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Tracking the mental health of a nation: prevalence and correlates of mental disorders in the second Singapore mental health study
- M. Subramaniam, E. Abdin, J. A. Vaingankar, S. Shafie, B. Y. Chua, R. Sambasivam, Y. J. Zhang, S. Shahwan, S. Chang, H. C. Chua, S. Verma, L. James, K. W. Kwok, D. Heng, S. A. Chong
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- Journal:
- Epidemiology and Psychiatric Sciences / Volume 29 / 2020
- Published online by Cambridge University Press:
- 05 April 2019, e29
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- Article
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Aims
The second Singapore Mental Health Study (SMHS) – a nationwide, cross-sectional, epidemiological survey - was initiated in 2016 with the intent of tracking the state of mental health of the general population in Singapore. The study employed the same methodology as the first survey initiated in 2010. The SMHS 2016 aimed to (i) establish the 12-month and lifetime prevalence and correlates of major depressive disorder (MDD), dysthymia, bipolar disorder, generalised anxiety disorder (GAD), obsessive compulsive disorder (OCD) and alcohol use disorder (AUD) (which included alcohol abuse and dependence) and (ii) compare the prevalence of these disorders with reference to data from the SMHS 2010.
MethodsDoor-to-door household surveys were conducted with adult Singapore residents aged 18 years and above from 2016 to 2018 (n = 6126) which yielded a response rate of 69.0%. The subjects were randomly selected using a disproportionate stratified sampling method and assessed using World Health Organization Composite International Diagnostic Interview version 3.0 (WHO-CIDI 3.0). The diagnoses of lifetime and 12-month selected mental disorders including MDD, dysthymia, bipolar disorder, GAD, OCD, and AUD (alcohol abuse and alcohol dependence), were based on the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria.
ResultsThe lifetime prevalence of at least one mood, anxiety or alcohol use disorder was 13.9% in the adult population. MDD had the highest lifetime prevalence (6.3%) followed by alcohol abuse (4.1%). The 12-month prevalence of any DSM-IV mental disorders was 6.5%. OCD had the highest 12-month prevalence (2.9%) followed by MDD (2.3%). Lifetime and 12-month prevalence of mental disorders assessed in SMHS 2016 (13.8% and 6.4%) was significantly higher than that in SMHS 2010 (12.0% and 4.4%). A significant increase was observed in the prevalence of lifetime GAD (0.9% to 1.6%) and alcohol abuse (3.1% to 4.1%). The 12-month prevalence of GAD (0.8% vs. 0.4%) and OCD (2.9% vs. 1.1%) was significantly higher in SMHS 2016 as compared to SMHS 2010.
ConclusionsThe high prevalence of OCD and the increase across the two surveys needs to be tackled at a population level both in terms of creating awareness of the disorder and the need for early treatment. Youth emerge as a vulnerable group who are more likely to be associated with mental disorders and thus targeted interventions in this group with a focus on youth friendly and accessible care centres may lead to earlier detection and treatment of mental disorders.
Contributors
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- By Rony A. Adam, Gloria Bachmann, Nichole M. Barker, Randall B. Barnes, John Bennett, Inbar Ben-Shachar, Jonathan S. Berek, Sarah L. Berga, Monica W. Best, Eric J. Bieber, Frank M. Biro, Shan Biscette, Anita K. Blanchard, Candace Brown, Ronald T. Burkman, Joseph Buscema, John E. Buster, Michael Byas-Smith, Sandra Ann Carson, Judy C. Chang, Annie N. Y. Cheung, Mindy S. Christianson, Karishma Circelli, Daniel L. Clarke-Pearson, Larry J. Copeland, Bryan D. Cowan, Navneet Dhillon, Michael P. Diamond, Conception Diaz-Arrastia, Nicole M. Donnellan, Michael L. Eisenberg, Eric Eisenhauer, Sebastian Faro, J. Stuart Ferriss, Lisa C. Flowers, Susan J. Freeman, Leda Gattoc, Claudine Marie Gayle, Timothy M. Geiger, Jennifer S. Gell, Alan N. Gordon, Victoria L. Green, Jon K. Hathaway, Enrique Hernandez, S. Paige Hertweck, Randall S. Hines, Ira R. Horowitz, Fred M. Howard, William W. Hurd, Fidan Israfilbayli, Denise J. Jamieson, Carolyn R. Jaslow, Erika B. Johnston-MacAnanny, Rohna M. Kearney, Namita Khanna, Caroline C. King, Jeremy A. King, Ira J. Kodner, Tamara Kolev, Athena P. Kourtis, S. Robert Kovac, Ertug Kovanci, William H. Kutteh, Eduardo Lara-Torre, Pallavi Latthe, Herschel W. Lawson, Ronald L. Levine, Frank W. Ling, Larry I. Lipshultz, Steven D. McCarus, Robert McLellan, Shruti Malik, Suketu M. Mansuria, Mohamed K. Mehasseb, Pamela J. Murray, Saloney Nazeer, Farr R. Nezhat, Hextan Y. S. Ngan, Gina M. Northington, Peggy A. Norton, Ruth M. O'Regan, Kristiina Parviainen, Resad P. Pasic, Tanja Pejovic, K. Ulrich Petry, Nancy A. Phillips, Ashish Pradhan, Elizabeth E. Puscheck, Suneetha Rachaneni, Devon M. Ramaeker, David B. Redwine, Robert L. Reid, Carla P. Roberts, Walter Romano, Peter G. Rose, Robert L. Rosenfield, Shon P. Rowan, Mack T. Ruffin, Janice M. Rymer, Evis Sala, Ritu Salani, Joseph S. Sanfilippo, Mahmood I. Shafi, Roger P. Smith, Meredith L. Snook, Thomas E. Snyder, Mary D. Stephenson, Thomas G. Stovall, Richard L. Sweet, Philip M. Toozs-Hobson, Togas Tulandi, Elizabeth R. Unger, Denise S. Uyar, Marion S. Verp, Rahi Victory, Tamara J. Vokes, Michelle J. Washington, Katharine O'Connell White, Paul E. Wise, Frank M. Wittmaack, Miya P. Yamamoto, Christine Yu, Howard A. Zacur
- Edited by Eric J. Bieber, Joseph S. Sanfilippo, University of Pittsburgh, Ira R. Horowitz, Emory University, Atlanta, Mahmood I. Shafi
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- Book:
- Clinical Gynecology
- Published online:
- 05 April 2015
- Print publication:
- 23 April 2015, pp viii-xiv
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Antibody capture radioimmunoassay for anti-rubella IgM
- P. P. Mortimer, R. S. Tedder, M. H. Hambling, M. S. Shafi, F. Burkhardt, U. Schilt
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- Journal:
- Journal of Hygiene / Volume 86 / Issue 2 / April 1981
- Published online by Cambridge University Press:
- 25 March 2010, pp. 139-153
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An M-antibody capture radioimmunoassay (MACRIA) for anti-rubella IgM was developed. Under optimum conditions positive serum specimens bound up to 20 times as much radioactivity as negative specimens. Positive reactions were expressed in arbitrary units/ml by comparison with a calibration curve derived from results obtained with dilutions of a standard serum.
The specificity of the assay was confirmed by testing IgM and IgG rich fractions of positive sera. One hundred and forty specimens from blood donors, patients whose sera contained rheumatoid factor and patients with acute, non-rubella, virus infections were tested by MACRIA. No significant non-specific reactions were detected.
Paired sera from acute rubella (25 patients) and individual sera from suspected rubella (69 patients) were tested for anti-rubella IgM by MACRIA and by haemagglutination inhibition following sucrose-density-gradient fractionation. There was close agreement between the two methods. The capture assay was more sensitive and could be used to detect the weak IgM response in women given RA 27/3 vaccine. After the natural infection, the MACRIA was strongly positive for two months and remained weakly so for a further two months. Repeat testing of sera demonstrated good reproducibility of the assay.
MACRIA proved a simple, sensitive and specific test for anti-rubella IgM and compared favourably with currently used techniques.
Carcass composition of fattened rams and wethers of Sudan Desert sheep
- A. H. Osman, S. A. El Shafie, A. G. H. Khattab
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- Journal:
- The Journal of Agricultural Science / Volume 75 / Issue 2 / October 1970
- Published online by Cambridge University Press:
- 27 March 2009, pp. 257-263
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Carcass yield and chemical composition of edible meat of fifteen fattened yearling rams and fifteen fattened yearling wethers of Sudan Desert sheep were studied. The animals studied were random samples from groups which had been fattened for 2 months on three different rations. They were about 14 months old at slaughter, and their weights at slaughter ranged from 25 to 52 kg. The average dressing percentage for rams and wethers was 53·0 and 52·2% respectively. Warm carcass weights were 20·22 kg for rams and 19·64 kg for wethers, and these carcasses lost 4·2 and 3·1% of their weight respectively, after 48 h storage in the cold room at 0°C. The bone content of carcasses of rams and wethers was 23·4 and 21·3% respectively. The longissimus dorsi ‘loin eye’ area at the 12th rib was 8·6 cm2 and 8·3 cm2 for rams and wethers. The proportions of wholesale cuts in ram and wether carcasses were comparable, whereas the proportions of slaughter by-products varied between the two ‘sexes’. Mean weight of kidney fat in wethers was 50% greater than in intact rams, but the mesenteric and caul fat was heavier in rams than in wethers.
Ram carcasses had higher specific gravity than those of wether carcasses. Specific gravity was negatively correlated with fat content and positively correlated with protein, moisture and ash content of the edible meat of the carcass. The regression equations relating specific gravity to the major chemical components of meat had too high standard errors to be of predictive value in a practical sense.
Lateral vorticity measurements in a turbulent wake
- R. A. Antonia, Y. Zhu, H. S. Shafi
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- Journal:
- Journal of Fluid Mechanics / Volume 323 / 25 September 1996
- Published online by Cambridge University Press:
- 26 April 2006, pp. 173-200
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The accurate measurement of vorticity has proven difficult because of the difficulty of estimating spatial derivatives of velocity fluctuations reliably. A method is proposed for correcting the lateral vorticity spectrum measured using a four-wire probe. The attenuation of the measured spectrum increases as the wavenumber increases but does not vanish when the wavenumber is zero. Although the correction procedure assumes local isotropy, the major contributor to the high-wavenumber part of the vorticity spectrum is the streamwise derivative of the lateral velocity fluctuation, and the correction of this latter quantity does not depend on local isotropy. Satisfactory support for local isotropy is provided by the high-wavenumber parts of the velocity, velocity derivative and vorticity spectra measured on the centreline of a turbulent wake. Second- and fourth-order moments of vorticity show departures from local isotropy but the degree of departure seems unaffected by the turbulence Reynolds number Rλ. The vorticity probability density function is approximately exponential and has tails which stretch out to larger amplitudes as Rλ increases. The vorticity flatness factor, which is appreciably larger than the flatness factor of the streamwise velocity derivative, also increases with Rλ. When Rλ is sufficiently large for velocity structure functions to indicate a r2/3 inertial range, two-point longitudinal correlations of lateral vorticity fluctuations give encouraging support for the theoretical r−4/3 behaviour.
Small-scale characteristics of a turbulent boundary layer over a rough wall
- H. S. SHAFI, R. A. ANTONIA
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- Journal:
- Journal of Fluid Mechanics / Volume 342 / 10 July 1997
- Published online by Cambridge University Press:
- 10 July 1997, pp. 263-293
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Measurements of the spanwise and wall-normal components of vorticity and their constituent velocity derivative fluctuations have been made in a turbulent boundary layer over a mesh-screen rough wall using a four-hot-wire vorticity probe. The measured spectra and variances of vorticity and velocity derivatives have been corrected for the effect of spatial resolution. The high-wavenumber behaviour of the spectra conforms closely with isotropy. Over most of the outer layer, the normalized magnitudes of the velocity derivative variances differ significantly from those over a smooth wall layer. The differences are such that the variances are much more nearly isotropic over the rough wall than on the smooth wall. This behaviour is consistent with earlier observations that the large-scale structure in this rough wall layer is more isotropic than that in a smooth wall layer. Isotropy-based approximations for the mean energy dissipation rate and mean enstrophy are consequently more reliable in this rough wall layer than in a smooth wall layer. In the outer layer, the vorticity variances are slightly larger than those over a smooth wall; reflecting structural differences between the two flows.