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Chapter 22 - Management of Common Overdoses

A Severe Case of Amitriptyline Overdose

Published online by Cambridge University Press:  04 May 2017

By
Ascanio Tridente
Edited by
Daniele Bryden  and
Andrew Temple
Daniele Bryden
Affiliation:
Sheffield Teaching Hospitals NHS Trust
Andrew Temple
Affiliation:
Sheffield Teaching Hospitals NHS Trust
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Information
Case Studies in Adult Intensive Care Medicine , pp. 166 - 171
Publisher: Cambridge University Press
Print publication year: 2017

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References

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Spiker, DG, Biggs, JT. Tricyclic antidepressants. Prolonged plasma levels after overdose. Jama 1976;236(15):1711–12.CrossRefGoogle ScholarPubMed
Petit, JM, Spiker, DG, Ruwitch, JF, Ziegler, VE, Weiss, AN, Biggs, JT. Tricyclic antidepressant plasma levels and adverse effects after overdose. Clin Pharmacol Ther 1977;21(1):47–51.CrossRefGoogle ScholarPubMed
Boehnert, MT, Lovejoy, FH Jr. Value of the QRS duration versus the serum drug level in predicting seizures and ventricular arrhythmias after an acute overdose of tricyclic antidepressants. N Engl J Med 1985;313(8):474–9.CrossRefGoogle ScholarPubMed
Foulke, GE, Albertson, TE. QRS interval in tricyclic antidepressant overdosage: inaccuracy as a toxicity indicator in emergency settings. Ann Emerg Med 1987;16(2):160–3.CrossRefGoogle ScholarPubMed
Sasyniuk, BI, Jhamandas, V. Mechanism of reversal of toxic effects of amitriptyline on cardiac Purkinje fibers by sodium bicarbonate. J Pharmacol Exp Ther 1984;231(2):387–94.Google Scholar
Pentel, PR, Benowitz, NL. Tricyclic antidepressant poisoning. Management of arrhythmias. Med Toxicol 1986;1(2):101–21.Google Scholar
Kiberd, MB, Minor, SF. Lipid therapy for the treatment of a refractory amitriptyline overdose. Cjem 2012;14(3):193–7.CrossRefGoogle ScholarPubMed
Levine, M, Brooks, DE, Franken, A, Graham, R. Delayed-onset seizure and cardiac arrest after amitriptyline overdose, treated with intravenous lipid emulsion therapy. Pediatrics 2012;130(2):e432–8.CrossRefGoogle ScholarPubMed

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