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Ever since Shor's quantum algorithm for factoring integers was discovered three decades ago, showing that quantum algorithms could solve a problem relevant to everyday cryptography, researchers have been working to expand the list of real-world problems to which quantum computing can be applied. This book surveys the fruits of this effort, covering proposed quantum algorithms for concrete problems in many application areas, including quantum chemistry, optimization, finance, and machine learning. The book clearly states the problem being solved and the full computational complexity of the quantum algorithm, making sure to account for the contribution from all the underlying primitive ingredients. Separately, the book also provides a detailed, independent summary of the most common algorithmic primitives. The book has a modular, encyclopedic format to facilitate navigation of the material, and to provide a quick reference for designers of quantum algorithms and quantum computing researchers. This title is also available as open access on Cambridge Core.
Empirical evidence on the functioning of utility model (UM) systems is scarce compared to patent systems. This chapter applies the framework introduced by Heikkilä (2023a) to the empirical analysis of the Finnish UM system and its interaction with the Finnish patent system. The findings suggest that the UM system has promoted flexibility and inclusiveness of the Finnish patent system. There are systematic differences between Finnish UMs and patents: 1) UMs are members of smaller patent families, 2) UMs have smaller inventor teams, 3) grant lags of UMs are significantly shorter and 4) both Finnish patents and UMs receive few citations, but UMs receive systematically less. The aforementioned average differences between Finnish patents and UMs were much larger before Finland joined the European Patent Convention in 1996 which emphasizes the need to consider European integration and the evolution of European IPR institutions when evaluating UM systems.
We have conducted a widefield, wideband, snapshot survey using the Australian SKA Pathfinder (ASKAP) referred to as the Rapid ASKAP Continuum Survey (RACS). RACS covers ≈ 90% of the sky, with multiple observing epochs in three frequency bands sampling the ASKAP frequency range of 700–1 800 MHz. This paper describes the third major epoch at 1 655.5 MHz, RACS-high, and the subsequent imaging and catalogue data release. The RACS-high observations at 1 655.5MHz are otherwise similar to the previously released RACS-mid (at 1367.5 MHz), and were calibrated and imaged with minimal changes. From the 1 493 images covering the sky up to declination ≈ +48°, we present a catalogue of 2 677 509 radio sources. The catalogue is constructed from images with a median root-mean-square noise of ≈ 195 μJy PSF−1 (point-spread function) and a median angular resolution of 11″. 8 × 8″. 1. The overall reliability of the catalogue is estimated to be 99.18 %, and we find a decrease in reliability as angular resolution improves. We estimate the brightness scale to be accurate to 10 %, and the astrometric accuracy to be within ≈ 0″. 6 in right ascension and ≈ 0″. 7 in declination after correction of a systematic declination-dependent offset. All data products from RACS-high, including calibrated visibility datasets, images from individual observations, full-sensitivity mosaics, and the all-sky catalogue are available at the CSIRO ASKAP Science Data Archive.
Research on campaign finance suggests that Americans prefer candidates who are not funded by Political Action Committees (PACs). However, prior research has not examined how perceptions of a candidate who is PAC-funded vs. PAC-free might differ for racial minority and female candidates compared to White, male candidates. Using experimental vignettes, we test the causal impact of PAC funding, race, and gender on voter perceptions of the candidate. We find that refusing PAC funds, for example, is associated with appearing more ethical and more likely to work for voters’ interests over special interests, less corrupt, and more capable of winning elections. However, we show that race, more than gender, interacts with PAC funding to impact voter perceptions. We find that White female and male candidates benefit the most from PAC refusal. While Black female and male candidates receive little or no significant change in perceptions, Black PAC-funded candidates are perceived favorably compared to White PAC-funded candidates. Our results have implications for White and Black political candidates considering their funding strategies. Additionally, we contribute to existing literature by showing that refusing PAC funds status does not signal the same qualities for all candidates.
We present the first results from a new backend on the Australian Square Kilometre Array Pathfinder, the Commensal Realtime ASKAP Fast Transient COherent (CRACO) upgrade. CRACO records millisecond time resolution visibility data, and searches for dispersed fast transient signals including fast radio bursts (FRB), pulsars, and ultra-long period objects (ULPO). With the visibility data, CRACO can localise the transient events to arcsecond-level precision after the detection. Here, we describe the CRACO system and report the result from a sky survey carried out by CRACO at 110-ms resolution during its commissioning phase. During the survey, CRACO detected two FRBs (including one discovered solely with CRACO, FRB 20231027A), reported more precise localisations for four pulsars, discovered two new RRATs, and detected one known ULPO, GPM J1839 $-$10, through its sub-pulse structure. We present a sensitivity calibration of CRACO, finding that it achieves the expected sensitivity of 11.6 Jy ms to bursts of 110 ms duration or less. CRACO is currently running at a 13.8 ms time resolution and aims at a 1.7 ms time resolution before the end of 2024. The planned CRACO has an expected sensitivity of 1.5 Jy ms to bursts of 1.7 ms duration or less and can detect $10\times$ more FRBs than the current CRAFT incoherent sum system (i.e. 0.5 $-$2 localised FRBs per day), enabling us to better constrain the models for FRBs and use them as cosmological probes.
Thrust changes near walls and the ground plane are influenced by the rotor’s position in indoor flight environments. This study evaluates variations in rotor thrust near a corner, which includes one wall and the ground plane, as well as a vertex, which involves two walls and the ground plane; these phenomena are referred to as the corner and vertex effects, respectively. Additionally, the rotor wake in the vertex effect was visualised using the laser sheet method, and wake velocity was measured with a hot-wire probe. The thrust change in the corner effect on the ground side was minimal, primarily depending on the ground effect. In the vertex effect, thrust decreased to 93% of the thrust outside the vertex effect when the rotor height above ground was 2.5 times the rotor radius, and the rotor was distanced from the two walls by 1.5 times the rotor radius. Flow visualisation and hot-wire velocimetry results suggest that the thrust decrease was caused by the flow recirculation structure between the fountain flow developed along the vertical corner and rotor inflow. The thrust decreases under conditions where the circulation structure appears, and fountain flow velocity accelerates the recirculation. These findings aid in planning the flight path of small multirotors in indoor flight conditions by providing guidance on distances that do not alter rotor thrust near corners and vertices.
This paper considers the guidance issue for attackers against aircraft with active defense in a two-on-two engagement, which includes an attacker, a protector, a defender and a target. A cooperative line-of-sight guidance scheme with prescribed performance and input saturation is proposed utilising the sliding mode control and line-of-sight guidance theories, which guarantees that the attacker is able to capture the target with the assistance of the protector remaining on the line-of-sight between the defender and the attacker in order to intercept the defender. A fixed-time prescribed performance function and first-order anti-saturation auxiliary variable are designed in the game guidance strategy to constrain the overshoot of the guidance variable and satisfy the requirement of an overload manoeuver. The proposed guidance strategy alleviates the influence of external disturbance by implementing a fixed-time observer and the chattering phenomenon caused by the sign function. Finally, nonlinear numerical simulations verify the cooperative guidance strategies.
With wide-field phased array feed technology, the Australian Square Kilometre Array Pathfinder (ASKAP) is ideally suited to search for seemingly rare radio transient sources that are difficult to discover previous-generation narrow-field telescopes. The Commensal Real-time ASKAP Fast Transient (CRAFT) Survey Science Project has developed instrumentation to continuously search for fast radio transients (duration ≲ 1 second) with ASKAP, with a particular focus on finding and localising Fast Radio Bursts (FRBs). Since 2018, the CRAFT survey has been searching for FRBs and other fast transients by incoherently adding the intensities received by individual ASKAP antennas, and then correcting for the impact of frequency dispersion on these short-duration signals in the resultant incoherent sum (ICS) in real-time. This low-latency detection enables the triggering of voltage buffers, which facilitates the localisation of the transient source and the study of spectro-polarimetric properties at high time resolution. Here we report the sample of 43 FRBs discovered in this CRAFT/ICS survey to date. This includes 22 FRBs that had not previously been reported: 16 FRBs localised by ASKAP to. ≲ 1 arcsec and 6 FRBs localised to ∼ 10 arcmin. Of the new arcsecond-localised FRBs, we have identified and characterised host galaxies (and measured redshifts) for 11. The median of all 30 measured host redshifts from the survey to date is z = 0.23. We summarise results from the searches, in particular those contributing to our understanding of the burst progenitors and emission mechanisms, and on the use of bursts as probes of intervening media. We conclude by foreshadowing future FRB surveys with ASKAP using a coherent detection system that is currently being commissioned. This will increase the burst detection rate by a factor of approximately ten and also the distance to which ASKAP can localise FRBs.
The presented research investigates the impact of interference on the performance of aircraft Global Navigation Satellite System (GNSS) receivers with a specific focus on the behaviour of Automatic Dependent Surveillance-Broadcast (ADS-B) position quality indicators. Several experiments were performed with different aircraft types, such as Airbus, Boeing, Beechcraft King Air B350 or Tecnam, and using various intensities of GNSS jamming. The behaviour of various quality indicators, such as the Navigation Integrity Category, Navigation Accuracy Category, Source Integrity Level and System Design Assurance transmitted in different types of ADS-B messages, is analysed. We investigate not only situations where the quality indicators drop to zero, but also the complete evolution of the changes in the indicators as a function of the increasing power of the jamming signal. Based on the analysis of changes in the ADS-B quality indicators, the estimation of the most likely interference signal power required to discontinue the tracking of an already acquired GPS L1 Coarse/Acquisition signal is made. Additionally, the interference signal power to prevent re-acquisition is also estimated. The findings improve the understanding of interference effects and can support the development of robust interference mitigation techniques in aviation applications.
During 2021 through 2023, the golden mussel Limnoperna fortunei and freshwater fishes were sampled from 28 sites in the Tone River system, Japan, and adult trematodes of Dollfustrema were found in the fishes. Molecular and morphological analyses based on 28S rDNA and the ITS1−5.8S−ITS2 region revealed the trematode as ‘Dollfustrema hefeiense’, previously reported in Mainland China and likely introduced to Japan. Given that its scientific name was considered invalid, we re-described the species as Dollfustrema invadens n. sp. Additionally, the DNA-based survey helped clarify the trematode’s life cycle in the river system. A sporocyst and metacercariae were detected in the golden mussel’s visceral mass and in the muscles of two small freshwater fish species, respectively. The channel catfish Ictalurus punctatus harboured mature trematodes in its intestine, and adult trematodes were also found in the muscles of fishes infected with metacercariae, suggesting direct metacercariae development in fish muscle. Furthermore, another introduced bucephalid trematode, Prosorhynchoides ozakii, previously reported in the river system, was detected in the mussels and fishes. Moreover, co-infection of both bucephalid trematodes was observed in certain fishes.
Obsessive-compulsive disorder (OCD) is a neurobehavioral condition that can lead to functional impairment and decreased quality of life. In this chapter, clinical presentation, diagnostic considerations, and pathophysiology of OCD are reviewed. An overview of the theoretical models of OCD are provided, and evidence-based treatments for OCD, specifically cognitive behavioral therapy (CBT) with exposure and response prevention (ERP), pharmacotherapy, and neurosurgery, are discussed. The chapter concludes with suggestions for future research directions.
Accurate diagnosis of bipolar disorder (BPD) is difficult in clinical practice, with an average delay between symptom onset and diagnosis of about 7 years. A depressive episode often precedes the first manic episode, making it difficult to distinguish BPD from unipolar major depressive disorder (MDD).
Aims
We use genome-wide association analyses (GWAS) to identify differential genetic factors and to develop predictors based on polygenic risk scores (PRS) that may aid early differential diagnosis.
Method
Based on individual genotypes from case–control cohorts of BPD and MDD shared through the Psychiatric Genomics Consortium, we compile case–case–control cohorts, applying a careful quality control procedure. In a resulting cohort of 51 149 individuals (15 532 BPD patients, 12 920 MDD patients and 22 697 controls), we perform a variety of GWAS and PRS analyses.
Results
Although our GWAS is not well powered to identify genome-wide significant loci, we find significant chip heritability and demonstrate the ability of the resulting PRS to distinguish BPD from MDD, including BPD cases with depressive onset (BPD-D). We replicate our PRS findings in an independent Danish cohort (iPSYCH 2015, N = 25 966). We observe strong genetic correlation between our case–case GWAS and that of case–control BPD.
Conclusions
We find that MDD and BPD, including BPD-D are genetically distinct. Our findings support that controls, MDD and BPD patients primarily lie on a continuum of genetic risk. Future studies with larger and richer samples will likely yield a better understanding of these findings and enable the development of better genetic predictors distinguishing BPD and, importantly, BPD-D from MDD.
We demonstrate how few-shot prompts to large language models (LLMs) can be effectively applied to a wide range of text-as-data tasks in political science—including sentiment analysis, document scaling, and topic modeling. In a series of pre-registered analyses, this approach outperforms conventional supervised learning methods without the need for extensive data pre-processing or large sets of labeled training data. Performance is comparable to expert and crowd-coding methods at a fraction of the cost. We propose a set of best practices for adapting these models to social science measurement tasks, and develop an open-source software package for researchers.
Adolescence is a critical developmental phase during which young people are vulnerable to the experiences of mental ill-health and social exclusion (consisting of various domains including education and employment, housing, finances and social supports and relationships). The aims of this study were to (i) obtain an understanding of the relationships between social exclusion, mental health and wellbeing of young people; and (ii) identify potentially modifiable targets, or population groups that require greater or targeted supports.
Methods
Data were obtained from the Mission Australia 2022 Youth Survey, Australia’s largest annual population-wide survey of young people aged 15–19 years (n = 18,800). Participants’ experiences of social exclusion in different domains were explored (e.g., prevalence, co-occurrence and controlling for differences in demographic characteristics). Multivariable linear regression models were used to map the relationships between social exclusion domains and mental health and wellbeing, controlling for confounding factors where necessary.
Results
Sixty per cent of all young people experienced social exclusion in at least one domain, 25% in multiple. Young people who identified as gender diverse, Indigenous, living in a remote/rural or socio-economically disadvantaged area and with a culturally diverse background were more likely to report social exclusion. A strong association was seen between all domains of social exclusion and poor mental health (e.g., higher psychological distress and loneliness, reduced personal wellbeing, reduced sense of control over their life and a more negative outlook on the future). Notably, difficulties in socialising and obtaining social support were critical factors linked to increased psychological distress and reduced wellbeing.
Conclusions
Findings underscore the need to address multiple domains of social exclusion concurrently, and in collaboration with youth mental healthcare. Prevention efforts aimed at early identification and intervention should be prioritised to support young people vulnerable to social exclusion. Screening approaches are needed to identify individuals and groups of young people in need of support, and to facilitate care coordination across multiple providers.
People frequently engage in dishonest behavior, which entails costs to society. A common advice to increase honesty is to enhance observability. However, previous research produced conflicting findings, making it unclear when and why observability increases honesty. Here we show that observability enhances honesty when observers can gossip to relevant others (i.e., to future interaction partners who can influence the gossip target’s outcome), because it increases reputational concern. In 2 incentivized and pre-registered studies, participants privately rolled a die 30 times and were informed that reporting higher numbers would lead to higher outcomes (total N = 1608; 28650 observations). We manipulated observability and gossip. Both studies revealed that gossip to relevant others decreased dishonest reporting, whereas mere observation did not. Importantly, reputational concern partly mediated the impact of gossip on dishonesty. Moreover, gossip influenced recipients’ trust in gossip targets, with messages denoting dishonesty swaying trust more than messages denoting honesty. Our findings demonstrate when and why observability promotes honesty.
Cystic Echinococcosis (CE) is a zoonotic disease caused by Echinococcus granulosus sensu lato. Diagnosing CE primarily relies on imaging techniques, and there is a crucial need for an objective laboratory test to enhance the diagnostic process. Today, cell-free DNAs (cfDNAs) have gained importance regarding their biomarker potential. This study aims to investigate the diagnostic capabilities of different cfDNA targets (Echinococcus-specific repeat sequences (mgs-4 and mgs-12) and partial fragment of repetitive sequence (EG1 Hae III)) and evaluate their diagnostic effectiveness when compared to a frequently used commercial E.granulosus-specific IgG ELISA. Seventy-six confirmed hepatic CE patients and healthy controls were included in the study. The EG1 Hae III region was assessed using nested PCR, whereas real-time PCR was employed to investigate other cfDNA targets. Analysis of the cfDNA-targeted tests indicated that mgs-4 demonstrated the highest diagnostic efficacy in distinguishing CE patients from healthy controls, achieving a sensitivity of 60.5% (p = 0.002). Combining ELISA with the mgs-4 target led to an increased sensitivity of 72.4% for distinguishing between CE patients and the control group. The sensitivity rates for ELISA and the three cfDNA targets varied among the groups. Active CE patients showed sensitivity rates of 52.9%, 52.9%, 23.5%, and 52.9% for ELISA, mgs-4, mgs-12, and EG1 Hae III assays, respectively. In contrast, inactive cyst patients displayed sensitivity rates of 21.4%, 66.7%, 19%, and 42.9% for the corresponding assays. The mgs-4, either alone or in combination with ELISA, demonstrated notably higher sensitivity values for CE diagnosis in all group comparisons compared to serology.