Skip to main content Accessibility help
×
Hostname: page-component-848d4c4894-x5gtn Total loading time: 0 Render date: 2024-05-24T22:51:03.895Z Has data issue: false hasContentIssue false

OPTOGENETICS

Published online by Cambridge University Press:  05 July 2015

Marta García-Matos
Affiliation:
Institut de Ciències Fotòniques (ICFO)
Lluís Torner
Affiliation:
Institut de Ciències Fotòniques (ICFO)
Get access

Summary

He had no acquaintances at the party, and was not really an extrovert. The food was not tasty, the music insipid, and thus – forced to stay by external circumstances, and not wanting to give the impression of being idle – he turned to the single occupation he found worth trying: looking at people's behavior. How they chose to dress, what they chose to eat, where they chose to sit. It was entertaining – just entertaining, he was aware he would probably miss in all his conclusions – to try to discover their motivations, the root of their choices. Well… as if such thing as having a choice ever existed. He smiled in amusement thinking about Buridan's ass.

Buridan's ass is a thought experiment, dating back to medieval times, devised precisely to discuss whether a choice is always based on a rational decision. It presents an ass, equally thirsty and hungry, and equally distanced from a pile of hay and a bucket of water. Since the animal cannot find a reason to prefer one option to the other, unable to take action, he dies, of both hunger and thirst. The thought experiment, that exposes the complex nature of free will by reducing its assumption to an absurd situation, is framed in a (perhaps endless) discussion that for centuries was the battleground of philosophers, now joined by neuroscientists.

For an experimental neuroscientist, analyzing behavior is a phenomenal task. The patterns behind choices and actions are woven up from tens of millions of interconnected neurons, whose firing activity takes place in a millisecond timescale. To understand in full any of those events, to lay any causal connection between them, it is necessary to have certain control of the neuronal activity, exciting and inhibiting it on demand. An example of an external tool for such control is the use of electrodes, but those may cause unintentional firing in the surroundings of the targeted neuron. Luckily for researchers, there exist algae and bacteria that find in sunlight the reason to excite or inhibit their behavior.

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2015

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G., Deisseroth, K. (2005) Millisecond-timescale, genetically targeted optical control of neural activity. Nature Neuroscience 8: 1263–1268CrossRefGoogle ScholarPubMed
Deisseroth, K. (2010) Controlling the brain with light. Scientific American 303: 48–55CrossRefGoogle Scholar
Gorostiza, P., Isacoff, E. Y. (2008) Optical switches for remote and noninvasive control of cell signaling. Science 322: 395–399CrossRefGoogle ScholarPubMed
Reiner, A., Isacoff, E. Y. (2013) The Brain Prize 2013: The optogenetics revolution. Trends Neuroscience 36(10): 557–560. Available at http://www.ncbi.nlm.nih.gov/pubmed/24054067CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×