Traditionally, philosophy of science has focused on the product of science: the scientific hypothesis, principle, law, or more grandiosely, the theory. Using logician's license I'll think of hypotheses and theories as ‘little’ and ‘big’ (or ‘weak’ and ‘strong’) propositions. The tradition spoke of the product as (scientific) knowledge; the more recent phrase “current scientific opinion” carries the same connotation of uniqueness. For this to make sense, something is required: a proposition must be capable of being true or false, capable of being fully believed or disbelieved (and if you like, known).
Probabilism requires us to look at every aspect of science in a new way. In his radical brand of probabilism, Richard Jeffrey told us to reconceptualize knowledge as 'probable knowledge’ and propositions as ‘probasitions’—and never to resolve doubt but simply to quantify it, keeping all possibilities in play.