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Suppression of the immune response to Trichuris muris in lactating mice

Published online by Cambridge University Press:  06 April 2009

Gwendoline R. Selby  and
D. Wakelin
Gwendoline R. Selby
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden Road, Glasgow G61 1QH
D. Wakelin
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden Road, Glasgow G61 1QH
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Extract

Mice infected with Trichuris muris during lactation were unable to expel the infection at the normal time, but expulsion occurred when lactation was terminated. Suppression of expulsion was uniform in mice suckling more than five young but variable with smaller litters. Mice exposed to a primary infection while lactating were shown to have serum antibodies capable of passively transferring immunity to recipient mice and showed near normal immunity to a secondary infection given after lactation had ceased.

Acquired immunity to T. muris was also suppressed by lactation, but the worms which became established in lactating resistant mice were fewer and smaller than those in non-lactating, non-resistant controls.

It is suggested that the suppressive effect of lactation in this hostparasite relationship is exerted on the second, lymphoid cell-mediated phase of worm expulsion.

Type
Research Article
Information
Parasitology , Volume 71 , Issue 1 , August 1975 , pp. 77 - 85
Copyright
Copyright © Cambridge University Press 1975

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References

Connan, R. M. (1967). Observations on the post parturient rise in the faecal nematode egg count in ewes. Veterinary Record 80, 401–5.CrossRefGoogle ScholarPubMed
Connan, R. M. (1968). The post parturient rise in the faecal egg count in ewes. Its aetiology and epidemiological significance. World Review of Animal Production 4, 53–7.Google Scholar
Connan, R. M. (1970). The effect of host lactation on the self cure of Nippostrongylus brasiliensis in rats. Parasitology 61, 27–33.CrossRefGoogle Scholar
Connan, R. M. (1972). The effect of host lactation on a second infection of Nippostrongylus brasiliensis in rats. Parasitology 64, 229–33.CrossRefGoogle ScholarPubMed
Connan, R. M. (1973). The immune response of lactating rats to Nippostrongylus brasiliensis. Immunology 25, 261–8.Google ScholarPubMed
Dineen, J. K. & Kelly, J. D. (1972). The suppression of rejection of Nippostrongyls brasiliensis in lactating rats: the nature of the immunological defect. Immunology 22, 1–12.Google ScholarPubMed
Dineen, J. K., Ogilvie, B. M. & Kelly, J. D. (1973). Expulsion of Nippostrongylus brasiliensis from the intestine of rats: collaboration between cellular and humoral components of the immune response. Immunology 24, 467–76.Google ScholarPubMed
Dunsmore, J. D. (1965). Ostertagia spp. in lambs and pregnant ewes. Journial of Helminthology 39, 159–84.CrossRefGoogle ScholarPubMed
Dunsmore, J. D. (1966). Influence of host reproduction on the number of trichostrongylid nematodes in the European rabbit, Oryctolagus cuniculus (L). Journal of Parasitology 52, 1129–33.CrossRefGoogle ScholarPubMed
Meites, J. & Nicoll, C. S. (1959). Hormonal prolongation of lactation for 75 days after litter withdrawal in post-partum rats. Endocrinology 65, 572–9.CrossRefGoogle Scholar
O'Sullivan, B. M. (1974). Effects of lactation on Trichostrongylus colubriformis infections in the guinea pig. International Journal for Parasitology 4, 177–81.CrossRefGoogle ScholarPubMed
O'Sullivan, B. M. & Donald, A. D. (1970). A field study of nematode parasitic populations in the lactating ewe. Parasitology 61, 301–15.CrossRefGoogle ScholarPubMed
O'Sullivan, B. M. & Donald, A. D. (1973). Responses to infection with Haemonchus contortus and Trichostrongylus colubriformis in ewes of different reproductive status. International Journal for Parasitology 3, 521–30.CrossRefGoogle ScholarPubMed
Selby, G. R. & Wakelin, D. (1973). Transfer of immunity against Trichuris muris in the mouse by serum and cells. International Journal of Parasitology 3, 717–22.CrossRefGoogle ScholarPubMed
Wakelin, D. (1967). Acquired immunity to Trichuris muris in the albino laboratory mouse. Parasitology 57, 515–24.CrossRefGoogle ScholarPubMed
Wakelin, D. (1969). Studies on the immunity of albino mice to Trichuris muris. The stimulation of immunity by chemically abbreviated infections. Parasitology 59, 549–55.CrossRefGoogle ScholarPubMed
Wakelin, D. (1975 a). Immune expulsion of Trichuris muris from mice during a primary infection. Analysis of the components involved. Parasitology (in the Press).CrossRefGoogle ScholarPubMed
Wakelin, D. (1975 b). Genetic control of immunity to parasites. I. Immunity to Trichuris muris in inbred and random-bred strains of mice. Parasitology (in the Press).Google ScholarPubMed