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Determinants of incomplete childhood hepatitis B vaccination in Sierra Leone, Liberia, and Guinea: Analysis of national surveys (2018–2020)
- George A. Yendewa, Peter B. James, Amir Mohareb, Umaru Barrie, Samuel P. E. Massaquoi, Sahr A. Yendewa, Manal Ghazzawi, Tahir Bockarie, Peterlyn E. Cummings, Ibrahima S. Diallo, Ambulai Johnson, Benjamin Vohnm, Lawrence S. Babawo, Gibrilla F. Deen, Mustapha Kabba, Foday Sahr, Sulaiman Lakoh, Robert A. Salata
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- Journal:
- Epidemiology & Infection / Volume 151 / 2023
- Published online by Cambridge University Press:
- 03 November 2023, e193
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Vaccination against hepatitis B virus (HBV) is effective at preventing vertical transmission. Sierra Leone, Liberia, and Guinea are hyperendemic West African countries; yet, childhood vaccination coverage is suboptimal, and the determinants of incomplete vaccination are poorly understood. We analyzed national survey data (2018–2020) of children aged 4–35 months to assess complete HBV vaccination (receiving 3 doses of the pentavalent vaccine) and incomplete vaccination (receiving <3 doses). Statistical analysis was conducted using the complex sample command in SPSS (version 28). Multivariate logistic regression was used to identify determinants of incomplete immunization. Overall, 11,181 mothers were analyzed (4,846 from Sierra Leone, 2,788 from Liberia, and 3,547 from Guinea). Sierra Leone had the highest HBV childhood vaccination coverage (70.3%), followed by Liberia (64.6%) and Guinea (39.3%). Within countries, HBV vaccination coverage varied by socioeconomic characteristics and healthcare access. In multivariate regression analysis, factors that were significantly associated with incomplete vaccination in at least one country included sex of the child, Muslim mothers, lower household wealth index, <4 antenatal visits, home delivery, and distance to health facility vaccination (all p < 0.05). Understanding and addressing modifiable determinants of incomplete vaccination will be essential to help achieve the 2030 viral hepatitis elimination goals.
Building an infrastructure to support the development, conduct, and reporting of informative clinical studies: The Rockefeller University experience
- Rhonda G. Kost, Rita K. Devine, Mark Fernands, Riva Gottesman, Manoj Kandpal, Robert B. MacArthur, Barbara O’Sullivan, Michelle Romanick, Andrea Ronning, Sarah Schlesinger, Jonathan N. Tobin, Roger Vaughan, Maija Neville-Williams, James G. Krueger, Barry S. Coller
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- Journal:
- Journal of Clinical and Translational Science / Volume 7 / Issue 1 / 2023
- Published online by Cambridge University Press:
- 13 April 2023, e104
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Introduction:
Clinical trials are a vital component of translational science, providing crucial information on the efficacy and safety of new interventions and forming the basis for regulatory approval and/or clinical adoption. At the same time, they are complex to design, conduct, monitor, and report successfully. Concerns over the last two decades about the quality of the design and the lack of completion and reporting of clinical trials, characterized as a lack of “informativeness,” highlighted by the experience during the COVID-19 pandemic, have led to several initiatives to address the serious shortcomings of the United States clinical research enterprise.
Methods and Results:Against this background, we detail the policies, procedures, and programs that we have developed in The Rockefeller University Center for Clinical and Translational Science (CCTS), supported by a Clinical and Translational Science Award (CTSA) program grant since 2006, to support the development, conduct, and reporting of informative clinical studies.
Conclusions:We have focused on building a data-driven infrastructure to both assist individual investigators and bring translational science to each element of the clinical investigation process, with the goal of both generating new knowledge and accelerating the uptake of that knowledge into practice.
High levels of surgical antibiotic prophylaxis: Implications for hospital-based antibiotic stewardship in Sierra Leone
- Sulaiman Lakoh, Joseph Sam Kanu, Sarah K. Conteh, James B.W. Russell, Stephen Sevalie, Christine Ellen Elleanor Williams, Umu Barrie, Aminata Kadie Kabia, Fatmata Conteh, Mohamed Boie Jalloh, Gibrilla F. Deen, Mustapha S. Kabba, Aiah Lebbie, Ibrahim Franklyn Kamara, Bobson Derrick Fofanah, Anna Maruta, Christiana Kallon, Foday Sahr, Mohamed Samai, Olukemi Adekanmbi, Le Yi, Xuejun Guo, Rugiatu Z. Kamara, Darlinda F. Jiba, Joseph Chukwudi Okeibunor, George A. Yendewa, Emmanuel Firima
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- Journal:
- Antimicrobial Stewardship & Healthcare Epidemiology / Volume 2 / Issue 1 / 2022
- Published online by Cambridge University Press:
- 07 July 2022, e111
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Objective:
Despite the impact of inappropriate prescribing on antibiotic resistance, data on surgical antibiotic prophylaxis in sub-Saharan Africa are limited. In this study, we evaluated antibiotic use and consumption in surgical prophylaxis in 4 hospitals located in 2 geographic regions of Sierra Leone.
Methods:We used a prospective cohort design to collect data from surgical patients aged 18 years or older between February and October 2021. Data were analyzed using Stata version 16 software.
Results:Of the 753 surgical patients, 439 (58.3%) were females, and 723 (96%) had received at least 1 dose of antibiotics. Only 410 (54.4%) patients had indications for surgical antibiotic prophylaxis consistent with local guidelines. Factors associated with preoperative antibiotic prophylaxis were the type of surgery, wound class, and consistency of surgical antibiotic prophylaxis with local guidelines. Postoperatively, type of surgery, wound class, and consistency of antibiotic use with local guidelines were important factors associated with antibiotic use. Of the 2,482 doses administered, 1,410 (56.8%) were given postoperatively. Preoperative and intraoperative antibiotic use was reported in 645 (26%) and 427 (17.2%) cases, respectively. The most commonly used antibiotic was ceftriaxone 949 (38.2%) with a consumption of 41.6 defined daily doses (DDD) per 100 bed days. Overall, antibiotic consumption was 117.9 DDD per 100 bed days. The Access antibiotics had 72.7 DDD per 100 bed days (61.7%).
Conclusions:We report a high rate of antibiotic consumption for surgical prophylaxis, most of which was not based on local guidelines. To address this growing threat, urgent action is needed to reduce irrational antibiotic prescribing for surgical prophylaxis.
Odontogenic sinusitis – case series and review of literature
- S Garry, I O'Riordan, D James, M Corbett, T Barry, M Thornton
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- Journal:
- The Journal of Laryngology & Otology / Volume 136 / Issue 1 / January 2022
- Published online by Cambridge University Press:
- 26 November 2021, pp. 49-54
- Print publication:
- January 2022
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Background
Odontogenic sinusitis is a common cause of rhinosinusitis that is often undiagnosed and overlooked. No single sign or symptom is specific for odontogenic sinusitis, and failure to focus on the specific radiological features can delay diagnosis.
ObjectiveThis paper presents four cases of chronic sinusitis that had an odontogenic origin. Each case was referred for a second opinion. Three patients had previously undergone unsuccessful surgical management.
MethodsThe literature, and the associated contributory clinical, radiological and microbiological features required for correct diagnosis and management, are reviewed.
ResultsEach case resulted in a positive patient outcome following the involvement of both otolaryngology and maxillofacial surgery departments.
ConclusionA high index of suspicion is advocated for odontogenic sinusitis in cases not responding to standard management plans. Collaboration with a maxillofacial specialist is important for diagnosis and management. This should be considered where standard management fails, or clinical features and radiological signs of odontogenic sinusitis are present. This paper also highlights the need for otolaryngologists to incorporate, at the very least, a basic dental history and examination as part of their assessment in recalcitrant cases.
Cardiac responses in paediatric Pompe disease in the ADVANCE patient cohort
- Part of
- Barry J. Byrne, Steven D. Colan, Priya S. Kishnani, Meredith C. Foster, Susan E. Sparks, James B. Gibson, Kristina An Haack, David W. Stockton, Loren D. M. Peña, Si Houn Hahn, Judith Johnson, Pranoot X. Tanpaiboon, Nancy D. Leslie, David Kronn, Richard E. Hillman, Raymond Y. Wang
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- Journal:
- Cardiology in the Young / Volume 32 / Issue 3 / March 2022
- Published online by Cambridge University Press:
- 23 August 2021, pp. 364-373
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Pompe disease results from lysosomal acid α-glucosidase deficiency, which leads to cardiomyopathy in all infantile-onset and occasional late-onset patients. Cardiac assessment is important for its diagnosis and management. This article presents unpublished cardiac findings, concomitant medications, and cardiac efficacy and safety outcomes from the ADVANCE study; trajectories of patients with abnormal left ventricular mass z score at enrolment; and post hoc analyses of on-treatment left ventricular mass and systolic blood pressure z scores by disease phenotype, GAA genotype, and “fraction of life” (defined as the fraction of life on pre-study 160 L production-scale alglucosidase alfa). ADVANCE evaluated 52 weeks’ treatment with 4000 L production-scale alglucosidase alfa in ≥1-year-old United States of America patients with Pompe disease previously receiving 160 L production-scale alglucosidase alfa. M-mode echocardiography and 12-lead electrocardiography were performed at enrolment and Week 52. Sixty-seven patients had complete left ventricular mass z scores, decreasing at Week 52 (infantile-onset patients, change −0.8 ± 1.83; 95% confidence interval −1.3 to −0.2; all patients, change −0.5 ± 1.71; 95% confidence interval −1.0 to −0.1). Patients with “fraction of life” <0.79 had left ventricular mass z score decreasing (enrolment: +0.1 ± 3.0; Week 52: −1.1 ± 2.0); those with “fraction of life” ≥0.79 remained stable (enrolment: −0.9 ± 1.5; Week 52: −0.9 ± 1.4). Systolic blood pressure z scores were stable from enrolment to Week 52, and no cohort developed systemic hypertension. Eight patients had Wolff–Parkinson–White syndrome. Cardiac hypertrophy and dysrhythmia in ADVANCE patients at or before enrolment were typical of Pompe disease. Four-thousand L alglucosidase alfa therapy maintained fractional shortening, left ventricular posterior and septal end-diastolic thicknesses, and improved left ventricular mass z score.
Trial registry: ClinicalTrials.gov Identifier: NCT01526785 https://clinicaltrials.gov/ct2/show/NCT01526785.
Social Media Statement: Post hoc analyses of the ADVANCE study cohort of 113 children support ongoing cardiac monitoring and concomitant management of children with Pompe disease on long-term alglucosidase alfa to functionally improve cardiomyopathy and/or dysrhythmia.
The Rockefeller Team Science Leadership training program: Curriculum, standardized assessment of competencies, and impact of returning assessments
- Roger Vaughan, Michelle Romanick, Donna Brassil, Rhonda Kost, Maija Neville-Williams, Riva Gottesman, Rita Devine, Prasanth Manukonda, Andrea Ronning, Barbara O’Sullivan, Bernadette Capili, Robert Macarthur, Jonathan N. Tobin, Tesheia Johnson, Eugene D. Shapiro, Emma Meagher, James Krueger, Sarah Schlesinger, Barry S. Coller
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- Journal:
- Journal of Clinical and Translational Science / Volume 5 / Issue 1 / 2021
- Published online by Cambridge University Press:
- 13 August 2021, e165
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The ability to effectively lead an interdisciplinary translational team is a crucial component of team science success. Most KL2 Clinical Scholars have been members of scientific teams, but few have been team science leaders. There is a dearth of literature and outcome measures of effective Team Science Leadership in clinical and translational research. We focused our curriculum to emphasize Team Science Leadership, developed a list of Team Science Leadership competencies for translational investigators using a modified Delphi method, and incorporated the competencies into a quantitative evaluation survey. The survey is completed on entry and annually thereafter by the Scholar; the Scholar’s primary mentor and senior staff who educate and interact with the Scholar rate the Scholar at the end of each year. The program leaders and mentor review the results with each Scholar. The survey scales had high internal consistency and good factor structure. Overall ratings by mentors and senior staff were generally high, but ratings by Scholars tended to be lower, offering opportunities for discussion and career planning. Scholars rated the process favorably. A Team Science Leadership curriculum and periodic survey of attained competencies can inform individual career development and guide team science curriculum development.
The Rockefeller University Clinical Scholars (KL2) program 2006–2016
- Sarah J. Schlesinger, Michelle Romanick, Jonathan N. Tobin, Donna Brassil, Rhonda G. Kost, Rita Devine, Barbara O’Sullivan, Roger D. Vaughan, Yupu Liang, Joel Correa da Rosa, Maija Williams, James G. Krueger, Barry S. Coller
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- Journal:
- Journal of Clinical and Translational Science / Volume 1 / Issue 5 / October 2017
- Published online by Cambridge University Press:
- 02 February 2018, pp. 285-291
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Introduction and Methods
The Rockefeller Clinical Scholars (KL2) program began in 1976 and transitioned into a 3-year Master’s degree program in 2006 when Rockefeller joined the National Institute of Health Clinical and Translational Science Award program. The program consists of ∼15 trainees supported by the Clinical and Translational Science Award KL2 award and University funds. It is designed to provide an optimal environment for junior translational investigators to develop team science and leadership skills by designing and performing a human subjects protocol under the supervision of a distinguished senior investigator mentor and a team of content expert educators. This is complemented by a tutorial focused on important translational skills.
ResultsSince 2006, 40 Clinical Scholars have graduated from the programs and gone on to careers in academia (72%), government service (5%), industry (15%), and private medical practice (3%); 2 (5%) remain in training programs; 39/40 remain in translational research careers with 23 National Institute of Health awards totaling $23 million, foundation and philanthropic support of $20.3 million, and foreign government and foundation support of $6 million. They have made wide ranging scientific discoveries and have endeavored to translate those discoveries into improved human health.
ConclusionThe Rockefeller Clinical Scholars (KL2) program provides one model for translational science training.
Contributors
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- By Mitchell Aboulafia, Frederick Adams, Marilyn McCord Adams, Robert M. Adams, Laird Addis, James W. Allard, David Allison, William P. Alston, Karl Ameriks, C. Anthony Anderson, David Leech Anderson, Lanier Anderson, Roger Ariew, David Armstrong, Denis G. Arnold, E. J. Ashworth, Margaret Atherton, Robin Attfield, Bruce Aune, Edward Wilson Averill, Jody Azzouni, Kent Bach, Andrew Bailey, Lynne Rudder Baker, Thomas R. Baldwin, Jon Barwise, George Bealer, William Bechtel, Lawrence C. Becker, Mark A. Bedau, Ernst Behler, José A. Benardete, Ermanno Bencivenga, Jan Berg, Michael Bergmann, Robert L. Bernasconi, Sven Bernecker, Bernard Berofsky, Rod Bertolet, Charles J. Beyer, Christian Beyer, Joseph Bien, Joseph Bien, Peg Birmingham, Ivan Boh, James Bohman, Daniel Bonevac, Laurence BonJour, William J. Bouwsma, Raymond D. Bradley, Myles Brand, Richard B. Brandt, Michael E. Bratman, Stephen E. Braude, Daniel Breazeale, Angela Breitenbach, Jason Bridges, David O. Brink, Gordon G. Brittan, Justin Broackes, Dan W. Brock, Aaron Bronfman, Jeffrey E. Brower, Bartosz Brozek, Anthony Brueckner, Jeffrey Bub, Lara Buchak, Otavio Bueno, Ann E. Bumpus, Robert W. Burch, John Burgess, Arthur W. Burks, Panayot Butchvarov, Robert E. Butts, Marina Bykova, Patrick Byrne, David Carr, Noël Carroll, Edward S. Casey, Victor Caston, Victor Caston, Albert Casullo, Robert L. Causey, Alan K. L. Chan, Ruth Chang, Deen K. Chatterjee, Andrew Chignell, Roderick M. Chisholm, Kelly J. Clark, E. J. Coffman, Robin Collins, Brian P. Copenhaver, John Corcoran, John Cottingham, Roger Crisp, Frederick J. Crosson, Antonio S. Cua, Phillip D. Cummins, Martin Curd, Adam Cureton, Andrew Cutrofello, Stephen Darwall, Paul Sheldon Davies, Wayne A. Davis, Timothy Joseph Day, Claudio de Almeida, Mario De Caro, Mario De Caro, John Deigh, C. F. Delaney, Daniel C. Dennett, Michael R. DePaul, Michael Detlefsen, Daniel Trent Devereux, Philip E. Devine, John M. Dillon, Martin C. Dillon, Robert DiSalle, Mary Domski, Alan Donagan, Paul Draper, Fred Dretske, Mircea Dumitru, Wilhelm Dupré, Gerald Dworkin, John Earman, Ellery Eells, Catherine Z. Elgin, Berent Enç, Ronald P. Endicott, Edward Erwin, John Etchemendy, C. Stephen Evans, Susan L. Feagin, Solomon Feferman, Richard Feldman, Arthur Fine, Maurice A. Finocchiaro, William FitzPatrick, Richard E. Flathman, Gvozden Flego, Richard Foley, Graeme Forbes, Rainer Forst, Malcolm R. Forster, Daniel Fouke, Patrick Francken, Samuel Freeman, Elizabeth Fricker, Miranda Fricker, Michael Friedman, Michael Fuerstein, Richard A. Fumerton, Alan Gabbey, Pieranna Garavaso, Daniel Garber, Jorge L. A. Garcia, Robert K. Garcia, Don Garrett, Philip Gasper, Gerald Gaus, Berys Gaut, Bernard Gert, Roger F. Gibson, Cody Gilmore, Carl Ginet, Alan H. Goldman, Alvin I. Goldman, Alfonso Gömez-Lobo, Lenn E. Goodman, Robert M. Gordon, Stefan Gosepath, Jorge J. E. Gracia, Daniel W. Graham, George A. Graham, Peter J. Graham, Richard E. Grandy, I. Grattan-Guinness, John Greco, Philip T. Grier, Nicholas Griffin, Nicholas Griffin, David A. Griffiths, Paul J. Griffiths, Stephen R. Grimm, Charles L. Griswold, Charles B. Guignon, Pete A. Y. Gunter, Dimitri Gutas, Gary Gutting, Paul Guyer, Kwame Gyekye, Oscar A. Haac, Raul Hakli, Raul Hakli, Michael Hallett, Edward C. Halper, Jean Hampton, R. James Hankinson, K. R. Hanley, Russell Hardin, Robert M. Harnish, William Harper, David Harrah, Kevin Hart, Ali Hasan, William Hasker, John Haugeland, Roger Hausheer, William Heald, Peter Heath, Richard Heck, John F. Heil, Vincent F. Hendricks, Stephen Hetherington, Francis Heylighen, Kathleen Marie Higgins, Risto Hilpinen, Harold T. Hodes, Joshua Hoffman, Alan Holland, Robert L. Holmes, Richard Holton, Brad W. Hooker, Terence E. Horgan, Tamara Horowitz, Paul Horwich, Vittorio Hösle, Paul Hoβfeld, Daniel Howard-Snyder, Frances Howard-Snyder, Anne Hudson, Deal W. Hudson, Carl A. Huffman, David L. Hull, Patricia Huntington, Thomas Hurka, Paul Hurley, Rosalind Hursthouse, Guillermo Hurtado, Ronald E. Hustwit, Sarah Hutton, Jonathan Jenkins Ichikawa, Harry A. Ide, David Ingram, Philip J. Ivanhoe, Alfred L. Ivry, Frank Jackson, Dale Jacquette, Joseph Jedwab, Richard Jeffrey, David Alan Johnson, Edward Johnson, Mark D. Jordan, Richard Joyce, Hwa Yol Jung, Robert Hillary Kane, Tomis Kapitan, Jacquelyn Ann K. Kegley, James A. Keller, Ralph Kennedy, Sergei Khoruzhii, Jaegwon Kim, Yersu Kim, Nathan L. King, Patricia Kitcher, Peter D. Klein, E. D. Klemke, Virginia Klenk, George L. Kline, Christian Klotz, Simo Knuuttila, Joseph J. Kockelmans, Konstantin Kolenda, Sebastian Tomasz Kołodziejczyk, Isaac Kramnick, Richard Kraut, Fred Kroon, Manfred Kuehn, Steven T. Kuhn, Henry E. Kyburg, John Lachs, Jennifer Lackey, Stephen E. Lahey, Andrea Lavazza, Thomas H. Leahey, Joo Heung Lee, Keith Lehrer, Dorothy Leland, Noah M. Lemos, Ernest LePore, Sarah-Jane Leslie, Isaac Levi, Andrew Levine, Alan E. Lewis, Daniel E. Little, Shu-hsien Liu, Shu-hsien Liu, Alan K. L. Chan, Brian Loar, Lawrence B. Lombard, John Longeway, Dominic McIver Lopes, Michael J. Loux, E. J. Lowe, Steven Luper, Eugene C. Luschei, William G. Lycan, David Lyons, David Macarthur, Danielle Macbeth, Scott MacDonald, Jacob L. Mackey, Louis H. Mackey, Penelope Mackie, Edward H. Madden, Penelope Maddy, G. B. Madison, Bernd Magnus, Pekka Mäkelä, Rudolf A. Makkreel, David Manley, William E. Mann (W.E.M.), Vladimir Marchenkov, Peter Markie, Jean-Pierre Marquis, Ausonio Marras, Mike W. Martin, A. P. Martinich, William L. McBride, David McCabe, Storrs McCall, Hugh J. McCann, Robert N. McCauley, John J. McDermott, Sarah McGrath, Ralph McInerny, Daniel J. McKaughan, Thomas McKay, Michael McKinsey, Brian P. McLaughlin, Ernan McMullin, Anthonie Meijers, Jack W. Meiland, William Jason Melanson, Alfred R. Mele, Joseph R. Mendola, Christopher Menzel, Michael J. Meyer, Christian B. Miller, David W. Miller, Peter Millican, Robert N. Minor, Phillip Mitsis, James A. Montmarquet, Michael S. Moore, Tim Moore, Benjamin Morison, Donald R. Morrison, Stephen J. Morse, Paul K. Moser, Alexander P. D. Mourelatos, Ian Mueller, James Bernard Murphy, Mark C. Murphy, Steven Nadler, Jan Narveson, Alan Nelson, Jerome Neu, Samuel Newlands, Kai Nielsen, Ilkka Niiniluoto, Carlos G. Noreña, Calvin G. Normore, David Fate Norton, Nikolaj Nottelmann, Donald Nute, David S. Oderberg, Steve Odin, Michael O’Rourke, Willard G. Oxtoby, Heinz Paetzold, George S. Pappas, Anthony J. Parel, Lydia Patton, R. P. Peerenboom, Francis Jeffry Pelletier, Adriaan T. Peperzak, Derk Pereboom, Jaroslav Peregrin, Glen Pettigrove, Philip Pettit, Edmund L. Pincoffs, Andrew Pinsent, Robert B. Pippin, Alvin Plantinga, Louis P. Pojman, Richard H. Popkin, John F. Post, Carl J. Posy, William J. Prior, Richard Purtill, Michael Quante, Philip L. Quinn, Philip L. Quinn, Elizabeth S. Radcliffe, Diana Raffman, Gerard Raulet, Stephen L. Read, Andrews Reath, Andrew Reisner, Nicholas Rescher, Henry S. Richardson, Robert C. Richardson, Thomas Ricketts, Wayne D. Riggs, Mark Roberts, Robert C. Roberts, Luke Robinson, Alexander Rosenberg, Gary Rosenkranz, Bernice Glatzer Rosenthal, Adina L. Roskies, William L. Rowe, T. M. Rudavsky, Michael Ruse, Bruce Russell, Lilly-Marlene Russow, Dan Ryder, R. M. Sainsbury, Joseph Salerno, Nathan Salmon, Wesley C. Salmon, Constantine Sandis, David H. Sanford, Marco Santambrogio, David Sapire, Ruth A. Saunders, Geoffrey Sayre-McCord, Charles Sayward, James P. Scanlan, Richard Schacht, Tamar Schapiro, Frederick F. Schmitt, Jerome B. Schneewind, Calvin O. Schrag, Alan D. Schrift, George F. Schumm, Jean-Loup Seban, David N. Sedley, Kenneth Seeskin, Krister Segerberg, Charlene Haddock Seigfried, Dennis M. Senchuk, James F. Sennett, William Lad Sessions, Stewart Shapiro, Tommie Shelby, Donald W. Sherburne, Christopher Shields, Roger A. Shiner, Sydney Shoemaker, Robert K. Shope, Kwong-loi Shun, Wilfried Sieg, A. John Simmons, Robert L. Simon, Marcus G. Singer, Georgette Sinkler, Walter Sinnott-Armstrong, Matti T. Sintonen, Lawrence Sklar, Brian Skyrms, Robert C. Sleigh, Michael Anthony Slote, Hans Sluga, Barry Smith, Michael Smith, Robin Smith, Robert Sokolowski, Robert C. Solomon, Marta Soniewicka, Philip Soper, Ernest Sosa, Nicholas Southwood, Paul Vincent Spade, T. L. S. Sprigge, Eric O. Springsted, George J. Stack, Rebecca Stangl, Jason Stanley, Florian Steinberger, Sören Stenlund, Christopher Stephens, James P. Sterba, Josef Stern, Matthias Steup, M. A. Stewart, Leopold Stubenberg, Edith Dudley Sulla, Frederick Suppe, Jere Paul Surber, David George Sussman, Sigrún Svavarsdóttir, Zeno G. Swijtink, Richard Swinburne, Charles C. Taliaferro, Robert B. Talisse, John Tasioulas, Paul Teller, Larry S. Temkin, Mark Textor, H. S. Thayer, Peter Thielke, Alan Thomas, Amie L. Thomasson, Katherine Thomson-Jones, Joshua C. Thurow, Vzalerie Tiberius, Terrence N. Tice, Paul Tidman, Mark C. Timmons, William Tolhurst, James E. Tomberlin, Rosemarie Tong, Lawrence Torcello, Kelly Trogdon, J. D. Trout, Robert E. Tully, Raimo Tuomela, John Turri, Martin M. Tweedale, Thomas Uebel, Jennifer Uleman, James Van Cleve, Harry van der Linden, Peter van Inwagen, Bryan W. Van Norden, René van Woudenberg, Donald Phillip Verene, Samantha Vice, Thomas Vinci, Donald Wayne Viney, Barbara Von Eckardt, Peter B. M. Vranas, Steven J. Wagner, William J. Wainwright, Paul E. Walker, Robert E. Wall, Craig Walton, Douglas Walton, Eric Watkins, Richard A. Watson, Michael V. Wedin, Rudolph H. Weingartner, Paul Weirich, Paul J. Weithman, Carl Wellman, Howard Wettstein, Samuel C. Wheeler, Stephen A. White, Jennifer Whiting, Edward R. Wierenga, Michael Williams, Fred Wilson, W. Kent Wilson, Kenneth P. Winkler, John F. Wippel, Jan Woleński, Allan B. Wolter, Nicholas P. Wolterstorff, Rega Wood, W. Jay Wood, Paul Woodruff, Alison Wylie, Gideon Yaffe, Takashi Yagisawa, Yutaka Yamamoto, Keith E. Yandell, Xiaomei Yang, Dean Zimmerman, Günter Zoller, Catherine Zuckert, Michael Zuckert, Jack A. Zupko (J.A.Z.)
- Edited by Robert Audi, University of Notre Dame, Indiana
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- The Cambridge Dictionary of Philosophy
- Published online:
- 05 August 2015
- Print publication:
- 27 April 2015, pp ix-xxx
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- By Dor Abrahamson, Jerry Andriessen, Roger Azevedo, Michael Baker, Ryan Baker, Sasha Barab, Carl Bereiter, Susan Bridges, Mario Carretero, Carol K. K. Chan, Clark A. Chinn, Paul Cobb, Allan Collins, Kevin Crowley, Elizabeth A. Davis, Chris Dede, Sharon J. Derry, Andrea A. diSessa, Michael Eisenberg, Yrjö Engeström, Noel Enyedy, Barry J. Fishman, Ricki Goldman, James G. Greeno, Erica Rosenfeld Halverson, Cindy E. Hmelo-Silver, Michael J. Jacobson, Sanna Järvelä, Yasmin B. Kafai, Yael Kali, Manu Kapur, Paul A. Kirschner, Karen Knutson, Timothy Koschmann, Joseph S. Krajcik, Carol D. Lee, Peter Lee, Robb Lindgren, Jingyan Lu, Richard E. Mayer, Naomi Miyake, Na’ilah Suad Nasir, Mitchell J. Nathan, Narcis Pares, Roy Pea, James W. Pellegrino, William R. Penuel, Palmyre Pierroux, Brian J. Reiser, K. Ann Renninger, Ann S. Rosebery, R. Keith Sawyer, Marlene Scardamalia, Anna Sfard, Mike Sharples, Kimberly M. Sheridan, Bruce L. Sherin, Namsoo Shin, George Siemens, Peter Smagorinsky, Nancy Butler Songer, James P. Spillane, Kurt Squire, Gerry Stahl, Constance Steinkuehler, Reed Stevens, Daniel Suthers, Iris Tabak, Beth Warren, Uri Wilensky, Philip H. Winne, Carmen Zahn
- Edited by R. Keith Sawyer, University of North Carolina, Chapel Hill
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- The Cambridge Handbook of the Learning Sciences
- Published online:
- 05 November 2014
- Print publication:
- 17 November 2014, pp xv-xviii
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- By Lenard A. Adler, Pinky Agarwal, Rehan Ahmed, Jagga Rao Alluri, Fawaz Al-Mufti, Samuel Alperin, Michael Amoashiy, Michael Andary, David J. Anschel, Padmaja Aradhya, Vandana Aspen, Esther Baldinger, Jee Bang, George D. Baquis, John J. Barry, Jason J. S. Barton, Julius Bazan, Amanda R. Bedford, Marlene Behrmann, Lourdes Bello-Espinosa, Ajay Berdia, Alan R. Berger, Mark Beyer, Don C. Bienfang, Kevin M. Biglan, Thomas M. Boes, Paul W. Brazis, Jonathan L. Brisman, Jeffrey A. Brown, Scott E. Brown, Ryan R. Byrne, Rina Caprarella, Casey A. Chamberlain, Wan-Tsu W. Chang, Grace M. Charles, Jasvinder Chawla, David Clark, Todd J. Cohen, Joe Colombo, Howard Crystal, Vladimir Dadashev, Sarita B. Dave, Jean Robert Desrouleaux, Richard L. Doty, Robert Duarte, Jeffrey S. Durmer, Christyn M. Edmundson, Eric R. Eggenberger, Steven Ender, Noam Epstein, Alberto J. Espay, Alan B. Ettinger, Niloofar (Nelly) Faghani, Amtul Farheen, Edward Firouztale, Rod Foroozan, Anne L. Foundas, David Elliot Friedman, Deborah I. Friedman, Steven J. Frucht, Oded Gerber, Tal Gilboa, Martin Gizzi, Teneille G. Gofton, Louis J. Goodrich, Malcolm H. Gottesman, Varda Gross-Tsur, Deepak Grover, David A. Gudis, John J. Halperin, Maxim D. Hammer, Andrew R. Harrison, L. Anne Hayman, Galen V. Henderson, Steven Herskovitz, Caitlin Hoffman, Laryssa A. Huryn, Andres M. Kanner, Gary P. Kaplan, Bashar Katirji, Kenneth R. Kaufman, Annie Killoran, Nina Kirz, Gad E. Klein, Danielle G. Koby, Christopher P. Kogut, W. Curt LaFrance, Patrick J.M. Lavin, Susan W. Law, James L. Levenson, Richard B. Lipton, Glenn Lopate, Daniel J. Luciano, Reema Maindiratta, Robert M. Mallery, Georgios Manousakis, Alan Mazurek, Luis J. Mejico, Dragana Micic, Ali Mokhtarzadeh, Walter J. Molofsky, Heather E. Moss, Mark L. Moster, Manpreet Multani, Siddhartha Nadkarni, George C. Newman, Rolla Nuoman, Paul A. Nyquist, Gaia Donata Oggioni, Odi Oguh, Denis Ostrovskiy, Kristina Y. Pao, Juwen Park, Anastas F. Pass, Victoria S. Pelak, Jeffrey Peterson, John Pile-Spellman, Misha L. Pless, Gregory M. Pontone, Aparna M. Prabhu, Michael T. Pulley, Philip Ragone, Prajwal Rajappa, Venkat Ramani, Sindhu Ramchandren, Ritesh A. Ramdhani, Ramses Ribot, Heidi D. Riney, Diana Rojas-Soto, Michael Ronthal, Daniel M. Rosenbaum, David B. Rosenfield, Durga Roy, Michael J. Ruckenstein, Max C. Rudansky, Eva Sahay, Friedhelm Sandbrink, Jade S. Schiffman, Angela Scicutella, Maroun T. Semaan, Robert C. Sergott, Aashit K. Shah, David M. Shaw, Amit M. Shelat, Claire A. Sheldon, Anant M. Shenoy, Yelizaveta Sher, Jessica A. Shields, Tanya Simuni, Rajpaul Singh, Eric E. Smouha, David Solomon, Mehri Songhorian, Steven A. Sparr, Egilius L. H. Spierings, Eve G. Spratt, Beth Stein, S.H. Subramony, Rosa Ana Tang, Cara Tannenbaum, Hakan Tekeli, Amanda J. Thompson, Michael J. Thorpy, Matthew J. Thurtell, Pedro J. Torrico, Ira M. Turner, Scott Uretsky, Ruth H. Walker, Deborah M. Weisbrot, Michael A. Williams, Jacques Winter, Randall J. Wright, Jay Elliot Yasen, Shicong Ye, G. Bryan Young, Huiying Yu, Ryan J. Zehnder
- Edited by Alan B. Ettinger, Albert Einstein College of Medicine, New York, Deborah M. Weisbrot, State University of New York, Stony Brook
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- Neurologic Differential Diagnosis
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- 05 June 2014
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- 17 April 2014, pp xi-xx
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12 - The Ends of Storytelling
- Edited by Charlotte Brewer, Professor of English Language and Literature at Oxford University and a Fellow of Hertford College, Oxford, Barry Windeatt, Professor of English in the University of Cambridge and a Fellow of Emmanuel College, Cambridge
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- Traditions and Innovations in the Study of Medieval English Literature
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- Boydell & Brewer
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- 05 September 2013
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Summary
Storytelling may be one of the very oldest human activities after the acquisition of language. Language is a symbolic process that produces signifying sounds as a substitute for the things themselves; story allows those sounds to be linked to describe a sequence of events that are not present as fact but that have their existence in the mind, as memory or conjecture or imagination. The very earliest cave paintings or rock art suggest pre-existing stories of some kind behind them. Studies of memory formation and of childhood psychology suggest that it is the ability to form narratives, to shape random events into the syntax of a story, that enables an infant to make sense of the world it finds itself in.
Derek Brewer was increasingly fascinated by story and storytelling – not just in particular stories, though his delight in those masters of narrative Chaucer and Malory makes that evident, but in the principles underlying story itself. That is apparent even in the titles of some of his publications, in his Symbolic Stories: Traditional Narratives of the Family Drama in English Literature (1980), or in the collection of articles he entitled Chaucer: The Poet as Storyteller (1984b). That contains a reprint of his earlier Gollancz lecture, delivered in 1974, ‘Towards a Chaucerian Poetic’, which is perhaps his most concise and detailed consideration of the principles underlying story as such, and of the importance of story – especially traditional forms of narrative, folk-tales, fairy-tales and many medieval romances – over whatever meanings might be attached to them.
Acknowledgements
- Edited by Charlotte Brewer, Professor of English Language and Literature at Oxford University and a Fellow of Hertford College, Oxford, Barry Windeatt, Professor of English in the University of Cambridge and a Fellow of Emmanuel College, Cambridge
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- Traditions and Innovations in the Study of Medieval English Literature
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Frontmatter
- Edited by Charlotte Brewer, Professor of English Language and Literature at Oxford University and a Fellow of Hertford College, Oxford, Barry Windeatt, Professor of English in the University of Cambridge and a Fellow of Emmanuel College, Cambridge
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13 - Manuscripts, Facsimiles, Approaches to Editing
- Edited by Charlotte Brewer, Professor of English Language and Literature at Oxford University and a Fellow of Hertford College, Oxford, Barry Windeatt, Professor of English in the University of Cambridge and a Fellow of Emmanuel College, Cambridge
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- Traditions and Innovations in the Study of Medieval English Literature
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Summary
The trajectory of Derek Brewer's academic career does not invariably reflect trends of modern scholarship. Relatively few of his many publications are directly concerned with the topics of this chapter. But his activities in these areas of manuscript and textual study show that his sense of the potential for new forms of scholarly enquiry in medieval English studies was often remarkably prescient. By the time of his death, Middle English manuscript study and editing had come to enjoy positions of importance in which their historical and cultural significance were increasingly acknowledged. Brewer's own roles in these developments warrant some exploration, not least for what they suggest about the changing climate of Middle English scholarship in these areas over the course of his long careers as scholar, publisher and teacher.
Brewer's interest in manuscript study can be traced back to his uncompleted BLitt thesis, which he began at Oxford in 1948. Some of the research from this period was published in an early article that described Gloucester Cathedral, MS 22, a collection of sixty-six fifteenth-century sermons, some associated with Mirk's Festial, bound with a fragment of the Gesta Romanorum, in a different hand, all in Middle English. Brewer's article is perhaps less interesting for its substance than for some aspects of its method, particularly his consideration of the whole manuscript itself as a proper object of study.
Index
- Edited by Charlotte Brewer, Professor of English Language and Literature at Oxford University and a Fellow of Hertford College, Oxford, Barry Windeatt, Professor of English in the University of Cambridge and a Fellow of Emmanuel College, Cambridge
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- Traditions and Innovations in the Study of Medieval English Literature
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1 - Derek Brewer: Chaucerian Studies 1953–78
- Edited by Charlotte Brewer, Professor of English Language and Literature at Oxford University and a Fellow of Hertford College, Oxford, Barry Windeatt, Professor of English in the University of Cambridge and a Fellow of Emmanuel College, Cambridge
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- Traditions and Innovations in the Study of Medieval English Literature
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Summary
Having completed his studies at Oxford after military service in the war, Derek Brewer took up a lectureship at the University of Birmingham in 1949. He joined there with Geoffrey Shepherd and, two years later, Eric Stanley to form a remarkable medieval triumvirate. During the years in which they worked together, Birmingham was a power-house of Old English and Middle English Studies, perhaps second to none in its day. Derek Brewer, who left for Cambridge in 1964, taught across the medieval syllabus, including Anglo-Saxon, but Chaucer, even in those earliest days, was the principal focus of his interest. He soon took over the Chaucer lectures from Margaret Galway, a scholar of the old school whose principal interest was in speculations about the details of Chaucer's life at court and the identity of his ‘Muse’. Derek Brewer's ambition, by contrast, was to share with students his love and understanding of Chaucer, not as a subject of biographical speculation nor as a repertoire of linguistic data, nor as a ‘set text’ to be hammered through remorselessly and translated line by line, but as a full member of the European community of poets and of the English poetic tradition. It was a revelation to those of us who were privileged to be his students at that time to hear Chaucer talked about as if he were important to us now, and important in the same way as Shakespeare or Milton or T. S. Eliot. We had heard of the New Criticism: we thought this was it.
6 - Falling in Love in the Middle Ages
- Edited by Charlotte Brewer, Professor of English Language and Literature at Oxford University and a Fellow of Hertford College, Oxford, Barry Windeatt, Professor of English in the University of Cambridge and a Fellow of Emmanuel College, Cambridge
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- Traditions and Innovations in the Study of Medieval English Literature
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Summary
‘I love you,’ he says, kissing her throat, stroking her breasts, tracing the curve of her hip.
‘No, you don't, Vic.’
‘I've been in love with you for weeks.’
‘There's no such thing,’ she says. ‘It's a rhetorical device. It's a bourgeois fallacy.’
‘Haven't you ever been in love, then?’
‘When I was younger,’ she says, ‘I allowed myself to be constructed by the discourse of romantic love for a while, yes.’
(David Lodge, Nice Work)‘Years ago when I wrote about medieval love-poetry and described its strange, half make-believe, “religion of love”, I was blind enough to treat this as an almost purely literary phenomenon. I know better now.’
(C. S. Lewis, The Four Loves)My title carries an implicit question: was falling in love in the Middle Ages different from falling in love today? The question reflects the still widespread belief that medieval lovers adhered to a systematized ‘code’ of ‘courtly love, a special, artificial variety of romantic love that obliged the lover to act in strange and exaggerated ways – to love without necessarily revealing his love to the lady concerned, to remain her devoted slave for years without seeking so much as a kiss by way of reward, to obey her every whim, however humiliating, to faint, to weep, to adore her as if she were a goddess rather than a woman.
5 - Virtue, Intention and the Mind's Eye in Troilus and Criseyde
- Edited by Charlotte Brewer, Professor of English Language and Literature at Oxford University and a Fellow of Hertford College, Oxford, Barry Windeatt, Professor of English in the University of Cambridge and a Fellow of Emmanuel College, Cambridge
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- Traditions and Innovations in the Study of Medieval English Literature
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Early on in Chaucer's Troilus and Criseyde, the adolescent prince Troilus, while cruising the Trojan girls at the Palladion festival in Troy, happens to see the young widow Criseyde standing in the crowd (1. 269–301). ‘His eye percede’ the crowd deeply until it ‘smote’ Criseyde and stopped (‘stente’), like an arrow (1. 272–3; cf. 1. 325). The effect on him is immediate: ‘he wax ther-with astoned … And of hire look [appearance] in him ther gan to quyken/ So gret desire … / That in his hertes botme gan to stiken/ Of hir his fixe and depe impressioun’ (1. 274, 295–8). Snail-like, he draws in his horns (1. 300), quits the scene at once, and goes home to his bed chamber, alone. This is emphasized. There he rehearses in full detail the event that had at first so ‘astoned’ him and turned him mentally to stone. He sees again Criseyde in the temple, fully and exactly as she appeared and acted:
And whan that he in chambre was allone,
He doun vp-on his beddes feet hym sette,
And first he gan to sike, and eft to grone,
And thought ay on hire so with-outen lette,
That as he sat and wook, his spirit mette
That he hire saw, and temple, and al the wise
Right of hire look, and gan it newe a-vise.
(1. 358–64)He is completely alone, sitting on his bed, groaning, and in that physical posture, undertaken deliberately like a preparatory exercise, he thinks on his experience of Criseyde with such complete concentration that his ‘spirit’ – animus, mind – sees it all again: ‘Thus gan he make a mirour of his mynde,/In which he saugh al holly hire figure’ (1. 365–6).
Introduction: A Modern Medievalist's Career
- Edited by Charlotte Brewer, Professor of English Language and Literature at Oxford University and a Fellow of Hertford College, Oxford, Barry Windeatt, Professor of English in the University of Cambridge and a Fellow of Emmanuel College, Cambridge
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- Traditions and Innovations in the Study of Medieval English Literature
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Derek brewer was the founding figure in the post-war study of Chaucer. Through his eponymous publishing firm, he subsequently went on to contribute more than any other individual to furthering modern study of the early literatures and cultures of these islands. An irrepressibly positive and genial personality, his humanity and kindness as a teacher, scholar and publisher enabled and changed many lives. In a sixty-year career as a critic of medieval English and other literature, Brewer foresaw and pioneered much that has since developed into defining aspects of the field. Far from being a backward-looking memorial volume or Festschrift, the present book celebrates how some of the topics Brewer made central to the study of medieval literature are being taken forward, both because of his influence and beyond it. In so doing, this book aims to build towards an intellectual biography of a very modern medievalist.
Derek Brewer was born into a relatively modest background, the son of a clerk with the General Electric Company. Educated at his local Crypt Grammar School in Gloucester, he won a scholarship (‘demyship’) to Magdalen College, Oxford for the year 1941–42. As he later remarked, ‘getting to Oxford to read English had been my heart's desire’, and he wrote in his eighties that Magdalen was still, for him, simply the most beautiful place in the world. But after one short year at Oxford he joined the army and in 1944 was posted to Italy; he taught himself Italian on the troopship with the aid of a Hugo's language course, a characteristic foresight.
2 - Brewer's Chaucer and the Knightly Virtues
- Edited by Charlotte Brewer, Professor of English Language and Literature at Oxford University and a Fellow of Hertford College, Oxford, Barry Windeatt, Professor of English in the University of Cambridge and a Fellow of Emmanuel College, Cambridge
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- Traditions and Innovations in the Study of Medieval English Literature
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The consonance between the character of Derek Brewer and the character of much medieval literature was elegantly noted in the fine obituary which Barry Windeatt wrote for The Independent newspaper:
People often commented that it was the moral concerns of English medieval literature – courtesy, honour, loyalty and integrity – that they observed to be lived out in Brewer's life.
(Windeatt 2008)Here Windeatt evokes the gentlemanly virtues – the remnants of a knightly value-system wherein great store was set by honour and gentilesse (nobility of birth or rank together with the attendant moral qualities of nobility of character or manners; generosity, kindness, gentleness, graciousness and the like). Indeed, it was no surprise to read, in the Telegraph obituary, Derek Brewer being described as ‘a gentlemanly, kindly man’. The thought that I want to offer in this paper is that those same virtues enabled Derek to gain some of his greatest insights into Chaucer's mind and art (to use a phrase in vogue in the late 1960s and early 1970s, when he was producing much of his best work). I am going to celebrate some of those insights – expanding them here, qualifying them there – because I believe they have withstood very well the buffets of changing academic fashions.