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vogt koyanagi harada (vkh) disease

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Chapter 1.2 - Chapter
from 1 - Inflammatory Conditions
Edited by Derya Uluduz, Istanbul Üniversitesi
Anita Arsovska
Book:

Rare Causes of Stroke

Published online:

06 October 2022

Print publication:

01 September 2022, pp 50-53
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Summary

Vogt Koyanagi Harada (VKH) disease is an idiopathic autoimmune disease primarily manifesting as bilateral, chronic, and diffuse granulomatous panuveitis associated with auditory, neurological, and integumentary findings. Clinical suspicious of VKH is female dominance, flu-like symptoms with meningismus preceding acute blurring of vision, ocular disease, recurrent aseptic meningitis with or without focal neurologic findings, sunset glow fundus. Patients has four clinical stages; prodromal or early stage, uveitic stage, convalescent stage which is characterized by depigmentation of the choroid, hair and skin, and chronic stage usually occurs in the first six months. The emergency or primary care physician may be the point of first contact with a patient with VKH disease. The key components of managing this disease are awareness of symptoms that lead to early diagnosis and a multidisciplinary approach. For patients with severe visual loss and bilateral serous retinal detachments, systemic prednisolone at 1-2mg/kg/day is started