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Meta-analysis of the response of growing pigs to the isoleucine concentration in the diet

Published online by Cambridge University Press:  28 February 2012

J. van Milgen ,
M. Gloaguen ,
N. Le Floc'h ,
L. Brossard ,
Y. Primot  and
E. Corrent
J. van Milgen*
Affiliation:
INRA, UMR1348 PEGASE, F-35590 Saint-Gilles, France Agrocampus Ouest, UMR1348 PEGASE, F-35000 Rennes, France
M. Gloaguen
Affiliation:
INRA, UMR1348 PEGASE, F-35590 Saint-Gilles, France Agrocampus Ouest, UMR1348 PEGASE, F-35000 Rennes, France AJINOMOTO EUROLYSINE S.A.S., 75817 Paris Cedex 17, France
N. Le Floc'h
Affiliation:
INRA, UMR1348 PEGASE, F-35590 Saint-Gilles, France Agrocampus Ouest, UMR1348 PEGASE, F-35000 Rennes, France
L. Brossard
Affiliation:
INRA, UMR1348 PEGASE, F-35590 Saint-Gilles, France Agrocampus Ouest, UMR1348 PEGASE, F-35000 Rennes, France
Y. Primot
Affiliation:
AJINOMOTO EUROLYSINE S.A.S., 75817 Paris Cedex 17, France
E. Corrent
Affiliation:
AJINOMOTO EUROLYSINE S.A.S., 75817 Paris Cedex 17, France
*
†Email: jaap.vanmilgen@rennes.inra.fr
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Abstract

The efficiency of nitrogen utilization will be highest when the amino acid (AA) supply approaches the requirement of the animal. With the availability of different crystalline AA, it is theoretically possible to formulate low-protein diets for growing pigs in which seven AA are co-limiting for performance. In such a diet, the concentration of Lys, Met, Met + Cys, Thr, Trp and Val and a seventh AA would exactly match the requirement. To determine the extent to which low-protein diets can be used, it is important to have reliable information about the requirements for these AA. Isoleucine is often considered the seventh-limiting AA in diets for growing pigs; however, information about the Ile requirement is limited and sometimes conflicting. The purpose of this study was to carry out a meta-analysis of the available literature information to determine the Ile requirement in growing pigs. A total of 46 Ile dose–response experiments were identified that used at least four concentrations of Ile in the diet. Because of differences in experimental design, both the Ile concentration and the response criteria were standardized. In 13 dose–response experiments, there was no indication of a response to an increasing Ile concentration. For the other 33 experiments, a response to the increasing Ile concentration was observed and the Ile requirement estimates ranged from 53% to 114% of that of the National Research Council (1998). An Ile concentration below the requirement resulted in important reductions in both feed intake and growth. A 10% reduction in the Ile concentration (below the requirement) resulted in a 15% reduction in feed intake and a 21% reduction in daily gain. The use of blood products in the diet was the main factor determining whether a response to the Ile concentration was observed or not. Blood meal and blood cells are protein sources with a very low Ile concentration, but with high or very high concentrations of Leu, Val, Phe and His. Some of these AA compete with Ile for catabolic pathways or transport across the blood–brain barrier, thereby potentially increasing the requirement for Ile. In diets without blood products, the Ile requirement appears to be lower than the currently recommended requirement. On the basis of the outcome of this study, we recommend a Ile : Lys requirement ratio of at least 50% on a standardized ileal digestible basis.

Keywords

isoleucinepigsnutrient requirementsmeta-analysisamino acids
Type
Full Paper
Information
animal , Volume 6 , Issue 10 , October 2012 , pp. 1601 - 1608
Copyright
Copyright © The Animal Consortium 2012

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References

Barea, R, Brossard, L, Le Floc'h, N, Primot, Y, van Milgen, J 2009a. The standardized ileal digestible isoleucine-to-lysine requirement ratio may be lower than fifty percent in eleven- to twenty-three-kilogram piglets. Journal of Animal Science 87, 4022–4031.CrossRefGoogle Scholar
Barea, R, Brossard, L, Le Floc'h, N, Primot, Y, Melchior, D, van Milgen, J 2009b. The standardized ileal digestible valine-to-lysine requirement ratio is at least seventy percent in postweaned piglets. Journal of Animal Science 87, 935–947.CrossRefGoogle ScholarPubMed
Becker, DE, Jensen, AH, Terrill, SW, Smith, ID, Norton, HW 1957. The isoleucine requirement of weanling swine fed two protein levels. Journal of Animal Science 16, 26–34.CrossRefGoogle Scholar
Becker, DE, Smith, ID, Terrill, SW, Jensen, AH, Norton, HW 1963. Isoleucine need of swine at two stages of development. Journal of Animal Science 22, 1093–1096.CrossRefGoogle Scholar
Bergström, JR, Nelssen, JL, Tokach, MD, Goodband, RD, Dritz, SS, Loughmiller, JA, Musser, RE, Nessmith, WB Jr 1996a. Determining the optimal isoleucine:lysine ratio for the 25 to 50 lb pig. Kansas State University Swine Day 1996, pp. 30–33.CrossRefGoogle Scholar
Bergström, JR, Nelssen, JL, Tokach, MD, Goodband, RD, Dritz, SS, Loughmiller, JA, Musser, RE, Nessmith, WB Jr 1996b. Determining the optimal isoleucine:lysine ratio in diets for the segregated early-weaned pig. Kansas State University Swine Day 1996, pp. 26–30.CrossRefGoogle Scholar
Boisen, S 2003. Ideal dietary amino acid profiles for pigs. In Amino acids in animal nutrition (ed. JPF D'Mello), pp. 157–168. CABI Publishing, Oxon, UK.CrossRefGoogle Scholar
Bravo, FO, Meade, RJ, Stockland, WL, Nordstrom, JW 1970. Reevaluation of the insoleucine requirement of the growing pig – plasma free isoleucine as a response criterion. Journal of Animal Science 31, 1137–1141.CrossRefGoogle ScholarPubMed
Brinegar, MJ, Loosli, JK, Maynard, LA, Williams, HH 1950. The isoleucine requirement for the growth of swine. Journal of Nutrition 42, 619–624.CrossRefGoogle ScholarPubMed
British Society of Animal Science 2003. Nutrient requirement standards for pigs. British Society of Animal Science, Penicuik, UK.Google Scholar
Dean, DW, Southern, LL, Kerr, BJ, Bidner, TD 2005. Isoleucine requirement of 80- to 120-kilogram barrows fed corn–soybean meal or corn–blood cell diets. Journal of Animal Science 83, 2543–2553.CrossRefGoogle ScholarPubMed
Fu, SX 2005. Isoleucine requirement and imbalance in swine. PhD, Univ. Missouri.Google Scholar
Fu, SX, Fent, RW, Allee, GL, Usry, JL 2006. Branched chain amino acid interactions increases isoleucine requirement in late-finishing pigs. Journal of Animal Science 84 (suppl. 1), 283–284.Google Scholar
Gahl, MJ, Crenshaw, TD, Benevenga, NJ 1995. Diminishing returns in weight, nitrogen, and lysine gain of pigs fed six levels of lysine from three supplemental sources. Journal of Animal Science 73, 3177–3187.Google Scholar
Gaines, AM, Kendall, DC, Allee, GL, Usry, JL, Kerr, BJ 2011. Estimation of the standardized ileal digestible valine to lysine ratio in 13 to 32 kg pigs. Journal of Animal Science 89, 736–742.CrossRefGoogle Scholar
Gietzen, DW, Magrum, LJ 2001. Molecular mechanisms in the brain involved in the anorexia of branched-chain amino acid deficiency. Journal of Nutrition 131, S851–S885.CrossRefGoogle ScholarPubMed
Harper, AE, Millar, RH, Block, KP 1984. Branched-chain amino acid metabolism. Annual Review of Nutrition 4, 409–454.CrossRefGoogle ScholarPubMed
Henry, Y 1993. Affinement du concept de la protéine idéale pour le porc en croissance. INRA Productions Animales 6, 199–212.CrossRefGoogle Scholar
Henry, Y, Duée, PH, Rérat, A 1976. Isoleucine requirement of the growing pig and leucine–isoleucine interrelationship. Journal of Animal Science 42, 357–364.CrossRefGoogle ScholarPubMed
Htoo, J, Quant, AD, Cho, JH, Kerr, BJ, Cromwell, GL, Lindemann, MD 2010. Optimum isoleucine to lysine ratio in wheat and barley based diets fed to growing pigs. In Proceedings of the 3rd International Symposium on Energy and Protein Metabolism and Nutrition, Parma, Italy (ed. GM Crovetto), pp. 611–612, Wageningen Academic Publishers, Wageningen, the Netherlands.Google Scholar
James, BW, Goodband, RD, Tokach, MD, Nelssen, JL, DeRouchey, JM 2000. The optimum isoleucine:lysine ratio in starter diets to maximize growth performance of the early-weaned pigs. Kansas State University Swine Day 2000, pp. 20–26.CrossRefGoogle Scholar
Kendall, DC 2004. Opportunities and limitations for low-protein diet formulation in swine. PhD, Univ. Missouri.Google Scholar
Kendall, DC, Gaines, AM, Allee, GL, Usry, JL 2008. Commercial validation of the true ileal digestible lysine requirement for eleven- to twenty-seven-kilogram pigs. Journal of Animal Science 86, 324–332.CrossRefGoogle ScholarPubMed
Kerr, BJ, Kidd, MT, Cuaron, JA, Bryant, KL, Parr, TM, Maxwell, CV, Campbell, JM 2004. Isoleucine requirements and ratios in starting (7 to 11 kg) pigs. Journal of Animal Science 82, 2333–2342.CrossRefGoogle ScholarPubMed
Langer, S, Fuller, MF 2000. Interactions among the branched-chain amino acids and their effects on methionine utilization in growing pigs: effects of nitrogen retention and amino acid utilization. British Journal of Nutrition 83, 43–48.CrossRefGoogle ScholarPubMed
Lawrence, BV, Hahn, JD, Hansen, SA, Hansen, J, Hansen, E, Musser, R, Rademacher, M 2004. Standard ileal digestible isoleucine and tryptophan ratios to lysine for late finishing pigs. Journal of Animal Science 82 (suppl. 2), 45.Google Scholar
Lenis, NP, van Diepen, JTM 1997. Requirement for apparent ileal digestible isoleucine of young pigs. Journal of Animal Science 75 (suppl. 1), 186.Google Scholar
Lewis, AJ, Baker, DH 1995. Bioavailability of d-amino acids and dl-hydroxy-methionine. In Bioavailabiloity of nutrients for animals. Amino acids, minerals, and vitamins (ed. CB Ammerman, DH Baker and AJ Lewis), pp. 67–81. Academic Press, San Diego, USA.Google Scholar
Lordelo, MM, Gaspar, AM, Le Bellego, L, Freire, JPB 2008. Isoleucine and valine supplementation of a low-protein corn-wheat-soybean meal-based diet for piglets: growth performance and nitrogen balance. Journal of Animal Science 86, 2936–2941.CrossRefGoogle ScholarPubMed
Nørgaard, JV, Fernández, JA 2009. Isoleucine and valine supplementation of crude protein-reduced diets for pigs aged 5–8 weeks. Animal Feed Science and Technology 154, 248–253.CrossRefGoogle Scholar
National Research Council 1998. Nutrient requirements of swine, 10th revised edition. National Academy Press, Washington, DC, USA.Google Scholar
Oestemer, GA, Hanson, LE, Meade, RJ 1973. Reevaluation of the isoleucine requirement of the young pig. Journal of Animal Science 36, 679–683.CrossRefGoogle ScholarPubMed
Parr, TM, Kerr, BJ, Baker, DH 2003. Isoleucine requirement of growing (25 to 45 kg) pigs. Journal of Animal Science 81, 745–752.CrossRefGoogle ScholarPubMed
Parr, TM, Kerr, BJ, Baker, DH 2004. Isoleucine requirement for late-finishing (87 to 100 kg) pigs. Journal of Animal Science 82, 1334–1338.CrossRefGoogle ScholarPubMed
Pomar, C, Kyriazakis, I, Emmans, GC, Knap, PW 2003. Modeling stochasticity: dealing with populations rather than individual pigs. Journal of Animal Science 81 (E. suppl. 2), E178–E186.Google Scholar
SAS 2000. SAS/STAT user's guide, version 8. SAS Publishing, Cary, NC, USA.Google Scholar
Sauvant, D, Perez, J-M, Tran, G 2004. Tables of composition and nutritional value of feed materials. Pigs, poultry, cattle, sheep, goats, rabbits, horses, fish. INRA Editions, Paris, France.CrossRefGoogle Scholar
Smith, QR 2000. Transport of glutamate and other amino acids at the blood-brain barrier. Journal of Nutrition 130, 1016S–1022S.CrossRefGoogle ScholarPubMed
Taylor, SJ, Cole, DJA, Lewis, D 1985. Amino acid requirements of growing pigs. 6. Isoleucine. Animal Production 40, 153–160.Google Scholar
Trautwein, J, Dusel, G, Bartelt, J, Corrent, E 2010. Valine and isoleucine requirement of weaned piglets fed low-protein diet. In 11. Tagung Schweine- und Geflügelernährung, Martin Luther Universität, Halle-Wittenberg, Germany, 3pp.Google Scholar
Wiltafsky, MK, Pfaffl, MW, Roth, FX 2010. The effects of branched-chain amino acid interactions on growth performance, blood metabolites, enzyme kinetics and transcriptomics in weaned pigs. British Journal of Nutrition 103, 964–976.CrossRefGoogle ScholarPubMed
Wiltafsky, MK, Bartelt, J, Relandeau, C, Roth, FX 2009. Estimation of the optimum ratio of standardized ileal digestible isoleucine to lysine for eight- to twenty-five-kilogram pigs in diets containing spray-dried blood cells or corn gluten feed as a protein source. Journal of Animal Science 87, 2554–2564.CrossRefGoogle ScholarPubMed
Zhu, CL, Htoo, JK, de Lange, CFM 2009. Optimum isoleucine to lysine ratio in a barley and wheat based pig starter diet. Canadian Journal of Animal Science 89, 174.Google Scholar
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