After a rapid review of the sociocultural aspects justifying that rare breeds be protected, of the aim of a conservation programme. and of the possible strategies, this paper describes in details the activities implemented at the National Centre for the preservation of germplasm of animals at risk of extinction, at Circello, in the south of Italy. In this centre, established on 310 ha, are presently raised 281 animals of more than 30 different breeds, among which 11 cattle breeds, 7 sheep breeds and 10 goat breeds. Activities of the centre include preservation, description, multiplication, improvement and use of the breeds at risk. Collaboration with other insttitutions within the Mediterranean region are listed.