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Possible immunological damage to the tegument of Hymenolepis diminuta in mice and rats

Published online by Cambridge University Press:  06 April 2009

A. D. Befus  and
L. T. Threadgold
A. D. Befus
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden, Glasgow, G61 1QH, Scotland
L. T. Threadgold
Affiliation:
Department of Zoology, The Queen's University, Belfast, BT7 1NN, Northern Ireland
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Extract

Opaque or darkened areas (DA) of variable size and position occur on Hymenolepis diminuta in mice and rats. In mice DA normally first appear in the neck region of the worm but subsequently they appear elsewhere and increase in number until destrobilation or worm expulsion. The posterior of destrobilated worms is often darkened. In the more immunogenic infections with six cysticercoids there are more DA per worm than in infections with one cysticercoid. DA are areas of the tegument with a homogeneous increase in electron density; abnormal mitochondria; reduced granular endoplasmic reticulum, Golgi complexes and discoidal secretory bodies; and accumulation of lipid droplets. DA disappear from worms maintained for up to 4 h in Hanks' balanced salt solution and can be induced by mechanical damage to the worms.

As the numbers of DA increase with the duration and intensity of infection and have similarities with types of cell injury, they are probably sites of worm pathology induced by host immunity.

Type
Research Article
Information
Parasitology , Volume 71 , Issue 3 , December 1975 , pp. 525 - 534
Copyright
Copyright © Cambridge University Press 1975

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