Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
  1. Home
  2. Search

Refine search

Refine search

Access:
Content type:
Publication date:
Apply   From and To filters
Subject: Show more
Journals Show more
Publishers: Show more
Societies Show more
Series: Show more
Collections: Show more

Actions for selected content:

Select all | Deselect all
  • View selected items
  • Export citations
  • Download PDF (zip)
  • Save to Kindle
  • Save to Dropbox
  • Save to Google Drive

Save Search

You can save your searches here and later view and run them again in "My saved searches".

Please provide a title, maximum of 40 characters.
Cancel
×

16 results

  • Global patterns of large copy number variations in the human genome reveal complexity in chromosome organization

  • AVINASH M. VEERAPPA, RAVIRAJ V. SURESH, SANGEETHA VISHWESWARAIAH, KUSUMA LINGAIAH, MEGHA MURTHY, DINESH S. MANJEGOWDA, PRAKASH PADAKANNAYA, NALLUR B. RAMACHANDRA
  • Journal:
    Genetics Research / Volume 97 / 2015
    Published online by Cambridge University Press:
    22 September 2015, e18
    • Article
      • You have access
    • PDF
    • HTML
    • Export citation

  • Global patterns of copy number variations (CNVs) in chromosomes are required to understand the dynamics of genome organization and complexity. For this study, analysis was performed using the Affymetrix Genome-Wide Human SNP Array 6.0 chip and CytoScan High-Density arrays. We identified a total of 44 109 CNVs from 1715 genomes with a mean of 25 CNVs in an individual, which established the first drafts of population-specific CNV maps providing a rationale for prioritizing chromosomal regions. About 19 905 ancient CNVs were identified across all chromosomes and populations at varying frequencies. CNV count, and sometimes CNV size, contributed to the bulk CNV size of the chromosome. Population specific lengthening and shortening of chromosomal length was observed. Sex bias for CNV presence was largely dependent on ethnicity. Lower CNV inheritance rate was observed for India, compared to YRI and CEU. A total of 33 candidate CNV hotspots from 5382 copy number (CN) variable region (CNVR) clusters were identified. Population specific CNV distribution patterns in p and q arms disturbed the assumption that CNV counts in the p arm are less common compared to long arms, and the CNV occurrence and distribution in chromosomes is length independent. This study unraveled the force of independent evolutionary dynamics on genome organization and complexity across chromosomes and populations.

South and Southeast Asian Psycholinguistics
  • Edited by Heather Winskel, Prakash Padakannaya
  • Published online:
    05 December 2013
    Print publication:
    28 November 2013
  • A large body of knowledge has accumulated in recent years on the cognitive processes underlying language, much of which comes from studies of Indo-European languages, in particular English. This groundbreaking volume explores the languages of South and Southeast Asia, which differ significantly from Indo-European languages in their grammar, lexicon and spoken forms. This book raises new questions in psycholinguistics and enables readers to re-evaluate previous models in light of new research. With thirty-six chapters divided into three parts - Language Acquisition, Language Processing and Language and Brain - it examines contemporary topics alongside new findings in areas such as first and second language acquisition, the development of literacy, the diagnosis of language and reading disorders, and the relationship between language, brain, culture and cognition. It will be invaluable to all those interested in the languages of South and Southeast Asia, as well as psychologists, linguists, educationalists, speech therapists and neuroscientists.