3 results
Characterisation of age and polarity at onset in bipolar disorder
- Janos L. Kalman, Loes M. Olde Loohuis, Annabel Vreeker, Andrew McQuillin, Eli A. Stahl, Douglas Ruderfer, Maria Grigoroiu-Serbanescu, Georgia Panagiotaropoulou, Stephan Ripke, Tim B. Bigdeli, Frederike Stein, Tina Meller, Susanne Meinert, Helena Pelin, Fabian Streit, Sergi Papiol, Mark J. Adams, Rolf Adolfsson, Kristina Adorjan, Ingrid Agartz, Sofie R. Aminoff, Heike Anderson-Schmidt, Ole A. Andreassen, Raffaella Ardau, Jean-Michel Aubry, Ceylan Balaban, Nicholas Bass, Bernhard T. Baune, Frank Bellivier, Antoni Benabarre, Susanne Bengesser, Wade H Berrettini, Marco P. Boks, Evelyn J. Bromet, Katharina Brosch, Monika Budde, William Byerley, Pablo Cervantes, Catina Chillotti, Sven Cichon, Scott R. Clark, Ashley L. Comes, Aiden Corvin, William Coryell, Nick Craddock, David W. Craig, Paul E. Croarkin, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Udo Dannlowski, Franziska Degenhardt, Maria Del Zompo, J. Raymond DePaulo, Srdjan Djurovic, Howard J. Edenberg, Mariam Al Eissa, Torbjørn Elvsåshagen, Bruno Etain, Ayman H. Fanous, Frederike Fellendorf, Alessia Fiorentino, Andreas J. Forstner, Mark A. Frye, Janice M. Fullerton, Katrin Gade, Julie Garnham, Elliot Gershon, Michael Gill, Fernando S. Goes, Katherine Gordon-Smith, Paul Grof, Jose Guzman-Parra, Tim Hahn, Roland Hasler, Maria Heilbronner, Urs Heilbronner, Stephane Jamain, Esther Jimenez, Ian Jones, Lisa Jones, Lina Jonsson, Rene S. Kahn, John R. Kelsoe, James L. Kennedy, Tilo Kircher, George Kirov, Sarah Kittel-Schneider, Farah Klöhn-Saghatolislam, James A. Knowles, Thorsten M. Kranz, Trine Vik Lagerberg, Mikael Landen, William B. Lawson, Marion Leboyer, Qingqin S. Li, Mario Maj, Dolores Malaspina, Mirko Manchia, Fermin Mayoral, Susan L. McElroy, Melvin G. McInnis, Andrew M. McIntosh, Helena Medeiros, Ingrid Melle, Vihra Milanova, Philip B. Mitchell, Palmiero Monteleone, Alessio Maria Monteleone, Markus M. Nöthen, Tomas Novak, John I. Nurnberger, Niamh O'Brien, Kevin S. O'Connell, Claire O'Donovan, Michael C. O'Donovan, Nils Opel, Abigail Ortiz, Michael J. Owen, Erik Pålsson, Carlos Pato, Michele T. Pato, Joanna Pawlak, Julia-Katharina Pfarr, Claudia Pisanu, James B. Potash, Mark H Rapaport, Daniela Reich-Erkelenz, Andreas Reif, Eva Reininghaus, Jonathan Repple, Hélène Richard-Lepouriel, Marcella Rietschel, Kai Ringwald, Gloria Roberts, Guy Rouleau, Sabrina Schaupp, William A Scheftner, Simon Schmitt, Peter R. Schofield, K. Oliver Schubert, Eva C. Schulte, Barbara Schweizer, Fanny Senner, Giovanni Severino, Sally Sharp, Claire Slaney, Olav B. Smeland, Janet L. Sobell, Alessio Squassina, Pavla Stopkova, John Strauss, Alfonso Tortorella, Gustavo Turecki, Joanna Twarowska-Hauser, Marin Veldic, Eduard Vieta, John B. Vincent, Wei Xu, Clement C. Zai, Peter P. Zandi, Psychiatric Genomics Consortium (PGC) Bipolar Disorder Working Group, International Consortium on Lithium Genetics (ConLiGen), Colombia-US Cross Disorder Collaboration in Psychiatric Genetics, Arianna Di Florio, Jordan W. Smoller, Joanna M. Biernacka, Francis J. McMahon, Martin Alda, Bertram Müller-Myhsok, Nikolaos Koutsouleris, Peter Falkai, Nelson B. Freimer, Till F.M. Andlauer, Thomas G. Schulze, Roel A. Ophoff
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- Journal:
- The British Journal of Psychiatry / Volume 219 / Issue 6 / December 2021
- Published online by Cambridge University Press:
- 25 August 2021, pp. 659-669
- Print publication:
- December 2021
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- Article
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Background
Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools.
AimsTo examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics.
MethodGenome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of onset with disease characteristics was investigated in two of these cohorts.
ResultsEarlier AAO was associated with a higher probability of psychotic symptoms, suicidality, lower educational attainment, not living together and fewer episodes. Depressive onset correlated with suicidality and manic onset correlated with delusions and manic episodes. Systematic differences in AAO between cohorts and continents of origin were observed. This was also reflected in single-nucleotide variant-based heritability estimates, with higher heritabilities for stricter onset definitions. Increased PGS for autism spectrum disorder (β = −0.34 years, s.e. = 0.08), major depression (β = −0.34 years, s.e. = 0.08), schizophrenia (β = −0.39 years, s.e. = 0.08), and educational attainment (β = −0.31 years, s.e. = 0.08) were associated with an earlier AAO. The AAO GWAS identified one significant locus, but this finding did not replicate. Neither GWAS nor PGS analyses yielded significant associations with PAO.
ConclusionsAAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses.
Chapter 16 - Oral tradition, ethnography, and the practice of north American archaeology
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- By Julie E. Francis, 1403 Curtis Street, Laramie WY 82070, USA, Lawrence L. Loendorf, Albuquerque, New Mexico, USA
- Edited by Geoffrey Blundell, Christopher Chippindale, Benjamin Smith
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- Book:
- Seeing and Knowing
- Published by:
- Wits University Press
- Published online:
- 21 April 2018
- Print publication:
- 31 December 2010, pp 268-279
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Summary
THE CHANGING SHAPE OF NORTH AMERICAN ARCHAEOLOGY
Over the course of the last half of the 20th century, North American anthropology and archaeology have witnessed many changes, not the least of which has been the divergence of the sub-disciplines as most dramatically exemplified by the organisational split between the Society for American Archaeology and the American Anthropological Association in the mid- 1980s. Many academic departments have moved away from the traditional four-fields approach, with little to no crossover between sub-disciplines at the graduate level and specialisation within sub-disciplines for undergraduates. With increased specialisation, it has been many years since archaeologist and ethnographer have been the same individual, in the fashion of Frederica de Laguna (1960) in south-east Alaska. As a result, studies which explicitly seek to integrate oral tradition, ethnographic and archaeological data are extremely rare.
Specialisation has also been the dominating trend within North American archaeology. With the rise of the cultural ecological paradigm in the 1960s, many archaeologists began to employ a multidisciplinary approach, particularly with respect to natural sciences such as biology, plant and animal ecology, palynology, geology, chemistry and physics, giving rise to the technical specialist. As a result, many academic departments now offer tracks to train geo-archaeologists, ethnobotanists, faunal analysts, lithic analysts, or specialists in quantitative methods. It is notable that, with our roots in anthropology, the outside discipline that was left out was often cultural anthropology.
With the ‘New Archaeology’ of the 1960s and the goal to go beyond the reconstruction of culture history to the explanation of culture change (e.g. Fritz & Plog 1970), we archaeologists also desired to be viewed as ‘scientists’. We wished to use the scientific method to conduct experiments, to develop multiple working hypotheses and test them in a deductive manner, and to employ logical positivism (Hempel 1966) in a manner analogous to that of the natural sciences in order to discover laws governing human behaviour. We adopted the trappings of science in an effort to distance ourselves from the humanities.
AMS Radiocarbon and Cation-Ratio Dating of Rock Art in the Bighorn Basin of Wyoming and Montana
- Julie E. Francis, Lawrence L. Loendorf, Ronald I. Dorn
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- Journal:
- American Antiquity / Volume 58 / Issue 4 / October 1993
- Published online by Cambridge University Press:
- 20 January 2017, pp. 711-737
- Print publication:
- October 1993
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Samples of organic matter and rock varnish from seven rock-art sites in the Bighorn Basin of Wyoming and Montana were collected for dating purposes. Petroglyphs sampled include Dinwoody-style figures, shield-bearing warriors, and other well-known Plains rock-art motifs. Accelerator mass spectrometry (AMS) dating of 10 petroglyphs yielded dates from the Early Archaic to the Protohistoric periods. A strong numerical relation between varnish leaching and time was found for petroglyphs older than 1,000 years, permitting the derivation of a cation-leaching curve (CLC) and calibrated cation-ratio (CR) ages for 15 different petroglyphs. No clear numerical relation between varnish leaching and time was found for petroglyphs less than 1,000 years old, possibly due to historical damage or past environmental conditions. As a result, calibrated CR ages could not be derived for six petroglyphs, and they are considered to be only younger than 1,000 years. Although further research is needed to establish whether one CLC can be used for all petroglyphs in the region, these studies constitute the first numerical chronology for rock art in the Bighorn area. Results indicate the occurrence of spatially discrete, but temporally concurrent styles in the Bighorn Basin during the last 800-900 years.