2 results
The role of local agriculture in the new natural resource economy (NNRE) for rural economic development
- Susan Lurie, Christy Anderson Brekken
-
- Journal:
- Renewable Agriculture and Food Systems / Volume 34 / Issue 5 / October 2019
- Published online by Cambridge University Press:
- 05 December 2017, pp. 395-405
-
- Article
- Export citation
-
Rural communities have faced significant socio-economic challenges for the past several decades due to structural shifts and changing social expectations regarding the management, production of, and markets for natural resources, including production agriculture. The New Natural Resource Economy (NNRE) is an economic development approach to the use of natural resources, including agriculture, in ways that can build healthy environments and healthy, resilient local economies (Hibbard and Lurie, 2013). A major attribute of the NNRE is its focus on very small businesses, the predominant business type in rural settings. Emerging trends, such as regional food networks (RFNs) that connect food producers to consumers within a state or local region, may provide opportunities for rural communities to diversify and expand local businesses around the use of natural resources, thereby helping to restore greater capacity for self-direction and adding to local community vitality. Thus, we address whether RFNs in rural Oregon counties display characteristics of an NNRE development strategy through the relationships between agricultural producers and consumers that support very small agricultural enterprises. Based on analysis of Oregon producer survey data from 2016 in the more rural resource-dependent Oregon counties, we find that the RFN producer survey respondents are indeed very small businesses engaged in small-scale, multifunctional agriculture. They are motivated by economic, social, and environmental concerns as they contribute to the economic activity in their communities. We also surveyed Oregon consumers, finding that although consumer survey respondents in the same region are not primarily driven to buy local based on environmental considerations, they are nonetheless interested in supporting agriculture and local businesses. The demand for local products can create a virtuous cycle contributing to the economic, social, and environmental sustainability of the community. Given appropriate policy and program support, there is fertile ground to create new opportunities to generate farm income and acquire food within the NNRE healthy environment-healthy economy paradigm for rural economic development.
Genome-Wide Association Study for Ovarian Cancer Susceptibility Using Pooled DNA
- Yi Lu, Xiaoqing Chen, Jonathan Beesley, Sharon E. Johnatty, Anna deFazio, Australian Ovarian Cancer Study (AOCS) Study Group, Sandrina Lambrechts, Diether Lambrechts, Evelyn Despierre, Ignace Vergotes, Jenny Chang-Claude, Rebecca Hein, Stefan Nickels, Shan Wang-Gohrke, Thilo Dörk, Matthias Dürst, Natalia Antonenkova, Natalia Bogdanova, Marc T. Goodman, Galina Lurie, Lynne R. Wilkens, Michael E. Carney, Ralf Butzow, Heli Nevanlinna, Tuomas Heikkinen, Arto Leminen, Lambertus A. Kiemeney, Leon F.A.G. Massuger, Anne M. van Altena, Katja K. Aben, Susanne Krüger Kjaer, Estrid Høgdall, Allan Jensen, Angela Brooks-Wilson, Nhu Le, Linda Cook, Madalene Earp, Linda Kelemen, Douglas Easton, Paul Pharoah, Honglin Song, Jonathan Tyrer, Susan Ramus, Usha Menon, Alexandra Gentry-Maharaj, Simon A. Gayther, Elisa V. Bandera, Sara H. Olson, Irene Orlow, Lorna Rodriguez-Rodriguez, Stuart Macgregor, Georgia Chenevix-Trench
-
- Journal:
- Twin Research and Human Genetics / Volume 15 / Issue 5 / October 2012
- Published online by Cambridge University Press:
- 13 July 2012, pp. 615-623
-
- Article
-
- You have access Access
- HTML
- Export citation
-
Recent Genome-Wide Association Studies (GWAS) have identified four low-penetrance ovarian cancer susceptibility loci. We hypothesized that further moderate- or low-penetrance variants exist among the subset of single-nucleotide polymorphisms (SNPs) not well tagged by the genotyping arrays used in the previous studies, which would account for some of the remaining risk. We therefore conducted a time- and cost-effective stage 1 GWAS on 342 invasive serous cases and 643 controls genotyped on pooled DNA using the high-density Illumina 1M-Duo array. We followed up 20 of the most significantly associated SNPs, which are not well tagged by the lower density arrays used by the published GWAS, and genotyping them on individual DNA. Most of the top 20 SNPs were clearly validated by individually genotyping the samples used in the pools. However, none of the 20 SNPs replicated when tested for association in a much larger stage 2 set of 4,651 cases and 6,966 controls from the Ovarian Cancer Association Consortium. Given that most of the top 20 SNPs from pooling were validated in the same samples by individual genotyping, the lack of replication is likely to be due to the relatively small sample size in our stage 1 GWAS rather than due to problems with the pooling approach. We conclude that there are unlikely to be any moderate or large effects on ovarian cancer risk untagged by less dense arrays. However, our study lacked power to make clear statements on the existence of hitherto untagged small-effect variants.