2 results
Prognostic Factors in Oligodendroglioma
- D. Schiffer, A. Dutto, P. Cavalla, I. Bosone, A. Chiò, R. Villani, C. Bellotti
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- Journal:
- Canadian Journal of Neurological Sciences / Volume 24 / Issue 4 / November 1997
- Published online by Cambridge University Press:
- 18 September 2015, pp. 313-319
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Background:
A reliable marker for tumor oligodendroglial cells is not yet available, so that the histological recognition of the tumor still encounters uncertainties. There is no general agreement also on prognostic factors in oligodendroglioma. The inconsistency concerns mainly the histopathological factors. The aim of the study was recognition of prognostic factors in oligodendroglioma.
Methods:In a series of ninety-eight oligodendrogliomas, including twenty mixed oligoastrocytomas, clinical [sex, age at surgery, tumor location, symptoms at presentation], therapeutic [extent of resection, year of surgery, post-operative Karnofsky score, post-operative radiotherapy, post-operative chemotherapy], histological [cell density, nuclear pleomorphism, vascular endothelial proliferation, necrosis, microcysts, mitoses, mitotic index (MI), apoptosis, apoptotic index (AI)] and immunohistochemical parameters [MIB-1 and PCNA Labeling Indexes (Lis), staining for GFAP, positivity for p53] were correlated with survival in uni- and multivariate analysis in order to identify their prognostic significance.
Results:Age at surgery, extent of surgical resection, year of surgery, postoperative Karnofsky score and MIB-1 LI were associated with survival in both uni- and multivariate analysis. Location, symptoms at presentation, mitoses, MI, AI, and PCNA LI showed a significant correlation with survival in uni- but not in multivariate analysis. The twenty cases of oligoastrocytomas did not show any difference in survival from pure oligodendrogliomas.
Conclusions:Some clinical and therapeutic factors together with MIB-1 LI play a prognostic role. MIB-1 LI is prognostic with a cutoff of 8%. Histology gives a limited contribution to the prognosis. Oligoastrocytomas had the same outcome and prognostic factors as pure oligodendrogliomas.
Genetic history of cystic fibrosis mutations in Italy. I. Regional distribution
- S. RENDINE, F. CALAFELL, N. CAPPELLO, R. GAGLIARDINI, G. CARAMIA, N. RIGILLO, M. SILVETTI, M. ZANDA, A. MIANO, F. BATTISTINI, L. MARIANELLI, G. TACCETTI, M. C. DIANA, L. ROMANO, C. ROMANO, A. GIUNTA, R. PADOAN, A. PIANAROLI, V. RAIA, G. DE RITIS, A. BATTISTINI, G. GRZINCICH, L. JAPICHINO, F. PARDO, M. ANTONELLI, S. QUATTRUCCI, V. LUCIDI, M. CASTRO, B. SANTINI, M. CASTELLO, G. GUANTI, G. B. LEONI, A. CAO, C. TOFFOLI, E. LUCCI, C. VULLO, F. TORRICELLI, F. SBERNINI, G. ROMEO, P. RONCHETTO, M. SEIA, A. ROSSI, M. FERRARI, L. CREMONESI, F. SALVATORE, G. CASTALDO, E. D'ALCAMO, A. MAGGIO, F. SANGIUOLO, B. DALLAPICCOLA, P. MACERATESI, L. BISCEGLIA, P. GASPARINI, A. CARBONARA, A. BONIZZATO, G. CABRINI, C. BOMBIERI, P. F. PIGNATTI, G. BORGO, C. CASTELLANI, A. VILLANI, C. ARDUINO, D. SALVATORE, G. MASTELLA, A. PIAZZA
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- Journal:
- Annals of Human Genetics / Volume 61 / Issue 5 / September 1997
- Published online by Cambridge University Press:
- 01 September 1997, pp. 411-424
- Print publication:
- September 1997
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Earlier analysis of the Italian population showed patterns of genetic differentiation that were interpreted as being the result of population settlements going back to pre-Roman times. DNA disease mutations may be a powerful tool in further testing this hypothesis since the analysis of diseased individuals can detect variants too rare to be resolved in normal individuals. We present data on the relative frequencies of 60 cystic fibrosis (CF) mutations in Italy and the geographical distribution of the 12 most frequent CF mutations screened in 3492 CF chromosomes originating in 13 Italian regions. The 12 most frequent mutations characterize about 73% of the Italian CF chromosomes. The most common mutation, ΔF508, has an average frequency of 51%, followed by N1303K and G542X, both with average frequencies around 5%. Multivariate analyses show that the relative frequencies of CF mutations are heterogeneous among Italian regions, and that this heterogeneity is weakly correlated with the geographical pattern of non-DNA ‘classical’ genetic markers. The northern regions are well differentiated from the central-southern regions and within the former group the western and eastern regions are remarkably distinct. Moreover, Sardinia shows the presence of mutation T338I, which seems absent in any other European CF chromosome. The north-western regions of Italy, characterized by the mutation 1717-1G→A, were under Celtic influence, while the north-east regions, characterized by the mutations R1162X, 2183AA→G and 7115G→A, were under the influence of the Venetic culture.
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