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45 results

Page 1 of 3

  • Electroconvulsive therapy for depression: 80 years of progress

  • George Kirov, Sameer Jauhar, Pascal Sienaert, Charles H. Kellner, Declan M. McLoughlin
  • Journal:
    The British Journal of Psychiatry / Volume 219 / Issue 5 / November 2021
    Published online by Cambridge University Press:
    18 March 2021, pp. 594-597
    Print publication:
    November 2021
    • Article
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  • Electroconvulsive therapy is the most effective treatment for severe, psychotic or treatment-resistant depression. However, its effectiveness continues to be questioned, both in mainstream media and narratives within the scientific literature. In this analysis, we use an evidence-based approach to demonstrate the efficacy and safety of modern electroconvulsive therapy.

Handbook of ECT
  • A Guide to Electroconvulsive Therapy for Practitioners
  • Charles H. Kellner
  • Published online:
    17 December 2018
    Print publication:
    20 December 2018
  • The Handbook of ECT covers all aspects of contemporary electroconvulsive therapy (ECT) practice. This concise yet informed text provides medical practitioners with both the theoretical background and practical knowledge to guide them in the practice of ECT. The text is filled with 'clinical pearls' from an expert practitioner which will be of great use to both new and seasoned practitioners of ECT. Each chapter is comprehensively referenced with the latest ECT research and clinical literature. Topics covered include research on mechanisms of action, patient selection by diagnosis, pre-procedural medical and laboratory evaluation, patient preparation in the ECT suite, stimulus dosing strategies, ECT anesthesia, clinical decision making and continuation/maintenance treatment strategies. This book will be of particular value for practicing psychiatrists, psychiatric residents and medical students rotating in psychiatry.

  • Evaluation of the Effects of Severe Depression on Global Cognitive Function and Memory

  • Shawn M. McClintock, C. Munro Cullum, Mustafa M. Husain, A. John Rush, Rebedca G. Knapp, Martina Mueller, Georgios Petrides, Shirlene Sampson, Charles H. Kellner
  • Journal:
    CNS Spectrums / Volume 15 / Issue 5 / May 2010
    Published online by Cambridge University Press:
    07 November 2014, pp. 304-313

  • Introduction: Major depressive disorder (MDD) is thought to negatively impact cognitive function; however, the relationship has not been well explored.

    Objective: This study examined the association between depression severity and global cognitive function and memory in subjects with severe, treatment-resistant MDD.

    Methods: We enrolled 66 subjects with Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition diagnosed unipolar MDD in a multicenter trial to assess the efficacy and neurocognitive effects of electroconvulsive therapy (ECT). We measured depression severity with the 24 item Hamilton Rating Scale for Depression (HRSD24). Neuropsychologic measures included the Mini Mental State Examination (MMSE), Rey Auditory Verbal Learning Test (RAVLT), and the Complex Figure Test (CFT). Correlational and regression analyses were conducted to explore associations between depression severity and cognitive function.

    Results: The mean age of the subjects was 53.6 years (SD=15.8), 65% were female, and mean HRSD24 was 33.9 (SD=6.7). Mean demographic-corrected T-scores for each neurocognitive measure were in the average to borderline range, and HRSD24 values were unrelated to performance on the MMSE, RAVLT immediate and delayed recall, and CFT immediate and delayed recall.

    Conclusion: In this sample of severely depressed subjects referred for ECT, depression severity was unrelated to global cognitive function or memory. Future research should examine the interactions between other depressive characteristics and neurocognitive function.

Brain Stimulation in Psychiatry
  • ECT, DBS, TMS and Other Modalities
  • Charles H. Kellner
  • Published online:
    05 June 2012
    Print publication:
    31 May 2012
  • The field of brain stimulation is advancing at rapid pace with a growing number of techniques now approved for the treatment of psychiatric illness. This text acts both as a concise, quick reference for experienced practitioners and a guidebook for residents learning about clinical brain stimulation techniques. The techniques covered include: Electroconvulsive therapy (ECT)Deep brain stimulation (DBS)Transcranial magnetic stimulation (TMS) Vagus nerve stimulation (VNS) Magnetic seizure therapy (MST) Transcranial direct current stimulation (TDCS)All aspects of these treatments are covered, from patient selection, through the implementation of the technique, to patient aftercare. Potential future applications are discussed and select, up-to-date reference lists guide practitioners to the most important further reading around each technique. Portable, concise and easy to navigate, covering all the need-to-know information, Brain Stimulation in Psychiatry is essential reading for practitioners, residents and medical students in psychiatry and neurology.

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