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Macroscopic, modular, morphologically simple skeletons occur in the uppermost Mural Formation (Cambrian, Epoch 2, Bonnia–Olenellus Biozone), west-central Alberta and adjacent east-central British Columbia. They represent organisms that lived almost exclusively in reefal environments dominated by archaeocyaths. Some were attached to archaeocyaths or less commonly other surfaces, and some grew downward, apparently from overhangs or cavities in reefs. Qualitative and quantitative data from a large number of specimens, most of which were serially thin sectioned, indicate that they represent a single, remarkably variable species. The skeletal structure ranges among specimens from entirely cerioid to partially to entirely labyrinthine with irregularly incomplete walls. There is also a wide range of variability in growth form among skeletons, in module size and wall thickness among and within skeletons, in module shape within skeletons, and in number and location of projections extending from the wall into some modules. Module increase occurred by peripheral expansion at the basal surface of the skeleton and longitudinal fission involving projections from the wall as module size increased during vertical growth. Walls of skeletons, now composed of calcite cement, were probably originally aragonite. Modular skeletons from the uppermost Mural Formation are assigned to Rosellatana jamesi Kobluk, 1984a, previously represented only by a few cerioid specimens from correlative strata in the Rosella Formation of north-central British Columbia. The skeletal structure and types of module increase in R.jamesi, and a few similar but less well-known Cambrian taxa from elsewhere in North America, suggest a general biologic affinity with hypercalcified sponges.
Background: Data on antimicrobial use at the national level is crucial to establish domestic antimicrobial stewardship policies and enable medical institutions to benchmark against each other. This study aimed to analyze antimicrobial use in Korean hospitals. Methods: We investigated the antimicrobials prescribed in Korean hospitals between 2018 and 2021, using data from the Health Insurance Review and Assessment. Primary care hospitals (PCHs), secondary care hospitals (SCHs), and tertiary care hospitals (TCHs) were included in this analysis. Antimicrobials were categorized according to the Korea National Antimicrobial Use Analysis System (KONAS) classification, which is suitable for measuring antimicrobial use in Korean hospitals. Results: Out of more than 1,900 hospitals, PCHs and TCHs represented the largest and lowest percentage of hospitals, respectively. The most frequently prescribed antimicrobial in 2021 was piperacillin/β-lactamase inhibitor (9.3%) in TCHs, ceftriaxone (11.0%) in SCHs, and cefazedone (18.9%) in PCHs. Between 2018 and 2021, the most used antimicrobial class according to the KONAS classification was ‘broad-spectrum antibacterial agents predominantly used for community-acquired infections’ in TCHs and SCHs, and 'narrow spectrum beta-lactam agents' in PCH. Total consumption of antimicrobials has decreased from 951.7 to 929.9 days of therapy (DOT)/1,000 patient-days in TCHs and from 817.8 to 752.2 DOT/1,000 patient-days in SCHs during study period, but not in PCHs (from 504.3 to 527.2 DOT/1,000 patient-days). Moreover, in 2021, while use of reserve antimicrobials has decreased from 13.6 to 10.7 DOT/1,000 patient-days in TCHs and from 4.6 to 3.3 DOT/1,000 patient-days in SCHs, it has increased from 0.7 to 0.8 DOT/1,000 patient-days in PCHs. Conclusion: This study confirms that antimicrobial use differs by hospital type in Korea. Recent increases of use of antimicrobials, including reserve antimicrobials, in PCHs reflect the challenges that must be addressed.
Brain ageing, the primary risk factor for cognitive impairment, occurs because of the accumulation of age-related neuropathologies. Identifying effective nutrients that increase cognitive function may help maintain brain health. Tomatoes and lemons have various bioactive functions and exert protective effects against oxidative stress, ageing and cancer. Moreover, they have been shown to enhance cognitive function. In the present study, we aimed to investigate the effects of tomato and lemon ethanolic extracts (TEE and LEE, respectively) and their possible synergistic effects on the enhancement of cognitive function and neurogenesis in aged mice. The molecular mechanisms underlying the synergistic effect of TEE and LEE were investigated. For the in vivo experiment, TEE, LEE or their mixture was orally administered to 12-month-old mice for 9 weeks. A single administration of either TEE or LEE improved cognitive function and neurogenesis in aged mice to some extent, as determined using the novel object recognition test and doublecortin immunohistochemical staining, respectively. However, a significant enhancement of cognitive function and neurogenesis in aged mice was observed after the administration of the TEE + LEE mixture, which had a synergistic effect. N-methyl-d-aspartate receptor 2B, postsynaptic density protein 95, and brain-derived neurotrophic factor (BDNF) levels and tropomyosin receptor kinase B (TrkB)/extracellular signal-regulated kinase (ERK) phosphorylation also synergistically increased after the administration of the mixture compared with those in the individual treatments. In conclusion, compared with their separate treatments, treatment with the TEE + LEE mixture synergistically improved the cognitive function, neurogenesis and synaptic plasticity in aged mice via the BDNF/TrkB/ERK signalling pathway.
Attention deficit-hyperactivity disorder (ADHD) is related to depressive disorder, and adolescents with both present poor outcomes. However, evidence for the safety of concomitantly using a methylphenidate (MPH) and a selective serotonin reuptake inhibitor (SSRI) among adolescent ADHD patients is limited, a literature gap aimed to address through this investigation.
Methods
We conducted a new-user cohort study using a nationwide claims database in South Korea. We identified a study population as adolescents who were diagnosed both ADHD and depressive disorder. MPH-only users were compared with patients who prescribed both a SSRI and a MPH. Fluoxetine and escitalopram users were also compared to find a preferable treatment option. Thirteen outcomes including neuropsychiatric, gastrointestinal, and other events were assessed, taking respiratory tract infection as a negative control outcome. We matched the study groups using a propensity score and used the Cox proportional hazard model to calculate the hazard ratio. Subgroup and sensitivity analyses were conducted in various epidemiologic settings.
Results
The risks of all the outcomes between the MPH-only and SSRI groups were not significantly different. Regarding SSRI ingredients, the risk of tic disorder was significantly lower in the fluoxetine group than the escitalopram group [HR 0.43 (0.25–0.71)]. However, there was no significant difference in other outcomes between the fluoxetine and escitalopram groups.
Conclusion
The concomitant use of MPHs and SSRIs showed generally safe profiles in adolescent ADHD patients with depression. Most of the differences between fluoxetine and escitalopram, except those concerning tic disorder, were not significant.
We make the case in this chapter that work-life balance is an important topic because research has shown that work-life balance influences a host of organizational outcomes (e.g., organizational identification, loyalty, and commitment; turnover, job performance, employee morale, and organizational citizenship) and personal outcomes (employee stress, employee burnout, employee wellbeing, satisfaction with life overall, personal happiness, eudaimonia, satisfaction with family life, satisfaction with social life, satisfaction with leisure life, satisfaction with spiritual life, satisfaction with financial life, etc.).
This chapter addresses the topic of integration, a cognition-based personal intervention serving to balance work life with other important life domains such as family life, social life, and leisure life through the principle of spillover. Positive spillover refers to the mental process by which the individual allows positive feelings invested in one life domain to spill over to other domains. Positive spillover occurs when life domains are highly interdependent and integrated. We discuss four interventions that employees use to integrate their life domains to achieve work-life balance: (1) temporal, (2) physical, (3) behavior, and (4) communicative We also discuss intervention programs that organizations can institutionalize to achieve higher levels of employee work-life balance based on these personal strategies.
In this chapter we discuss how people try to achieve work-life balance and maintain a semblance of life satisfaction by allotting more time, energy, and financial resources in roles and life domains that can produce more personal happiness. Conversely, they decrease their involvement in roles and domains that are dissatisfying. We also discuss intervention programs that organizations can use to help their employees achieve greater work-life balance through behavior-based compensation.
In this chapter, we discuss much of the research that explains how work-life balance contributes significantly to life satisfaction. We explain the direct link between work-life balance and overall life satisfaction through satisfaction in multiple domains, positive spillover of domain satisfaction, and minimal role conflict. Furthermore, there are two indirect links, namely through domain satisfaction (satisfaction with marital life, family life, health and safety, and leisure life) and stress reduction (emotional exhaustion, psychological distress, and mental health).
This chapter covers the research focusing on how employees use a behavior-based personal intervention to balance their work life with other important life domains such as family life, social life, and leisure life. This personal intervention involves role engagement in multiple roles and domains. Role engagement can be implemented through (1) increasing role involvement in a manner consistent with life priorities, (2) engaging in multiple life domains to achieve positive balance, and (3) engaging in important roles with harmonious passion. We also discuss intervention programs that organizations can institutionalize to achieve higher levels of employee work-life balance through role engagement.
In this chapter we describe segmentation— a cognition-based intervention of work-life balance. Segmentation involves creating boundaries (or psychological walls) to insulate life domains. The goal is to prevent negative spillover from the segmented domain to other domains. We discuss four different segmentation interventions that people commonly use to prevent negative spillover: temporal, physical, behavior, and communicative. We also discuss intervention programs that organizations can institutionalize to achieve higher levels of employee work-life balance based on these segmentation interventions.
This chapter summarizes much of the books content, which is divided into three parts. The first part (Chapters 1-3) describes the conceptual foundation of the research on work-life balance (definitions, importance of the construct, and the link of the construct to employee wellbeing). The second part (Chapters 4-8) describes five behavior-based, personal interventions that people commonly used to achieve work-life balance, namely (1) engaging in multiple roles and domains, (2) increasing role enrichment, (3) engaging in behavior-based compensation, (4) managing role conflict, and (5) creating role balance. Part 3 of the book (Chapters 9-12) focuses on four personal interventions of work-life balance that are cognition-based. These are (1) segmenting roles and domains, (2) integrating roles and domains, (3) engaging in value-based compensation, and (4) applying whole-life perspective in decision-making. Based on the psychological principles underlying these nine personal interventions, we developed concrete training material for instructors of work-life balance to use in the context of workshops and seminars.
In this chapter we discuss the concept of value-based compensation and the research supporting it. This concept refers to individuals changing the way they perceive the importance of work and nonwork roles and life domains as a function of their successes and failures. They value those roles/domains they find satisfying and devalue those they find dissatisfying. Doing so allows them to maintain a semblance of life satisfaction overall. That is, they “compensate” for the dissatisfaction they experience in roles by decreasing their salience; and conversely, they increase the salience of satisfying roles. We discuss two specific interventions used in value-based compensation: (1) sequencing work and nonwork goals and (2) revising existing work and nonwork goals and selecting new goals. We also discuss intervention programs that organizations can institutionalize to achieve higher levels of employee work-life balance based on these personal interventions.
In this chapter we discuss how people try to achieve work-life balance and maintain an acceptable level of life satisfaction by reducing role conflict. Reducing role conflict is typically operationalized by (1) matching role resources with role demands, (2) managing time, and (3) managing stress. We also discuss intervention programs that organizations can use to help their employees achieve greater work-life balance through managing role conflict.