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46 results

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  • Incidence of surgical infection in cefazolin 3 g versus 2 g for colorectal surgery in obese patients

  • Curtis D. Collins, Eric Hartsfield, Robert K. Cleary, Rachel M. Kenney, Michael P. Veve, Kara K. Brockhaus
  • Journal:
    Infection Control & Hospital Epidemiology / Volume 46 / Issue 2 / February 2025
    Published online by Cambridge University Press:
    09 January 2025, pp. 115-119
    Print publication:
    February 2025
  • Objective:

    To compare the incidence of surgical site infection (SSI) between cefazolin 3 g and 2 g surgical prophylaxis in patients weighing ≥120 kg that undergo elective colorectal surgery.

    Methods:

    A multicenter, retrospective cohort study was performed utilizing a validated database of elective colorectal surgeries in Michigan acute care hospitals. Adults weighing ≥120 kg who received cefazolin and metronidazole for surgical prophylaxis between 7/2012 and 6/2021 were included. The primary outcome was SSI, which was defined as an infection diagnosed within 30 days following the principal operative procedure. Multivariable logistic regression was used to identify variables associated with SSI; the exposure of interest was cefazolin 3 g surgical prophylaxis.

    Results:

    A total of 581 patients were included; of these, 367 (63.1%) received cefazolin 3 g, while 214 (36.8%) received 2 g. Patients who received cefazolin 3 g had less optimal antibiotic timing (324 [88.3%] vs 200 [93.5%]; P = .043) and a higher receipt of at least 1 of the prophylaxis antibiotics after incision (22 [6%] vs 5 [2.3%]; P = .043). There was no SSI difference between cefazolin 3 g and 2 g cohorts (23 [6.3%] vs 16 [7.5%], P = .574). When accounting for age, smoking status, and surgical duration, cefazolin 3 g was not associated with a reduction in SSI (adjOR, .64; 95%CI, .32–1.29).

    Conclusions:

    Surgical prophylaxis with cefazolin 3 g, in combination with metronidazole, was not associated with decreased SSI compared to 2 g dosing in obese patients undergoing elective colorectal surgery.

A Commentary on Ovid's Metamorphoses
  • Volume 2, Books 7-12
  • General editor Alessandro Barchiesi
  • Edited by E. J. Kenney, Joseph D. Reed
  • Published online:
    11 January 2024
    Print publication:
    01 February 2024
  • Comprising fifteen books and over two hundred and fifty myths, Ovid's Metamorphoses is one of the longest extant Latin poems from the ancient world and one of the most influential works in Western culture. It is an epic on desire and transgression that became a gateway to the entire world of pagan mythology and visual imagination. This, the first complete commentary in English, covers all aspects of the text – from textual interpretation to poetics, imagination, and ideology – and will be useful as a teaching aid and an orientation for those who are interested in the text and its reception. Historically, the poem's audience includes readers interested in opera and ballet, psychology and sexuality, myth and painting, feminism and posthumanism, vegetarianism and metempsychosis (to name just a few outside the area of Classical Studies).

  • HYPEREION—A precision system for the detection of the absorption profile centred at 78 MHz in the radio background spectrum

  • N. Patra, R. Wayth, M. Sokolowski, D. Price, B. McKinley, D. Kenney
  • Journal:
    Publications of the Astronomical Society of Australia / Volume 40 / 2023
    Published online by Cambridge University Press:
    24 May 2023, e026
    • Article
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      • Open access
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  • The report of a detection of an absorption profile centred at 78 MHz in the continuum radio background spectrum by the EDGES experiment and its interpretation as the redshifted 21 cm signal of cosmological origin has become one of the most debated results of observational cosmology in recent times. The cosmological 21 cm has long been proposed to be a powerful probe for observing the early Universe and tracing its evolution over cosmic time. Even though the science case is well established, measurement challenges posed on the technical ground are not fully understood to the level of claiming a successful detection. EDGES’s detection has naturally motivated a number of experimental attempts worldwide to corroborate the findings. In this paper, we present a precision cross-correlation spectrometer HYPEREION purpose-designed for a precision radio background measurement between 50–120 MHz to detect the absorption profile reported by the EDGES experiment. HYPEREION implements a pre-correlation signal processing technique that self-calibrates any spurious additive contamination from within the system and delivers a differential measurement of the sky spectrum and a reference thermal load internal to the system. This ensures an unambiguous ‘zero-point’ of absolute calibration of the purported absorption profile. We present the system design, measurement equations of the ideal system, systematic effects in the real system, and finally, an assessment of the real system output for the detection of the absorption profile at 78 MHz in the continuum radio background spectrum.

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