Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-848d4c4894-p2v8j Total loading time: 0.001 Render date: 2024-05-17T03:33:41.636Z Has data issue: false hasContentIssue false

Chapter 12 - Multiple Sclerosis

Published online by Cambridge University Press:  27 July 2018

By
Lana Harder ,
Julie A. Bobholz  and
William S. MacAllister
Edited by
Jacobus Donders  and
Scott J. Hunter
Jacobus Donders
Affiliation:
Mary Free Bed Rehabilitation Hospital
Scott J. Hunter
Affiliation:
University of Chicago
Get access

Summary

A summary is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Chapter
Information
Neuropsychological Conditions Across the Lifespan , pp. 228 - 243
Publisher: Cambridge University Press
Print publication year: 2018

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Alonso, A., & Hernan, M. A. (2008). Temporal trends in the incidence of multiple sclerosis: A systematic review. Neurology, 71(2), 129–135.CrossRefGoogle ScholarPubMed
Amato, M. P., Goretti, B., Ghezzi, A., Hakiki, B., Niccolai, C., Lori, S., … Cilia, S. (2014). Neuropsychological features in childhood and juvenile multiple sclerosis: Five-year follow-up. Neurology, 83(16), 1432–1438.CrossRefGoogle ScholarPubMed
Amato, M. P., Goretti, B., Ghezzi, A., Lori, S., Zipoli, V., Portaccio, E., … Patti, F. (2008). Cognitive and psychosocial features of childhood and juvenile MS. Neurology, 70(20), 1891–1897.CrossRefGoogle ScholarPubMed
Amato, M. P., Langdon, D., Montalban, X., Benedict, R. H., DeLuca, J., Krupp, L. B., … Comi, G. (2013). Treatment of cognitive impairment in multiple sclerosis: Position paper. Journal of Neurology, 260(6), 1452–1468.CrossRefGoogle ScholarPubMed
Amato, M. P., Portaccio, E., Goretti, B., Zipoli, V., Hakiki, B., Giannini, M., … Razzolini, L. (2010). Cognitive impairment in early stages of multiple sclerosis. Neurological Sciences, 31(2), 211–214.CrossRefGoogle ScholarPubMed
Applebee, A., Goodman, A. D., Mayadev, A. S., Bethoux, F., Goldman, M. D., Klingler, M., … Carrazana, E. J. (2015). Effects of dalfampridine extended-release tablets on 6-minute walk distance in patients with multiple sclerosis: A post hoc analysis of a double-blind, placebo-controlled trial. Clinical Therapeutics, 37(12), 2780–2787.CrossRefGoogle ScholarPubMed
Belman, A. L., Krupp, L. B., Olsen, C. S., Rose, J. W., Aaen, G., Benson, L., … Lotze, T. (2016). Characteristics of children and adolescents with multiple sclerosis. Pediatrics, 138(1), 10.1542/peds.2016-0120.CrossRefGoogle ScholarPubMed
Benedict, R. H., Cookfair, D., Gavett, R., Gunther, M., Munschauer, F., Garg, N., & Weinstock-Guttman, B. (2006). Validity of the minimal assessment of cognitive function in multiple sclerosis (MACFIMS). Journal of the International Neuropsychological Society, 12(4), 549–558.CrossRefGoogle ScholarPubMed
Benedict, R. H., Munschauer, F., Zarevics, P., Erlanger, D., Rowe, V., Feaster, T., & Carpenter, R. L. (2008). Effects of l-amphetamine sulfate on cognitive function in multiple sclerosis patients. Journal of Neurology, 255(6), 848.CrossRefGoogle ScholarPubMed
Bobholz, J. A., Rao, S. M., Lobeck, L., Elsinger, C., Gleason, A., Kanz, J., … Maas, E. (2006). fMRI study of episodic memory in relapsing-remitting MS: Correlation with T2 lesion volume. Neurology, 67(9), 1640–1645.CrossRefGoogle ScholarPubMed
Braley, T. J., & Chervin, R. D. (2010). Fatigue in multiple sclerosis: Mechanisms, evaluation, and treatment. Sleep, 33(8), 1061–1067.CrossRefGoogle ScholarPubMed
Chabas, D., Ness, J., Belman, A., Yeh, E. A., Kuntz, N., Gorman, M. P., … Rodriguez, M.(2010). Younger children with MS have a distinct CSF inflammatory profile at disease onset. Neurology, 74(5), 399–405.CrossRefGoogle ScholarPubMed
Chan, W., Dobbs, B., Shaw, M., Kasschau, M., Sherman, K., Krupp, L., … Rodriguez, M. (2017). Baseline affect predicts improved fatigue with telerehabilitation using remotely-supervised transcranial direct current stimulation (RS-tDCS) in adults with multiple sclerosis (MS)(P3. 343). Neurology, 88(16 Supplement), P3. 343.CrossRefGoogle Scholar
Charvet, L., O’donnell, E., Belman, A., Chitnis, T., Ness, J., Parrish, J., … Krupp, L. B. (2014). Longitudinal evaluation of cognitive functioning in pediatric multiple sclerosis: Report from the US pediatric multiple sclerosis network. Multiple Sclerosis Journal, 20(11), 1502–1510.CrossRefGoogle ScholarPubMed
Charvet, L., Yang, J., Shaw, M., Sherman, K., Xu, J., Haider, L., & Krupp, L. (2016). An adaptive computer-based cognitive training program improves cognitive functioning in adults with multiple sclerosis (MS): Results of a double-blind randomized active-placebo-controlled 12-week trial (P2. 170). Neurology, 86(16 Supplement), P2. 170.CrossRefGoogle Scholar
Chiaravalloti, N. D., & DeLuca, J. (2008). Cognitive impairment in multiple sclerosis. The Lancet Neurology, 7(12), 1139–1151.CrossRefGoogle ScholarPubMed
Chiaravalloti, N. D., DeLuca, J., Moore, N. B., & Ricker, J. H. (2005). Treating learning impairments improves memory performance in multiple sclerosis: A randomized clinical trial. Multiple Sclerosis Journal, 11(1), 58–68.CrossRefGoogle ScholarPubMed
Chiaravalloti, N. D., Wylie, G., Leavitt, V., & DeLuca, J. (2012). Increased cerebral activation after behavioral treatment for memory deficits in MS. Journal of Neurology, 259(7), 1337–1346.CrossRefGoogle ScholarPubMed
Chitnis, T., Glanz, B., Jaffin, S., & Healy, B. (2009). Demographics of pediatric-onset multiple sclerosis in an MS center population from the northeastern united states. Multiple Sclerosis Journal, 15(5), 627–631.CrossRefGoogle Scholar
Christodoulou, C., Melville, P., Scherl, W. F., MacAllister, W. S., Elkins, L. E., & Krupp, L. B. (2006). Effects of donepezil on memory and cognition in multiple sclerosis. Journal of the Neurological Sciences, 245(1), 127–136.CrossRefGoogle ScholarPubMed
Comi, G., Radaelli, M., & Sørensen, P. S. (2017). Evolving concepts in the treatment of relapsing multiple sclerosis. The Lancet, 389(10076), 1347–1356.CrossRefGoogle ScholarPubMed
das Nair, R., Ferguson, H., Stark, D. L., & Lincoln, N. B. (2012). Memory rehabilitation for people with multiple sclerosis. Cochrane Database Syst Rev, 3.CrossRefGoogle Scholar
Dobbs, B., Shaw, M., Kasschau, M., Frontario, A., Krupp, L., & Charvet, L. (2017). Telerehabilitation using remotely-supervised transcranial direct current stimulation (RS-tDCS) enhances the benefit of at-home cognitive training in multiple sclerosis (P4. 335). Neurology, 88(16 Supplement), P4. 335.CrossRefGoogle Scholar
Feinstein, A. (2011). Multiple sclerosis and depression. Multiple Sclerosis (Houndmills, Basingstoke, England), 17(11), 1276–1281.CrossRefGoogle ScholarPubMed
Fiest, K., Walker, J., Bernstein, C., Graff, L., Zarychanski, R., Abou-Setta, A., … Fisk, J. D. (2016). Systematic review and meta-analysis of interventions for depression and anxiety in persons with multiple sclerosis. Multiple Sclerosis and Related Disorders, 5, 12–26.CrossRefGoogle ScholarPubMed
Goretti, B., Ghezzi, A., Portaccio, E., Lori, S., Zipoli, V., Razzolini, L., … Patti, F. (2010). Psychosocial issue in children and adolescents with multiple sclerosis. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 31(4), 467–470.CrossRefGoogle ScholarPubMed
Gourraud, P., Harbo, H. F., Hauser, S. L., & Baranzini, S. E. (2012). The genetics of multiple sclerosis: An up‐to‐date review. Immunological Reviews, 248(1), 87–103.CrossRefGoogle ScholarPubMed
Graves, J. S., Chitnis, T., Weinstock-Guttman, B., Rubin, J., Zelikovitch, A. S., Nourbakhsh, B., … Waubant, E. (2017). Maternal and perinatal exposures are associated with risk for pediatric-onset multiple sclerosis. Pediatrics, 139(4), e20162838.CrossRefGoogle ScholarPubMed
Hedström, A., Olsson, T., & Alfredsson, L. (2016). Smoking is a major preventable risk factor for multiple sclerosis. Multiple Sclerosis Journal, 22(8), 1021–1026.CrossRefGoogle Scholar
Hind, D., Cotter, J., Thake, A., Bradburn, M., Cooper, C., Isaac, C., & House, A. (2014). Cognitive behavioural therapy for the treatment of depression in people with multiple sclerosis: A systematic review and meta-analysis. BMC Psychiatry, 14(1), 5.CrossRefGoogle ScholarPubMed
Holland, A. A., Graves, D., Greenberg, B. M., & Harder, L. L. (2014). Fatigue, emotional functioning, and executive dysfunction in pediatric multiple sclerosis. Child Neuropsychology, 20(1), 71–85.CrossRefGoogle ScholarPubMed
Julian, L., Serafin, D., Charvet, L., Ackerson, J., Benedict, R., Braaten, E., … Zaccariello, M. (2013). Cognitive impairment occurs in children and adolescents with multiple sclerosis: Results from a United States network. Journal of Child Neurology, 28(1), 102–107.CrossRefGoogle ScholarPubMed
Kasschau, M., Sherman, K., Haider, L., Frontario, A., Shaw, M., Datta, A., … Charvet, L. (2015). A protocol for the use of remotely-supervised transcranial direct current stimulation (tDCS) in multiple sclerosis (MS). Journal of Visualized Experiments, (106):e53542. doi(106), e53542.Google Scholar
Kennedy, J., O’Connor, P., Sadovnick, A. D., Perara, M., Yee, I., & Banwell, B. (2006). Age at onset of multiple sclerosis may be influenced by place of residence during childhood rather than ancestry. Neuroepidemiology, 26(3), 162–167.CrossRefGoogle ScholarPubMed
Koch-Henriksen, N., & Sorensen, P. S. (2010). The changing demographic pattern of multiple sclerosis epidemiology. Lancet Neurology, 9(5), 520–532.CrossRefGoogle ScholarPubMed
Krupp, L. B., Christodoulou, C., Melville, P., Scherl, W. F., Pai, L. Y., Muenz, L. R., … Schwid, S. R. (2011). Multicenter randomized clinical trial of donepezil for memory impairment in multiple sclerosis. Neurology, 76(17), 1500–1507.CrossRefGoogle ScholarPubMed
Krupp, L. B., Tardieu, M., Amato, M. P., Banwell, B., Chitnis, T., Dale, R. C., … Rostasy, K. (2013). International pediatric multiple sclerosis study group criteria for pediatric multiple sclerosis and immune-mediated central nervous system demyelinating disorders: Revisions to the 2007 definitions. Multiple Sclerosis Journal, 19(10), 1261–1267.CrossRefGoogle Scholar
Langer-Gould, A., Smith, J. B., Hellwig, K., Gonzales, E., Haraszti, S., Koebnick, C., & Xiang, A. (2017). Breastfeeding, ovulatory years, and risk of multiple sclerosis. Neurology, 89(6), 563–569.CrossRefGoogle ScholarPubMed
Leavitt, V., Cirnigliaro, C., Cohen, A., Farag, A., Brooks, M., Wecht, J., … Sumowski, J. F. (2014). Aerobic exercise increases hippocampal volume and improves memory in multiple sclerosis: Preliminary findings. Neurocase, 20(6), 695–697.CrossRefGoogle ScholarPubMed
Lublin, F. D., Reingold, S. C., Cohen, J. A., Cutter, G. R., Sorensen, P. S., Thompson, A. J., … Bebo, B. (2014). Defining the clinical course of multiple sclerosis: The 2013 revisions. Neurology, 83(3), 278–286.CrossRefGoogle ScholarPubMed
MacAllister, W. S. (2010). Multiple sclerosis in children and adolescents: Neurocognitive disorders. In Riva, D. and Njiokiktjien, C. (Eds.), Brain lesion localization and developmental functions. Milan: John Libbey Eurotext.Google Scholar
MacAllister, W. S., Belman, A. L., Milazzo, M., Weisbrot, D. M., Christodoulou, C., Scherl, W. F., … Krupp, L. B. (2005). Cognitive functioning in children and adolescents with multiple sclerosis. Neurology, 64(8), 1422–1425.CrossRefGoogle ScholarPubMed
MacAllister, W. S., Christodoulou, C., Milazzo, M., & Krupp, L. B. (2007). Longitudinal neuropsychological assessment in pediatric multiple sclerosis. Developmental Neuropsychology, 32(2; 2), 625–644.CrossRefGoogle ScholarPubMed
MacAllister, W. S., Christodoulou, C., Milazzo, M., Preston, T. E., Serafin, D., Krupp, L. B., & Harder, L. (2013). Pediatric multiple sclerosis: What we know and where are we headed? Child Neuropsychology, 19(1), 1–22.CrossRefGoogle ScholarPubMed
MacAllister, W. S., Christodoulou, C., Troxell, R., Milazzo, M., Block, P., Preston, T. E., … & Krupp, L. (2009). Fatigue and quality of life in pediatric multiple sclerosis. Multiple Sclerosis, 15(12), 1502–1508.CrossRefGoogle ScholarPubMed
MacAllister, W. S., & Krupp, L. B. (2005). Multiple sclerosis-related fatigue. Physical Medicine and Rehabilitation Clinics of North America, 16(2), 483–502.CrossRefGoogle ScholarPubMed
Mikaeloff, Y., Caridade, G., Tardieu, M., Suissa, S., & Study Group, KIDSEP. (2007). Parental smoking at home and the risk of childhood-onset multiple sclerosis in children. Brain, 130(10), 2589–2595.CrossRefGoogle ScholarPubMed
Mokry, L. E., Ross, S., Ahmad, O. S., Forgetta, V., Smith, G. D., Leong, A., … Richards, J. B. (2015). Vitamin D and risk of multiple sclerosis: A mendelian randomization study. PLoS Medicine, 12(8), e1001866.CrossRefGoogle ScholarPubMed
Morrow, S. A., Kaushik, T., Zarevics, P., Erlanger, D., Bear, M. F., Munschauer, F. E., & Benedict, R. H. (2009). The effects of L-amphetamine sulfate on cognition in MS patients: Results of a randomized controlled trial. Journal of Neurology, 256(7), 1095–1102.CrossRefGoogle ScholarPubMed
Morrow, S. A., & Rosehart, H. (2015). Effects of single dose mixed amphetamine salts-extended release on processing speed in multiple sclerosis: A double blind placebo controlled study. Psychopharmacology, 232(23), 4253–4259.CrossRefGoogle ScholarPubMed
Narula, S., Hopkins, S. E., & Banwell, B. (2015). Treatment of pediatric multiple sclerosis. Current Treatment Options in Neurology, 17(3), 10.CrossRefGoogle ScholarPubMed
Nielsen, N. M., Munger, K. L., Koch-Henriksen, N., Hougaard, D. M., Magyari, M., Jorgensen, K. T., … Stenager, E. (2017). Neonatal vitamin D status and risk of multiple sclerosis: A population-based case-control study. Neurology, 88(1), 44–51.CrossRefGoogle ScholarPubMed
Olek, M. J. (2005). Differential diagnosis, clinical features, and prognosis of multiple sclerosis. In Olek, M. J. (Ed), Current Clinical Neurology: Multiple Sclerosis, 15–53, Human Press, Totowa, NJ.CrossRefGoogle Scholar
Pastò, L., Portaccio, E., Goretti, B., Ghezzi, A., Lori, S., Hakiki, B., … Moiola, L. (2016). The cognitive reserve theory in the setting of pediatric-onset multiple sclerosis. Multiple Sclerosis Journal, 22(13), 1741–1749.CrossRefGoogle ScholarPubMed
Planche, V., Gibelin, M., Cregut, D., Pereira, B., & Clavelou, P. (2016). Cognitive impairment in a population-based study of patients with multiple sclerosis: Differences between late relapsing− remitting, secondary progressive and primary progressive multiple sclerosis. European Journal of Neurology, 23(2), 282–289.CrossRefGoogle Scholar
Polman, C. H., Reingold, S. C., Banwell, B., Clanet, M., Cohen, J. A., Filippi, M., … Lublin, F. D. (2011). Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Annals of Neurology, 69(2), 292–302.CrossRefGoogle Scholar
Portaccio, E., Goretti, B., Lori, S., Zipoli, V., Centorrino, S., Ghezzi, A., … Amato, M. P. (2009). The brief neuropsychological battery for children: A screening tool for cognitive impairment in childhood and juvenile multiple sclerosis. Multiple Sclerosis Journal, 15(5), 620–626.CrossRefGoogle ScholarPubMed
Pucak, M. L., Carroll, K. A., Kerr, D. A., & Kaplin, A. I. (2007). Neuropsychiatric manifestations of depression in multiple sclerosis: Neuroinflammatory, neuroendocrine, and neurotrophic mechanisms in the pathogenesis of immune-mediated depression. Dialogues in Clinical Neuroscience, 9(2), 125–139.CrossRefGoogle ScholarPubMed
Rao, S. M., Grafman, J., DiGiulio, D., Mittenberg, W., Bernardin, L., Leo, G. J., … Unverzagt, F. (1993). Memory dysfunction in multiple sclerosis: Its relation to working memory, semantic encoding, and implicit learning. Neuropsychology, 7(3), 364.CrossRefGoogle Scholar
Strober, L., Englert, J., Munschauer, F., Weinstock-Guttman, B., Rao, S., & Benedict, R. (2009). Sensitivity of conventional memory tests in multiple sclerosis: Comparing the Rao brief repeatable neuropsychological battery and the minimal assessment of cognitive function in MS. Multiple Sclerosis Journal, 15(9), 1077–1084.CrossRefGoogle ScholarPubMed
Sumowski, J. F., Chiaravalloti, N., Erlanger, D., Kaushik, T., Benedict, R. H., & DeLuca, J. (2011). L-amphetamine improves memory in MS patients with objective memory impairment. Multiple Sclerosis (Houndmills, Basingstoke, England), 17(9), 1141–1145.CrossRefGoogle ScholarPubMed
Suppiej, A., & Cainelli, E. (2014). Cognitive dysfunction in pediatric multiple sclerosis. Neuropsychiatric Disease and Treatment, 10, 1385–1392.CrossRefGoogle ScholarPubMed
Tan, A., Hague, C., Greenberg, B. M., & Harder, L. (2017). Neuropsychological outcomes of pediatric demyelinating diseases: A review. Child Neuropsychology, 1–23.Google Scholar
Till, C., Ghassemi, R., Aubert-Broche, B., Kerbrat, A., Collins, D. L., Narayanan, S., … Banwell, B. L. (2011). MRI correlates of cognitive impairment in childhood-onset multiple sclerosis. Neuropsychology, 25(3), 319–332.CrossRefGoogle ScholarPubMed
Till, C., Ho, C., Dudani, A., Garcia-Lorenzo, D., Collins, D., & Banwell, B. (2012). Magnetic resonance imaging predictors of executive functioning in patients with pediatric-onset multiple sclerosis. Archives of Clinical Neuropsychology, 27(5), 495–509.CrossRefGoogle ScholarPubMed
Till, C., Racine, N., Araujo, D., Narayanan, S., Collins, D. L., Aubert-Broche, B., … Banwell, B. (2013). Changes in cognitive performance over a 1-year period in children and adolescents with multiple sclerosis. Neuropsychology, 27(2), 210.CrossRefGoogle Scholar
Vollmer, T. (2007). The natural history of relapses in multiple sclerosis. Journal of the Neurological Sciences, 256, S5–S13.CrossRefGoogle ScholarPubMed
Weisbrot, D. M., Ettinger, A. B., Gadow, K. D., Belman, A. L., MacAllister, W. S., Milazzo, M., … Krupp, L. B.(2010). Psychiatric comorbidity in pediatric patients with demyelinating disorders. Journal of Child Neurology, 25(2), 192–202.CrossRefGoogle ScholarPubMed
Yeh, E. A., Chitnis, T., Krupp, L., Ness, J., Chabas, D., Kuntz, N., & Waubant, E. (2009). Pediatric multiple sclerosis. Nature Reviews. Neurology, 5(11), 621–631.CrossRefGoogle ScholarPubMed
Yeh, E. A., Weinstock-Guttman, B., Ramanathan, M., Ramasamy, D. P., Willis, L., Cox, J. L., & Zivadinov, R.(2009). Magnetic resonance imaging characteristics of children and adults with paediatric-onset multiple sclerosis. Brain : A Journal of Neurology, 132(Pt 12), 3392–3400.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×