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Relationship between cannabis use and schizophrenia

Published online by Cambridge University Press:  01 September 2022

J.J. Vazquez Vazquez ,
M.M. Gutiérrez Rodríguez ,
M.D.L.A. Corral Y Alonso ,
C. Moreno Menguiano  and
F. Garcia Sánchez
J.J. Vazquez Vazquez*
Affiliation:
Centro de Salud Mental de Móstoles / Hospital Universitario de Móstoles, Psychiatry, Móstoles, Spain
M.M. Gutiérrez Rodríguez
Affiliation:
HOSPITAL UNIVERSITARIO DE MÓSTOLES, Psychiatry, MÓSTOLES (MADRID), Spain
M.D.L.A. Corral Y Alonso
Affiliation:
HOSPITAL UNIVERSITARIO DE MÓSTOLES, Psychiatry, MÓSTOLES (MADRID), Spain
C. Moreno Menguiano
Affiliation:
HOSPITAL UNIVERSITARIO DE MÓSTOLES, Psychiatry, MÓSTOLES (MADRID), Spain
F. Garcia Sánchez
Affiliation:
HOSPITAL UNIVERSITARIO DE MÓSTOLES, Psychiatry, MÓSTOLES (MADRID), Spain
*
*Corresponding author.

Abstract

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Introduction

Numerous studies have shown evidence that cannabis use increases the appearance of psychotic symptoms and disorders, and worsens the course of the disease in those with schizophrenia. However, a causal relationship between cannabis and schizophrenia has not been well established yet.

Objectives

In this presentation we try to review the relationship between cannabis use and prevalence of schizophrenia.

Methods

We performed a search of Medline looking for systematic reviews and methodologically robust studies in the field published in English in the last 5 years.

Results

A number of studies, both cross-sectional and prospective, find a prevalence of schizophrenia several times higher among cannabis users than in non-users. This association becomes stronger the lower the age of cannabis use onset, the higher the amount consumed and the higher the THC concentration are. Half of the patients with a cannabis-induced psychotic disorder turn into a diagnosis of schizophrenia within a few years. So far, it has not been possible to demonstrate a global increased prevalence of schizophrenia in relation to the increase of cannabis use in the population in recent decades.

Conclusions

Cannabis and schizophrenia have a complex relationship model; we still cannot clearly establish whether it is causal or the first works as a trigger for pathology in vulnerable subjects.

Disclosure

No significant relationships.

Keywords

Cannabisrelationshippsicosisschizophrénia
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S469
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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