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Section VI - Vaginal and Vulvar Cancer

Published online by Cambridge University Press:  20 July 2023

Dennis S. Chi
Affiliation:
Memorial Sloan-Kettering Cancer Center, New York
Nisha Lakhi
Affiliation:
Richmond University Medical Center, Staten Island
Nicoletta Colombo
Affiliation:
University of Milan-Bicocca
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Publisher: Cambridge University Press
Print publication year: 2023

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References

References

Van der Zee AGJ, et al. Sentinel node dissection is safe in the treatment of early-stage vulvar cancer. J Clin Oncol 2008;26:884889.CrossRefGoogle Scholar
Levenback, CF, et al. Lymphatic mapping and sentinel lymph node biopsy in women with squamous cell carcinoma of the vulva: a Gynecologic Oncology Group study. J Clin Oncol 2012;30:37863791.CrossRefGoogle ScholarPubMed
Stehman, FB, et al. Groin dissection vs groin radiation in carcinoma of the vulva: a Gynecologic Oncology Group study. Int J Rad Oncol Biol Phys 1992;24:389396.CrossRefGoogle Scholar
Oonk, MHM, et al. Size of sentinel-node metastasis and chances of non-sentinel-node involvement and survival in early-stage vulvar cancer: results from GROINSS-V, a multicentre observational study. Lancet Oncol 2010;11:646652.CrossRefGoogle ScholarPubMed
Oonk, MHM, et al. Radiotherapy instead of inguinofemoral lymphadenectomy in vulvar cancer patients with a metastatic sentinel node: results of GROINSS-V II. Int J Gynecol Cancer 2019;29(Suppl. 4):A14.Google Scholar

References

American Cancer Society. Cancer Facts & Figures 2022. Atlanta, GA: American Cancer Society, 2022.Google Scholar
Van der Zee, AG, et al. Sentinel node dissection is safe in the treatment of early-stage vulvar cancer. J Clin Oncol 2008;26(6):884889.CrossRefGoogle ScholarPubMed
Te Grootenhuis, NC, et al. Sentinel nodes in vulvar cancer: long-term follow-up of the GROningen INternational Study on Sentinel nodes in Vulvar cancer (GROINSS-V) I. Gynecol Oncol 2016;140(1):814.CrossRefGoogle Scholar
Levenback, CF, et al. Lymphatic mapping and sentinel lymph node biopsy in women with squamous cell carcinoma of the vulva: a Gynecologic Oncology Group study. J Clin Oncol 2012;30(31):37863791.CrossRefGoogle ScholarPubMed
Oonk, MHM, et al. Radiotherapy versus inguinofemoral lymphadenectomy as treatment for vulvar cancer patients with micrometastases in the sentinel node: results of GROINSS-V II. J Clin Oncol 2021;39(32):36233632.CrossRefGoogle ScholarPubMed
Glaser, S, et al. Inguinal nodal radiotherapy for vulvar cancer: are we missing the target again? Gynecol Oncol 2014;135(3):583585.CrossRefGoogle Scholar
Montana, GS, et al. Preoperative chemo-radiation for carcinoma of the vulva with N2/N3 nodes: a Gynecologic Oncology Group study. Int J Radiat Oncol Biol Phys 2000;48(4):10071013.CrossRefGoogle ScholarPubMed

References

Stehman, F, et al. Early stage I carcinoma of the vulva treated with ipsilateral superficial inguinal lymphadenectomy and modified radical hemivulvectomy: a prospective study of the Gynecologic Oncology Group. Obstet Gynecol 1992;79(4):490497.Google Scholar
Heaps, JM, et al. Surgical-pathologic variables predictive of local recurrence in squamous cell carcinoma of the vulva. Gynecol Oncol 1990;38(3):309314. https://doi.org/10.1016/0090-8258(90)90064-RCrossRefGoogle ScholarPubMed
Arvas, M, et al. The role of pathological margin distance and prognostic factors after primary surgery in squamous cell carcinoma of the vulva. Int J Gynecol Cancer 2018;28:623631.CrossRefGoogle ScholarPubMed
Bradley, K, et al. (Squamous Cell Carcinoma) Vulvar Cancer. 2020.Google Scholar
Bedell, SM, et al. Role of adjuvant radiation or re-excision for early stage vulvar squamous cell carcinoma with positive or close surgical margins. Gynecol Oncol 2019;154(2):276279. https://doi.org/10.1016/j.ygyno.2019.05.028CrossRefGoogle ScholarPubMed
Ioffe, YJ, et al. Low yield of residual vulvar carcinoma and dysplasia upon re-excision for close or positive margins. Gynecol Oncol 2013;129(3):528532. https://doi.org/10.1016/j.ygyno.2013.02.033CrossRefGoogle ScholarPubMed
Faul, CM, et al. Adjuvant radiation for vulvar carcinoma: improved local control. Int J Radiat Oncol Biol Phys 1997;38(2):381389. https://doi.org/10.1016/S0360-3016(97)82500-XCrossRefGoogle ScholarPubMed
Gaarenstroom, KN, et al. Postoperative complications after vulvectomy and inguinofemoral lymphadenectomy using separate groin incisions. Int J Gynecol Cancer 2003;13(4):522527. https://doi.org/10.1046/j.1525-1438.2003.13304.xCrossRefGoogle ScholarPubMed

References

SEER Database: Vulvar Cancer. Available from: https://seer.cancer.gov/statfacts/html/vulva.html [last accessed November 9, 2022].Google Scholar
Heaps, JM, et al. Surgical pathologic variables predictive of local recurrence in squamous cell carcinoma of the vulva. Gynecol Oncol 1990;38 (3):309.CrossRefGoogle ScholarPubMed
Ignatov, T, et al. Adjuvant radiotherapy for vulvar cancer with close or positive surgical margins. J Cancer Res Clin Oncol 2016;142:489495.CrossRefGoogle ScholarPubMed
Alimena, S, et al. Patient reported outcome measures among patients with vulvar cancer at various stages of treatment, recurrence and survivorship. Gynecol Oncol 2021;160:252259.Google ScholarPubMed
Grootenhuis, NC, et al. Margin status revisited in vulvar squamous cell carcinoma. Gynecol Oncol 2019;154(2):266275.CrossRefGoogle Scholar

References

Hacker, NF, et al. Individualization of treatment for stage I squamous cell vulvar carcinoma. Obstet Gynecol 1984;63(2):155.Google Scholar
National Comprehensive Cancer Network. NCCN guidelines. Available from: www.nccn.org/professionals/physician_gls/pdf/vulvar.pdfGoogle Scholar
Mahner, S, et al. Adjuvant therapy in lymph node positive vulvar cancer: the AGO-CaRE-1 study. J Natl Cancer Inst 2015;107(3):dju426.CrossRefGoogle ScholarPubMed
Parthasarathy, A, et al. The benefit of adjuvant radiation therapy in single node positive squamous cell vulvar carcinoma. Gynecol Oncol 2006;103:10951099.CrossRefGoogle ScholarPubMed

References

Woelber, L, et al. Prognostic role of lymph node metastases in vulvar cancer and implications for adjuvant treatment. Int J Gynecol Cancer 2012;22(3):503508.CrossRefGoogle ScholarPubMed
Homesley, HD, et al. Radiation therapy versus pelvic node resection for carcinoma of the vulva with positive groin nodes. Obstet Gynecol 1986;68(6):733740.Google ScholarPubMed
Mahner, S, et al. Adjuvant therapy in lymph node-positive vulvar cancer: the AGO-CaRE-1 study. J Natl Cancer Inst 2015;107(3):dju426.CrossRefGoogle ScholarPubMed
Fons, G, et al. Adjuvant radiotherapy in patients with vulvar cancer and one intra capsular lymph node metastasis is not beneficial. Gynecol Oncol 2009;114(2):343345.CrossRefGoogle Scholar
Parthasarathy, A, et al. The benefit of adjuvant radiation therapy in single-node-positive squamous cell vulvar carcinoma. Gynecol Oncol 2006;103(3):10951099.CrossRefGoogle ScholarPubMed

References

Boer, FL, et al. Vulvar malignant melanoma: pathogenesis, clinical behaviour and management: review of the literature. Cancer Treat Rev 2019;73:91103.CrossRefGoogle ScholarPubMed
Saito, T, et al. Japan Society of Gynecologic Oncology guidelines 2015 for the treatment of vulvar cancer and vaginal cancer. Int J Clin Oncol 2018;23:201234.CrossRefGoogle Scholar
Mert, I, et al. Vulvar/vaginal melanoma: an updated surveillance epidemiology and end results database review, comparison with cutaneous melanoma and significance of racial disparities. Int J Gynecol Cancer 2013;23:11181125.CrossRefGoogle ScholarPubMed
Geisler, JP, et al. Pelvic exenteration for malignant melanomas of the vagina or urethra with over 3 mm of invasion. Gynecol Oncol 1995;59:338341.CrossRefGoogle ScholarPubMed
Frumovitz, M, et al. Primary malignant melanoma of the vagina. Obstet Gynecol 2010;116:13581365.CrossRefGoogle ScholarPubMed
Look, KY, et al. Vulvar melanoma reconsidered. Cancer 1993;72:143146.3.0.CO;2-M>CrossRefGoogle ScholarPubMed
Agrawal, S, et al. The benefits of adjuvant radiation therapy after therapeutic lymphadenectomy for clinically advanced, high-risk, lymph node-metastatic melanoma. Cancer 2009;115:58365844.CrossRefGoogle ScholarPubMed
Xing, Y, et al. Contemporary diagnostic imaging modalities for the staging and surveillance of melanoma patients: a meta-analysis. J Natl Cancer Inst 2011;103:129142.CrossRefGoogle ScholarPubMed
Rezk, YA, et al. A prospective study of quality of life in patients undergoing pelvic exenteration: interim results. Gynecol Oncol 2013;128:191197.CrossRefGoogle ScholarPubMed
Schneider, A, et al. Current developments for pelvic exenteration in gynecologic oncology. Curr Opin Obstet Gynecol 2009;21:49.CrossRefGoogle ScholarPubMed

References

Mert, I, et al. Vulvar/vaginal melanoma: an updated Surveillance Epidemiology and End Results Database review, comparison with cutaneous melanoma and significance of racial disparities. Int J Gynecol Cancer 2013;23:11181125.CrossRefGoogle ScholarPubMed
Schiavone, MB, et al. Combined immunotherapy and radiation for treatment of mucosal melanomas of the lower genital tract. Gynecol Oncol Rep 2016;16:4246.CrossRefGoogle ScholarPubMed
Salama, AKS, et al. Ipilimumab and radiation in patients with high risk resected or regionally advanced melanoma. Clin Cancer Res 2021;27(5):12871295.CrossRefGoogle ScholarPubMed
National Comprehensive Cancer Network. Melanoma: cutaneous (Version 1.2021). Available from: www.nccn.org/professionals/physician_gls/pdf/cutaneous_melanoma.pdfGoogle Scholar
Dummer, R, et al. Overall survival in patients with BRAF-mutant melanoma receiving encorafenib plus binimetinib versus vemurafenib or encorafenib (COLUMBUS): a multicenter, open-label, randomized, phase 3 trial. Lancet Oncol 2018;19:13151327.CrossRefGoogle ScholarPubMed
Wasif, N, et al. Does metastatectomy improve survival in patients with stage IV melanoma? A cancer registry analysis of outcomes. J Surg Oncol 2011;104:111115.CrossRefGoogle Scholar

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