Book contents
- Frontmatter
- Contents
- Preface
- Contributors
- Part I Clinical Syndromes – General
- Part II Clinical Syndromes – Head and Neck
- Part III Clinical Syndromes – Eye
- Part IV Clinical Syndromes – Skin and Lymph Nodes
- Part V Clinical Syndromes – Respiratory Tract
- Part VI Clinical Syndromes – Heart and Blood Vessels
- Part VII Clinical Syndromes – Gastrointestinal Tract, Liver, and Abdomen
- Part VIII Clinical Syndromes – Genitourinary Tract
- Part IX Clinical Syndromes – Musculoskeletal System
- Part X Clinical Syndromes – Neurologic System
- Part XI The Susceptible Host
- Part XII HIV
- Part XIII Nosocomial Infection
- Part XIV Infections Related to Surgery and Trauma
- Part XV Prevention of Infection
- Part XVI Travel and Recreation
- Part XVII Bioterrorism
- Part XVIII Specific Organisms – Bacteria
- Part XIX Specific Organisms – Spirochetes
- Part XX Specific Organisms – Mycoplasma and Chlamydia
- Part XXI Specific Organisms – Rickettsia, Ehrlichia, and Anaplasma
- Part XXII Specific Organisms – Fungi
- Part XXIII Specific Organisms – Viruses
- 180 Cytomegalovirus
- 181 Dengue and Dengue-Like Illness
- 182 Enteroviruses
- 183 Epstein–Barr Virus and Other Causes of the Mononucleosis Syndrome
- 184 Hantavirus Cardiopulmonary Syndrome in the Americas
- 185 Herpes Simplex Viruses 1 and 2
- 186 Human Herpesviruses 6, 7, and 8
- 187 Influenza
- 188 Papillomavirus
- 189 Acute and Chronic Parvovirus Infection
- 190 Rabies
- 191 Varicella-Zoster Virus
- 192 Viral Hemorrhagic Fevers
- Part XXIV Specific Organisms – Parasites
- Part XXV Antimicrobial Therapy – General Considerations
- Index
183 - Epstein–Barr Virus and Other Causes of the Mononucleosis Syndrome
from Part XXIII - Specific Organisms – Viruses
Published online by Cambridge University Press: 05 March 2013
- Frontmatter
- Contents
- Preface
- Contributors
- Part I Clinical Syndromes – General
- Part II Clinical Syndromes – Head and Neck
- Part III Clinical Syndromes – Eye
- Part IV Clinical Syndromes – Skin and Lymph Nodes
- Part V Clinical Syndromes – Respiratory Tract
- Part VI Clinical Syndromes – Heart and Blood Vessels
- Part VII Clinical Syndromes – Gastrointestinal Tract, Liver, and Abdomen
- Part VIII Clinical Syndromes – Genitourinary Tract
- Part IX Clinical Syndromes – Musculoskeletal System
- Part X Clinical Syndromes – Neurologic System
- Part XI The Susceptible Host
- Part XII HIV
- Part XIII Nosocomial Infection
- Part XIV Infections Related to Surgery and Trauma
- Part XV Prevention of Infection
- Part XVI Travel and Recreation
- Part XVII Bioterrorism
- Part XVIII Specific Organisms – Bacteria
- Part XIX Specific Organisms – Spirochetes
- Part XX Specific Organisms – Mycoplasma and Chlamydia
- Part XXI Specific Organisms – Rickettsia, Ehrlichia, and Anaplasma
- Part XXII Specific Organisms – Fungi
- Part XXIII Specific Organisms – Viruses
- 180 Cytomegalovirus
- 181 Dengue and Dengue-Like Illness
- 182 Enteroviruses
- 183 Epstein–Barr Virus and Other Causes of the Mononucleosis Syndrome
- 184 Hantavirus Cardiopulmonary Syndrome in the Americas
- 185 Herpes Simplex Viruses 1 and 2
- 186 Human Herpesviruses 6, 7, and 8
- 187 Influenza
- 188 Papillomavirus
- 189 Acute and Chronic Parvovirus Infection
- 190 Rabies
- 191 Varicella-Zoster Virus
- 192 Viral Hemorrhagic Fevers
- Part XXIV Specific Organisms – Parasites
- Part XXV Antimicrobial Therapy – General Considerations
- Index
Summary
Epstein–Barr virus (EBV) infects nearly all persons in the world at some time. The virus persists indefinitely in their B lymphocytes and is shed intermittently from oropharyngeal tissue into oral secretions. Transmission of EBV occurs when susceptible individuals come in close oral contact with infectious saliva. Casual contact is generally insufficient to transmit infection, and spread of EBV among susceptible household contacts is infrequent. Occasionally, the virus is transmitted by blood products or donor tissues. About 95% of all persons will have acquired EBV by the end of their 3rd decade of life. Persons living with low standards of hygiene, such as occurs in developing countries or low socioeconomic conditions, often acquire EBV in childhood, and nearly everyone becomes infected by adulthood. In contrast, persons adhering to a high standard of hygiene often have EBV infection delayed until adolescence or early adulthood, when sexual intimacy becomes a factor in transmission.
INFECTIOUS MONONUCLEOSIS
Presentation
Most EBV infections do not produce illness. When EBV does cause disease, the spectrum of illness is varied (Table 183.1). Infectious mononucleosis (IM) is the paradigmatic illness associated with EBV infection. The IM syndrome is largely the product of an exuberant immunologic response to a newly acquired EBV infection, and in healthy persons IM does not arise from EBV reactivation. This illness commonly occurs among adolescents and young adults (15 to 25 years) and seldom appears in persons of other ages.
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- Chapter
- Information
- Clinical Infectious Disease , pp. 1263 - 1270Publisher: Cambridge University PressPrint publication year: 2008