5 results
Children and adolescents exposed to maltreatment already exhibit epigenetic patterns suggestive of heightened low-grade inflammation
- H. Palma-Gudiel, L. Marques Feixa, S. Romero, M. Rapado-Castro, H. Blasco-Fontecilla, I. Zorrilla, M. Martín, Á. Castro Quintas, J.L. Monteserin-Garcia, E. Font, M. Ramirez, D. Moreno, M. Marín-Vila, N. Moreno, E. Binder, L. Fañanas
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- Journal:
- European Psychiatry / Volume 65 / Issue S1 / June 2022
- Published online by Cambridge University Press:
- 01 September 2022, p. S71
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Introduction
Childhood maltreatment (CM) is one of the best described environmental risk factors for developing any psychiatric disorder, while it also confers increased odds for obesity, cardiometabolic disorders and all-cause mortality. Inflammation has been suggested to mediate the widespread clinical effects of CM. Previously, Ligthart et al. (2016) identified a polyepigenetic signature of circulating CRP levels, a measure of chronic low-grade inflammation, that has been reliably associated with a wide array of complex disorders. The study of this biomarker could dilucidate the mechanistic relationship between CM and psychiatric outcomes.
ObjectivesThus, CRP-associated epigenetic modifications were explored regarding proximal exposure to CM.
MethodsGenomic DNA was extracted from peripheral blood mononuclear cells of 157 children and adolescents (7 to 17 years old). Exposure to CM was assessed following the TASSCV criteria. Genome-wide DNA methylation was assessed by means of the EPIC array. Fifty-two out of the 58 original CRP-associated CpG sites surpassed quality control and were included in the analysis. Age, sex, psychopathological status and cell type proportions were included as covariates.
ResultsDNA methylation at 12 out of 52 CpG sites (23%) was significantly associated with exposure to CM (p < .05); 8 of these associations survived correction for multiple testing (q < .05).
ConclusionsThis is the first study to date to explore the relationship between childhood maltreatment and an epigenetic signature of chronic low-grade inflammation. Our findings underscore the presence of immune dysregulation early after exposure to CM; further studies are needed to assess the long-term clinical implications of this signature in psychiatric patients.
DisclosureNo significant relationships.
Tolerability and side effects of an extended-release injectable suspension of aripripazole in a series of inpatients in a dual diagnosis unit
- A. Farre, A. Palma, G. Mateu, J.L. Perez de Heredia, R. Martinez, C. Castillo, M.G. Hurtado, J. Martí, R. Sanchez, M.T. Campillo, M. Torrens
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- Journal:
- European Psychiatry / Volume 33 / Issue S1 / March 2016
- Published online by Cambridge University Press:
- 23 March 2020, p. S539
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Introduction
The integrated care in dual diagnosis units involves selecting pharmacological treatment strategies for both substance use disorder and the non-addictive psychiatric disorder. It is recommended to choose drugs with a favorable balance between efficacy/tolerability, an adequate side effects profile and the minimal drug interactions.
Objectives and aimsTo evaluate the tolerability and side effects after first administration-first dose of an extended-release injectable suspension of aripiprazole in a group of patients admitted to an acute dual diagnosis unit.
MethodsThe study included a series of patients admitted in our unit from May to August 2015 that received the first dose of the aripiprazole preparation (400 mg). Evaluations included different scales for side effects (SAS, ESRS, UKU) and the clinical global impression scale (CGI).
ResultsA total of 9 patients were included and evaluated (all men, mean age: 39-years-old). Diagnoses were: bipolar disorder (5/9), schizophrenia (2/9), schizoaffective disorder (1/9) and delusional disorder (1/9) with concomitant substance use disorder (6 cannabis, 2 alcohol, 1 cocaine). All of them without outpatient control and treatment at admission. The results of the clinical scales conclude that none of them had significant side effects, including extrapyramidal, with an improvement in the ICG scale.
ConclusionTolerability of extended-release injectable suspension of aripiprazole was good in all cases. In the future, new cases should be included to extend the sample and to evaluate other aspects such as the craving for substances.
Disclosure of interestThe authors have not supplied their declaration of competing interest.
1 - An introduction to global volcanic hazard and risk
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- By Susan C. Loughlin, British Geological Survey, UK, Charlotte Vye-Brown, British Geological Survey, UK, R.S.J. Sparks, University of Bristol, UK, Sarah K. Brown, University of Bristol, UK, J. Barclay, University of East Anglia, UK, E. Calder, University of Edinburgh, UK, E. Cottrell, Smithsonian Institution, USA, G. Jolly, GNS Science, New Zealand, J-C. Komorowski, Institut de Physique du Globe de Paris, France, C. Mandeville, US Geological Survey, USA, C.G. Newhall, Earth Observatory of Singapore, Singapore, J.L. Palma, University of Concepcion, Chile, S. Potter, GNS Science, New Zealand, G. Valentine, University at Buffalo, USA
- Edited by Susan C. Loughlin, Steve Sparks, University of Bristol, Sarah K. Brown, University of Bristol, Susanna F. Jenkins, University of Bristol, Charlotte Vye-Brown
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- Book:
- Global Volcanic Hazards and Risk
- Published online:
- 05 August 2015
- Print publication:
- 24 July 2015, pp 1-80
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2 - Global volcanic hazard and risk
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- By Sarah K. Brown, University of Bristol, UK, Susan C. Loughlin, British Geological Survey, UK, R.S.J. Sparks, University of Bristol, UK, Charlotte Vye-Brown, British Geological Survey, UK, J. Barclay, University of East Anglia, UK, E. Calder, University of Edinburgh, UK, E. Cottrell, Smithsonian Institution, USA, G. Jolly, GNS Science, New Zealand, J-C. Komorowski, Institut de Physique du Globe de Paris, France, C. Mandeville, US Geological Survey, USA, C.G. Newhall, Earth Observatory of Singapore, Singapore, J.L. Palma, University of Concepcion, Chile, S. Potter, GNS Science, New Zealand, G. Valentine, University at Buffalo, USA
- Edited by Susan C. Loughlin, Steve Sparks, University of Bristol, Sarah K. Brown, University of Bristol, Susanna F. Jenkins, University of Bristol, Charlotte Vye-Brown
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- Book:
- Global Volcanic Hazards and Risk
- Published online:
- 05 August 2015
- Print publication:
- 24 July 2015, pp 81-172
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Summary
Introduction
An estimated 800 million people live within 100 km of an active volcano in 86 countries and additional overseas territories worldwide [see Chapter 4 and Appendix B]1. Volcanoes are compelling evidence that the Earth is a dynamic planet characterised by endless change and renewal. Humans have always found volcanic activity fascinating and have often chosen to live close to volcanoes, which commonly provide favourable environments for life. Volcanoes bring many benefits to society: eruptions fertilise soils; elevated topography provides good sites for infrastructure (e.g. telecommunications on elevated ground); water resources are commonly plentiful; volcano tourism can be lucrative; and volcanoes can acquire spiritual, aesthetic or religious significance. Some volcanoes are also associated with geothermal resources, making them a target for exploration and a potential energy resource.
Much of the time volcanoes are not a threat because they erupt very infrequently or because communities have become resilient to frequently erupting volcanoes. However, there is an everpresent danger of a long-dormant volcano re-awakening or of volcanoes producing anomalously large or unexpected eruptions. Volcanic eruptions can cause loss of life and livelihoods in exposed communities, damage or disrupt critical infrastructure and add stress to already fragile environments. Their impacts can be both short-term, e.g. physical damage, and long-term, e.g. sustained or permanent displacement of populations. The risk from volcanic eruptions and their attendant hazards is often underestimated beyond areas within the immediate proximity of a volcano. For example, volcanic ash hazards can have effects hundreds of kilometres away from the vent and have an adverse impact on human and animal health, infrastructure, transport, agriculture and horticulture, the environment and economies. The products of volcanism and their impacts can extend beyond country borders, to be regional and even global in scale.
Although known historical loss of life from volcanic eruptions (since 1600 AD about 280,000 fatalities are recorded, Auker et al. (2013)) is modest compared to other major natural hazards, volcanic eruptions can be catastrophic for exposed communities. In 1985 the town of Armero in Colombia was buried by lahars (volcanic mudflows) with more than 21,000 fatalities due to relatively small explosive eruptions at the summit of Nevado del Ruiz volcano that partially melted a glacier (Voight, 1990).
22 - Development of a new global Volcanic Hazard Index (VHI)
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- By M.R. Auker, University of Bristol, UK, R.S.J. Sparks, University of Bristol, UK, S.F. Jenkins, University of Bristol, UK, W. Aspinall, University of Bristol, UK, Sarah K. Brown, University of Bristol, UK, N.I. Deligne, GNS Science, New Zealand, G. Jolly, GNS Science, New Zealand, Susan C. Loughlin, British Geological Survey, UK, W. Marzocchi, Istituto Nazionale di Geofisica e Vulcanologia, Italy, C.G. Newhall, Earth Observatory of Singapore, Singapore, J.L. Palma, University of Concepcion, Chile
- Edited by Susan C. Loughlin, Steve Sparks, University of Bristol, Sarah K. Brown, University of Bristol, Susanna F. Jenkins, University of Bristol, Charlotte Vye-Brown
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- Book:
- Global Volcanic Hazards and Risk
- Published online:
- 05 August 2015
- Print publication:
- 24 July 2015, pp 349-358
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Summary
Background
Globally, more than 800 million people live in areas that have the potential to be affected by volcanic hazards, and this number is growing [Chapter 4]. The need for informed judgements regarding the global extent of potential volcanic hazards and the relative threats is therefore more pressing than ever. There is also an imperative to identify areas of relatively high hazard where studies and risk reduction measures may be best focussed. Various authors have tackled this task at a range of spatial scales, using a variety of techniques. At some well-studied volcanoes, the geological record has been used in combination with numerical modelling to create probabilistic hazard maps of volcanic flows and tephra fall [Chapter 6 and 20]. Such sources of information can be hugely beneficial in land use planning during times of quiescence and in emergency planning during times of unrest. Unfortunately, creating high-resolution probabilistic hazard maps for all volcanoes is not yet feasible. There is therefore a need for a methodology for volcanic hazard assessment that can be applied universally and consistently, which is less data-and computing-intensive. The aim of such an approach is to identify, on some objective overall basis, those volcanoes that pose the greatest danger, in order that more indepth investigations and disaster risk reduction efforts can then be focused on them.
Previous methods
An index-based approach to volcanic hazard assessment involves assigning scores to a series of indicators, which are then combined to give an overall hazard score. Indicators typically include measures of the frequency of eruptions, the relative occurrence of different kinds of eruptions and their related hazards, the footprints of these hazards, and eruption size. Indices are well suited to the problem of volcanic hazard assessment, as they allow the decomposition of the complex system into a suite of volcanic system controls and simple quantitative variables and factors that jointly characterise threat potential.
Ewert (2007) presented an index-based methodology for assessing volcanic threat (the combination of hazard and exposure) in the USA, to permit prioritisation of research, monitoring and mitigation.