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Mycobiota, neuro-cognitif disorders and behavioural impairments: is there a relationship?
- B. Abdelmoula, H. Sellami, S. Neji, M. Torjmen, N. Bouayed Abdelmoula
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- Journal:
- European Psychiatry / Volume 66 / Issue S1 / March 2023
- Published online by Cambridge University Press:
- 19 July 2023, p. S349
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Introduction
The human body carries large and diverse communities of symbiotic microbes that are important for human health and development. While the impact of the bacterial microbiota, which are mostly found in the human gut, on host physiology is relatively well described, much less is known about the interactions between the mycobiota and the host and the resulting effects on human health. At the level of the nervous system, there is increasing evidence implicating the gut microbiota in a variety of neurological disorders. Similar demonstrations of a causal or supportive role of the mycobioma in neurological disorders are still rare, but several studies linking fungal dysbiosis to disease in humans suggest a contribution of symbiotic fungi to neurocognitive and behavioral disorders.
ObjectivesWe aim through this review to show the role of mycobiota in neurocognitive and behavioral disorders.
MethodsWe comprehensively review the scientific literature using Pubmed database and other search platforms such as Google scholar to state the role of mycobiota in neurocognitive and behavioral disorders.
ResultsOur bibliographic review revealed that, according to recent studies, Candida species are overrepresented in the stool of individuals with autism spectrum disorders and Rett syndrome compared to healthy controls. Other studies revealed mycobiome signatures specific to cognitive impairment and demonstrated that different diets modulate the mycobiome in association with Alzheimer’s disease markers and fungal-bacterial co-regulatory networks in patients with cognitive impairment.
ConclusionsOur understanding of the role of the mycobiota in the biology of neurocognitive disorders-whether causal, consequential, or predisposing-could open up new hypotheses in this area and inspire further research on potential mycobiotic signatures, associated dysbiosis and dysfunction in the neurocognitive developmental-homeostasis spectrum that may contribute to neurocognitive and behavioral developmental disorders and predisposition to cognitive decline, dementia, and progression of neurodegenerative diseases including Parkinson’s and Alzheimer’s disease in high-risk subjects.
Disclosure of InterestNone Declared
Emotional-psychological concerns of Turner’s patients regarding social discrimination
- N. Bouayed Abdelmoula, B. Abdelmoula, S. Sellami
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- Journal:
- European Psychiatry / Volume 66 / Issue S1 / March 2023
- Published online by Cambridge University Press:
- 19 July 2023, p. S889
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Introduction
Turner syndrome characterized by total/partial and/or homogeneous/mosaic X chromosome monosomy is associated with various physical health concerns, including facial dysmorphism, short stature, infertility, and other organ defects such as heart, kidney, bone, skin, … as well as variable degrees of cognitive impairments. Besides, social skills, communication and relationships are usually disordered.
ObjectivesThe aim of this study was to report social challenges of Turner syndrome particularly related to discrimination regarding physical and cognitive impairments.
MethodsA retrospective analysis of clinic data and karyotypes were carried out for the patients diagnosed with Turner syndrome among patients who consulted at our genetic counselling at the medical University of Sfax, during the last two decades.
Cytogenetic analysis were carried out using conventional methods and RHG banding with analysis of at least 20 metaphases and 3 karyotypes for each patient. Social challenges were recorded for each patient during pre-cytogenetic consultation and oriented questioning.
ResultsWe identified 23 cases referred with a cytogenetic diagnosis of monsomy X. The karyotyping was indicated for dysmorphism, primary or secondary amenorrhea, female infertility and recurrent pregnancy losses. Homogeneous X chromosome monosomy was recorded in 13% of cases, whereas mosaic forms with and without structural X/Y abnormalities were more frequent (82%). The mean age of patients in the study was twenty years. When the 45,X population was the predominant one (56,5%), dysmorphism and primary amenorrhea were constant. In the mosaic forms, clinical traits of Turner syndrome were insignificant. Discrimination based on physical appearance, intellectual disability, and failure to conceive were the three types of social challenges revealed by patients of our study. Parents of Turner patients were also concerned at the psychological level. They in fact revealed their emotional distress face to stressful experiences of their children with Turner syndrome regarding the social discrimination they encountered particularly in schools.
ConclusionsSocial challenges related to discrimination based on physical appearance, intellectual disability, and failure to conceive in Turner syndrome lead to depression, low self-esteem and anxiety.
Disclosure of InterestNone Declared
Chronic activation of inflammasome signaling complexes and enhancement of behavioral abnormalities
- B. Abdelmoula, N. Bouayed Abdelmoula
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- Journal:
- European Psychiatry / Volume 66 / Issue S1 / March 2023
- Published online by Cambridge University Press:
- 19 July 2023, pp. S333-S334
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Introduction
Inflammasomes are cytosolic multi-component signaling platforms critical to the innate immune response to infectious diseases and the dysregulation of their activation can lead to the development of neurodegeneration and cancer.
ObjectivesWe aim through this review to ass a possible interplay between dysregulation of inflammasome activation, development of chronic inflammatory disease and enhancement of behavioral abnormalities.
MethodsWe comprehensively review the scientific literature using Pubmed database and other search platforms such as Google scholar to assess the role and the actors of chronic activation of inflammasome signaling complexes to establish a potential association between dysregulation of inflammasome activation, chronic inflammatory disease and enhancement of behavioral abnormalities.
ResultsOur bibliographic review revealed that dysregulation of the inflammasome is associated with the onset and progression of several autoinflammatory and autoimmune diseases, including cryopyrin-associated periodic fever syndrome, familial Mediterranean fever, rheumatoid arthritis, and systemic lupus erythematosus. These multimeric complexes form in response to molecular patterns unique to pathogens and cellular damage, triggering a cascade of downstream responses, including the induction of pyroptotic cell death and release of proinflammatory cytokines. Some inflammasomes directly recognize these patterns, while others indirectly sense these patterns through changes in the homeostatic environment of the cell. Moreover, although being a normal part of the skin flora, yeasts of the genus Malassezia are associated with several inflammatory skin diseases including pityriasis versicolor (tinea versicolor), atopic eczema, psoriasis, Malassezia folliculitis and onychomycoses. In the context of tolerating fungi during colonization and eliciting, activation, of inflammasomes signaling complexes, has been identified as an integral part of antifungal host defense. While the activation of inflammasomes mainly the NLRP3 one, was shown to be pivotal for innate immunity against pathogenic fungi such as candida albicans, their role in the fungal genus Malassezia remains imprecise. Even though, many observations suggest that simultaneous activation of NLRP3, NLRC4 and AIM2 inflammasomes may play an important role.
ConclusionsWhereas, chronic inflammasome activation such as by chronic infectious has been tied to the development of metabolic syndromes, neurodegenerative diseases, and cancer progression, a possible interplay between chronic invasion by the genus Malassezia, vigorous immune response to eliminate invading fungal pathogens, disruption of immune sensors of genotoxic stress, development of chronic inflammatory disease and behavioral abnormalities may be a new field of scientific researches.
Disclosure of InterestNone Declared
Quality of life and psychological concerns of adult patients with disorders of sex development
- N. Bouayed Abdelmoula, B. Abdelmoula, A. Karra
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- Journal:
- European Psychiatry / Volume 66 / Issue S1 / March 2023
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- 19 July 2023, p. S1098
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Introduction
Disorders of sex development (DSD) are characterized by an atypical development of chromosomal, gonadal, and anatomic gender. DSD are divided to three classes with male normal, female normal and abnormal karyotypes and have an incidence at birth of approximately 1 in 5000. DSD patients are exposed during their long-term follow-up to severe psychological stress.
ObjectivesThe aim of our study was to determine the behavioral concerns of adults with DSD and to identify the major factors that may influence their emotional and psychological well-being.
MethodsWe explored, through our genetic counselling reports at the medical University of Sfax, the quality of life and the psychological concerns of all adults patients assessed for DSD with and without chromosomal and/or molecular genetic abnormalities. We also assessed their need of psychological support.
ResultsDuring the last two decades of our genetic counselling experience, 46 adult patients (age superior to 18 years) were selected for this study. The analysis of data revealed that the major psychological concern in our DSD patients was related to their reproductive capacity. In contrast, they have poor subjective norms of communicating sexual and reproductive issues with their partners. Patients who presented non-corrected ambiguous genitalia were in the majority anxious and depressed with a constant feeling of social shame.
ConclusionsSex development plays a fundamental role in determining the physical attributes of the body, the structure of the brain, behavioral tendencies, and the self-concept. The clinical and social approaches of DSD conditions in our society need to be improved. Genetic and psychological counselling should thorough a deep medical education regarding reproductive and sexual health in each particular case of DSD. We emphasis, that early genetic diagnosis, involvement of patients and families in a patient-centered decision-making process, and consideration of long-term health-related quality-of-life outcomes should be considered in DSD.
Disclosure of InterestNone Declared
Healthy architecture map and architecture health indices in healthcare environments for mental disorders in the era of wellness revolution
- B. Abdelmoula, E. Abdelmoula, N. Bouayed Abdelmoula
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- Journal:
- European Psychiatry / Volume 66 / Issue S1 / March 2023
- Published online by Cambridge University Press:
- 19 July 2023, p. S987
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Introduction
Well-being encompasses positive emotions and good physical health as well as, positive meaningful social relationships and connections or social well-being. Philosophies about the healing powers of nature, the value of spaces as a determinant of health and the impact of design of buildings on human health and wellbeing can be traced back for centuries. Bringing hospitality experience to inhospitable environments and humanizing’ healthcare environments according to a healthy architecture map and architecture health indices become currently an emergency to improve to improve the health of architectural environment and to promote the social and human wellbeing, in particular in healthcare environments.
ObjectivesGiven the increase in mental and social health problems, We aim through this review of literature to identify as architect what is a healthy architecture map and what are the architecture health indices in healthcare environments, in particular in hospitals for mental disorders.
MethodsWe comprehensively review the scientific literature using Pubmed database and Google scholar to state the presence of consensual healthy architecture maps and architecture health indices in mental healthcare environments.
ResultsOur bibliographic review revealed that, more than for other buildings, the construction of a hospital is extremely constrained involving highly complex program and multifaceted and interconnected factors with which the architect must deal. Medical and technological progress as well as the strong involvement of the healthcare personnel, who are requested, to turn towards the patient who must be at the heart of the medical and the space process make the program more complex. This lead all professionals, to have a deep reflection on the various and multi-layered challenges of the transformation of the hospital landscape especially when it is designed for patients with mental illnesses.
ConclusionsAt this era of wellness revolution and precision medicine, despite some ambitious projects there are not yet a consensual healthy architecture map and precise architecture health indicators focusing on how the architectural composition of a mental health hospital may be planned.
Disclosure of InterestNone Declared
Behavioral signs of CHARGE syndrome and CHD7 mutational spectrum
- N. Bouayed Abdelmoula, B. Abdelmoula
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- European Psychiatry / Volume 66 / Issue S1 / March 2023
- Published online by Cambridge University Press:
- 19 July 2023, p. S352
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Introduction
CHARGE syndrome is a genetic entity caused by mutations in the chromodomain helicase DNA-binding protein 7 gene (CHD7) at 8q12.1. There are pleiotropic signs among individuals with this disorder. Diagnosis is clinical using medical criteria. CHD7 gene mutations are usually found in 90% of affected patients.
ObjectivesThe aim of this study was to report behavioral signs of CHARGE syndrome and their phenotype-genotype correlations.
MethodsFour Tunisian males from Sfax (Tunisia) with clinical features suggestive of CHARGE syndrome were examined at our genetic counselling at the medical University of Sfax. Assessment of facial dysmorphic and behavioral features, karyotyping using RHG banding and molecular screening of CHD7 mutations were performed. Molecular analysis was made using direct Sanger sequencing of the entire CHD7 gene.
ResultsMolecular genetic analysis revealed two deletions of the CHD7 gene at exon 3 for the first patient and at exon 8 for the second. The two genetic alterations were associated to retarded growth development and genital hypoplasia. Sensory impairments included for the first visual defects and for the second auditory and olfactory defects. Besides constant delayed psychomotor development, the two patients shared receptive and expressive communication disorders, anxiety, attention deficit, cognitive impairment and intellectual disability. There were no aggressive traits nor major autistic features. Learning disabilities were also present for the two patients.
ConclusionsThe CHD7 gene controls the developmental pathways as a transcriptional regulator in the nucleoplasm through chromatin organization. Mutational alterations lead according to the affected domains, and the structure of the nonfunctional CHD7 protein, to the perturbation of the regulation of the developmental pathways’ genes expression. CHD7 is demonstrated as an important component of neurogenesis through two neuronal determination factors: Sox4 and Sox11. While nonsense, frameshift and missense mutations are most common, deletions and duplications are less frequent. Moreover, while exon 3 is commonly altered, mutations of exon 8, which is related to the CHD7 protein chromodomain, are very rare. Phenotype-genotype correlations according to the type of genomic alteration of CHD7 gene are rarely published, particularly concerning behavioral and psychological features of CHARGE association. Here, physical disorders of our two patients seem to be different but behavioral features seem to be common. Multidisciplinary care is thus required for CHARGE syndrome and molecular analysis must be indicated because the type of the genomic alterations may be a key step for a more accurate management of physical and behavioral disorders.
Disclosure of InterestNone Declared
Potential associations of food allergy and altered neurodevelopment in children
- B. Abdelmoula, N. Kharrat, R. Abdelhedi, N. Bouayed Abdelmoula
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- European Psychiatry / Volume 66 / Issue S1 / March 2023
- Published online by Cambridge University Press:
- 19 July 2023, p. S334
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Introduction
Allergic immune reactions and adverse reactions to foods, have been described as having growth concerns in children with food allergy. Moreover, immune dysregulation and inflammation have been documented as typical hallmarks in both allergic and neurodevelopmental conditions.
ObjectivesIn this review, we address the association of food allergy and altered neurodevelopment in children.
MethodsWe comprehensively review the scientific literature using Pubmed database and other search platforms to state the potential associations of food allergy and altered neurodevelopment in children.
ResultsFood allergy is a pathological, potentially deadly, immune reaction activated by normally inoffensive food protein antigens. It is an important public health problem that affects children (children under the age of 5 years: 5 %) and adults, and it has been increasing in prevalence in the last 2 to 3 decades. The enhancement of the knowledge of the pathophysiological mechanisms lead to many suggestions such as the important role of the intestinal microbiota, the role of the immunological adaptation of the mucosal immune system to food antigens and the nutritional impact and growth concerns of children with food allergy. In recent studies and reviews, a significant and a positive association of common allergic conditions, in particular food allergy, with autism spectrum disorder and with attention deficit hyperactivity disorders have been reported. At the mechanistic level, it was recently shown through animal models, the potential role of intracranial Mast cells in neuroinflammation and neuropathology associated with food allergy as well as the potential role of the dysfunction of the gut-brain axis in promoting white matter development during early life when the brain is vulnerable to environment (such as food restrictions) that can result in an a wide spectrum of neurodevelopmental disorders later in life. Food allergy was also associated in literature with enhanced mTOR signaling in the brain and gut, which may impact brain and behavioral development.
ConclusionsNeurodevelopmental disorders which occur in childhood in the context of food allergy is a challenging public health problem that need more human research studies to understand underlying mechanisms and promote therapeutic innovations.
Disclosure of InterestNone Declared
Architectural health indicators and the Building Information Model (BIM): Are they relevant to mental health?
- E. Abdelmoula, B. Abdelmoula, N. Bouayed Abdelmoula
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- Journal:
- European Psychiatry / Volume 66 / Issue S1 / March 2023
- Published online by Cambridge University Press:
- 19 July 2023, p. S987
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Introduction
BIM for Building Information Modeling is a process that ensures the planning, design, and construction of buildings in an efficient collaborative manner. BIM software encompasses computer files, which can be extracted, exchanged or networked to support decision-making regarding a built asset. It provides physical and functional/semantic digital data representations for building components as a single point of accuracy for all system users. As the design of the built environment plays an important role as a determinant of health, architectural health indicators provide quantitative and empirical data upon which all operators such as architects, customers, BIM users and other stakeholders (public health advisors, construction professionals, healthcare providers, social prescribers, etc.) might monitor and assess the healthiness of architectural design.
ObjectivesThe objective of this research is to explore the current state of knowledge about architectural health indicators for use in BIM models that address mental health and diseases.
MethodsWe comprehensively reviewed the scientific literature using PubMed and Google Scholar as well as electronic bibliographic databases to assess architectural health indicators currently in use by the BIM process, to explore their potential usage and to state the value of indicators focusing on factors affecting mental and social health.
ResultsOur bibliographic review revealed that used architectural health indicators in BIM computer systems are very limited. Most of them addressed communicable diseases through simple measurements e.g., air and water quality, etc. However, there is a gap in architectural health indicators pointing non-communicable diseases and their poor health outcomes. Very few indicators focusing on factors affecting mental and social health have been considered in scientific literature.
ConclusionsThe research reveals serious gaps in architectural health indicators that address mental health. As there is worldwide a decline of the mental health and given the increase in mental and social health problems, there is an urgent need to address this situation through the incorporation of mental health data, mental disorders and mental disabilities data to enrich the health information of the BIM models and provide an efficient decision support.
Disclosure of InterestNone Declared
Schizophrenia may be considered as a member of the spectrum of PBAFopathies
- B. Abdelmoula, S. Sellami, W. Smaoui, N. Bouayed Abdelmoula
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- Journal:
- European Psychiatry / Volume 66 / Issue S1 / March 2023
- Published online by Cambridge University Press:
- 19 July 2023, p. S349
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Introduction
Chromatin modifications and epigenetics are important pathogenesis mechanisms leading to various neurologic and psychiatric disorders including epilepsy, drug addictions, depression, autistic spectrum, learning disabilities and schizophrenia. Recently, the disruption of the chromatin remodeling BAF complex has been linked to several neurodevelopmental syndromes, commonly referred to as PBAFopathies.
ObjectivesHere, we review the implication of PBAF complex genes in schizophrenia and we outline syndromes caused by mutations in these chromatin-modifying enzymes labelled as PBAFopathies to discuss the functional consequences of reported mutations in the literature.
MethodsWe comprehensively review the scientific literature using Pubmed database and other search platforms such as Google scholar to state the role of PBAF complex genes in schizophrenia and to reveal the most frequent genes mutations reported in literature.
ResultsOur review revealed that the human analogs of the subfamily of ATP-dependent chromatin remodeling complexes, which are known in eukaryotes as the mammalian SWI/SNF complex (counting a group of proteins that associate and possess a DNA-stimulated ATPase activity that can destabilize histone-DNA interactions in reconstituted nucleosomes providing crucial nucleosome rearrangement and allowing the activation/repression of genes) are crucial for the regulation of genes expression and cells differentiation. They involve two well-known complexes which are SWI/SNF-A (known as BAF complex) and SWI/SNF-B (known as Polybromo-associated BAF or PBAF complex). SWI/SNF is a multisubunit chromatin-remodeling complex that performs fundamental roles in gene regulation, cell lineage specification, and organismal development and mutations that inactivate SWI/SNF subunits are found in nearly 20% of human cancers and in various developmental disorders, forming a continuum or spectrum of diseases. Since the first description of BRG1/BRM mutations in schizophrenia, other mutations of the SWI/SNF subunits have been reported: SMARCA1, SMARCA2, SMARCA4/BRG1, etc. Single nucleotide polymorphisms (SNPs) in these and other genes of PBAF have been also associated with schizophrenia.
ConclusionsThis review focuses on the PBAF SWI/SNF subunits to find out if schizophrenia may be considered as a member of the spectrum of PBAFopathies.
Disclosure of InterestNone Declared
Psychological benefits of pre-conceptional and pre-marital genetic diagnosis in conservative societies
- N. Bouayed Abdelmoula, B. Abdelmoula, S. Kammoun, F. Abid, S. Aloulou
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- Journal:
- European Psychiatry / Volume 65 / Issue S1 / June 2022
- Published online by Cambridge University Press:
- 01 September 2022, pp. S595-S596
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Introduction
Preconceptional genetic diagnosis help couples of genetic disorders carrier risk making an informed reproductive decision. The risk is considerably higher for consanguineous couples. Premarital screening can also offers a crucial health assessment of soon-to-be married couples with genetic risk factors based on specific family history. However, such approach is not usually easy to manage in conservative societies, particularly when the affected family refuse to deliver the necessary information about the genetic condition considered as a taboo.
ObjectivesHere, we addressed the psychological benefits of preconceptional and premarital genetic diagnosis through a retrospective study about the preconceptional diagnosis inquiries in our genetic counselling.
MethodsIn order to assess requests for autosomal recessive disorders during ten years of our genetic counselling activity at the medical university of Sfax, we reviewed 2500 medical files.
ResultsThree couples were recorded for genetic preconceptional diagnosis. Another couple was documented for seeking a premarital screening for an unknown neuropathy before wedding engagement decision. This single case was referred to us because of a familial history of a severe neuropathy that was noted in the offspring of a shared cousin. The couple was unable to bring us more information about the genetic condition because of the familial repugnance.
ConclusionsAlthough our study is limited at the genetic level, it could be socially interesting because it showed the negative attitudes of the general population towards the genetic conditions and the familial responsiveness, as well as the reticence of physicians towards genetic preconceptional and premarital carrier diagnosis.
DisclosureNo significant relationships.
Behavioral features in Williams Beuren syndrome: A Tunisian Cohort study
- N. Bouayed Abdelmoula, F. Abid, S. Sellami, B. Abdelmoula
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- European Psychiatry / Volume 65 / Issue S1 / June 2022
- Published online by Cambridge University Press:
- 01 September 2022, p. S682
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Introduction
The low prevalence of some genetic neuro-developmental syndromes associated to psychiatric disorders requests to be integrated in human genome-phenome databases from which pleiotropy can be compiled from by systematic integration of phenotypes associated with genetic loci using phenomic inference tools. Williams-Beuren syndrome (WBS) is a neurodevelopmental disorder related to elastin gene at 7q11.23. Anxiety, depression and attention problems are the main behavioral problems found in WBS with no gender differences. Significant differences between cohorts are reported in particular regarding somatic complaints and aggressive behavior.
ObjectivesHere, we report a Tunisian cohort of WBS patients for whom clinical behavioral phenotypes as well as genetic features are detailed.
MethodsSixteen patients from Sfax, Tunisia were referred for genetic assessment due to a suspected WBS syndrome.
ResultsGenetic evaluation using fluorescent in situ hybridization confirmed 7q11.23 microdeletion in only eight patients. Comparison of detailed behavioral phenotypes revealed differences between age groups, gender groups and genetic groups. Anxiety and depression were recorded in the two older male patients and aggressive behavior was recorded in only two boys. The severity of behavioral features were dependent to familial environment and to parental socio-economic and educational levels.
ConclusionsA more complete understanding of phenomic space is critical for elucidating genome-phenome relationships mediating neurodevelopmental disorder associated to psychiatric diseases for assessing and managing psychiatric and behavioral risks in young syndromic children.
DisclosureNo significant relationships.
Neonatal onset of bipolar spectrum disorder through a three-generation familial study
- B. Abdelmoula, S. Sellami, M. Keskes, N. Bouayed Abdelmoula
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- Journal:
- European Psychiatry / Volume 65 / Issue S1 / June 2022
- Published online by Cambridge University Press:
- 01 September 2022, pp. S407-S408
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Introduction
Age at onset of pediatric bipolar spectrum disorder (BSD) is an important marker of a more severe form and a highly heritable mood/mental disorder.
ObjectivesHere, we report a familial Tunisian BSD follow-up study showing a very early onset of the BSD at the neonatal period.
MethodsA 28-year-old female and her 30-year old sister were referred for genetic and psychological assessments due to recurrent depressive episodes.
ResultsPsychological assessment revealed a BSD type II with episodes of hypomania for both patients. The 30-year old sister presented a mixed form of BSD coupled with autistic traits, hyposomnia and obsessive-compulsive behaviors. Intellectual and cognitive abilities were without concerns. Familial history revealed BDS among paternal relatives including the brothers’ and sisters’ father as well as all their uncles offspring’s, and their grandparents, who were consanguineous. The depressive mood was a common sign in the three generations. Personal history revealed significant signs of a very early onset of the disorder since the neonatal period for the two sisters as well as for their four paternal cousins who also presented BSD features. Familial risk of BSD in this family correlates with a variably higher personal risk of other psychiatric disorders such as anxiety, drug abuse, personality disorders, and autism spectrum disorder.
ConclusionsEnvironmental conditions, familial care and educational level have a strong correlation with the severity and the efficiency of cognitive management of BSD and its psychiatric comorbidities. BSD is highly heterogeneous and polygenic and personalized management has considerable clinical repercussions benefits.
DisclosureNo significant relationships.
Sexual health in Tunisian women after menopause: There is a need to improve it to sustain emotional and mental wellbeing
- B. Abdelmoula, S. Sellami, I. Bouaziz, E. Khouaja, N. Bouayed Abdelmoula
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- European Psychiatry / Volume 65 / Issue S1 / June 2022
- Published online by Cambridge University Press:
- 01 September 2022, p. S853
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Introduction
Maintaining sexuality is important to the well-being of women, particularly after menopause and benefits of sexual satisfaction in terms of emotional well-being and quality of life have been well demonstrated.
ObjectivesThis study aims to assess the sexual health behaviors in Tunisian women during and after menopause and the awareness of Tunisian partners about the role of the quality of their sexuality regarding their physical and psychological wellbeing.
MethodsWe comprehensively review the scientific literature using Pubmed database to state Tunisian literature regarding sexual behaviors and function in women during and after menopause. Interviews with twenty Tunisian women after menopause about sexual health have been conducted.
ResultsOur bibliographic research revealed a poor literature with only two papers responding to our inquiry but among a specific female population investigated after experiencing breast cancer “Female sexuality in premenopausal patients with breast cancer on endocrine therapy and sexuality after breast cancer: cultural specificities of Tunisian population”. Interrogated women reported a poor sexual satisfaction as well as sexual difficulties in the partner or with him. In fact, there is an important wrong understanding of the female anatomy and physiology by both partners, for the female sexual satisfaction. There is also many wrong cultural ideas about menopause and sexuality.
ConclusionsCurrently, sexuality in Tunisian women during and after menopause is influenced by ageing, by previous sexual function and experiences, the male domination in partner’s sexual practices and the sexual functioning in the partner. In general, there is an unfavorable body image and disturbed sexual health.
DisclosureNo significant relationships.