Studies were conducted at two sites in South Dakota in 1992 and at one site in 1993 to measure the effect of velvetleaf on corn growth and yield. Velvetleaf was overseeded in corn rows and thinned to densities of 0, 1.3, 4, 12, and 24 plants/m2. Velvetleaf leaf area index and total biomass were positively correlated with velvetleaf density. Biomass per velvetleaf plant and corn biomass were correlated negatively with velvetleaf density. The percent corn yield reduction was similar for locations and years in spite of large yield differences. Maximum yield loss estimated by a hyperbolic yield reduction model was 37.2% with a loss of 4.4% per unit velvetleaf density.