8 results
Neuroinflammatory and morphological changes in late-life depression: the NIMROD study
- Li Su, Yetunde O. Faluyi, Young T. Hong, Tim D. Fryer, Elijah Mak, Silvy Gabel, Lawrence Hayes, Soteris Soteriades, Guy B. Williams, Robert Arnold, Luca Passamonti, Patricia Vázquez Rodríguez, Ajenthan Surendranathan, Richard W. Bevan-Jones, Jonathan Coles, Franklin Aigbirhio, James B. Rowe, John T. O'Brien
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- Journal:
- The British Journal of Psychiatry / Volume 209 / Issue 6 / December 2016
- Published online by Cambridge University Press:
- 02 January 2018, pp. 525-526
- Print publication:
- December 2016
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We studied neuroinflammation in individuals with late-life, depression, as a risk factor for dementia, using [11C]PK11195 positron emission tomography (PET). Five older participants with major depression and 13 controls underwent PET and multimodal 3T magnetic resonance imaging (MRI), with blood taken to measure C-reactive protein (CRP). We found significantly higher CRP levels in those with late-life depression and raised [11C]PK11195 binding compared with controls in brain regions associated with depression, including subgenual anterior cingulate cortex, and significant hippocampal subfield atrophy in cornu ammonis 1 and subiculum. Our findings suggest neuroinflammation requires further investigation in late-life depression, both as a possible aetiological factor and a potential therapeutic target.
Contributors
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- By Rose Teteki Abbey, K. C. Abraham, David Tuesday Adamo, LeRoy H. Aden, Efrain Agosto, Victor Aguilan, Gillian T. W. Ahlgren, Charanjit Kaur AjitSingh, Dorothy B E A Akoto, Giuseppe Alberigo, Daniel E. Albrecht, Ruth Albrecht, Daniel O. Aleshire, Urs Altermatt, Anand Amaladass, Michael Amaladoss, James N. Amanze, Lesley G. Anderson, Thomas C. Anderson, Victor Anderson, Hope S. Antone, María Pilar Aquino, Paula Arai, Victorio Araya Guillén, S. Wesley Ariarajah, Ellen T. Armour, Brett Gregory Armstrong, Atsuhiro Asano, Naim Stifan Ateek, Mahmoud Ayoub, John Alembillah Azumah, Mercedes L. García Bachmann, Irena Backus, J. Wayne Baker, Mieke Bal, Lewis V. Baldwin, William Barbieri, António Barbosa da Silva, David Basinger, Bolaji Olukemi Bateye, Oswald Bayer, Daniel H. Bays, Rosalie Beck, Nancy Elizabeth Bedford, Guy-Thomas Bedouelle, Chorbishop Seely Beggiani, Wolfgang Behringer, Christopher M. Bellitto, Byard Bennett, Harold V. Bennett, Teresa Berger, Miguel A. Bernad, Henley Bernard, Alan E. Bernstein, Jon L. Berquist, Johannes Beutler, Ana María Bidegain, Matthew P. Binkewicz, Jennifer Bird, Joseph Blenkinsopp, Dmytro Bondarenko, Paulo Bonfatti, Riet en Pim Bons-Storm, Jessica A. Boon, Marcus J. Borg, Mark Bosco, Peter C. Bouteneff, François Bovon, William D. Bowman, Paul S. Boyer, David Brakke, Richard E. Brantley, Marcus Braybrooke, Ian Breward, Ênio José da Costa Brito, Jewel Spears Brooker, Johannes Brosseder, Nicholas Canfield Read Brown, Robert F. Brown, Pamela K. Brubaker, Walter Brueggemann, Bishop Colin O. Buchanan, Stanley M. Burgess, Amy Nelson Burnett, J. Patout Burns, David B. Burrell, David Buttrick, James P. Byrd, Lavinia Byrne, Gerado Caetano, Marcos Caldas, Alkiviadis Calivas, William J. Callahan, Salvatore Calomino, Euan K. Cameron, William S. Campbell, Marcelo Ayres Camurça, Daniel F. Caner, Paul E. Capetz, Carlos F. Cardoza-Orlandi, Patrick W. Carey, Barbara Carvill, Hal Cauthron, Subhadra Mitra Channa, Mark D. Chapman, James H. Charlesworth, Kenneth R. Chase, Chen Zemin, Luciano Chianeque, Philip Chia Phin Yin, Francisca H. Chimhanda, Daniel Chiquete, John T. Chirban, Soobin Choi, Robert Choquette, Mita Choudhury, Gerald Christianson, John Chryssavgis, Sejong Chun, Esther Chung-Kim, Charles M. A. Clark, Elizabeth A. Clark, Sathianathan Clarke, Fred Cloud, John B. Cobb, W. Owen Cole, John A Coleman, John J. Collins, Sylvia Collins-Mayo, Paul K. Conkin, Beth A. Conklin, Sean Connolly, Demetrios J. Constantelos, Michael A. Conway, Paula M. Cooey, Austin Cooper, Michael L. Cooper-White, Pamela Cooper-White, L. William Countryman, Sérgio Coutinho, Pamela Couture, Shannon Craigo-Snell, James L. Crenshaw, David Crowner, Humberto Horacio Cucchetti, Lawrence S. Cunningham, Elizabeth Mason Currier, Emmanuel Cutrone, Mary L. Daniel, David D. Daniels, Robert Darden, Rolf Darge, Isaiah Dau, Jeffry C. Davis, Jane Dawson, Valentin Dedji, John W. de Gruchy, Paul DeHart, Wendy J. Deichmann Edwards, Miguel A. De La Torre, George E. Demacopoulos, Thomas de Mayo, Leah DeVun, Beatriz de Vasconcellos Dias, Dennis C. Dickerson, John M. Dillon, Luis Miguel Donatello, Igor Dorfmann-Lazarev, Susanna Drake, Jonathan A. Draper, N. Dreher Martin, Otto Dreydoppel, Angelyn Dries, A. J. Droge, Francis X. D'Sa, Marilyn Dunn, Nicole Wilkinson Duran, Rifaat Ebied, Mark J. Edwards, William H. Edwards, Leonard H. Ehrlich, Nancy L. Eiesland, Martin Elbel, J. Harold Ellens, Stephen Ellingson, Marvin M. Ellison, Robert Ellsberg, Jean Bethke Elshtain, Eldon Jay Epp, Peter C. Erb, Tassilo Erhardt, Maria Erling, Noel Leo Erskine, Gillian R. Evans, Virginia Fabella, Michael A. Fahey, Edward Farley, Margaret A. Farley, Wendy Farley, Robert Fastiggi, Seena Fazel, Duncan S. Ferguson, Helwar Figueroa, Paul Corby Finney, Kyriaki Karidoyanes FitzGerald, Thomas E. FitzGerald, John R. Fitzmier, Marie Therese Flanagan, Sabina Flanagan, Claude Flipo, Ronald B. Flowers, Carole Fontaine, David Ford, Mary Ford, Stephanie A. Ford, Jim Forest, William Franke, Robert M. Franklin, Ruth Franzén, Edward H. Friedman, Samuel Frouisou, Lorelei F. Fuchs, Jojo M. Fung, Inger Furseth, Richard R. Gaillardetz, Brandon Gallaher, China Galland, Mark Galli, Ismael García, Tharscisse Gatwa, Jean-Marie Gaudeul, Luis María Gavilanes del Castillo, Pavel L. Gavrilyuk, Volney P. Gay, Metropolitan Athanasios Geevargis, Kondothra M. George, Mary Gerhart, Simon Gikandi, Maurice Gilbert, Michael J. Gillgannon, Verónica Giménez Beliveau, Terryl Givens, Beth Glazier-McDonald, Philip Gleason, Menghun Goh, Brian Golding, Bishop Hilario M. Gomez, Michelle A. Gonzalez, Donald K. Gorrell, Roy Gottfried, Tamara Grdzelidze, Joel B. Green, Niels Henrik Gregersen, Cristina Grenholm, Herbert Griffiths, Eric W. Gritsch, Erich S. Gruen, Christoffer H. Grundmann, Paul H. Gundani, Jon P. Gunnemann, Petre Guran, Vidar L. Haanes, Jeremiah M. Hackett, Getatchew Haile, Douglas John Hall, Nicholas Hammond, Daphne Hampson, Jehu J. Hanciles, Barry Hankins, Jennifer Haraguchi, Stanley S. Harakas, Anthony John Harding, Conrad L. Harkins, J. William Harmless, Marjory Harper, Amir Harrak, Joel F. Harrington, Mark W. Harris, Susan Ashbrook Harvey, Van A. Harvey, R. Chris Hassel, Jione Havea, Daniel Hawk, Diana L. Hayes, Leslie Hayes, Priscilla Hayner, S. Mark Heim, Simo Heininen, Richard P. Heitzenrater, Eila Helander, David Hempton, Scott H. Hendrix, Jan-Olav Henriksen, Gina Hens-Piazza, Carter Heyward, Nicholas J. Higham, David Hilliard, Norman A. Hjelm, Peter C. Hodgson, Arthur Holder, M. Jan Holton, Dwight N. Hopkins, Ronnie Po-chia Hsia, Po-Ho Huang, James Hudnut-Beumler, Jennifer S. Hughes, Leonard M. Hummel, Mary E. Hunt, Laennec Hurbon, Mark Hutchinson, Susan E. Hylen, Mary Beth Ingham, H. Larry Ingle, Dale T. Irvin, Jon Isaak, Paul John Isaak, Ada María Isasi-Díaz, Hans Raun Iversen, Margaret C. Jacob, Arthur James, Maria Jansdotter-Samuelsson, David Jasper, Werner G. Jeanrond, Renée Jeffery, David Lyle Jeffrey, Theodore W. Jennings, David H. Jensen, Robin Margaret Jensen, David Jobling, Dale A. Johnson, Elizabeth A. Johnson, Maxwell E. Johnson, Sarah Johnson, Mark D. Johnston, F. Stanley Jones, James William Jones, John R. Jones, Alissa Jones Nelson, Inge Jonsson, Jan Joosten, Elizabeth Judd, Mulambya Peggy Kabonde, Robert Kaggwa, Sylvester Kahakwa, Isaac Kalimi, Ogbu U. Kalu, Eunice Kamaara, Wayne C. Kannaday, Musimbi Kanyoro, Veli-Matti Kärkkäinen, Frank Kaufmann, Léon Nguapitshi Kayongo, Richard Kearney, Alice A. Keefe, Ralph Keen, Catherine Keller, Anthony J. Kelly, Karen Kennelly, Kathi Lynn Kern, Fergus Kerr, Edward Kessler, George Kilcourse, Heup Young Kim, Kim Sung-Hae, Kim Yong-Bock, Kim Yung Suk, Richard King, Thomas M. King, Robert M. Kingdon, Ross Kinsler, Hans G. Kippenberg, Cheryl A. Kirk-Duggan, Clifton Kirkpatrick, Leonid Kishkovsky, Nadieszda Kizenko, Jeffrey Klaiber, Hans-Josef Klauck, Sidney Knight, Samuel Kobia, Robert Kolb, Karla Ann Koll, Heikki Kotila, Donald Kraybill, Philip D. W. Krey, Yves Krumenacker, Jeffrey Kah-Jin Kuan, Simanga R. Kumalo, Peter Kuzmic, Simon Shui-Man Kwan, Kwok Pui-lan, André LaCocque, Stephen E. Lahey, John Tsz Pang Lai, Emiel Lamberts, Armando Lampe, Craig Lampe, Beverly J. Lanzetta, Eve LaPlante, Lizette Larson-Miller, Ariel Bybee Laughton, Leonard Lawlor, Bentley Layton, Robin A. Leaver, Karen Lebacqz, Archie Chi Chung Lee, Marilyn J. Legge, Hervé LeGrand, D. L. LeMahieu, Raymond Lemieux, Bill J. Leonard, Ellen M. Leonard, Outi Leppä, Jean Lesaulnier, Nantawan Boonprasat Lewis, Henrietta Leyser, Alexei Lidov, Bernard Lightman, Paul Chang-Ha Lim, Carter Lindberg, Mark R. Lindsay, James R. Linville, James C. Livingston, Ann Loades, David Loades, Jean-Claude Loba-Mkole, Lo Lung Kwong, Wati Longchar, Eleazar López, David W. Lotz, Andrew Louth, Robin W. Lovin, William Luis, Frank D. Macchia, Diarmaid N. J. MacCulloch, Kirk R. MacGregor, Marjory A. MacLean, Donald MacLeod, Tomas S. Maddela, Inge Mager, Laurenti Magesa, David G. Maillu, Fortunato Mallimaci, Philip Mamalakis, Kä Mana, Ukachukwu Chris Manus, Herbert Robinson Marbury, Reuel Norman Marigza, Jacqueline Mariña, Antti Marjanen, Luiz C. L. Marques, Madipoane Masenya (ngwan'a Mphahlele), Caleb J. D. Maskell, Steve Mason, Thomas Massaro, Fernando Matamoros Ponce, András Máté-Tóth, Odair Pedroso Mateus, Dinis Matsolo, Fumitaka Matsuoka, John D'Arcy May, Yelena Mazour-Matusevich, Theodore Mbazumutima, John S. McClure, Christian McConnell, Lee Martin McDonald, Gary B. McGee, Thomas McGowan, Alister E. McGrath, Richard J. McGregor, John A. McGuckin, Maud Burnett McInerney, Elsie Anne McKee, Mary B. McKinley, James F. McMillan, Ernan McMullin, Kathleen E. McVey, M. 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Phan, Isabel Apawo Phiri, William S. F. Pickering, Derrick G. Pitard, William Elvis Plata, Zlatko Plese, John Plummer, James Newton Poling, Ronald Popivchak, Andrew Porter, Ute Possekel, James M. Powell, Enos Das Pradhan, Devadasan Premnath, Jaime Adrían Prieto Valladares, Anne Primavesi, Randall Prior, María Alicia Puente Lutteroth, Eduardo Guzmão Quadros, Albert Rabil, Laurent William Ramambason, Apolonio M. Ranche, Vololona Randriamanantena Andriamitandrina, Lawrence R. Rast, Paul L. Redditt, Adele Reinhartz, Rolf Rendtorff, Pål Repstad, James N. Rhodes, John K. Riches, Joerg Rieger, Sharon H. Ringe, Sandra Rios, Tyler Roberts, David M. Robinson, James M. Robinson, Joanne Maguire Robinson, Richard A. H. Robinson, Roy R. Robson, Jack B. Rogers, Maria Roginska, Sidney Rooy, Rev. Garnett Roper, Maria José Fontelas Rosado-Nunes, Andrew C. Ross, Stefan Rossbach, François Rossier, John D. Roth, John K. Roth, Phillip Rothwell, Richard E. 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Yee, Viktor Yelensky, Yeo Khiok-Khng, Gustav K. K. Yeung, Angela Yiu, Amos Yong, Yong Ting Jin, You Bin, Youhanna Nessim Youssef, Eliana Yunes, Robert Michael Zaller, Valarie H. Ziegler, Barbara Brown Zikmund, Joyce Ann Zimmerman, Aurora Zlotnik, Zhuo Xinping
- Edited by Daniel Patte, Vanderbilt University, Tennessee
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- The Cambridge Dictionary of Christianity
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- 05 August 2012
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- 20 September 2010, pp xi-xliv
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Contributors
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- By Gareth Allen, Rowan Burnstein, Mick Cafferkey, Joseph Carter, Jonathan Cole, Giles Critchley, Marek Czosnyka, Egidio J. da Silva, Bruce Downey, Susan Dutch, Jonathan J. Evans, Peter Farling, Judith Fewings, Clare N. Gallagher, Helen M. K. Gooday, Arun K. Gupta, Adel Helmy, Camilla Herbert, David A. Hilton, Peter J. Hutchinson, Roisin Jack, Thérèse Jackson, Deva S. Jeyaretna, Peter J. Kirkpatrick, W. Hiu Lam, Fiona Lecky, Paul McArdle, Duncan McAuley, William W. McKinlay, Chris Maimaris, Alexander R. Manara, Anjum Memon, Patrick Mitchell, H. C. Patel, Brian Pentland, Puneet Plaha, Ann-Marie Pringle, Richard Protheroe, Heinke Pülhorn, Robert Redfern, Jane V. Russell, Ayan Sen, Martin Smith, Fiona Summers, Matthew J. C. Thomas, Elfyn O. Thomas, I. Timofeev, Lorna Torrens, Rikin A. Trivedi, Martin B. Walker, Laurence Watkins, Ruwan Alwis Weerakkody, Peter C. Whitfield, Maggie Whyte, Maralyn Woodford
- Edited by Peter C. Whitfield, Elfyn O. Thomas, Fiona Summers, Maggie Whyte, Peter J. Hutchinson
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- Head Injury
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- 25 January 2010
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- 09 April 2009, pp ix-xii
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6 - Tardive dyskinesia and affective disorder
- from Part II - Clinical aspects of tardive dyskinesia
- Edited by Ramzy Yassa, Douglas Hospital, Quebec, N. P. V. Nair, Douglas Hospital, Quebec, Dilip V. Jeste, University of California, San Diego
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- Neuroleptic-induced Movement Disorders
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- 09 October 2009
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- 28 October 1996, pp 69-81
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Summary
Neuroleptic antipsychotic drugs are used in the treatment of a variety of psychiatric conditions, including affective disorder. This chapter concerns the association between tardive dyskinesia and affective disorder, inasmuch as affective illness has been established as a risk factor in the development of tardive dyskinesia (Gardos & Casey, 1984; Casey, 1988). The evidence for this association will be reviewed, and possible mechanisms will be considered. Because the somatic treatments used for bipolar and unipolar patients may influence the development and manifestations of tardive dyskinesia, we shall briefly review the effects on tardive dyskinesia of antidepressants, electroconvulsive treatment (ECT), lithium carbonate, and anticonvulsants.
Epidemiology
The earliest relevant studies grew out of clinical observations that some tardive dyskinesia patients were experiencing concurrent depression or had been depressed in the past (Rosenbaum et al., 1977). Other studies suggested that many patients with tardive dyskinesia had been improperly diagnosed as schizophrenic and that the more appropriate psychiatric diagnosis would have been affective disorder (Davis, Berger, & Hollister, 1976; Rush, Diamond, & Alpert, 1982; Casey & Toenniessen, 1983). Several studies compared tardive dyskinesia patients with non-dyskinetic control subjects and found affective disorder to be more common in the tardive dyskinesia groups (Hamra et al., 1983b; Alpert & Rush, 1984; Wolf et al., 1985). In a recent study, Yassa et al. (1992) showed that major depression among tardive dyskinesia patients was significantly more frequent (12 of 20, or 60%) than was primary degenerative dementia (42 of 49, or 24.5%) among a cohort of psychogeriatric inpatients.
9 - Neuroleptic treatment and tardive dyskinesia
- from Part II - Clinical aspects of tardive dyskinesia
- Edited by Ramzy Yassa, Douglas Hospital, Quebec, N. P. V. Nair, Douglas Hospital, Quebec, Dilip V. Jeste, University of California, San Diego
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- Neuroleptic-induced Movement Disorders
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- 09 October 2009
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- 28 October 1996, pp 104-116
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Summary
Any reasonable, informed clinician will accept the overwhelming epidemiologic evidence implicating neuroleptic drugs in the causation of tardive dyskinesia, with the caveat that not every case that looks like tardive dyskinesia is neuroleptic-related. Spontaneous dyskinesia (Marsden, 1985; Casey, 1987) and dyskinesias induced by drugs other than neuroleptics, such as antihistamines, antidepressants, and metoclopramide, often are indistinguishable from tardive dyskinesia. As Marsden (1985) pointed out, the causative relationship implies either that neuroleptics induce tardive dyskinesia in individuals who otherwise would not develop it or that neuroleptics precipitate tardive dyskinesia in patients who already carry the substrate for development of tardive dyskinesia.
Patients exposed to neuroleptics differ regarding variables such as age at first neuroleptic exposure, time since the start of neuroleptic treatment, duration of neuroleptic treatment (i.e., actual time on neuroleptics), number and duration of neuroleptic-free intervals, number of neuroleptics used, amount of neuroleptic (i.e., total quantity delivered), average neuroleptic dosage, and maximum neuroleptic dosage. Other areas of interest include comparisons of exposures to high- and low-potency neuroleptics, the number of neuroleptics simultaneously prescribed, the route of administration (depot vs. oral), and different schedules, such as a dose once daily versus twice daily (BID), or doses as needed (PRN) (oral and/or intramuscular). Only adequate knowledge of the pathogenesis of tardive dyskinesia will enable us to decide which of these drug variables are of particular relevance to tardive dyskinesia.
The Dexamethasone Suppression Test as a Discriminator among Subtypes of Psychotic Patients
- Anthony J. Rothschild, Alan F. Schatzberg, Alan H. Rosenbaum, Julie B. Stahl, Jonathan O. Cole
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- The British Journal of Psychiatry / Volume 141 / Issue 5 / November 1982
- Published online by Cambridge University Press:
- 29 January 2018, pp. 471-474
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- November 1982
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Plasma Cortisol levels examined at 16.00 hours after dexamethasone in 31 controls and in 34 psychotic patients with various diagnoses, suggests that the ranges of such levels may help to discriminate among subtypes of psychotic patients. They were significantly higher in the unipolar depressed psychotic group than in control subjects or in psychotic patients with bipolar depression or schizophrenia. Moreover, the distribution of values differed between groups. Whereas 8 of 14 psychotic patients with unipolar depressive illness had post-dexamethasone Cortisol values ≥ 14 μg/dl, none of the remaining psychotic patients had similarly high values. Implications of these data are discussed.
Relapse in Chronic Schizophrenics following Abrupt Withdrawal of Tranquilizing Medication
- Robert F. Prien, Jonathan O. Cole, Naomi F. Belkin§
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- Journal:
- The British Journal of Psychiatry / Volume 115 / Issue 523 / June 1969
- Published online by Cambridge University Press:
- 29 January 2018, pp. 679-686
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- June 1969
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Physicians are often faced with the problem of determining whether long-stay schizophrenics require continuous treatment with tranquillizers. Prolonged ingestion of ataractics has both physical and economic disadvantages. Recent reports on oculo-cutaneous changes (3, 13, 20, 27, 28), persistent dyskinesia (6, 18) and sudden deaths (16, 25) have focused attention on the potential dangers of prolonged use of tranquillizing medication. On the other hand, discontinuation of medication may lead to recurrence of acute psychotic behaviour. The literature on drug withdrawal provides no solution to the dilemma. The results from drug discontinuation studies are complex and contradictory. Some investigators report extremely high relapse rates while others report little deterioration even when drugs are withdrawn for long periods of time. A brief review of the literature will give some indication of the contradictory nature of results.
Changes in Schizophrenic Psychopathology and Ward Behaviour as a Function of Phenothiazine Treatment
- Solomon C. Goldberg, Gerald L. Klerman, Jonathan O. Cole
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- Journal:
- The British Journal of Psychiatry / Volume 111 / Issue 471 / February 1965
- Published online by Cambridge University Press:
- 29 January 2018, pp. 120-133
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- February 1965
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Although the efficacy of chlorpromazine and other phenothiazine derivatives in the treatment of schizophrenic psychotic reactions has been established for almost a decade, there remain differences of opinion regarding which symptoms and behaviours are affected favourably by psychopharmacologic treatment. By and large, the phenothiazines have been characterized as “ataractics” or “tranquillizers”, the implication being that their predominant action is to calm excited patients by relieving the patient's anxiety or other forms of psychic distress. However, clinical experience increasingly asserts that the phenothiazines influence many manifestations of schizophrenic patients other than anxiety and excitement, including symptoms such as incoherent thought and apathy.