6 results
Characterisation of age and polarity at onset in bipolar disorder
- Janos L. Kalman, Loes M. Olde Loohuis, Annabel Vreeker, Andrew McQuillin, Eli A. Stahl, Douglas Ruderfer, Maria Grigoroiu-Serbanescu, Georgia Panagiotaropoulou, Stephan Ripke, Tim B. Bigdeli, Frederike Stein, Tina Meller, Susanne Meinert, Helena Pelin, Fabian Streit, Sergi Papiol, Mark J. Adams, Rolf Adolfsson, Kristina Adorjan, Ingrid Agartz, Sofie R. Aminoff, Heike Anderson-Schmidt, Ole A. Andreassen, Raffaella Ardau, Jean-Michel Aubry, Ceylan Balaban, Nicholas Bass, Bernhard T. Baune, Frank Bellivier, Antoni Benabarre, Susanne Bengesser, Wade H Berrettini, Marco P. Boks, Evelyn J. Bromet, Katharina Brosch, Monika Budde, William Byerley, Pablo Cervantes, Catina Chillotti, Sven Cichon, Scott R. Clark, Ashley L. Comes, Aiden Corvin, William Coryell, Nick Craddock, David W. Craig, Paul E. Croarkin, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Udo Dannlowski, Franziska Degenhardt, Maria Del Zompo, J. Raymond DePaulo, Srdjan Djurovic, Howard J. Edenberg, Mariam Al Eissa, Torbjørn Elvsåshagen, Bruno Etain, Ayman H. Fanous, Frederike Fellendorf, Alessia Fiorentino, Andreas J. Forstner, Mark A. Frye, Janice M. Fullerton, Katrin Gade, Julie Garnham, Elliot Gershon, Michael Gill, Fernando S. Goes, Katherine Gordon-Smith, Paul Grof, Jose Guzman-Parra, Tim Hahn, Roland Hasler, Maria Heilbronner, Urs Heilbronner, Stephane Jamain, Esther Jimenez, Ian Jones, Lisa Jones, Lina Jonsson, Rene S. Kahn, John R. Kelsoe, James L. Kennedy, Tilo Kircher, George Kirov, Sarah Kittel-Schneider, Farah Klöhn-Saghatolislam, James A. Knowles, Thorsten M. Kranz, Trine Vik Lagerberg, Mikael Landen, William B. Lawson, Marion Leboyer, Qingqin S. Li, Mario Maj, Dolores Malaspina, Mirko Manchia, Fermin Mayoral, Susan L. McElroy, Melvin G. McInnis, Andrew M. McIntosh, Helena Medeiros, Ingrid Melle, Vihra Milanova, Philip B. Mitchell, Palmiero Monteleone, Alessio Maria Monteleone, Markus M. Nöthen, Tomas Novak, John I. Nurnberger, Niamh O'Brien, Kevin S. O'Connell, Claire O'Donovan, Michael C. O'Donovan, Nils Opel, Abigail Ortiz, Michael J. Owen, Erik Pålsson, Carlos Pato, Michele T. Pato, Joanna Pawlak, Julia-Katharina Pfarr, Claudia Pisanu, James B. Potash, Mark H Rapaport, Daniela Reich-Erkelenz, Andreas Reif, Eva Reininghaus, Jonathan Repple, Hélène Richard-Lepouriel, Marcella Rietschel, Kai Ringwald, Gloria Roberts, Guy Rouleau, Sabrina Schaupp, William A Scheftner, Simon Schmitt, Peter R. Schofield, K. Oliver Schubert, Eva C. Schulte, Barbara Schweizer, Fanny Senner, Giovanni Severino, Sally Sharp, Claire Slaney, Olav B. Smeland, Janet L. Sobell, Alessio Squassina, Pavla Stopkova, John Strauss, Alfonso Tortorella, Gustavo Turecki, Joanna Twarowska-Hauser, Marin Veldic, Eduard Vieta, John B. Vincent, Wei Xu, Clement C. Zai, Peter P. Zandi, Psychiatric Genomics Consortium (PGC) Bipolar Disorder Working Group, International Consortium on Lithium Genetics (ConLiGen), Colombia-US Cross Disorder Collaboration in Psychiatric Genetics, Arianna Di Florio, Jordan W. Smoller, Joanna M. Biernacka, Francis J. McMahon, Martin Alda, Bertram Müller-Myhsok, Nikolaos Koutsouleris, Peter Falkai, Nelson B. Freimer, Till F.M. Andlauer, Thomas G. Schulze, Roel A. Ophoff
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- Journal:
- The British Journal of Psychiatry / Volume 219 / Issue 6 / December 2021
- Published online by Cambridge University Press:
- 25 August 2021, pp. 659-669
- Print publication:
- December 2021
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Background
Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools.
AimsTo examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics.
MethodGenome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of onset with disease characteristics was investigated in two of these cohorts.
ResultsEarlier AAO was associated with a higher probability of psychotic symptoms, suicidality, lower educational attainment, not living together and fewer episodes. Depressive onset correlated with suicidality and manic onset correlated with delusions and manic episodes. Systematic differences in AAO between cohorts and continents of origin were observed. This was also reflected in single-nucleotide variant-based heritability estimates, with higher heritabilities for stricter onset definitions. Increased PGS for autism spectrum disorder (β = −0.34 years, s.e. = 0.08), major depression (β = −0.34 years, s.e. = 0.08), schizophrenia (β = −0.39 years, s.e. = 0.08), and educational attainment (β = −0.31 years, s.e. = 0.08) were associated with an earlier AAO. The AAO GWAS identified one significant locus, but this finding did not replicate. Neither GWAS nor PGS analyses yielded significant associations with PAO.
ConclusionsAAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses.
Contributors
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- By Rony A. Adam, Gloria Bachmann, Nichole M. Barker, Randall B. Barnes, John Bennett, Inbar Ben-Shachar, Jonathan S. Berek, Sarah L. Berga, Monica W. Best, Eric J. Bieber, Frank M. Biro, Shan Biscette, Anita K. Blanchard, Candace Brown, Ronald T. Burkman, Joseph Buscema, John E. Buster, Michael Byas-Smith, Sandra Ann Carson, Judy C. Chang, Annie N. Y. Cheung, Mindy S. Christianson, Karishma Circelli, Daniel L. Clarke-Pearson, Larry J. Copeland, Bryan D. Cowan, Navneet Dhillon, Michael P. Diamond, Conception Diaz-Arrastia, Nicole M. Donnellan, Michael L. Eisenberg, Eric Eisenhauer, Sebastian Faro, J. Stuart Ferriss, Lisa C. Flowers, Susan J. Freeman, Leda Gattoc, Claudine Marie Gayle, Timothy M. Geiger, Jennifer S. Gell, Alan N. Gordon, Victoria L. Green, Jon K. Hathaway, Enrique Hernandez, S. Paige Hertweck, Randall S. Hines, Ira R. Horowitz, Fred M. Howard, William W. Hurd, Fidan Israfilbayli, Denise J. Jamieson, Carolyn R. Jaslow, Erika B. Johnston-MacAnanny, Rohna M. Kearney, Namita Khanna, Caroline C. King, Jeremy A. King, Ira J. Kodner, Tamara Kolev, Athena P. Kourtis, S. Robert Kovac, Ertug Kovanci, William H. Kutteh, Eduardo Lara-Torre, Pallavi Latthe, Herschel W. Lawson, Ronald L. Levine, Frank W. Ling, Larry I. Lipshultz, Steven D. McCarus, Robert McLellan, Shruti Malik, Suketu M. Mansuria, Mohamed K. Mehasseb, Pamela J. Murray, Saloney Nazeer, Farr R. Nezhat, Hextan Y. S. Ngan, Gina M. Northington, Peggy A. Norton, Ruth M. O'Regan, Kristiina Parviainen, Resad P. Pasic, Tanja Pejovic, K. Ulrich Petry, Nancy A. Phillips, Ashish Pradhan, Elizabeth E. Puscheck, Suneetha Rachaneni, Devon M. Ramaeker, David B. Redwine, Robert L. Reid, Carla P. Roberts, Walter Romano, Peter G. Rose, Robert L. Rosenfield, Shon P. Rowan, Mack T. Ruffin, Janice M. Rymer, Evis Sala, Ritu Salani, Joseph S. Sanfilippo, Mahmood I. Shafi, Roger P. Smith, Meredith L. Snook, Thomas E. Snyder, Mary D. Stephenson, Thomas G. Stovall, Richard L. Sweet, Philip M. Toozs-Hobson, Togas Tulandi, Elizabeth R. Unger, Denise S. Uyar, Marion S. Verp, Rahi Victory, Tamara J. Vokes, Michelle J. Washington, Katharine O'Connell White, Paul E. Wise, Frank M. Wittmaack, Miya P. Yamamoto, Christine Yu, Howard A. Zacur
- Edited by Eric J. Bieber, Joseph S. Sanfilippo, University of Pittsburgh, Ira R. Horowitz, Emory University, Atlanta, Mahmood I. Shafi
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- Book:
- Clinical Gynecology
- Published online:
- 05 April 2015
- Print publication:
- 23 April 2015, pp viii-xiv
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Multisymplectic structures and the variational bicomplex
- THOMAS J. BRIDGES, PETER E. HYDON, JEFFREY K. LAWSON
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- Journal:
- Mathematical Proceedings of the Cambridge Philosophical Society / Volume 148 / Issue 1 / January 2010
- Published online by Cambridge University Press:
- 04 August 2009, pp. 159-178
- Print publication:
- January 2010
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Multisymplecticity and the variational bicomplex are two subjects which have developed independently. Our main observation is that re-analysis of multisymplectic systems from the view of the variational bicomplex not only is natural but also generates new fundamental ideas about multisymplectic Hamiltonian PDEs. The variational bicomplex provides a natural grading of differential forms according to their base and fibre components, and this structure generates a new relation between the geometry of the base, covariant multisymplectic PDEs and the conservation of symplecticity. Our formulation also suggests a new view of Noether theory for multisymplectic systems, leading to a definition of multimomentum maps that we apply to give a coordinate-free description of multisymplectic relative equilibria. Our principal example is the class of multisymplectic systems on the total exterior algebra bundle over a Riemannian manifold.
The Norse landnám on the North Atlantic islands: an environmental impact assessment
- Andrew J. Dugmore, Mike J. Church, Paul C. Buckland, Kevin J. Edwards, Ian Lawson, Thomas H. McGovern, Eva Panagiotakopulu, Ian A. Simpson, Peter Skidmore, Guðrún Sveinbjarnardóttir
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- Journal:
- Polar Record / Volume 41 / Issue 1 / January 2005
- Published online by Cambridge University Press:
- 10 February 2005, pp. 21-37
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The Norse colonisation or landnám of the North Atlantic islands of the Faroes, Iceland, and Greenland from the ninth century AD onwards provides opportunities to examine human environmental impacts on ‘pristine’ landscapes on an environmental gradient from warmer, more maritime conditions in the east to colder, more continental conditions in the west. This paper considers key environmental contrasts across the Atlantic and initial settlement impacts on the biota and landscape. Before landnám, the modes of origin of the biota (which resulted in boreo-temperate affinities), a lack of endemic species, limited diversity, and no grazing mammals on the Faroes or Iceland, were crucial in determining environmental sensitivity to human impact and, in particular, the impact of introduced domestic animals. Gathering new data and understanding their geographical patterns and changes through time are seen as crucial when tackling fundamental questions about human interactions with the environment, which are relevant to both understanding the past and planning for the future.
5 - The investigation of diarrhoea
- Edited by Ranjit N. Ratnaike, University of Adelaide
- Foreword by Gary R. Andrews
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- Book:
- Diarrhoea and Constipation in Geriatric Practice
- Published online:
- 17 August 2009
- Print publication:
- 12 August 1999, pp 40-69
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Summary
The diagnosis of diarrhoea, due to the numerous causative factors, requires a multidisciplinary investigative approach. This chapter deals with several investigative procedures and laboratory tests.
The sections in this chapter are not prioritized to reflect greater importance to a particular specialty. For example, the decision whether to first request a stool microscopy and culture to identify an enteric pathogen or to request a double contrast barium study depends on the clinical circumstances.
INVASIVE PROCEDURES
Ranjit N.Ratnaike
Sigmoidoscopy is an extremely rewarding investigation and should be regarded as mandatory before a barium enema is performed. Sigmoidoscopy may reveal the presence of a tumour, lesions suggesting inflammatory bowel disease, ulceration due to infectious colitis, or plaques characteristic of pseudomembraneous colitis. In patients with proven bacillary dysentery, sigmoidoscopy is an extremely painful procedure and is unnecessary. A high rectal swab should be sent for immediate examination if a parasitic infection, for example amoebic dysentery, is suspected.
In diarrhoea suggesting large bowel pathology (diarrhoea with blood and mucus), the choice of the initial investigation lies between a double contrast barium enema (DCBE) and colonoscopy. In a study of 76 patients with colonic disease, colonoscopy was more accurate, particularly in the diagnosis of inflammatory bowel disease, where DCBE missed the diagnosis in 9 (64 per cent) of 14 patients. The advantages of colonoscopy include the opportunities to obtain biopsies and remove polyps.
The Fringe Tracking Servo in SUSI
- Peter R. Lawson, Andrew J. Booth
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- Journal:
- Symposium - International Astronomical Union / Volume 158 / 1994
- Published online by Cambridge University Press:
- 19 July 2016, pp. 184-186
- Print publication:
- 1994
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We present a description of the pathlength compensation system used in the Sydney University Stellar Interferometer, and report on the method of fringe tracking that is being implemented. The components of this system are discussed, including the PAPA camera used to detect chromatic fringes, the fringe tracking servo, the delay line and its control.