Giant reed recently was promoted as a biofuel crop in Oregon. Because giant reed is a highly invasive plant in North American rivers, the planting of this species in Oregon is a cause for concern to scientists and local land managers. However, some growers in the area were interested in producing giant reed as a rotational crop. To find potential herbicides to control the giant reed or to control it as a volunteer, 13 foliar and 13 cut-and-spray herbicide treatments were preevaluated in greenhouse studies. We chose 10% and 85% reduction in aboveground biomass for either crop safety or control, respectively. When applied at the standard rates, acetochlor and dimethenamid-p reduced aboveground dry biomass of the crop by 10% or less. Acetochlor+atrazine, atrazine, flufenacet, and mesotrione reduced aboveground biomass of the crop by at least 85%, indicating that these compounds have the potential to serve as controls against giant reed.