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The potential role of cholecystokinin in schizophrenia: review and update

Published online by Cambridge University Press:  16 April 2020

R Payeur ,
MK Nixon ,
M Bourin ,
J Bradwejn  and
JM Legrand
R Payeur
Affiliation:
Département de pharmacologie et GIS Médicament, Faculté de Médecine, 1 rue Gaston Veil, 44035 Nantes Cedex, France
MK Nixon
Affiliation:
Département de pharmacologie et GIS Médicament, Faculté de Médecine, 1 rue Gaston Veil, 44035 Nantes Cedex, France
M Bourin*
Affiliation:
Département de pharmacologie et GIS Médicament, Faculté de Médecine, 1 rue Gaston Veil, 44035 Nantes Cedex, France
J Bradwejn
Affiliation:
St Mary’s Hospital – Mc Gill University, 3830 Lacombe Av, Montréal, Canada
JM Legrand
Affiliation:
Département de pharmacologie et GIS Médicament, Faculté de Médecine, 1 rue Gaston Veil, 44035 Nantes Cedex, France
*
*Correspondence and reprints.
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Summary

The role of the neuropeptide cholecystokinin in schizophrenia has been widely explored because of its modulating action on midbrain dopamine neurons. The recent discovery of more specific receptor subtype cholecystokinin antagonists should be considered as potential treatment for schizophrenia with fewer side effects. This paper reviews cholecystokinin/dopamine interactions in animal and human studies. Clinical trials with cholecystokinin agonists and antagonists in schizophrenia are updated.

Keywords

CholecystokininschizophreniaCCK A receptorCCK B receptordopamine/CCK interaction
Type
Review
Information
European Psychiatry , Volume 8 , Issue 2 , 1993 , pp. 67 - 78
Copyright
Copyright © Elsevier, Paris 1993

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