, Oliveira, P, Schwenkglenks, M, Vainer, B, Varma, M, Verger, V, Camparo, P. Interactive Digital Slides with Heat Maps: A Novel Method to Improve the Reproducibility of Gleason Grading. Virchows Arch. 2011 Aug; 459(2): 175–82. Epub 2011 Jun 23.Google Scholar
Mazzucchelli, R, Barbisan, F, Santinelli, A, Lopez-Beltran, A, Cheng, L, Scarpelli, M, Montironi, R. Immunohistochemical Expression of Prostate Tumor Overexpressed 1 in Cystoprostatectomies with Incidental and Insignificant Prostate Cancer. Further Evidence for Field Effect in Prostatic Carcinogenesis. Hum Pathol. 2011 Dec; 42(12): 1931–36. Epub 2011 Jun 14.CrossRefGoogle ScholarPubMed
Williamson, SR, Zhang, S, Yao, JL, Huang, J, Lopez-Beltran, A, Shen, S, Osunkoya, AO, MacLennan, GT, Montironi, R, Cheng, L. ERG-TMPRSS2 Rearrangement Is Shared by Concurrent Prostatic Adenocarcinoma and Prostatic Small Cell Carcinoma and Absent in Small Cell Carcinoma of the Urinary Bladder: Evidence Supporting Monoclonal Origin. Mod Pathol. 2011 Aug; 24(8): 1120–27. doi: 10.1038/modpathol.2011.56.Google Scholar
Capitanio, U, Cheng, L, Lopez-Beltran, A, Scarpelli, M, Freschi, M, Montorsi, F, Montironi, R. The Importance of Interaction between Urologists and Pathologists in Incidental Prostate Cancer Management. Eur Urol. 2011 Jul; 60(1): 7577.CrossRefGoogle ScholarPubMed
Montironi, R, Cheng, L, Lopez-Beltran, A, Mazzucchelli, R, Scarpelli, M. Editorial Comment to When Should We Expect no Residual Tumor (pT0) Once We Submit Incidental T1a-b Prostate Cancers to Radical Prostatectomy? Int J Urol. 2011 Feb; 18(2): 153–54. doi: 10.1111/j.1442-2042.2010.02717.x.Google Scholar
Mazzucchelli, R, Nesseris, I, Cheng, L, Lopez-Beltran, A, Montironi, R, Scarpelli, M. Active Surveillance for Low-risk Prostate Cancer. Anticancer Res. 2010 Sep; 30(9): 3683–92.Google Scholar
Montironi, R, Mazzucchelli, R, Lopez-Beltran, A, Cheng, L. Words of Wisdom. Re: Peripheral Zone Prostate Cancers: Location and Intraprostatic Patterns of Spread at Histopathology. Eur Urol. 2010 Jul; 58(1): 180–82.Google Scholar
Montironi, R, Cheng, L, Lopez-Beltran, A, Scarpelli, M, Mazzucchelli, R, Mikuz, G, Kirkali, Z, Montorsi, F. Original Gleason System Versus 2005 ISUP Modified Gleason System: The Importance of Indicating Which System Is Used in the Patient’s Pathology and Clinical Reports. Eur Urol. 2010 Sep; 58(3): 369–73.CrossRefGoogle ScholarPubMed
Montironi, R, Vela Navarrete, R, Lopez-Beltran, A, Mazzucchelli, R, Mikuz, G, Bono, AV. Histopathology Reporting of Prostate Needle Biopsies. 2005 Update. Virchows Arch. 2006; 449(1): 113.Google Scholar
Lopez-Beltran, A, Mikuz, G, Luque, RJ, Mazzucchelli, R, Montironi, R. Current Practice of Gleason Grading of Prostate Carcinoma. Virchows Arch. 2006 Feb; 448(2): 111–18.Google Scholar
Marks, RA, Koch, MO, Lopez-Beltran, A, Montironi, R, Juliar, BE, Cheng, L. The Relationship between the Extent of Surgical Margin Positivity and Prostate Specific Antigen Recurrence in Radical Prostatectomy Specimens. Hum Pathol. 2007 Aug; 38(8): 1207–11.CrossRefGoogle ScholarPubMed
Cheng, L, Bishop, E, Zhou, H, Maclennan, GT, Lopez-Beltran, A, Zhang, S, Badve, S, Baldridge, LA, Montironi, R. Lymphatic Vessel Density in Radical Prostatectomy Specimens. Hum Pathol. 2008 Apr; 39(4): 610–15.Google Scholar
Mazzucchelli, R, Lopez-Beltran, A, Cheng, L, Scarpelli, M, Kirkali, Z, Montironi, R. Rare and Unusual Histological Variants of Prostatic Carcinoma: Clinical Significance. BJU Int. 2008 Nov; 102(10): 1369–74.Google Scholar
Montironi, R, Cheng, L, Mazzucchelli, R, Lopez-Beltran, A. Pathological Definition and Difficulties in Assessing Positive Margins in Radical Prostatectomy Specimens. BJU Int. 2009 Feb; 103(3): 286–88.CrossRefGoogle ScholarPubMed
Lopez-Beltran, A, Cheng, L, Prieto, R, Blanca, A, Montironi, R. Lymphoepithelioma-like Carcinoma of the Prostate. Hum Pathol. 2009 Jul; 40(7): 982–87.CrossRefGoogle ScholarPubMed
Montironi, R, Cheng, L, Lopez-Beltran, A, Mazzucchelli, R, Scarpelli, M, Kirkali, Z, Montorsi, F. Joint Appraisal of the Radical Prostatectomy Specimen by the Urologist and the Uropathologist: Together, We Can Do It Better. Eur Urol. 2009 Dec; 56(6): 951–55.Google Scholar
Montironi, R, Gasparrini, S, Mazzucchelli, R, Massari, F, Cheng, L, Lopez-Beltran, A, Montorsi, F, Scarpelli, M. Re: Touijer, Karim A., Eastham, James A.. The Sentinel Lymph Node Concept and Novel Approaches in Detecting Lymph Node Metastasis in Prostate Cancer. Eur Urol. 2016 Aug 24; pii: S0302-2838(16)30503–6. doi: 10.1016/j.eururo.2016.08.036. In press. www.dx.doi.org/10.1016/j.eururo.2016.02.047.Google Scholar
Conti, A, Santoni, M, Burattini, L, Scarpelli, M, Mazzucchelli, R, Galosi, AB, Cheng, L, Lopez-Beltran, A, Briganti, A, Montorsi, F, Montironi, R. Update on Histopathological Evaluation of Lymphadenectomy Specimens from Prostate Cancer Patients. World J Urol. 2015 Dec 22; [Epub ahead of print]Google Scholar
Haki Yuksel, O, Urkmez, A, Verit, A. Can Perineural Invasion Detected in Prostate Needle Biopsy Specimens Predict Surgical Margin Positivity in D’Amico Low Risk Patients? Arch Ital Urol Androl. 2016 Jul 4; 88(2): 8992.Google Scholar
Bostwick, DG, Day, CE, Meiers, I. Optimizing Prostate Specimen Handling for Diagnosis and Prognosis. Methods Mol Biol. 2014; 1180: 337–52.Google Scholar
Flood, TA, Schieda, N, Keefe, DT, Morash, C, Bateman, J, Mai, KT, Belanger, EC, Robertson, SJ, Breau, RH. Perineural Invasion on Biopsy Is Associated with Upstaging at Radical Prostatectomy in Gleason Score 3 + 4 = 7 Prostate Cancer. Pathol Int. 2016 Nov; 66(11): 629–32.Google Scholar
Nunez, AL, Giannico, GA, Mukhtar, F, Dailey, V, El-Galley, R, Hameed, O. Frozen Section Evaluation of Margins in Radical Prostatectomy Specimens: A Contemporary Study and Literature Review. Ann Diagn Pathol. 2016 Oct; 24: 11–8.Google Scholar
Park, YH, Kim, Y, Yu, H, Choi, IY, Byun, SS, Kwak, C, Chung, BH, Lee, HM, Kim, CS, Lee, JY. Is Lymphovascular Invasion a Powerful Predictor for Biochemical Recurrence in pT3 N0 Prostate Cancer? Results from the K-CaP Database. Sci Rep. 2016 May 5; 6: 25419.CrossRefGoogle Scholar
Fleshner, K, Assel, M, Benfante, N, Lee, J, Vickers, A, Fine, S, Carlsson, S, Eastham, J. Clinical Findings and Treatment Outcomes in Patients with Extraprostatic Extension Identified on Prostate Biopsy. J Urol. 2016 Sep; 196(3): 703–08.CrossRefGoogle ScholarPubMed
Kim, DK, Koo, KC, Abdel Raheem, A, Kim, KH, Chung, BH, Choi, YD, Rha, KH. Single Positive Lymph Node Prostate Cancer Can Be Treated Surgically without Recurrence. PLoS One. 2016 Mar 31; 11(3): e0152391.CrossRefGoogle ScholarPubMed
Kang, M, Oh, JJ, Lee, S, Hong, SK, Lee, SE, Byun, SS. Perineural Invasion and Lymphovascular Invasion Are Associated with Increased Risk of Biochemical Recurrence in Patients Undergoing Radical Prostatectomy. Ann Surg Oncol. 2016 Aug; 23(8): 2699–706.CrossRefGoogle ScholarPubMed
Meng, Y, Liao, YB, Xu, P, Wei, WR, Wang, J. Perineural Invasion Is an Independent Predictor of Biochemical Recurrence of Prostate Cancer after Local Treatment: M meta-analysis. Int J Clin Exp Med. 2015 Aug 15; 8(8): 13267–74.Google Scholar

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